Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen
The mechanism by which SV40 large T-antigen immortalizes human lung fibroblasts is not yet understood, and the frequency with which immortalization occurs is unknown. Here we report detailed studies of the kinetics of immortalization. Approximately 20-50% of individual T-antigen transfected clones o...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1989 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Experimental Cell Research - Amsterdam : Elsevier, 184(1989), 1, Seite 109-118 |
| Übergeordnetes Werk: |
volume:184 ; year:1989 ; number:1 ; pages:109-118 |
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| 520 | |a The mechanism by which SV40 large T-antigen immortalizes human lung fibroblasts is not yet understood, and the frequency with which immortalization occurs is unknown. Here we report detailed studies of the kinetics of immortalization. Approximately 20-50% of individual T-antigen transfected clones of IMR-90 human lung fibroblasts are able to immortalize. The failure of some clones to immortalize is consistent with the hypothesis that in some cells the aneuploidy induced by T-antigen produces extra copies of the chromosome containing a factor that must be inactivated before immortalization occurs. Within immortalization-competent clones, the frequency of immortalization is about 3x10^-^7. This frequency is consistent with a mutational mechanism for the inactivation of the factor that causes crisis in T-antigen expressing cells. | ||
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(DE-627)NLEJ183674014 (DE-599)GBVNLZ183674014 DE-627 ger DE-627 rakwb eng Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen 1989 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The mechanism by which SV40 large T-antigen immortalizes human lung fibroblasts is not yet understood, and the frequency with which immortalization occurs is unknown. Here we report detailed studies of the kinetics of immortalization. Approximately 20-50% of individual T-antigen transfected clones of IMR-90 human lung fibroblasts are able to immortalize. The failure of some clones to immortalize is consistent with the hypothesis that in some cells the aneuploidy induced by T-antigen produces extra copies of the chromosome containing a factor that must be inactivated before immortalization occurs. Within immortalization-competent clones, the frequency of immortalization is about 3x10^-^7. This frequency is consistent with a mutational mechanism for the inactivation of the factor that causes crisis in T-antigen expressing cells. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Shay, J.W. oth Wright, W.E. oth in Experimental Cell Research Amsterdam : Elsevier 184(1989), 1, Seite 109-118 (DE-627)NLEJ177031808 (DE-600)1466780-0 0014-4827 nnns volume:184 year:1989 number:1 pages:109-118 http://dx.doi.org/10.1016/0014-4827(89)90369-8 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 184 1989 1 109-118 |
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(DE-627)NLEJ183674014 (DE-599)GBVNLZ183674014 DE-627 ger DE-627 rakwb eng Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen 1989 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The mechanism by which SV40 large T-antigen immortalizes human lung fibroblasts is not yet understood, and the frequency with which immortalization occurs is unknown. Here we report detailed studies of the kinetics of immortalization. Approximately 20-50% of individual T-antigen transfected clones of IMR-90 human lung fibroblasts are able to immortalize. The failure of some clones to immortalize is consistent with the hypothesis that in some cells the aneuploidy induced by T-antigen produces extra copies of the chromosome containing a factor that must be inactivated before immortalization occurs. Within immortalization-competent clones, the frequency of immortalization is about 3x10^-^7. This frequency is consistent with a mutational mechanism for the inactivation of the factor that causes crisis in T-antigen expressing cells. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Shay, J.W. oth Wright, W.E. oth in Experimental Cell Research Amsterdam : Elsevier 184(1989), 1, Seite 109-118 (DE-627)NLEJ177031808 (DE-600)1466780-0 0014-4827 nnns volume:184 year:1989 number:1 pages:109-118 http://dx.doi.org/10.1016/0014-4827(89)90369-8 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 184 1989 1 109-118 |
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(DE-627)NLEJ183674014 (DE-599)GBVNLZ183674014 DE-627 ger DE-627 rakwb eng Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen 1989 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The mechanism by which SV40 large T-antigen immortalizes human lung fibroblasts is not yet understood, and the frequency with which immortalization occurs is unknown. Here we report detailed studies of the kinetics of immortalization. Approximately 20-50% of individual T-antigen transfected clones of IMR-90 human lung fibroblasts are able to immortalize. The failure of some clones to immortalize is consistent with the hypothesis that in some cells the aneuploidy induced by T-antigen produces extra copies of the chromosome containing a factor that must be inactivated before immortalization occurs. Within immortalization-competent clones, the frequency of immortalization is about 3x10^-^7. This frequency is consistent with a mutational mechanism for the inactivation of the factor that causes crisis in T-antigen expressing cells. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Shay, J.W. oth Wright, W.E. oth in Experimental Cell Research Amsterdam : Elsevier 184(1989), 1, Seite 109-118 (DE-627)NLEJ177031808 (DE-600)1466780-0 0014-4827 nnns volume:184 year:1989 number:1 pages:109-118 http://dx.doi.org/10.1016/0014-4827(89)90369-8 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 184 1989 1 109-118 |
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(DE-627)NLEJ183674014 (DE-599)GBVNLZ183674014 DE-627 ger DE-627 rakwb eng Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen 1989 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The mechanism by which SV40 large T-antigen immortalizes human lung fibroblasts is not yet understood, and the frequency with which immortalization occurs is unknown. Here we report detailed studies of the kinetics of immortalization. Approximately 20-50% of individual T-antigen transfected clones of IMR-90 human lung fibroblasts are able to immortalize. The failure of some clones to immortalize is consistent with the hypothesis that in some cells the aneuploidy induced by T-antigen produces extra copies of the chromosome containing a factor that must be inactivated before immortalization occurs. Within immortalization-competent clones, the frequency of immortalization is about 3x10^-^7. This frequency is consistent with a mutational mechanism for the inactivation of the factor that causes crisis in T-antigen expressing cells. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Shay, J.W. oth Wright, W.E. oth in Experimental Cell Research Amsterdam : Elsevier 184(1989), 1, Seite 109-118 (DE-627)NLEJ177031808 (DE-600)1466780-0 0014-4827 nnns volume:184 year:1989 number:1 pages:109-118 http://dx.doi.org/10.1016/0014-4827(89)90369-8 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 184 1989 1 109-118 |
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(DE-627)NLEJ183674014 (DE-599)GBVNLZ183674014 DE-627 ger DE-627 rakwb eng Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen 1989 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The mechanism by which SV40 large T-antigen immortalizes human lung fibroblasts is not yet understood, and the frequency with which immortalization occurs is unknown. Here we report detailed studies of the kinetics of immortalization. Approximately 20-50% of individual T-antigen transfected clones of IMR-90 human lung fibroblasts are able to immortalize. The failure of some clones to immortalize is consistent with the hypothesis that in some cells the aneuploidy induced by T-antigen produces extra copies of the chromosome containing a factor that must be inactivated before immortalization occurs. Within immortalization-competent clones, the frequency of immortalization is about 3x10^-^7. This frequency is consistent with a mutational mechanism for the inactivation of the factor that causes crisis in T-antigen expressing cells. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Shay, J.W. oth Wright, W.E. oth in Experimental Cell Research Amsterdam : Elsevier 184(1989), 1, Seite 109-118 (DE-627)NLEJ177031808 (DE-600)1466780-0 0014-4827 nnns volume:184 year:1989 number:1 pages:109-118 http://dx.doi.org/10.1016/0014-4827(89)90369-8 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 184 1989 1 109-118 |
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quantitation of the frequency of immortalization of normal human diploid fibroblasts by sv40 large t-antigen |
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Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen |
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The mechanism by which SV40 large T-antigen immortalizes human lung fibroblasts is not yet understood, and the frequency with which immortalization occurs is unknown. Here we report detailed studies of the kinetics of immortalization. Approximately 20-50% of individual T-antigen transfected clones of IMR-90 human lung fibroblasts are able to immortalize. The failure of some clones to immortalize is consistent with the hypothesis that in some cells the aneuploidy induced by T-antigen produces extra copies of the chromosome containing a factor that must be inactivated before immortalization occurs. Within immortalization-competent clones, the frequency of immortalization is about 3x10^-^7. This frequency is consistent with a mutational mechanism for the inactivation of the factor that causes crisis in T-antigen expressing cells. |
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The mechanism by which SV40 large T-antigen immortalizes human lung fibroblasts is not yet understood, and the frequency with which immortalization occurs is unknown. Here we report detailed studies of the kinetics of immortalization. Approximately 20-50% of individual T-antigen transfected clones of IMR-90 human lung fibroblasts are able to immortalize. The failure of some clones to immortalize is consistent with the hypothesis that in some cells the aneuploidy induced by T-antigen produces extra copies of the chromosome containing a factor that must be inactivated before immortalization occurs. Within immortalization-competent clones, the frequency of immortalization is about 3x10^-^7. This frequency is consistent with a mutational mechanism for the inactivation of the factor that causes crisis in T-antigen expressing cells. |
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The mechanism by which SV40 large T-antigen immortalizes human lung fibroblasts is not yet understood, and the frequency with which immortalization occurs is unknown. Here we report detailed studies of the kinetics of immortalization. Approximately 20-50% of individual T-antigen transfected clones of IMR-90 human lung fibroblasts are able to immortalize. The failure of some clones to immortalize is consistent with the hypothesis that in some cells the aneuploidy induced by T-antigen produces extra copies of the chromosome containing a factor that must be inactivated before immortalization occurs. Within immortalization-competent clones, the frequency of immortalization is about 3x10^-^7. This frequency is consistent with a mutational mechanism for the inactivation of the factor that causes crisis in T-antigen expressing cells. |
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