Evidence That Pioglitazone Increases Intracellular Free Magnesium Concentration in Freshly Isolated Rat Adipocytes
Pioglitazone is one of a new class of oral agents being developed as antidiabetic agents which can increase insulin sensitivity, reduce blood pressure and improve abnormalities in lipid metabolism. The mechanism of action of pioglitazone is not known. Increasing evidence suggests that magnesium can...
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1994 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Biochemical and Biophysical Research Communications - Amsterdam : Elsevier, 202(1994), 1, Seite 416-421 |
| Übergeordnetes Werk: |
volume:202 ; year:1994 ; number:1 ; pages:416-421 |
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| 245 | 1 | 0 | |a Evidence That Pioglitazone Increases Intracellular Free Magnesium Concentration in Freshly Isolated Rat Adipocytes |
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| 520 | |a Pioglitazone is one of a new class of oral agents being developed as antidiabetic agents which can increase insulin sensitivity, reduce blood pressure and improve abnormalities in lipid metabolism. The mechanism of action of pioglitazone is not known. Increasing evidence suggests that magnesium can play an important role in regulating glucose homeostasis and vascular tone. To clarify a potential mechanism of pioglitazone action we determined the effects of pioglitazone on intracellular free magnesium concentration in freshly isolated rat adipocytes. Concentrations of pioglitazone as low as 300 nM markedly increased the free magnesium concentration in the adipocytes. Pioglitazone action was selective for magnesium since intracellular free calcium concentration was not altered. These new data suggest that a potentially important mechanism explaining the metabolic and vascular actions of these new anti-diabetic agents is increasing free magnesium concentration in target tissues. | ||
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(DE-627)NLEJ183478053 (DE-599)GBVNLZ183478053 DE-627 ger DE-627 rakwb eng Evidence That Pioglitazone Increases Intracellular Free Magnesium Concentration in Freshly Isolated Rat Adipocytes 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pioglitazone is one of a new class of oral agents being developed as antidiabetic agents which can increase insulin sensitivity, reduce blood pressure and improve abnormalities in lipid metabolism. The mechanism of action of pioglitazone is not known. Increasing evidence suggests that magnesium can play an important role in regulating glucose homeostasis and vascular tone. To clarify a potential mechanism of pioglitazone action we determined the effects of pioglitazone on intracellular free magnesium concentration in freshly isolated rat adipocytes. Concentrations of pioglitazone as low as 300 nM markedly increased the free magnesium concentration in the adipocytes. Pioglitazone action was selective for magnesium since intracellular free calcium concentration was not altered. These new data suggest that a potentially important mechanism explaining the metabolic and vascular actions of these new anti-diabetic agents is increasing free magnesium concentration in target tissues. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Nadler, J. oth Scott, S. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 202(1994), 1, Seite 416-421 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:202 year:1994 number:1 pages:416-421 http://dx.doi.org/10.1006/bbrc.1994.1944 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 202 1994 1 416-421 |
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(DE-627)NLEJ183478053 (DE-599)GBVNLZ183478053 DE-627 ger DE-627 rakwb eng Evidence That Pioglitazone Increases Intracellular Free Magnesium Concentration in Freshly Isolated Rat Adipocytes 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pioglitazone is one of a new class of oral agents being developed as antidiabetic agents which can increase insulin sensitivity, reduce blood pressure and improve abnormalities in lipid metabolism. The mechanism of action of pioglitazone is not known. Increasing evidence suggests that magnesium can play an important role in regulating glucose homeostasis and vascular tone. To clarify a potential mechanism of pioglitazone action we determined the effects of pioglitazone on intracellular free magnesium concentration in freshly isolated rat adipocytes. Concentrations of pioglitazone as low as 300 nM markedly increased the free magnesium concentration in the adipocytes. Pioglitazone action was selective for magnesium since intracellular free calcium concentration was not altered. These new data suggest that a potentially important mechanism explaining the metabolic and vascular actions of these new anti-diabetic agents is increasing free magnesium concentration in target tissues. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Nadler, J. oth Scott, S. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 202(1994), 1, Seite 416-421 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:202 year:1994 number:1 pages:416-421 http://dx.doi.org/10.1006/bbrc.1994.1944 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 202 1994 1 416-421 |
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(DE-627)NLEJ183478053 (DE-599)GBVNLZ183478053 DE-627 ger DE-627 rakwb eng Evidence That Pioglitazone Increases Intracellular Free Magnesium Concentration in Freshly Isolated Rat Adipocytes 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pioglitazone is one of a new class of oral agents being developed as antidiabetic agents which can increase insulin sensitivity, reduce blood pressure and improve abnormalities in lipid metabolism. The mechanism of action of pioglitazone is not known. Increasing evidence suggests that magnesium can play an important role in regulating glucose homeostasis and vascular tone. To clarify a potential mechanism of pioglitazone action we determined the effects of pioglitazone on intracellular free magnesium concentration in freshly isolated rat adipocytes. Concentrations of pioglitazone as low as 300 nM markedly increased the free magnesium concentration in the adipocytes. Pioglitazone action was selective for magnesium since intracellular free calcium concentration was not altered. These new data suggest that a potentially important mechanism explaining the metabolic and vascular actions of these new anti-diabetic agents is increasing free magnesium concentration in target tissues. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Nadler, J. oth Scott, S. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 202(1994), 1, Seite 416-421 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:202 year:1994 number:1 pages:416-421 http://dx.doi.org/10.1006/bbrc.1994.1944 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 202 1994 1 416-421 |
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(DE-627)NLEJ183478053 (DE-599)GBVNLZ183478053 DE-627 ger DE-627 rakwb eng Evidence That Pioglitazone Increases Intracellular Free Magnesium Concentration in Freshly Isolated Rat Adipocytes 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pioglitazone is one of a new class of oral agents being developed as antidiabetic agents which can increase insulin sensitivity, reduce blood pressure and improve abnormalities in lipid metabolism. The mechanism of action of pioglitazone is not known. Increasing evidence suggests that magnesium can play an important role in regulating glucose homeostasis and vascular tone. To clarify a potential mechanism of pioglitazone action we determined the effects of pioglitazone on intracellular free magnesium concentration in freshly isolated rat adipocytes. Concentrations of pioglitazone as low as 300 nM markedly increased the free magnesium concentration in the adipocytes. Pioglitazone action was selective for magnesium since intracellular free calcium concentration was not altered. These new data suggest that a potentially important mechanism explaining the metabolic and vascular actions of these new anti-diabetic agents is increasing free magnesium concentration in target tissues. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Nadler, J. oth Scott, S. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 202(1994), 1, Seite 416-421 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:202 year:1994 number:1 pages:416-421 http://dx.doi.org/10.1006/bbrc.1994.1944 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 202 1994 1 416-421 |
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(DE-627)NLEJ183478053 (DE-599)GBVNLZ183478053 DE-627 ger DE-627 rakwb eng Evidence That Pioglitazone Increases Intracellular Free Magnesium Concentration in Freshly Isolated Rat Adipocytes 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Pioglitazone is one of a new class of oral agents being developed as antidiabetic agents which can increase insulin sensitivity, reduce blood pressure and improve abnormalities in lipid metabolism. The mechanism of action of pioglitazone is not known. Increasing evidence suggests that magnesium can play an important role in regulating glucose homeostasis and vascular tone. To clarify a potential mechanism of pioglitazone action we determined the effects of pioglitazone on intracellular free magnesium concentration in freshly isolated rat adipocytes. Concentrations of pioglitazone as low as 300 nM markedly increased the free magnesium concentration in the adipocytes. Pioglitazone action was selective for magnesium since intracellular free calcium concentration was not altered. These new data suggest that a potentially important mechanism explaining the metabolic and vascular actions of these new anti-diabetic agents is increasing free magnesium concentration in target tissues. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Nadler, J. oth Scott, S. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 202(1994), 1, Seite 416-421 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:202 year:1994 number:1 pages:416-421 http://dx.doi.org/10.1006/bbrc.1994.1944 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 202 1994 1 416-421 |
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evidence that pioglitazone increases intracellular free magnesium concentration in freshly isolated rat adipocytes |
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Evidence That Pioglitazone Increases Intracellular Free Magnesium Concentration in Freshly Isolated Rat Adipocytes |
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Pioglitazone is one of a new class of oral agents being developed as antidiabetic agents which can increase insulin sensitivity, reduce blood pressure and improve abnormalities in lipid metabolism. The mechanism of action of pioglitazone is not known. Increasing evidence suggests that magnesium can play an important role in regulating glucose homeostasis and vascular tone. To clarify a potential mechanism of pioglitazone action we determined the effects of pioglitazone on intracellular free magnesium concentration in freshly isolated rat adipocytes. Concentrations of pioglitazone as low as 300 nM markedly increased the free magnesium concentration in the adipocytes. Pioglitazone action was selective for magnesium since intracellular free calcium concentration was not altered. These new data suggest that a potentially important mechanism explaining the metabolic and vascular actions of these new anti-diabetic agents is increasing free magnesium concentration in target tissues. |
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Pioglitazone is one of a new class of oral agents being developed as antidiabetic agents which can increase insulin sensitivity, reduce blood pressure and improve abnormalities in lipid metabolism. The mechanism of action of pioglitazone is not known. Increasing evidence suggests that magnesium can play an important role in regulating glucose homeostasis and vascular tone. To clarify a potential mechanism of pioglitazone action we determined the effects of pioglitazone on intracellular free magnesium concentration in freshly isolated rat adipocytes. Concentrations of pioglitazone as low as 300 nM markedly increased the free magnesium concentration in the adipocytes. Pioglitazone action was selective for magnesium since intracellular free calcium concentration was not altered. These new data suggest that a potentially important mechanism explaining the metabolic and vascular actions of these new anti-diabetic agents is increasing free magnesium concentration in target tissues. |
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Pioglitazone is one of a new class of oral agents being developed as antidiabetic agents which can increase insulin sensitivity, reduce blood pressure and improve abnormalities in lipid metabolism. The mechanism of action of pioglitazone is not known. Increasing evidence suggests that magnesium can play an important role in regulating glucose homeostasis and vascular tone. To clarify a potential mechanism of pioglitazone action we determined the effects of pioglitazone on intracellular free magnesium concentration in freshly isolated rat adipocytes. Concentrations of pioglitazone as low as 300 nM markedly increased the free magnesium concentration in the adipocytes. Pioglitazone action was selective for magnesium since intracellular free calcium concentration was not altered. These new data suggest that a potentially important mechanism explaining the metabolic and vascular actions of these new anti-diabetic agents is increasing free magnesium concentration in target tissues. |
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