Tumor escape from immune elimination: Simplified precursor bound cytotoxicity models
In this paper we present a series of models on cytotoxic T-cell activation derived, by successive simplifications, from the model for Tumor Escape from Immune Elimination of Grossman & Berke (1980). In their model Grossman & Berke (1980) investigate the ''sneaking through'...
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1985 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Journal of Theoretical Biology - Amsterdam : Elsevier, 113(1985), 4, Seite 719-736 |
| Übergeordnetes Werk: |
volume:113 ; year:1985 ; number:4 ; pages:719-736 |
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| 520 | |a In this paper we present a series of models on cytotoxic T-cell activation derived, by successive simplifications, from the model for Tumor Escape from Immune Elimination of Grossman & Berke (1980). In their model Grossman & Berke (1980) investigate the ''sneaking through'' phenomenon, by which they mean that small tumors grow progressively, medium-sized tumors are rejected and large ones break through again. We define precursor bound cytotoxicity models as systems incapable of infinite proliferation. We show that sneaking through can occur in a broad class of very simple precursor bound cytotoxicity models due to the depletion of the precursor cells. The simplest process by which precursors can be depleted is long-lasting antigenic stimulation. We conclude that in precursor bound cytotoxicity models sneaking through does not need the rather intricate combination of counteracting feedback loops, memory and blocking described by Grossman & Berke (1980). | ||
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(DE-627)NLEJ184823404 (DE-599)GBVNLZ184823404 DE-627 ger DE-627 rakwb eng Tumor escape from immune elimination: Simplified precursor bound cytotoxicity models 1985 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this paper we present a series of models on cytotoxic T-cell activation derived, by successive simplifications, from the model for Tumor Escape from Immune Elimination of Grossman & Berke (1980). In their model Grossman & Berke (1980) investigate the ''sneaking through'' phenomenon, by which they mean that small tumors grow progressively, medium-sized tumors are rejected and large ones break through again. We define precursor bound cytotoxicity models as systems incapable of infinite proliferation. We show that sneaking through can occur in a broad class of very simple precursor bound cytotoxicity models due to the depletion of the precursor cells. The simplest process by which precursors can be depleted is long-lasting antigenic stimulation. We conclude that in precursor bound cytotoxicity models sneaking through does not need the rather intricate combination of counteracting feedback loops, memory and blocking described by Grossman & Berke (1980). Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 De Boer, R.J. oth Hogeweg, P. oth in Journal of Theoretical Biology Amsterdam : Elsevier 113(1985), 4, Seite 719-736 (DE-627)NLEJ176864393 (DE-600)1470953-3 0022-5193 nnns volume:113 year:1985 number:4 pages:719-736 http://dx.doi.org/10.1016/S0022-5193(85)80189-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 113 1985 4 719-736 |
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(DE-627)NLEJ184823404 (DE-599)GBVNLZ184823404 DE-627 ger DE-627 rakwb eng Tumor escape from immune elimination: Simplified precursor bound cytotoxicity models 1985 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this paper we present a series of models on cytotoxic T-cell activation derived, by successive simplifications, from the model for Tumor Escape from Immune Elimination of Grossman & Berke (1980). In their model Grossman & Berke (1980) investigate the ''sneaking through'' phenomenon, by which they mean that small tumors grow progressively, medium-sized tumors are rejected and large ones break through again. We define precursor bound cytotoxicity models as systems incapable of infinite proliferation. We show that sneaking through can occur in a broad class of very simple precursor bound cytotoxicity models due to the depletion of the precursor cells. The simplest process by which precursors can be depleted is long-lasting antigenic stimulation. We conclude that in precursor bound cytotoxicity models sneaking through does not need the rather intricate combination of counteracting feedback loops, memory and blocking described by Grossman & Berke (1980). Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 De Boer, R.J. oth Hogeweg, P. oth in Journal of Theoretical Biology Amsterdam : Elsevier 113(1985), 4, Seite 719-736 (DE-627)NLEJ176864393 (DE-600)1470953-3 0022-5193 nnns volume:113 year:1985 number:4 pages:719-736 http://dx.doi.org/10.1016/S0022-5193(85)80189-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 113 1985 4 719-736 |
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(DE-627)NLEJ184823404 (DE-599)GBVNLZ184823404 DE-627 ger DE-627 rakwb eng Tumor escape from immune elimination: Simplified precursor bound cytotoxicity models 1985 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this paper we present a series of models on cytotoxic T-cell activation derived, by successive simplifications, from the model for Tumor Escape from Immune Elimination of Grossman & Berke (1980). In their model Grossman & Berke (1980) investigate the ''sneaking through'' phenomenon, by which they mean that small tumors grow progressively, medium-sized tumors are rejected and large ones break through again. We define precursor bound cytotoxicity models as systems incapable of infinite proliferation. We show that sneaking through can occur in a broad class of very simple precursor bound cytotoxicity models due to the depletion of the precursor cells. The simplest process by which precursors can be depleted is long-lasting antigenic stimulation. We conclude that in precursor bound cytotoxicity models sneaking through does not need the rather intricate combination of counteracting feedback loops, memory and blocking described by Grossman & Berke (1980). Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 De Boer, R.J. oth Hogeweg, P. oth in Journal of Theoretical Biology Amsterdam : Elsevier 113(1985), 4, Seite 719-736 (DE-627)NLEJ176864393 (DE-600)1470953-3 0022-5193 nnns volume:113 year:1985 number:4 pages:719-736 http://dx.doi.org/10.1016/S0022-5193(85)80189-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 113 1985 4 719-736 |
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(DE-627)NLEJ184823404 (DE-599)GBVNLZ184823404 DE-627 ger DE-627 rakwb eng Tumor escape from immune elimination: Simplified precursor bound cytotoxicity models 1985 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this paper we present a series of models on cytotoxic T-cell activation derived, by successive simplifications, from the model for Tumor Escape from Immune Elimination of Grossman & Berke (1980). In their model Grossman & Berke (1980) investigate the ''sneaking through'' phenomenon, by which they mean that small tumors grow progressively, medium-sized tumors are rejected and large ones break through again. We define precursor bound cytotoxicity models as systems incapable of infinite proliferation. We show that sneaking through can occur in a broad class of very simple precursor bound cytotoxicity models due to the depletion of the precursor cells. The simplest process by which precursors can be depleted is long-lasting antigenic stimulation. We conclude that in precursor bound cytotoxicity models sneaking through does not need the rather intricate combination of counteracting feedback loops, memory and blocking described by Grossman & Berke (1980). Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 De Boer, R.J. oth Hogeweg, P. oth in Journal of Theoretical Biology Amsterdam : Elsevier 113(1985), 4, Seite 719-736 (DE-627)NLEJ176864393 (DE-600)1470953-3 0022-5193 nnns volume:113 year:1985 number:4 pages:719-736 http://dx.doi.org/10.1016/S0022-5193(85)80189-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 113 1985 4 719-736 |
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(DE-627)NLEJ184823404 (DE-599)GBVNLZ184823404 DE-627 ger DE-627 rakwb eng Tumor escape from immune elimination: Simplified precursor bound cytotoxicity models 1985 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In this paper we present a series of models on cytotoxic T-cell activation derived, by successive simplifications, from the model for Tumor Escape from Immune Elimination of Grossman & Berke (1980). In their model Grossman & Berke (1980) investigate the ''sneaking through'' phenomenon, by which they mean that small tumors grow progressively, medium-sized tumors are rejected and large ones break through again. We define precursor bound cytotoxicity models as systems incapable of infinite proliferation. We show that sneaking through can occur in a broad class of very simple precursor bound cytotoxicity models due to the depletion of the precursor cells. The simplest process by which precursors can be depleted is long-lasting antigenic stimulation. We conclude that in precursor bound cytotoxicity models sneaking through does not need the rather intricate combination of counteracting feedback loops, memory and blocking described by Grossman & Berke (1980). Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 De Boer, R.J. oth Hogeweg, P. oth in Journal of Theoretical Biology Amsterdam : Elsevier 113(1985), 4, Seite 719-736 (DE-627)NLEJ176864393 (DE-600)1470953-3 0022-5193 nnns volume:113 year:1985 number:4 pages:719-736 http://dx.doi.org/10.1016/S0022-5193(85)80189-2 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 113 1985 4 719-736 |
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Tumor escape from immune elimination: Simplified precursor bound cytotoxicity models |
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In this paper we present a series of models on cytotoxic T-cell activation derived, by successive simplifications, from the model for Tumor Escape from Immune Elimination of Grossman & Berke (1980). In their model Grossman & Berke (1980) investigate the ''sneaking through'' phenomenon, by which they mean that small tumors grow progressively, medium-sized tumors are rejected and large ones break through again. We define precursor bound cytotoxicity models as systems incapable of infinite proliferation. We show that sneaking through can occur in a broad class of very simple precursor bound cytotoxicity models due to the depletion of the precursor cells. The simplest process by which precursors can be depleted is long-lasting antigenic stimulation. We conclude that in precursor bound cytotoxicity models sneaking through does not need the rather intricate combination of counteracting feedback loops, memory and blocking described by Grossman & Berke (1980). |
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In this paper we present a series of models on cytotoxic T-cell activation derived, by successive simplifications, from the model for Tumor Escape from Immune Elimination of Grossman & Berke (1980). In their model Grossman & Berke (1980) investigate the ''sneaking through'' phenomenon, by which they mean that small tumors grow progressively, medium-sized tumors are rejected and large ones break through again. We define precursor bound cytotoxicity models as systems incapable of infinite proliferation. We show that sneaking through can occur in a broad class of very simple precursor bound cytotoxicity models due to the depletion of the precursor cells. The simplest process by which precursors can be depleted is long-lasting antigenic stimulation. We conclude that in precursor bound cytotoxicity models sneaking through does not need the rather intricate combination of counteracting feedback loops, memory and blocking described by Grossman & Berke (1980). |
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In this paper we present a series of models on cytotoxic T-cell activation derived, by successive simplifications, from the model for Tumor Escape from Immune Elimination of Grossman & Berke (1980). In their model Grossman & Berke (1980) investigate the ''sneaking through'' phenomenon, by which they mean that small tumors grow progressively, medium-sized tumors are rejected and large ones break through again. We define precursor bound cytotoxicity models as systems incapable of infinite proliferation. We show that sneaking through can occur in a broad class of very simple precursor bound cytotoxicity models due to the depletion of the precursor cells. The simplest process by which precursors can be depleted is long-lasting antigenic stimulation. We conclude that in precursor bound cytotoxicity models sneaking through does not need the rather intricate combination of counteracting feedback loops, memory and blocking described by Grossman & Berke (1980). |
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