Changing levels of UV light and carcinogen-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation
Mouse oocytes were exposed in vitro to various DNA-damaging agents at the germinal vesicle (GV), metaphase I (M I) or metaphase II (M II) stage of meiotic maturation and then labelled with [^3H]thymidine for 2.0 h following their exposure. Variable levels of unscheduled DNA synthesis were induced in...
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| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1978 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
|---|---|
| Übergeordnetes Werk: |
in: Experimental Cell Research - Amsterdam : Elsevier, 112(1978), 1, Seite 121-125 |
| Übergeordnetes Werk: |
volume:112 ; year:1978 ; number:1 ; pages:121-125 |
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|---|
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NLEJ184352878 |
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| 245 | 1 | 0 | |a Changing levels of UV light and carcinogen-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation |
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| 520 | |a Mouse oocytes were exposed in vitro to various DNA-damaging agents at the germinal vesicle (GV), metaphase I (M I) or metaphase II (M II) stage of meiotic maturation and then labelled with [^3H]thymidine for 2.0 h following their exposure. Variable levels of unscheduled DNA synthesis were induced in the oocytes at the different stages of maturation by the damaging agents. These levels may be ranked in the following order: GV>M I=M II when exposed to UV light; GV>M I>M II when exposed to 4-nitroquinoline-1-oxide (4-NQO); GV=M I=M II when exposed to methyl methanesulfonate (MMS). When the oocytes were exposed to UV light or 4-NQO at the M II stage the levels of unscheduled DNA synthesis in the polar bodies were considerably lower than those in the oocytes, but MMS exposure at the M II stage resulted in the same levels of unscheduled DNA synthesis in both the polar bodies and the oocytes. Factors which may account for both the variable levels of unscheduled DNA synthesis at the different stages as well as the differential response of the oocytes and the polar bodies are discussed. | ||
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(DE-627)NLEJ184352878 (DE-599)GBVNLZ184352878 DE-627 ger DE-627 rakwb eng Changing levels of UV light and carcinogen-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation 1978 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Mouse oocytes were exposed in vitro to various DNA-damaging agents at the germinal vesicle (GV), metaphase I (M I) or metaphase II (M II) stage of meiotic maturation and then labelled with [^3H]thymidine for 2.0 h following their exposure. Variable levels of unscheduled DNA synthesis were induced in the oocytes at the different stages of maturation by the damaging agents. These levels may be ranked in the following order: GV>M I=M II when exposed to UV light; GV>M I>M II when exposed to 4-nitroquinoline-1-oxide (4-NQO); GV=M I=M II when exposed to methyl methanesulfonate (MMS). When the oocytes were exposed to UV light or 4-NQO at the M II stage the levels of unscheduled DNA synthesis in the polar bodies were considerably lower than those in the oocytes, but MMS exposure at the M II stage resulted in the same levels of unscheduled DNA synthesis in both the polar bodies and the oocytes. Factors which may account for both the variable levels of unscheduled DNA synthesis at the different stages as well as the differential response of the oocytes and the polar bodies are discussed. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brazill, J.L. oth Masui, Y. oth in Experimental Cell Research Amsterdam : Elsevier 112(1978), 1, Seite 121-125 (DE-627)NLEJ177031808 (DE-600)1466780-0 0014-4827 nnns volume:112 year:1978 number:1 pages:121-125 http://dx.doi.org/10.1016/0014-4827(78)90532-3 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 112 1978 1 121-125 |
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(DE-627)NLEJ184352878 (DE-599)GBVNLZ184352878 DE-627 ger DE-627 rakwb eng Changing levels of UV light and carcinogen-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation 1978 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Mouse oocytes were exposed in vitro to various DNA-damaging agents at the germinal vesicle (GV), metaphase I (M I) or metaphase II (M II) stage of meiotic maturation and then labelled with [^3H]thymidine for 2.0 h following their exposure. Variable levels of unscheduled DNA synthesis were induced in the oocytes at the different stages of maturation by the damaging agents. These levels may be ranked in the following order: GV>M I=M II when exposed to UV light; GV>M I>M II when exposed to 4-nitroquinoline-1-oxide (4-NQO); GV=M I=M II when exposed to methyl methanesulfonate (MMS). When the oocytes were exposed to UV light or 4-NQO at the M II stage the levels of unscheduled DNA synthesis in the polar bodies were considerably lower than those in the oocytes, but MMS exposure at the M II stage resulted in the same levels of unscheduled DNA synthesis in both the polar bodies and the oocytes. Factors which may account for both the variable levels of unscheduled DNA synthesis at the different stages as well as the differential response of the oocytes and the polar bodies are discussed. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brazill, J.L. oth Masui, Y. oth in Experimental Cell Research Amsterdam : Elsevier 112(1978), 1, Seite 121-125 (DE-627)NLEJ177031808 (DE-600)1466780-0 0014-4827 nnns volume:112 year:1978 number:1 pages:121-125 http://dx.doi.org/10.1016/0014-4827(78)90532-3 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 112 1978 1 121-125 |
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(DE-627)NLEJ184352878 (DE-599)GBVNLZ184352878 DE-627 ger DE-627 rakwb eng Changing levels of UV light and carcinogen-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation 1978 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Mouse oocytes were exposed in vitro to various DNA-damaging agents at the germinal vesicle (GV), metaphase I (M I) or metaphase II (M II) stage of meiotic maturation and then labelled with [^3H]thymidine for 2.0 h following their exposure. Variable levels of unscheduled DNA synthesis were induced in the oocytes at the different stages of maturation by the damaging agents. These levels may be ranked in the following order: GV>M I=M II when exposed to UV light; GV>M I>M II when exposed to 4-nitroquinoline-1-oxide (4-NQO); GV=M I=M II when exposed to methyl methanesulfonate (MMS). When the oocytes were exposed to UV light or 4-NQO at the M II stage the levels of unscheduled DNA synthesis in the polar bodies were considerably lower than those in the oocytes, but MMS exposure at the M II stage resulted in the same levels of unscheduled DNA synthesis in both the polar bodies and the oocytes. Factors which may account for both the variable levels of unscheduled DNA synthesis at the different stages as well as the differential response of the oocytes and the polar bodies are discussed. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brazill, J.L. oth Masui, Y. oth in Experimental Cell Research Amsterdam : Elsevier 112(1978), 1, Seite 121-125 (DE-627)NLEJ177031808 (DE-600)1466780-0 0014-4827 nnns volume:112 year:1978 number:1 pages:121-125 http://dx.doi.org/10.1016/0014-4827(78)90532-3 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 112 1978 1 121-125 |
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(DE-627)NLEJ184352878 (DE-599)GBVNLZ184352878 DE-627 ger DE-627 rakwb eng Changing levels of UV light and carcinogen-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation 1978 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Mouse oocytes were exposed in vitro to various DNA-damaging agents at the germinal vesicle (GV), metaphase I (M I) or metaphase II (M II) stage of meiotic maturation and then labelled with [^3H]thymidine for 2.0 h following their exposure. Variable levels of unscheduled DNA synthesis were induced in the oocytes at the different stages of maturation by the damaging agents. These levels may be ranked in the following order: GV>M I=M II when exposed to UV light; GV>M I>M II when exposed to 4-nitroquinoline-1-oxide (4-NQO); GV=M I=M II when exposed to methyl methanesulfonate (MMS). When the oocytes were exposed to UV light or 4-NQO at the M II stage the levels of unscheduled DNA synthesis in the polar bodies were considerably lower than those in the oocytes, but MMS exposure at the M II stage resulted in the same levels of unscheduled DNA synthesis in both the polar bodies and the oocytes. Factors which may account for both the variable levels of unscheduled DNA synthesis at the different stages as well as the differential response of the oocytes and the polar bodies are discussed. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brazill, J.L. oth Masui, Y. oth in Experimental Cell Research Amsterdam : Elsevier 112(1978), 1, Seite 121-125 (DE-627)NLEJ177031808 (DE-600)1466780-0 0014-4827 nnns volume:112 year:1978 number:1 pages:121-125 http://dx.doi.org/10.1016/0014-4827(78)90532-3 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 112 1978 1 121-125 |
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(DE-627)NLEJ184352878 (DE-599)GBVNLZ184352878 DE-627 ger DE-627 rakwb eng Changing levels of UV light and carcinogen-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation 1978 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Mouse oocytes were exposed in vitro to various DNA-damaging agents at the germinal vesicle (GV), metaphase I (M I) or metaphase II (M II) stage of meiotic maturation and then labelled with [^3H]thymidine for 2.0 h following their exposure. Variable levels of unscheduled DNA synthesis were induced in the oocytes at the different stages of maturation by the damaging agents. These levels may be ranked in the following order: GV>M I=M II when exposed to UV light; GV>M I>M II when exposed to 4-nitroquinoline-1-oxide (4-NQO); GV=M I=M II when exposed to methyl methanesulfonate (MMS). When the oocytes were exposed to UV light or 4-NQO at the M II stage the levels of unscheduled DNA synthesis in the polar bodies were considerably lower than those in the oocytes, but MMS exposure at the M II stage resulted in the same levels of unscheduled DNA synthesis in both the polar bodies and the oocytes. Factors which may account for both the variable levels of unscheduled DNA synthesis at the different stages as well as the differential response of the oocytes and the polar bodies are discussed. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brazill, J.L. oth Masui, Y. oth in Experimental Cell Research Amsterdam : Elsevier 112(1978), 1, Seite 121-125 (DE-627)NLEJ177031808 (DE-600)1466780-0 0014-4827 nnns volume:112 year:1978 number:1 pages:121-125 http://dx.doi.org/10.1016/0014-4827(78)90532-3 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 112 1978 1 121-125 |
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changing levels of uv light and carcinogen-induced unscheduled dna synthesis in mouse oocytes during meiotic maturation |
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Changing levels of UV light and carcinogen-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation |
| abstract |
Mouse oocytes were exposed in vitro to various DNA-damaging agents at the germinal vesicle (GV), metaphase I (M I) or metaphase II (M II) stage of meiotic maturation and then labelled with [^3H]thymidine for 2.0 h following their exposure. Variable levels of unscheduled DNA synthesis were induced in the oocytes at the different stages of maturation by the damaging agents. These levels may be ranked in the following order: GV>M I=M II when exposed to UV light; GV>M I>M II when exposed to 4-nitroquinoline-1-oxide (4-NQO); GV=M I=M II when exposed to methyl methanesulfonate (MMS). When the oocytes were exposed to UV light or 4-NQO at the M II stage the levels of unscheduled DNA synthesis in the polar bodies were considerably lower than those in the oocytes, but MMS exposure at the M II stage resulted in the same levels of unscheduled DNA synthesis in both the polar bodies and the oocytes. Factors which may account for both the variable levels of unscheduled DNA synthesis at the different stages as well as the differential response of the oocytes and the polar bodies are discussed. |
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Mouse oocytes were exposed in vitro to various DNA-damaging agents at the germinal vesicle (GV), metaphase I (M I) or metaphase II (M II) stage of meiotic maturation and then labelled with [^3H]thymidine for 2.0 h following their exposure. Variable levels of unscheduled DNA synthesis were induced in the oocytes at the different stages of maturation by the damaging agents. These levels may be ranked in the following order: GV>M I=M II when exposed to UV light; GV>M I>M II when exposed to 4-nitroquinoline-1-oxide (4-NQO); GV=M I=M II when exposed to methyl methanesulfonate (MMS). When the oocytes were exposed to UV light or 4-NQO at the M II stage the levels of unscheduled DNA synthesis in the polar bodies were considerably lower than those in the oocytes, but MMS exposure at the M II stage resulted in the same levels of unscheduled DNA synthesis in both the polar bodies and the oocytes. Factors which may account for both the variable levels of unscheduled DNA synthesis at the different stages as well as the differential response of the oocytes and the polar bodies are discussed. |
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Mouse oocytes were exposed in vitro to various DNA-damaging agents at the germinal vesicle (GV), metaphase I (M I) or metaphase II (M II) stage of meiotic maturation and then labelled with [^3H]thymidine for 2.0 h following their exposure. Variable levels of unscheduled DNA synthesis were induced in the oocytes at the different stages of maturation by the damaging agents. These levels may be ranked in the following order: GV>M I=M II when exposed to UV light; GV>M I>M II when exposed to 4-nitroquinoline-1-oxide (4-NQO); GV=M I=M II when exposed to methyl methanesulfonate (MMS). When the oocytes were exposed to UV light or 4-NQO at the M II stage the levels of unscheduled DNA synthesis in the polar bodies were considerably lower than those in the oocytes, but MMS exposure at the M II stage resulted in the same levels of unscheduled DNA synthesis in both the polar bodies and the oocytes. Factors which may account for both the variable levels of unscheduled DNA synthesis at the different stages as well as the differential response of the oocytes and the polar bodies are discussed. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ184352878</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706230056.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070506s1978 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ184352878</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ184352878</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Changing levels of UV light and carcinogen-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturation</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1978</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Mouse oocytes were exposed in vitro to various DNA-damaging agents at the germinal vesicle (GV), metaphase I (M I) or metaphase II (M II) stage of meiotic maturation and then labelled with [^3H]thymidine for 2.0 h following their exposure. Variable levels of unscheduled DNA synthesis were induced in the oocytes at the different stages of maturation by the damaging agents. These levels may be ranked in the following order: GV>M I=M II when exposed to UV light; GV>M I>M II when exposed to 4-nitroquinoline-1-oxide (4-NQO); GV=M I=M II when exposed to methyl methanesulfonate (MMS). When the oocytes were exposed to UV light or 4-NQO at the M II stage the levels of unscheduled DNA synthesis in the polar bodies were considerably lower than those in the oocytes, but MMS exposure at the M II stage resulted in the same levels of unscheduled DNA synthesis in both the polar bodies and the oocytes. Factors which may account for both the variable levels of unscheduled DNA synthesis at the different stages as well as the differential response of the oocytes and the polar bodies are discussed.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Brazill, J.L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Masui, Y.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Experimental Cell Research</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">112(1978), 1, Seite 121-125</subfield><subfield code="w">(DE-627)NLEJ177031808</subfield><subfield code="w">(DE-600)1466780-0</subfield><subfield code="x">0014-4827</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:112</subfield><subfield code="g">year:1978</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:121-125</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1016/0014-4827(78)90532-3</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">112</subfield><subfield code="j">1978</subfield><subfield code="e">1</subfield><subfield code="h">121-125</subfield></datafield></record></collection>
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