Lack of tolerance or sensitization to the effects of chronic d-amphetamine on substantia nigra self-stimulation
The effects of repeated administration of d-amphetamine on intracranial self-stimulation were investigated through substantia nigra electrodes in rats. Doses of d-amphetamine (0.1, 0.5, and 1.5 mg/kg), which facilitated bar-pressing for self-stimulation on the first day of treatment, were administer...
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1976 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Behavioral Biology - Amsterdam : Elsevier, 16(1976), 2, Seite 211-220 |
| Übergeordnetes Werk: |
volume:16 ; year:1976 ; number:2 ; pages:211-220 |
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NLEJ184604605 |
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| 520 | |a The effects of repeated administration of d-amphetamine on intracranial self-stimulation were investigated through substantia nigra electrodes in rats. Doses of d-amphetamine (0.1, 0.5, and 1.5 mg/kg), which facilitated bar-pressing for self-stimulation on the first day of treatment, were administered 30 min before daily testing for 10-12 days. Self-stimulation rates on the last day of treatment did not differ significantly from that on the first day at any dose tested. These results are in contrast to previous reports of progressive facilitation of locomotor activity and stereotypy by repeated d-amphetamine administration. To the extent that self-stimulation in substantia nigra reflects the functional state of dopaminergic neurotransmission, progressive augmentation of activity and stereotypy by repeated d-amphetamine administration may not involve dopaminergic processes. | ||
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(DE-627)NLEJ184604605 (DE-599)GBVNLZ184604605 DE-627 ger DE-627 rakwb eng Lack of tolerance or sensitization to the effects of chronic d-amphetamine on substantia nigra self-stimulation 1976 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of repeated administration of d-amphetamine on intracranial self-stimulation were investigated through substantia nigra electrodes in rats. Doses of d-amphetamine (0.1, 0.5, and 1.5 mg/kg), which facilitated bar-pressing for self-stimulation on the first day of treatment, were administered 30 min before daily testing for 10-12 days. Self-stimulation rates on the last day of treatment did not differ significantly from that on the first day at any dose tested. These results are in contrast to previous reports of progressive facilitation of locomotor activity and stereotypy by repeated d-amphetamine administration. To the extent that self-stimulation in substantia nigra reflects the functional state of dopaminergic neurotransmission, progressive augmentation of activity and stereotypy by repeated d-amphetamine administration may not involve dopaminergic processes. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Liebman, J.M. oth Segal, D.S. oth in Behavioral Biology Amsterdam : Elsevier 16(1976), 2, Seite 211-220 (DE-627)NLEJ177095490 (DE-600)2196589-4 0091-6773 nnns volume:16 year:1976 number:2 pages:211-220 http://dx.doi.org/10.1016/S0091-6773(76)91324-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 16 1976 2 211-220 |
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(DE-627)NLEJ184604605 (DE-599)GBVNLZ184604605 DE-627 ger DE-627 rakwb eng Lack of tolerance or sensitization to the effects of chronic d-amphetamine on substantia nigra self-stimulation 1976 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of repeated administration of d-amphetamine on intracranial self-stimulation were investigated through substantia nigra electrodes in rats. Doses of d-amphetamine (0.1, 0.5, and 1.5 mg/kg), which facilitated bar-pressing for self-stimulation on the first day of treatment, were administered 30 min before daily testing for 10-12 days. Self-stimulation rates on the last day of treatment did not differ significantly from that on the first day at any dose tested. These results are in contrast to previous reports of progressive facilitation of locomotor activity and stereotypy by repeated d-amphetamine administration. To the extent that self-stimulation in substantia nigra reflects the functional state of dopaminergic neurotransmission, progressive augmentation of activity and stereotypy by repeated d-amphetamine administration may not involve dopaminergic processes. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Liebman, J.M. oth Segal, D.S. oth in Behavioral Biology Amsterdam : Elsevier 16(1976), 2, Seite 211-220 (DE-627)NLEJ177095490 (DE-600)2196589-4 0091-6773 nnns volume:16 year:1976 number:2 pages:211-220 http://dx.doi.org/10.1016/S0091-6773(76)91324-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 16 1976 2 211-220 |
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(DE-627)NLEJ184604605 (DE-599)GBVNLZ184604605 DE-627 ger DE-627 rakwb eng Lack of tolerance or sensitization to the effects of chronic d-amphetamine on substantia nigra self-stimulation 1976 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of repeated administration of d-amphetamine on intracranial self-stimulation were investigated through substantia nigra electrodes in rats. Doses of d-amphetamine (0.1, 0.5, and 1.5 mg/kg), which facilitated bar-pressing for self-stimulation on the first day of treatment, were administered 30 min before daily testing for 10-12 days. Self-stimulation rates on the last day of treatment did not differ significantly from that on the first day at any dose tested. These results are in contrast to previous reports of progressive facilitation of locomotor activity and stereotypy by repeated d-amphetamine administration. To the extent that self-stimulation in substantia nigra reflects the functional state of dopaminergic neurotransmission, progressive augmentation of activity and stereotypy by repeated d-amphetamine administration may not involve dopaminergic processes. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Liebman, J.M. oth Segal, D.S. oth in Behavioral Biology Amsterdam : Elsevier 16(1976), 2, Seite 211-220 (DE-627)NLEJ177095490 (DE-600)2196589-4 0091-6773 nnns volume:16 year:1976 number:2 pages:211-220 http://dx.doi.org/10.1016/S0091-6773(76)91324-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 16 1976 2 211-220 |
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(DE-627)NLEJ184604605 (DE-599)GBVNLZ184604605 DE-627 ger DE-627 rakwb eng Lack of tolerance or sensitization to the effects of chronic d-amphetamine on substantia nigra self-stimulation 1976 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of repeated administration of d-amphetamine on intracranial self-stimulation were investigated through substantia nigra electrodes in rats. Doses of d-amphetamine (0.1, 0.5, and 1.5 mg/kg), which facilitated bar-pressing for self-stimulation on the first day of treatment, were administered 30 min before daily testing for 10-12 days. Self-stimulation rates on the last day of treatment did not differ significantly from that on the first day at any dose tested. These results are in contrast to previous reports of progressive facilitation of locomotor activity and stereotypy by repeated d-amphetamine administration. To the extent that self-stimulation in substantia nigra reflects the functional state of dopaminergic neurotransmission, progressive augmentation of activity and stereotypy by repeated d-amphetamine administration may not involve dopaminergic processes. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Liebman, J.M. oth Segal, D.S. oth in Behavioral Biology Amsterdam : Elsevier 16(1976), 2, Seite 211-220 (DE-627)NLEJ177095490 (DE-600)2196589-4 0091-6773 nnns volume:16 year:1976 number:2 pages:211-220 http://dx.doi.org/10.1016/S0091-6773(76)91324-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 16 1976 2 211-220 |
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(DE-627)NLEJ184604605 (DE-599)GBVNLZ184604605 DE-627 ger DE-627 rakwb eng Lack of tolerance or sensitization to the effects of chronic d-amphetamine on substantia nigra self-stimulation 1976 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of repeated administration of d-amphetamine on intracranial self-stimulation were investigated through substantia nigra electrodes in rats. Doses of d-amphetamine (0.1, 0.5, and 1.5 mg/kg), which facilitated bar-pressing for self-stimulation on the first day of treatment, were administered 30 min before daily testing for 10-12 days. Self-stimulation rates on the last day of treatment did not differ significantly from that on the first day at any dose tested. These results are in contrast to previous reports of progressive facilitation of locomotor activity and stereotypy by repeated d-amphetamine administration. To the extent that self-stimulation in substantia nigra reflects the functional state of dopaminergic neurotransmission, progressive augmentation of activity and stereotypy by repeated d-amphetamine administration may not involve dopaminergic processes. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Liebman, J.M. oth Segal, D.S. oth in Behavioral Biology Amsterdam : Elsevier 16(1976), 2, Seite 211-220 (DE-627)NLEJ177095490 (DE-600)2196589-4 0091-6773 nnns volume:16 year:1976 number:2 pages:211-220 http://dx.doi.org/10.1016/S0091-6773(76)91324-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 16 1976 2 211-220 |
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lack of tolerance or sensitization to the effects of chronic d-amphetamine on substantia nigra self-stimulation |
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Lack of tolerance or sensitization to the effects of chronic d-amphetamine on substantia nigra self-stimulation |
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The effects of repeated administration of d-amphetamine on intracranial self-stimulation were investigated through substantia nigra electrodes in rats. Doses of d-amphetamine (0.1, 0.5, and 1.5 mg/kg), which facilitated bar-pressing for self-stimulation on the first day of treatment, were administered 30 min before daily testing for 10-12 days. Self-stimulation rates on the last day of treatment did not differ significantly from that on the first day at any dose tested. These results are in contrast to previous reports of progressive facilitation of locomotor activity and stereotypy by repeated d-amphetamine administration. To the extent that self-stimulation in substantia nigra reflects the functional state of dopaminergic neurotransmission, progressive augmentation of activity and stereotypy by repeated d-amphetamine administration may not involve dopaminergic processes. |
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The effects of repeated administration of d-amphetamine on intracranial self-stimulation were investigated through substantia nigra electrodes in rats. Doses of d-amphetamine (0.1, 0.5, and 1.5 mg/kg), which facilitated bar-pressing for self-stimulation on the first day of treatment, were administered 30 min before daily testing for 10-12 days. Self-stimulation rates on the last day of treatment did not differ significantly from that on the first day at any dose tested. These results are in contrast to previous reports of progressive facilitation of locomotor activity and stereotypy by repeated d-amphetamine administration. To the extent that self-stimulation in substantia nigra reflects the functional state of dopaminergic neurotransmission, progressive augmentation of activity and stereotypy by repeated d-amphetamine administration may not involve dopaminergic processes. |
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The effects of repeated administration of d-amphetamine on intracranial self-stimulation were investigated through substantia nigra electrodes in rats. Doses of d-amphetamine (0.1, 0.5, and 1.5 mg/kg), which facilitated bar-pressing for self-stimulation on the first day of treatment, were administered 30 min before daily testing for 10-12 days. Self-stimulation rates on the last day of treatment did not differ significantly from that on the first day at any dose tested. These results are in contrast to previous reports of progressive facilitation of locomotor activity and stereotypy by repeated d-amphetamine administration. To the extent that self-stimulation in substantia nigra reflects the functional state of dopaminergic neurotransmission, progressive augmentation of activity and stereotypy by repeated d-amphetamine administration may not involve dopaminergic processes. |
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