Correlation between cardiac hypertrophy and plasma levels of atrial natriuretic factor in non-spontaneous models of hypertension in the rat
We have compared atrial and plasma concentration of atrial natriuretic factor (ANF) in 4 models of non spontaneous experimental hypertension with different pathogenic mechanisms in the rat: two-kidney, one-clip (2-K, 1-C), one-kidney, one-clip (1-K, 1-C), DOCA-NaCl and adrenal regeneration hypertens...
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1987 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Biochemical and Biophysical Research Communications - Amsterdam : Elsevier, 145(1987), 1, Seite 532-541 |
| Übergeordnetes Werk: |
volume:145 ; year:1987 ; number:1 ; pages:532-541 |
| Links: |
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NLEJ184190851 |
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| 520 | |a We have compared atrial and plasma concentration of atrial natriuretic factor (ANF) in 4 models of non spontaneous experimental hypertension with different pathogenic mechanisms in the rat: two-kidney, one-clip (2-K, 1-C), one-kidney, one-clip (1-K, 1-C), DOCA-NaCl and adrenal regeneration hypertension (ARH) and their respective normotensive controls. All hypertensive groups developed cardiac hypertrophy. In all hypertensive groups plasma ANF was higher than in controls. Atrial ANF concentration was lower in the right and left atrium of 1-K, 1-C rats and in the left atrium of ARH. A good correlation was found between systolic BP and plasma ANF in 2-K, 1-C (r=0.82; p < 0.01) and 1-K, 1-C animals (r=0.70; p < 0.01). This correlation was less good in DOCA-NaCl (r=0.41; p < 0.05) and non existent in ARH (r=0.28; NS). A negative correlation between plasma ANF and atrial ANF concentrations was found only in the 1-K, 1-C group (r=0.41; p < 0.01). A good correlation between plasma ANF levels and cardiac weight was found in all groups: 2-K, 1-C (r=0.83; p < 0.01), 1-K, 1-C (r=0.73; p < 0.01), DOCA-NaCl (r=0.69; p < 0.01) and ARH (r=0.71; p < 0.01). We suggest that the release of ANF in experimental hypertension depends of the pathogenesis and could be related either to the level of BP (hence the magnitude of the left ventricular enddiastolic pressure) or to the existance of an expanded blood volume. The correlation between plasma ANF levels and cardiac hypertrophy suggests that ANF could be partially released by the ventricles. | ||
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| 700 | 1 | |a Cantin, M. |4 oth | |
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(DE-627)NLEJ184190851 (DE-599)GBVNLZ184190851 DE-627 ger DE-627 rakwb eng Correlation between cardiac hypertrophy and plasma levels of atrial natriuretic factor in non-spontaneous models of hypertension in the rat 1987 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We have compared atrial and plasma concentration of atrial natriuretic factor (ANF) in 4 models of non spontaneous experimental hypertension with different pathogenic mechanisms in the rat: two-kidney, one-clip (2-K, 1-C), one-kidney, one-clip (1-K, 1-C), DOCA-NaCl and adrenal regeneration hypertension (ARH) and their respective normotensive controls. All hypertensive groups developed cardiac hypertrophy. In all hypertensive groups plasma ANF was higher than in controls. Atrial ANF concentration was lower in the right and left atrium of 1-K, 1-C rats and in the left atrium of ARH. A good correlation was found between systolic BP and plasma ANF in 2-K, 1-C (r=0.82; p < 0.01) and 1-K, 1-C animals (r=0.70; p < 0.01). This correlation was less good in DOCA-NaCl (r=0.41; p < 0.05) and non existent in ARH (r=0.28; NS). A negative correlation between plasma ANF and atrial ANF concentrations was found only in the 1-K, 1-C group (r=0.41; p < 0.01). A good correlation between plasma ANF levels and cardiac weight was found in all groups: 2-K, 1-C (r=0.83; p < 0.01), 1-K, 1-C (r=0.73; p < 0.01), DOCA-NaCl (r=0.69; p < 0.01) and ARH (r=0.71; p < 0.01). We suggest that the release of ANF in experimental hypertension depends of the pathogenesis and could be related either to the level of BP (hence the magnitude of the left ventricular enddiastolic pressure) or to the existance of an expanded blood volume. The correlation between plasma ANF levels and cardiac hypertrophy suggests that ANF could be partially released by the ventricles. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Garcia, R. oth Thibault, G. oth Cantin, M. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 145(1987), 1, Seite 532-541 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:145 year:1987 number:1 pages:532-541 http://dx.doi.org/10.1016/0006-291X(87)91353-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 145 1987 1 532-541 |
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(DE-627)NLEJ184190851 (DE-599)GBVNLZ184190851 DE-627 ger DE-627 rakwb eng Correlation between cardiac hypertrophy and plasma levels of atrial natriuretic factor in non-spontaneous models of hypertension in the rat 1987 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We have compared atrial and plasma concentration of atrial natriuretic factor (ANF) in 4 models of non spontaneous experimental hypertension with different pathogenic mechanisms in the rat: two-kidney, one-clip (2-K, 1-C), one-kidney, one-clip (1-K, 1-C), DOCA-NaCl and adrenal regeneration hypertension (ARH) and their respective normotensive controls. All hypertensive groups developed cardiac hypertrophy. In all hypertensive groups plasma ANF was higher than in controls. Atrial ANF concentration was lower in the right and left atrium of 1-K, 1-C rats and in the left atrium of ARH. A good correlation was found between systolic BP and plasma ANF in 2-K, 1-C (r=0.82; p < 0.01) and 1-K, 1-C animals (r=0.70; p < 0.01). This correlation was less good in DOCA-NaCl (r=0.41; p < 0.05) and non existent in ARH (r=0.28; NS). A negative correlation between plasma ANF and atrial ANF concentrations was found only in the 1-K, 1-C group (r=0.41; p < 0.01). A good correlation between plasma ANF levels and cardiac weight was found in all groups: 2-K, 1-C (r=0.83; p < 0.01), 1-K, 1-C (r=0.73; p < 0.01), DOCA-NaCl (r=0.69; p < 0.01) and ARH (r=0.71; p < 0.01). We suggest that the release of ANF in experimental hypertension depends of the pathogenesis and could be related either to the level of BP (hence the magnitude of the left ventricular enddiastolic pressure) or to the existance of an expanded blood volume. The correlation between plasma ANF levels and cardiac hypertrophy suggests that ANF could be partially released by the ventricles. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Garcia, R. oth Thibault, G. oth Cantin, M. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 145(1987), 1, Seite 532-541 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:145 year:1987 number:1 pages:532-541 http://dx.doi.org/10.1016/0006-291X(87)91353-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 145 1987 1 532-541 |
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(DE-627)NLEJ184190851 (DE-599)GBVNLZ184190851 DE-627 ger DE-627 rakwb eng Correlation between cardiac hypertrophy and plasma levels of atrial natriuretic factor in non-spontaneous models of hypertension in the rat 1987 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We have compared atrial and plasma concentration of atrial natriuretic factor (ANF) in 4 models of non spontaneous experimental hypertension with different pathogenic mechanisms in the rat: two-kidney, one-clip (2-K, 1-C), one-kidney, one-clip (1-K, 1-C), DOCA-NaCl and adrenal regeneration hypertension (ARH) and their respective normotensive controls. All hypertensive groups developed cardiac hypertrophy. In all hypertensive groups plasma ANF was higher than in controls. Atrial ANF concentration was lower in the right and left atrium of 1-K, 1-C rats and in the left atrium of ARH. A good correlation was found between systolic BP and plasma ANF in 2-K, 1-C (r=0.82; p < 0.01) and 1-K, 1-C animals (r=0.70; p < 0.01). This correlation was less good in DOCA-NaCl (r=0.41; p < 0.05) and non existent in ARH (r=0.28; NS). A negative correlation between plasma ANF and atrial ANF concentrations was found only in the 1-K, 1-C group (r=0.41; p < 0.01). A good correlation between plasma ANF levels and cardiac weight was found in all groups: 2-K, 1-C (r=0.83; p < 0.01), 1-K, 1-C (r=0.73; p < 0.01), DOCA-NaCl (r=0.69; p < 0.01) and ARH (r=0.71; p < 0.01). We suggest that the release of ANF in experimental hypertension depends of the pathogenesis and could be related either to the level of BP (hence the magnitude of the left ventricular enddiastolic pressure) or to the existance of an expanded blood volume. The correlation between plasma ANF levels and cardiac hypertrophy suggests that ANF could be partially released by the ventricles. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Garcia, R. oth Thibault, G. oth Cantin, M. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 145(1987), 1, Seite 532-541 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:145 year:1987 number:1 pages:532-541 http://dx.doi.org/10.1016/0006-291X(87)91353-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 145 1987 1 532-541 |
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(DE-627)NLEJ184190851 (DE-599)GBVNLZ184190851 DE-627 ger DE-627 rakwb eng Correlation between cardiac hypertrophy and plasma levels of atrial natriuretic factor in non-spontaneous models of hypertension in the rat 1987 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We have compared atrial and plasma concentration of atrial natriuretic factor (ANF) in 4 models of non spontaneous experimental hypertension with different pathogenic mechanisms in the rat: two-kidney, one-clip (2-K, 1-C), one-kidney, one-clip (1-K, 1-C), DOCA-NaCl and adrenal regeneration hypertension (ARH) and their respective normotensive controls. All hypertensive groups developed cardiac hypertrophy. In all hypertensive groups plasma ANF was higher than in controls. Atrial ANF concentration was lower in the right and left atrium of 1-K, 1-C rats and in the left atrium of ARH. A good correlation was found between systolic BP and plasma ANF in 2-K, 1-C (r=0.82; p < 0.01) and 1-K, 1-C animals (r=0.70; p < 0.01). This correlation was less good in DOCA-NaCl (r=0.41; p < 0.05) and non existent in ARH (r=0.28; NS). A negative correlation between plasma ANF and atrial ANF concentrations was found only in the 1-K, 1-C group (r=0.41; p < 0.01). A good correlation between plasma ANF levels and cardiac weight was found in all groups: 2-K, 1-C (r=0.83; p < 0.01), 1-K, 1-C (r=0.73; p < 0.01), DOCA-NaCl (r=0.69; p < 0.01) and ARH (r=0.71; p < 0.01). We suggest that the release of ANF in experimental hypertension depends of the pathogenesis and could be related either to the level of BP (hence the magnitude of the left ventricular enddiastolic pressure) or to the existance of an expanded blood volume. The correlation between plasma ANF levels and cardiac hypertrophy suggests that ANF could be partially released by the ventricles. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Garcia, R. oth Thibault, G. oth Cantin, M. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 145(1987), 1, Seite 532-541 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:145 year:1987 number:1 pages:532-541 http://dx.doi.org/10.1016/0006-291X(87)91353-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 145 1987 1 532-541 |
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(DE-627)NLEJ184190851 (DE-599)GBVNLZ184190851 DE-627 ger DE-627 rakwb eng Correlation between cardiac hypertrophy and plasma levels of atrial natriuretic factor in non-spontaneous models of hypertension in the rat 1987 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We have compared atrial and plasma concentration of atrial natriuretic factor (ANF) in 4 models of non spontaneous experimental hypertension with different pathogenic mechanisms in the rat: two-kidney, one-clip (2-K, 1-C), one-kidney, one-clip (1-K, 1-C), DOCA-NaCl and adrenal regeneration hypertension (ARH) and their respective normotensive controls. All hypertensive groups developed cardiac hypertrophy. In all hypertensive groups plasma ANF was higher than in controls. Atrial ANF concentration was lower in the right and left atrium of 1-K, 1-C rats and in the left atrium of ARH. A good correlation was found between systolic BP and plasma ANF in 2-K, 1-C (r=0.82; p < 0.01) and 1-K, 1-C animals (r=0.70; p < 0.01). This correlation was less good in DOCA-NaCl (r=0.41; p < 0.05) and non existent in ARH (r=0.28; NS). A negative correlation between plasma ANF and atrial ANF concentrations was found only in the 1-K, 1-C group (r=0.41; p < 0.01). A good correlation between plasma ANF levels and cardiac weight was found in all groups: 2-K, 1-C (r=0.83; p < 0.01), 1-K, 1-C (r=0.73; p < 0.01), DOCA-NaCl (r=0.69; p < 0.01) and ARH (r=0.71; p < 0.01). We suggest that the release of ANF in experimental hypertension depends of the pathogenesis and could be related either to the level of BP (hence the magnitude of the left ventricular enddiastolic pressure) or to the existance of an expanded blood volume. The correlation between plasma ANF levels and cardiac hypertrophy suggests that ANF could be partially released by the ventricles. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Garcia, R. oth Thibault, G. oth Cantin, M. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 145(1987), 1, Seite 532-541 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:145 year:1987 number:1 pages:532-541 http://dx.doi.org/10.1016/0006-291X(87)91353-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 145 1987 1 532-541 |
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Correlation between cardiac hypertrophy and plasma levels of atrial natriuretic factor in non-spontaneous models of hypertension in the rat |
| abstract |
We have compared atrial and plasma concentration of atrial natriuretic factor (ANF) in 4 models of non spontaneous experimental hypertension with different pathogenic mechanisms in the rat: two-kidney, one-clip (2-K, 1-C), one-kidney, one-clip (1-K, 1-C), DOCA-NaCl and adrenal regeneration hypertension (ARH) and their respective normotensive controls. All hypertensive groups developed cardiac hypertrophy. In all hypertensive groups plasma ANF was higher than in controls. Atrial ANF concentration was lower in the right and left atrium of 1-K, 1-C rats and in the left atrium of ARH. A good correlation was found between systolic BP and plasma ANF in 2-K, 1-C (r=0.82; p < 0.01) and 1-K, 1-C animals (r=0.70; p < 0.01). This correlation was less good in DOCA-NaCl (r=0.41; p < 0.05) and non existent in ARH (r=0.28; NS). A negative correlation between plasma ANF and atrial ANF concentrations was found only in the 1-K, 1-C group (r=0.41; p < 0.01). A good correlation between plasma ANF levels and cardiac weight was found in all groups: 2-K, 1-C (r=0.83; p < 0.01), 1-K, 1-C (r=0.73; p < 0.01), DOCA-NaCl (r=0.69; p < 0.01) and ARH (r=0.71; p < 0.01). We suggest that the release of ANF in experimental hypertension depends of the pathogenesis and could be related either to the level of BP (hence the magnitude of the left ventricular enddiastolic pressure) or to the existance of an expanded blood volume. The correlation between plasma ANF levels and cardiac hypertrophy suggests that ANF could be partially released by the ventricles. |
| abstractGer |
We have compared atrial and plasma concentration of atrial natriuretic factor (ANF) in 4 models of non spontaneous experimental hypertension with different pathogenic mechanisms in the rat: two-kidney, one-clip (2-K, 1-C), one-kidney, one-clip (1-K, 1-C), DOCA-NaCl and adrenal regeneration hypertension (ARH) and their respective normotensive controls. All hypertensive groups developed cardiac hypertrophy. In all hypertensive groups plasma ANF was higher than in controls. Atrial ANF concentration was lower in the right and left atrium of 1-K, 1-C rats and in the left atrium of ARH. A good correlation was found between systolic BP and plasma ANF in 2-K, 1-C (r=0.82; p < 0.01) and 1-K, 1-C animals (r=0.70; p < 0.01). This correlation was less good in DOCA-NaCl (r=0.41; p < 0.05) and non existent in ARH (r=0.28; NS). A negative correlation between plasma ANF and atrial ANF concentrations was found only in the 1-K, 1-C group (r=0.41; p < 0.01). A good correlation between plasma ANF levels and cardiac weight was found in all groups: 2-K, 1-C (r=0.83; p < 0.01), 1-K, 1-C (r=0.73; p < 0.01), DOCA-NaCl (r=0.69; p < 0.01) and ARH (r=0.71; p < 0.01). We suggest that the release of ANF in experimental hypertension depends of the pathogenesis and could be related either to the level of BP (hence the magnitude of the left ventricular enddiastolic pressure) or to the existance of an expanded blood volume. The correlation between plasma ANF levels and cardiac hypertrophy suggests that ANF could be partially released by the ventricles. |
| abstract_unstemmed |
We have compared atrial and plasma concentration of atrial natriuretic factor (ANF) in 4 models of non spontaneous experimental hypertension with different pathogenic mechanisms in the rat: two-kidney, one-clip (2-K, 1-C), one-kidney, one-clip (1-K, 1-C), DOCA-NaCl and adrenal regeneration hypertension (ARH) and their respective normotensive controls. All hypertensive groups developed cardiac hypertrophy. In all hypertensive groups plasma ANF was higher than in controls. Atrial ANF concentration was lower in the right and left atrium of 1-K, 1-C rats and in the left atrium of ARH. A good correlation was found between systolic BP and plasma ANF in 2-K, 1-C (r=0.82; p < 0.01) and 1-K, 1-C animals (r=0.70; p < 0.01). This correlation was less good in DOCA-NaCl (r=0.41; p < 0.05) and non existent in ARH (r=0.28; NS). A negative correlation between plasma ANF and atrial ANF concentrations was found only in the 1-K, 1-C group (r=0.41; p < 0.01). A good correlation between plasma ANF levels and cardiac weight was found in all groups: 2-K, 1-C (r=0.83; p < 0.01), 1-K, 1-C (r=0.73; p < 0.01), DOCA-NaCl (r=0.69; p < 0.01) and ARH (r=0.71; p < 0.01). We suggest that the release of ANF in experimental hypertension depends of the pathogenesis and could be related either to the level of BP (hence the magnitude of the left ventricular enddiastolic pressure) or to the existance of an expanded blood volume. The correlation between plasma ANF levels and cardiac hypertrophy suggests that ANF could be partially released by the ventricles. |
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Correlation between cardiac hypertrophy and plasma levels of atrial natriuretic factor in non-spontaneous models of hypertension in the rat |
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