Localized memories in idiotypic networks
The present paper investigates conditions under which immunological memory can be maintained by stimulatory idiotypic network interactions. The paper was motivated by the work of (De Boer & Hogeweg, 1989b, Bull. math. Biol.51, 381-408.) which claimed that idiotypic memory is not possible because...
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1990 |
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Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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in: Journal of Theoretical Biology - Amsterdam : Elsevier, 146(1990), 4, Seite 483-499 |
| Übergeordnetes Werk: |
volume:146 ; year:1990 ; number:4 ; pages:483-499 |
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| 520 | |a The present paper investigates conditions under which immunological memory can be maintained by stimulatory idiotypic network interactions. The paper was motivated by the work of (De Boer & Hogeweg, 1989b, Bull. math. Biol.51, 381-408.) which claimed that idiotypic memory is not possible because of percolation within the network. Here we reinvestigate the issue of percolation using both the previous model and a simpler one (Weisbuch, 1990, J. theor. Biol.143, 507-522.) that allows analytic analysis. We focus on network topologies in which each Ab1 is connected to several Ab2s, which in turn are connected to several Ab3s. It is demonstrated that, for a considerable range of parameters, both models account for the existence of localized memory-states in which only the Ab1 and the Ab2 clones are activated and the clones of the Ab3 level remain virgin. The existence of localized memory-states seems to contradict the previous percolation result. This discrepancy will be shown to depend on the system dynamics. By simulation we explore the parameter regimes for which one finds percolation and those for which localized memory-states exists. We show that the conditions required for attaining the localized memory-state are considerably more stringent than those required for its existence and local stability. We conclude that both localized memory and percolation are possible in stimulatory idiotypic networks. | ||
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(DE-627)NLEJ184819431 (DE-599)GBVNLZ184819431 DE-627 ger DE-627 rakwb eng Localized memories in idiotypic networks 1990 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present paper investigates conditions under which immunological memory can be maintained by stimulatory idiotypic network interactions. The paper was motivated by the work of (De Boer & Hogeweg, 1989b, Bull. math. Biol.51, 381-408.) which claimed that idiotypic memory is not possible because of percolation within the network. Here we reinvestigate the issue of percolation using both the previous model and a simpler one (Weisbuch, 1990, J. theor. Biol.143, 507-522.) that allows analytic analysis. We focus on network topologies in which each Ab1 is connected to several Ab2s, which in turn are connected to several Ab3s. It is demonstrated that, for a considerable range of parameters, both models account for the existence of localized memory-states in which only the Ab1 and the Ab2 clones are activated and the clones of the Ab3 level remain virgin. The existence of localized memory-states seems to contradict the previous percolation result. This discrepancy will be shown to depend on the system dynamics. By simulation we explore the parameter regimes for which one finds percolation and those for which localized memory-states exists. We show that the conditions required for attaining the localized memory-state are considerably more stringent than those required for its existence and local stability. We conclude that both localized memory and percolation are possible in stimulatory idiotypic networks. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Weisbuch, G. oth De Boer, R.J. oth Perelson, A.S. oth in Journal of Theoretical Biology Amsterdam : Elsevier 146(1990), 4, Seite 483-499 (DE-627)NLEJ176864393 (DE-600)1470953-3 0022-5193 nnns volume:146 year:1990 number:4 pages:483-499 http://dx.doi.org/10.1016/S0022-5193(05)80374-1 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 146 1990 4 483-499 |
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(DE-627)NLEJ184819431 (DE-599)GBVNLZ184819431 DE-627 ger DE-627 rakwb eng Localized memories in idiotypic networks 1990 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present paper investigates conditions under which immunological memory can be maintained by stimulatory idiotypic network interactions. The paper was motivated by the work of (De Boer & Hogeweg, 1989b, Bull. math. Biol.51, 381-408.) which claimed that idiotypic memory is not possible because of percolation within the network. Here we reinvestigate the issue of percolation using both the previous model and a simpler one (Weisbuch, 1990, J. theor. Biol.143, 507-522.) that allows analytic analysis. We focus on network topologies in which each Ab1 is connected to several Ab2s, which in turn are connected to several Ab3s. It is demonstrated that, for a considerable range of parameters, both models account for the existence of localized memory-states in which only the Ab1 and the Ab2 clones are activated and the clones of the Ab3 level remain virgin. The existence of localized memory-states seems to contradict the previous percolation result. This discrepancy will be shown to depend on the system dynamics. By simulation we explore the parameter regimes for which one finds percolation and those for which localized memory-states exists. We show that the conditions required for attaining the localized memory-state are considerably more stringent than those required for its existence and local stability. We conclude that both localized memory and percolation are possible in stimulatory idiotypic networks. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Weisbuch, G. oth De Boer, R.J. oth Perelson, A.S. oth in Journal of Theoretical Biology Amsterdam : Elsevier 146(1990), 4, Seite 483-499 (DE-627)NLEJ176864393 (DE-600)1470953-3 0022-5193 nnns volume:146 year:1990 number:4 pages:483-499 http://dx.doi.org/10.1016/S0022-5193(05)80374-1 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 146 1990 4 483-499 |
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(DE-627)NLEJ184819431 (DE-599)GBVNLZ184819431 DE-627 ger DE-627 rakwb eng Localized memories in idiotypic networks 1990 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present paper investigates conditions under which immunological memory can be maintained by stimulatory idiotypic network interactions. The paper was motivated by the work of (De Boer & Hogeweg, 1989b, Bull. math. Biol.51, 381-408.) which claimed that idiotypic memory is not possible because of percolation within the network. Here we reinvestigate the issue of percolation using both the previous model and a simpler one (Weisbuch, 1990, J. theor. Biol.143, 507-522.) that allows analytic analysis. We focus on network topologies in which each Ab1 is connected to several Ab2s, which in turn are connected to several Ab3s. It is demonstrated that, for a considerable range of parameters, both models account for the existence of localized memory-states in which only the Ab1 and the Ab2 clones are activated and the clones of the Ab3 level remain virgin. The existence of localized memory-states seems to contradict the previous percolation result. This discrepancy will be shown to depend on the system dynamics. By simulation we explore the parameter regimes for which one finds percolation and those for which localized memory-states exists. We show that the conditions required for attaining the localized memory-state are considerably more stringent than those required for its existence and local stability. We conclude that both localized memory and percolation are possible in stimulatory idiotypic networks. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Weisbuch, G. oth De Boer, R.J. oth Perelson, A.S. oth in Journal of Theoretical Biology Amsterdam : Elsevier 146(1990), 4, Seite 483-499 (DE-627)NLEJ176864393 (DE-600)1470953-3 0022-5193 nnns volume:146 year:1990 number:4 pages:483-499 http://dx.doi.org/10.1016/S0022-5193(05)80374-1 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 146 1990 4 483-499 |
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(DE-627)NLEJ184819431 (DE-599)GBVNLZ184819431 DE-627 ger DE-627 rakwb eng Localized memories in idiotypic networks 1990 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present paper investigates conditions under which immunological memory can be maintained by stimulatory idiotypic network interactions. The paper was motivated by the work of (De Boer & Hogeweg, 1989b, Bull. math. Biol.51, 381-408.) which claimed that idiotypic memory is not possible because of percolation within the network. Here we reinvestigate the issue of percolation using both the previous model and a simpler one (Weisbuch, 1990, J. theor. Biol.143, 507-522.) that allows analytic analysis. We focus on network topologies in which each Ab1 is connected to several Ab2s, which in turn are connected to several Ab3s. It is demonstrated that, for a considerable range of parameters, both models account for the existence of localized memory-states in which only the Ab1 and the Ab2 clones are activated and the clones of the Ab3 level remain virgin. The existence of localized memory-states seems to contradict the previous percolation result. This discrepancy will be shown to depend on the system dynamics. By simulation we explore the parameter regimes for which one finds percolation and those for which localized memory-states exists. We show that the conditions required for attaining the localized memory-state are considerably more stringent than those required for its existence and local stability. We conclude that both localized memory and percolation are possible in stimulatory idiotypic networks. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Weisbuch, G. oth De Boer, R.J. oth Perelson, A.S. oth in Journal of Theoretical Biology Amsterdam : Elsevier 146(1990), 4, Seite 483-499 (DE-627)NLEJ176864393 (DE-600)1470953-3 0022-5193 nnns volume:146 year:1990 number:4 pages:483-499 http://dx.doi.org/10.1016/S0022-5193(05)80374-1 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 146 1990 4 483-499 |
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(DE-627)NLEJ184819431 (DE-599)GBVNLZ184819431 DE-627 ger DE-627 rakwb eng Localized memories in idiotypic networks 1990 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present paper investigates conditions under which immunological memory can be maintained by stimulatory idiotypic network interactions. The paper was motivated by the work of (De Boer & Hogeweg, 1989b, Bull. math. Biol.51, 381-408.) which claimed that idiotypic memory is not possible because of percolation within the network. Here we reinvestigate the issue of percolation using both the previous model and a simpler one (Weisbuch, 1990, J. theor. Biol.143, 507-522.) that allows analytic analysis. We focus on network topologies in which each Ab1 is connected to several Ab2s, which in turn are connected to several Ab3s. It is demonstrated that, for a considerable range of parameters, both models account for the existence of localized memory-states in which only the Ab1 and the Ab2 clones are activated and the clones of the Ab3 level remain virgin. The existence of localized memory-states seems to contradict the previous percolation result. This discrepancy will be shown to depend on the system dynamics. By simulation we explore the parameter regimes for which one finds percolation and those for which localized memory-states exists. We show that the conditions required for attaining the localized memory-state are considerably more stringent than those required for its existence and local stability. We conclude that both localized memory and percolation are possible in stimulatory idiotypic networks. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Weisbuch, G. oth De Boer, R.J. oth Perelson, A.S. oth in Journal of Theoretical Biology Amsterdam : Elsevier 146(1990), 4, Seite 483-499 (DE-627)NLEJ176864393 (DE-600)1470953-3 0022-5193 nnns volume:146 year:1990 number:4 pages:483-499 http://dx.doi.org/10.1016/S0022-5193(05)80374-1 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 146 1990 4 483-499 |
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The present paper investigates conditions under which immunological memory can be maintained by stimulatory idiotypic network interactions. The paper was motivated by the work of (De Boer & Hogeweg, 1989b, Bull. math. Biol.51, 381-408.) which claimed that idiotypic memory is not possible because of percolation within the network. Here we reinvestigate the issue of percolation using both the previous model and a simpler one (Weisbuch, 1990, J. theor. Biol.143, 507-522.) that allows analytic analysis. We focus on network topologies in which each Ab1 is connected to several Ab2s, which in turn are connected to several Ab3s. It is demonstrated that, for a considerable range of parameters, both models account for the existence of localized memory-states in which only the Ab1 and the Ab2 clones are activated and the clones of the Ab3 level remain virgin. The existence of localized memory-states seems to contradict the previous percolation result. This discrepancy will be shown to depend on the system dynamics. By simulation we explore the parameter regimes for which one finds percolation and those for which localized memory-states exists. We show that the conditions required for attaining the localized memory-state are considerably more stringent than those required for its existence and local stability. We conclude that both localized memory and percolation are possible in stimulatory idiotypic networks. |
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The present paper investigates conditions under which immunological memory can be maintained by stimulatory idiotypic network interactions. The paper was motivated by the work of (De Boer & Hogeweg, 1989b, Bull. math. Biol.51, 381-408.) which claimed that idiotypic memory is not possible because of percolation within the network. Here we reinvestigate the issue of percolation using both the previous model and a simpler one (Weisbuch, 1990, J. theor. Biol.143, 507-522.) that allows analytic analysis. We focus on network topologies in which each Ab1 is connected to several Ab2s, which in turn are connected to several Ab3s. It is demonstrated that, for a considerable range of parameters, both models account for the existence of localized memory-states in which only the Ab1 and the Ab2 clones are activated and the clones of the Ab3 level remain virgin. The existence of localized memory-states seems to contradict the previous percolation result. This discrepancy will be shown to depend on the system dynamics. By simulation we explore the parameter regimes for which one finds percolation and those for which localized memory-states exists. We show that the conditions required for attaining the localized memory-state are considerably more stringent than those required for its existence and local stability. We conclude that both localized memory and percolation are possible in stimulatory idiotypic networks. |
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The present paper investigates conditions under which immunological memory can be maintained by stimulatory idiotypic network interactions. The paper was motivated by the work of (De Boer & Hogeweg, 1989b, Bull. math. Biol.51, 381-408.) which claimed that idiotypic memory is not possible because of percolation within the network. Here we reinvestigate the issue of percolation using both the previous model and a simpler one (Weisbuch, 1990, J. theor. Biol.143, 507-522.) that allows analytic analysis. We focus on network topologies in which each Ab1 is connected to several Ab2s, which in turn are connected to several Ab3s. It is demonstrated that, for a considerable range of parameters, both models account for the existence of localized memory-states in which only the Ab1 and the Ab2 clones are activated and the clones of the Ab3 level remain virgin. The existence of localized memory-states seems to contradict the previous percolation result. This discrepancy will be shown to depend on the system dynamics. By simulation we explore the parameter regimes for which one finds percolation and those for which localized memory-states exists. We show that the conditions required for attaining the localized memory-state are considerably more stringent than those required for its existence and local stability. We conclude that both localized memory and percolation are possible in stimulatory idiotypic networks. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ184819431</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707001331.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070506s1990 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ184819431</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ184819431</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Localized memories in idiotypic networks</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1990</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The present paper investigates conditions under which immunological memory can be maintained by stimulatory idiotypic network interactions. The paper was motivated by the work of (De Boer & Hogeweg, 1989b, Bull. math. Biol.51, 381-408.) which claimed that idiotypic memory is not possible because of percolation within the network. Here we reinvestigate the issue of percolation using both the previous model and a simpler one (Weisbuch, 1990, J. theor. Biol.143, 507-522.) that allows analytic analysis. We focus on network topologies in which each Ab1 is connected to several Ab2s, which in turn are connected to several Ab3s. It is demonstrated that, for a considerable range of parameters, both models account for the existence of localized memory-states in which only the Ab1 and the Ab2 clones are activated and the clones of the Ab3 level remain virgin. The existence of localized memory-states seems to contradict the previous percolation result. This discrepancy will be shown to depend on the system dynamics. By simulation we explore the parameter regimes for which one finds percolation and those for which localized memory-states exists. We show that the conditions required for attaining the localized memory-state are considerably more stringent than those required for its existence and local stability. We conclude that both localized memory and percolation are possible in stimulatory idiotypic networks.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Weisbuch, G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">De Boer, R.J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Perelson, A.S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Journal of Theoretical Biology</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">146(1990), 4, Seite 483-499</subfield><subfield code="w">(DE-627)NLEJ176864393</subfield><subfield code="w">(DE-600)1470953-3</subfield><subfield code="x">0022-5193</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:146</subfield><subfield code="g">year:1990</subfield><subfield code="g">number:4</subfield><subfield code="g">pages:483-499</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1016/S0022-5193(05)80374-1</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">146</subfield><subfield code="j">1990</subfield><subfield code="e">4</subfield><subfield code="h">483-499</subfield></datafield></record></collection>
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