Leukotriene B"4 production by stimulated whole blood: Comparative studies with isolated polymorphonuclear cells
A new method was developed to study leukotriene B"4 (LTB"4) production by stimulated whole blood. The calcium ionophore A23187 and serum-treated zymosan induced LTB"4 production, measured by radioimmunoassay, in a dose- and time-dependent manner. The pattern of LTB"4 production b...
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1986 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Biochemical and Biophysical Research Communications - Amsterdam : Elsevier, 137(1986), 1, Seite 334-342 |
| Übergeordnetes Werk: |
volume:137 ; year:1986 ; number:1 ; pages:334-342 |
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| 520 | |a A new method was developed to study leukotriene B"4 (LTB"4) production by stimulated whole blood. The calcium ionophore A23187 and serum-treated zymosan induced LTB"4 production, measured by radioimmunoassay, in a dose- and time-dependent manner. The pattern of LTB"4 production by whole blood differed markedly from that observed with isolated, purified polymorphonuclear leukocytes. Higher levels of LTB"4 were reached and maintained in whole blood. The system allowed to detect drug effects on LTB"4 synthesis in vitro. This new method to study the synthesis of LTB"4 takes into account the complex interactions between different cell types which can modulate LTB"4 metabolism. | ||
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(DE-627)NLEJ184117860 (DE-599)GBVNLZ184117860 DE-627 ger DE-627 rakwb eng Leukotriene B"4 production by stimulated whole blood: Comparative studies with isolated polymorphonuclear cells 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new method was developed to study leukotriene B"4 (LTB"4) production by stimulated whole blood. The calcium ionophore A23187 and serum-treated zymosan induced LTB"4 production, measured by radioimmunoassay, in a dose- and time-dependent manner. The pattern of LTB"4 production by whole blood differed markedly from that observed with isolated, purified polymorphonuclear leukocytes. Higher levels of LTB"4 were reached and maintained in whole blood. The system allowed to detect drug effects on LTB"4 synthesis in vitro. This new method to study the synthesis of LTB"4 takes into account the complex interactions between different cell types which can modulate LTB"4 metabolism. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Gresele, P. oth Arnout, J. oth Coene, M.C. oth Deckmyn, H. oth Vermylen, J. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 137(1986), 1, Seite 334-342 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:137 year:1986 number:1 pages:334-342 http://dx.doi.org/10.1016/0006-291X(86)91215-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 137 1986 1 334-342 |
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(DE-627)NLEJ184117860 (DE-599)GBVNLZ184117860 DE-627 ger DE-627 rakwb eng Leukotriene B"4 production by stimulated whole blood: Comparative studies with isolated polymorphonuclear cells 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new method was developed to study leukotriene B"4 (LTB"4) production by stimulated whole blood. The calcium ionophore A23187 and serum-treated zymosan induced LTB"4 production, measured by radioimmunoassay, in a dose- and time-dependent manner. The pattern of LTB"4 production by whole blood differed markedly from that observed with isolated, purified polymorphonuclear leukocytes. Higher levels of LTB"4 were reached and maintained in whole blood. The system allowed to detect drug effects on LTB"4 synthesis in vitro. This new method to study the synthesis of LTB"4 takes into account the complex interactions between different cell types which can modulate LTB"4 metabolism. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Gresele, P. oth Arnout, J. oth Coene, M.C. oth Deckmyn, H. oth Vermylen, J. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 137(1986), 1, Seite 334-342 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:137 year:1986 number:1 pages:334-342 http://dx.doi.org/10.1016/0006-291X(86)91215-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 137 1986 1 334-342 |
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(DE-627)NLEJ184117860 (DE-599)GBVNLZ184117860 DE-627 ger DE-627 rakwb eng Leukotriene B"4 production by stimulated whole blood: Comparative studies with isolated polymorphonuclear cells 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new method was developed to study leukotriene B"4 (LTB"4) production by stimulated whole blood. The calcium ionophore A23187 and serum-treated zymosan induced LTB"4 production, measured by radioimmunoassay, in a dose- and time-dependent manner. The pattern of LTB"4 production by whole blood differed markedly from that observed with isolated, purified polymorphonuclear leukocytes. Higher levels of LTB"4 were reached and maintained in whole blood. The system allowed to detect drug effects on LTB"4 synthesis in vitro. This new method to study the synthesis of LTB"4 takes into account the complex interactions between different cell types which can modulate LTB"4 metabolism. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Gresele, P. oth Arnout, J. oth Coene, M.C. oth Deckmyn, H. oth Vermylen, J. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 137(1986), 1, Seite 334-342 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:137 year:1986 number:1 pages:334-342 http://dx.doi.org/10.1016/0006-291X(86)91215-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 137 1986 1 334-342 |
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(DE-627)NLEJ184117860 (DE-599)GBVNLZ184117860 DE-627 ger DE-627 rakwb eng Leukotriene B"4 production by stimulated whole blood: Comparative studies with isolated polymorphonuclear cells 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new method was developed to study leukotriene B"4 (LTB"4) production by stimulated whole blood. The calcium ionophore A23187 and serum-treated zymosan induced LTB"4 production, measured by radioimmunoassay, in a dose- and time-dependent manner. The pattern of LTB"4 production by whole blood differed markedly from that observed with isolated, purified polymorphonuclear leukocytes. Higher levels of LTB"4 were reached and maintained in whole blood. The system allowed to detect drug effects on LTB"4 synthesis in vitro. This new method to study the synthesis of LTB"4 takes into account the complex interactions between different cell types which can modulate LTB"4 metabolism. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Gresele, P. oth Arnout, J. oth Coene, M.C. oth Deckmyn, H. oth Vermylen, J. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 137(1986), 1, Seite 334-342 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:137 year:1986 number:1 pages:334-342 http://dx.doi.org/10.1016/0006-291X(86)91215-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 137 1986 1 334-342 |
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(DE-627)NLEJ184117860 (DE-599)GBVNLZ184117860 DE-627 ger DE-627 rakwb eng Leukotriene B"4 production by stimulated whole blood: Comparative studies with isolated polymorphonuclear cells 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A new method was developed to study leukotriene B"4 (LTB"4) production by stimulated whole blood. The calcium ionophore A23187 and serum-treated zymosan induced LTB"4 production, measured by radioimmunoassay, in a dose- and time-dependent manner. The pattern of LTB"4 production by whole blood differed markedly from that observed with isolated, purified polymorphonuclear leukocytes. Higher levels of LTB"4 were reached and maintained in whole blood. The system allowed to detect drug effects on LTB"4 synthesis in vitro. This new method to study the synthesis of LTB"4 takes into account the complex interactions between different cell types which can modulate LTB"4 metabolism. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Gresele, P. oth Arnout, J. oth Coene, M.C. oth Deckmyn, H. oth Vermylen, J. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 137(1986), 1, Seite 334-342 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:137 year:1986 number:1 pages:334-342 http://dx.doi.org/10.1016/0006-291X(86)91215-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 137 1986 1 334-342 |
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Leukotriene B"4 production by stimulated whole blood: Comparative studies with isolated polymorphonuclear cells |
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A new method was developed to study leukotriene B"4 (LTB"4) production by stimulated whole blood. The calcium ionophore A23187 and serum-treated zymosan induced LTB"4 production, measured by radioimmunoassay, in a dose- and time-dependent manner. The pattern of LTB"4 production by whole blood differed markedly from that observed with isolated, purified polymorphonuclear leukocytes. Higher levels of LTB"4 were reached and maintained in whole blood. The system allowed to detect drug effects on LTB"4 synthesis in vitro. This new method to study the synthesis of LTB"4 takes into account the complex interactions between different cell types which can modulate LTB"4 metabolism. |
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A new method was developed to study leukotriene B"4 (LTB"4) production by stimulated whole blood. The calcium ionophore A23187 and serum-treated zymosan induced LTB"4 production, measured by radioimmunoassay, in a dose- and time-dependent manner. The pattern of LTB"4 production by whole blood differed markedly from that observed with isolated, purified polymorphonuclear leukocytes. Higher levels of LTB"4 were reached and maintained in whole blood. The system allowed to detect drug effects on LTB"4 synthesis in vitro. This new method to study the synthesis of LTB"4 takes into account the complex interactions between different cell types which can modulate LTB"4 metabolism. |
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A new method was developed to study leukotriene B"4 (LTB"4) production by stimulated whole blood. The calcium ionophore A23187 and serum-treated zymosan induced LTB"4 production, measured by radioimmunoassay, in a dose- and time-dependent manner. The pattern of LTB"4 production by whole blood differed markedly from that observed with isolated, purified polymorphonuclear leukocytes. Higher levels of LTB"4 were reached and maintained in whole blood. The system allowed to detect drug effects on LTB"4 synthesis in vitro. This new method to study the synthesis of LTB"4 takes into account the complex interactions between different cell types which can modulate LTB"4 metabolism. |
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