Partial characterisation and subcellular distribution patterns of endothelin-1, -2 and -3 binding sites in human liver
For the first time, endothelin-1, -2 and -3 (ET-1, -2, -3) binding sites were characterized in human liver and shown to differ significantly in their respective dissociation constants and densities. In addition, subcellular distribution patterns of these binding sites in biochemically analysed fract...
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1991 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Biochemical and Biophysical Research Communications - Amsterdam : Elsevier, 181(1991), 2, Seite 840-845 |
| Übergeordnetes Werk: |
volume:181 ; year:1991 ; number:2 ; pages:840-845 |
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| 245 | 1 | 0 | |a Partial characterisation and subcellular distribution patterns of endothelin-1, -2 and -3 binding sites in human liver |
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| 520 | |a For the first time, endothelin-1, -2 and -3 (ET-1, -2, -3) binding sites were characterized in human liver and shown to differ significantly in their respective dissociation constants and densities. In addition, subcellular distribution patterns of these binding sites in biochemically analysed fractions obtained after differential centrifugation were shown to be heterogeneous. Thus, the bulk of ET-1 and ET-3 binding sites seemed to be present in plasma membranes, although their partial presence in a compartment sedimenting together with the endoplasmic reticulum cannot be excluded. In contrast, a major proportion of the ET-2 binding sites appeared to be associated with a compartment sedimenting together with mitochondria, suggesting a special accumulation of ET-2 binding sites in human liver. A significant portion of ET-1, -2 and -3 binding sites seems to be localized also in lysosomes, presumably indicating their participation in the internalisation process. | ||
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(DE-627)NLEJ184163528 (DE-599)GBVNLZ184163528 DE-627 ger DE-627 rakwb eng Partial characterisation and subcellular distribution patterns of endothelin-1, -2 and -3 binding sites in human liver 1991 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For the first time, endothelin-1, -2 and -3 (ET-1, -2, -3) binding sites were characterized in human liver and shown to differ significantly in their respective dissociation constants and densities. In addition, subcellular distribution patterns of these binding sites in biochemically analysed fractions obtained after differential centrifugation were shown to be heterogeneous. Thus, the bulk of ET-1 and ET-3 binding sites seemed to be present in plasma membranes, although their partial presence in a compartment sedimenting together with the endoplasmic reticulum cannot be excluded. In contrast, a major proportion of the ET-2 binding sites appeared to be associated with a compartment sedimenting together with mitochondria, suggesting a special accumulation of ET-2 binding sites in human liver. A significant portion of ET-1, -2 and -3 binding sites seems to be localized also in lysosomes, presumably indicating their participation in the internalisation process. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Loffler, B.-M. oth Kalina, B. oth Kunze, H. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 181(1991), 2, Seite 840-845 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:181 year:1991 number:2 pages:840-845 http://dx.doi.org/10.1016/0006-291X(91)91266-F GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 181 1991 2 840-845 |
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(DE-627)NLEJ184163528 (DE-599)GBVNLZ184163528 DE-627 ger DE-627 rakwb eng Partial characterisation and subcellular distribution patterns of endothelin-1, -2 and -3 binding sites in human liver 1991 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For the first time, endothelin-1, -2 and -3 (ET-1, -2, -3) binding sites were characterized in human liver and shown to differ significantly in their respective dissociation constants and densities. In addition, subcellular distribution patterns of these binding sites in biochemically analysed fractions obtained after differential centrifugation were shown to be heterogeneous. Thus, the bulk of ET-1 and ET-3 binding sites seemed to be present in plasma membranes, although their partial presence in a compartment sedimenting together with the endoplasmic reticulum cannot be excluded. In contrast, a major proportion of the ET-2 binding sites appeared to be associated with a compartment sedimenting together with mitochondria, suggesting a special accumulation of ET-2 binding sites in human liver. A significant portion of ET-1, -2 and -3 binding sites seems to be localized also in lysosomes, presumably indicating their participation in the internalisation process. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Loffler, B.-M. oth Kalina, B. oth Kunze, H. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 181(1991), 2, Seite 840-845 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:181 year:1991 number:2 pages:840-845 http://dx.doi.org/10.1016/0006-291X(91)91266-F GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 181 1991 2 840-845 |
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(DE-627)NLEJ184163528 (DE-599)GBVNLZ184163528 DE-627 ger DE-627 rakwb eng Partial characterisation and subcellular distribution patterns of endothelin-1, -2 and -3 binding sites in human liver 1991 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For the first time, endothelin-1, -2 and -3 (ET-1, -2, -3) binding sites were characterized in human liver and shown to differ significantly in their respective dissociation constants and densities. In addition, subcellular distribution patterns of these binding sites in biochemically analysed fractions obtained after differential centrifugation were shown to be heterogeneous. Thus, the bulk of ET-1 and ET-3 binding sites seemed to be present in plasma membranes, although their partial presence in a compartment sedimenting together with the endoplasmic reticulum cannot be excluded. In contrast, a major proportion of the ET-2 binding sites appeared to be associated with a compartment sedimenting together with mitochondria, suggesting a special accumulation of ET-2 binding sites in human liver. A significant portion of ET-1, -2 and -3 binding sites seems to be localized also in lysosomes, presumably indicating their participation in the internalisation process. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Loffler, B.-M. oth Kalina, B. oth Kunze, H. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 181(1991), 2, Seite 840-845 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:181 year:1991 number:2 pages:840-845 http://dx.doi.org/10.1016/0006-291X(91)91266-F GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 181 1991 2 840-845 |
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(DE-627)NLEJ184163528 (DE-599)GBVNLZ184163528 DE-627 ger DE-627 rakwb eng Partial characterisation and subcellular distribution patterns of endothelin-1, -2 and -3 binding sites in human liver 1991 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For the first time, endothelin-1, -2 and -3 (ET-1, -2, -3) binding sites were characterized in human liver and shown to differ significantly in their respective dissociation constants and densities. In addition, subcellular distribution patterns of these binding sites in biochemically analysed fractions obtained after differential centrifugation were shown to be heterogeneous. Thus, the bulk of ET-1 and ET-3 binding sites seemed to be present in plasma membranes, although their partial presence in a compartment sedimenting together with the endoplasmic reticulum cannot be excluded. In contrast, a major proportion of the ET-2 binding sites appeared to be associated with a compartment sedimenting together with mitochondria, suggesting a special accumulation of ET-2 binding sites in human liver. A significant portion of ET-1, -2 and -3 binding sites seems to be localized also in lysosomes, presumably indicating their participation in the internalisation process. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Loffler, B.-M. oth Kalina, B. oth Kunze, H. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 181(1991), 2, Seite 840-845 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:181 year:1991 number:2 pages:840-845 http://dx.doi.org/10.1016/0006-291X(91)91266-F GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 181 1991 2 840-845 |
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(DE-627)NLEJ184163528 (DE-599)GBVNLZ184163528 DE-627 ger DE-627 rakwb eng Partial characterisation and subcellular distribution patterns of endothelin-1, -2 and -3 binding sites in human liver 1991 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For the first time, endothelin-1, -2 and -3 (ET-1, -2, -3) binding sites were characterized in human liver and shown to differ significantly in their respective dissociation constants and densities. In addition, subcellular distribution patterns of these binding sites in biochemically analysed fractions obtained after differential centrifugation were shown to be heterogeneous. Thus, the bulk of ET-1 and ET-3 binding sites seemed to be present in plasma membranes, although their partial presence in a compartment sedimenting together with the endoplasmic reticulum cannot be excluded. In contrast, a major proportion of the ET-2 binding sites appeared to be associated with a compartment sedimenting together with mitochondria, suggesting a special accumulation of ET-2 binding sites in human liver. A significant portion of ET-1, -2 and -3 binding sites seems to be localized also in lysosomes, presumably indicating their participation in the internalisation process. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Loffler, B.-M. oth Kalina, B. oth Kunze, H. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 181(1991), 2, Seite 840-845 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:181 year:1991 number:2 pages:840-845 http://dx.doi.org/10.1016/0006-291X(91)91266-F GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 181 1991 2 840-845 |
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Partial characterisation and subcellular distribution patterns of endothelin-1, -2 and -3 binding sites in human liver |
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For the first time, endothelin-1, -2 and -3 (ET-1, -2, -3) binding sites were characterized in human liver and shown to differ significantly in their respective dissociation constants and densities. In addition, subcellular distribution patterns of these binding sites in biochemically analysed fractions obtained after differential centrifugation were shown to be heterogeneous. Thus, the bulk of ET-1 and ET-3 binding sites seemed to be present in plasma membranes, although their partial presence in a compartment sedimenting together with the endoplasmic reticulum cannot be excluded. In contrast, a major proportion of the ET-2 binding sites appeared to be associated with a compartment sedimenting together with mitochondria, suggesting a special accumulation of ET-2 binding sites in human liver. A significant portion of ET-1, -2 and -3 binding sites seems to be localized also in lysosomes, presumably indicating their participation in the internalisation process. |
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For the first time, endothelin-1, -2 and -3 (ET-1, -2, -3) binding sites were characterized in human liver and shown to differ significantly in their respective dissociation constants and densities. In addition, subcellular distribution patterns of these binding sites in biochemically analysed fractions obtained after differential centrifugation were shown to be heterogeneous. Thus, the bulk of ET-1 and ET-3 binding sites seemed to be present in plasma membranes, although their partial presence in a compartment sedimenting together with the endoplasmic reticulum cannot be excluded. In contrast, a major proportion of the ET-2 binding sites appeared to be associated with a compartment sedimenting together with mitochondria, suggesting a special accumulation of ET-2 binding sites in human liver. A significant portion of ET-1, -2 and -3 binding sites seems to be localized also in lysosomes, presumably indicating their participation in the internalisation process. |
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For the first time, endothelin-1, -2 and -3 (ET-1, -2, -3) binding sites were characterized in human liver and shown to differ significantly in their respective dissociation constants and densities. In addition, subcellular distribution patterns of these binding sites in biochemically analysed fractions obtained after differential centrifugation were shown to be heterogeneous. Thus, the bulk of ET-1 and ET-3 binding sites seemed to be present in plasma membranes, although their partial presence in a compartment sedimenting together with the endoplasmic reticulum cannot be excluded. In contrast, a major proportion of the ET-2 binding sites appeared to be associated with a compartment sedimenting together with mitochondria, suggesting a special accumulation of ET-2 binding sites in human liver. A significant portion of ET-1, -2 and -3 binding sites seems to be localized also in lysosomes, presumably indicating their participation in the internalisation process. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ184163528</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706223105.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070506s1991 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ184163528</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ184163528</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Partial characterisation and subcellular distribution patterns of endothelin-1, -2 and -3 binding sites in human liver</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1991</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">For the first time, endothelin-1, -2 and -3 (ET-1, -2, -3) binding sites were characterized in human liver and shown to differ significantly in their respective dissociation constants and densities. In addition, subcellular distribution patterns of these binding sites in biochemically analysed fractions obtained after differential centrifugation were shown to be heterogeneous. Thus, the bulk of ET-1 and ET-3 binding sites seemed to be present in plasma membranes, although their partial presence in a compartment sedimenting together with the endoplasmic reticulum cannot be excluded. In contrast, a major proportion of the ET-2 binding sites appeared to be associated with a compartment sedimenting together with mitochondria, suggesting a special accumulation of ET-2 binding sites in human liver. A significant portion of ET-1, -2 and -3 binding sites seems to be localized also in lysosomes, presumably indicating their participation in the internalisation process.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Loffler, B.-M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kalina, B.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kunze, H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Biochemical and Biophysical Research Communications</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">181(1991), 2, Seite 840-845</subfield><subfield code="w">(DE-627)NLEJ176855645</subfield><subfield code="w">(DE-600)1461396-7</subfield><subfield code="x">0006-291X</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:181</subfield><subfield code="g">year:1991</subfield><subfield code="g">number:2</subfield><subfield code="g">pages:840-845</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1016/0006-291X(91)91266-F</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">181</subfield><subfield code="j">1991</subfield><subfield code="e">2</subfield><subfield code="h">840-845</subfield></datafield></record></collection>
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