Alteration of human lymphocyte triosephosphate isomerase isozymes during blastogenesis
Human lymphocytes contain a single isozyme of triosephosphate isomerase (pI=5.6). However, when induced to undergo blastogenesis by culturing in the presense of mitogens, a more acidic isozyme (pI=5.2) is also produced concomitant with DNA replication. Culturing of lymphocytes in the absence of mito...
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1975 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
|---|---|
| Übergeordnetes Werk: |
in: Biochemical and Biophysical Research Communications - Amsterdam : Elsevier, 65(1975), 4, Seite 1270-1277 |
| Übergeordnetes Werk: |
volume:65 ; year:1975 ; number:4 ; pages:1270-1277 |
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| 245 | 1 | 0 | |a Alteration of human lymphocyte triosephosphate isomerase isozymes during blastogenesis |
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| 520 | |a Human lymphocytes contain a single isozyme of triosephosphate isomerase (pI=5.6). However, when induced to undergo blastogenesis by culturing in the presense of mitogens, a more acidic isozyme (pI=5.2) is also produced concomitant with DNA replication. Culturing of lymphocytes in the absence of mitogens or incubation of homogenates from lymphoblasts with fresh lymphocyte extracts does not generate the new isozyme. This system provides, for the first time, an invivo method for studying the molecular basis and factors regulating the expression of the different isozymes of human triosephosphate isomerase. | ||
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| 700 | 1 | |a Gracy, R.W. |4 oth | |
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(DE-627)NLEJ185272649 (DE-599)GBVNLZ185272649 DE-627 ger DE-627 rakwb eng Alteration of human lymphocyte triosephosphate isomerase isozymes during blastogenesis 1975 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Human lymphocytes contain a single isozyme of triosephosphate isomerase (pI=5.6). However, when induced to undergo blastogenesis by culturing in the presense of mitogens, a more acidic isozyme (pI=5.2) is also produced concomitant with DNA replication. Culturing of lymphocytes in the absence of mitogens or incubation of homogenates from lymphoblasts with fresh lymphocyte extracts does not generate the new isozyme. This system provides, for the first time, an invivo method for studying the molecular basis and factors regulating the expression of the different isozymes of human triosephosphate isomerase. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kester, M.V. oth Gracy, R.W. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 65(1975), 4, Seite 1270-1277 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:65 year:1975 number:4 pages:1270-1277 http://dx.doi.org/10.1016/S0006-291X(75)80367-6 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 65 1975 4 1270-1277 |
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(DE-627)NLEJ185272649 (DE-599)GBVNLZ185272649 DE-627 ger DE-627 rakwb eng Alteration of human lymphocyte triosephosphate isomerase isozymes during blastogenesis 1975 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Human lymphocytes contain a single isozyme of triosephosphate isomerase (pI=5.6). However, when induced to undergo blastogenesis by culturing in the presense of mitogens, a more acidic isozyme (pI=5.2) is also produced concomitant with DNA replication. Culturing of lymphocytes in the absence of mitogens or incubation of homogenates from lymphoblasts with fresh lymphocyte extracts does not generate the new isozyme. This system provides, for the first time, an invivo method for studying the molecular basis and factors regulating the expression of the different isozymes of human triosephosphate isomerase. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kester, M.V. oth Gracy, R.W. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 65(1975), 4, Seite 1270-1277 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:65 year:1975 number:4 pages:1270-1277 http://dx.doi.org/10.1016/S0006-291X(75)80367-6 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 65 1975 4 1270-1277 |
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(DE-627)NLEJ185272649 (DE-599)GBVNLZ185272649 DE-627 ger DE-627 rakwb eng Alteration of human lymphocyte triosephosphate isomerase isozymes during blastogenesis 1975 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Human lymphocytes contain a single isozyme of triosephosphate isomerase (pI=5.6). However, when induced to undergo blastogenesis by culturing in the presense of mitogens, a more acidic isozyme (pI=5.2) is also produced concomitant with DNA replication. Culturing of lymphocytes in the absence of mitogens or incubation of homogenates from lymphoblasts with fresh lymphocyte extracts does not generate the new isozyme. This system provides, for the first time, an invivo method for studying the molecular basis and factors regulating the expression of the different isozymes of human triosephosphate isomerase. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kester, M.V. oth Gracy, R.W. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 65(1975), 4, Seite 1270-1277 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:65 year:1975 number:4 pages:1270-1277 http://dx.doi.org/10.1016/S0006-291X(75)80367-6 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 65 1975 4 1270-1277 |
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(DE-627)NLEJ185272649 (DE-599)GBVNLZ185272649 DE-627 ger DE-627 rakwb eng Alteration of human lymphocyte triosephosphate isomerase isozymes during blastogenesis 1975 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Human lymphocytes contain a single isozyme of triosephosphate isomerase (pI=5.6). However, when induced to undergo blastogenesis by culturing in the presense of mitogens, a more acidic isozyme (pI=5.2) is also produced concomitant with DNA replication. Culturing of lymphocytes in the absence of mitogens or incubation of homogenates from lymphoblasts with fresh lymphocyte extracts does not generate the new isozyme. This system provides, for the first time, an invivo method for studying the molecular basis and factors regulating the expression of the different isozymes of human triosephosphate isomerase. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kester, M.V. oth Gracy, R.W. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 65(1975), 4, Seite 1270-1277 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:65 year:1975 number:4 pages:1270-1277 http://dx.doi.org/10.1016/S0006-291X(75)80367-6 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 65 1975 4 1270-1277 |
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(DE-627)NLEJ185272649 (DE-599)GBVNLZ185272649 DE-627 ger DE-627 rakwb eng Alteration of human lymphocyte triosephosphate isomerase isozymes during blastogenesis 1975 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Human lymphocytes contain a single isozyme of triosephosphate isomerase (pI=5.6). However, when induced to undergo blastogenesis by culturing in the presense of mitogens, a more acidic isozyme (pI=5.2) is also produced concomitant with DNA replication. Culturing of lymphocytes in the absence of mitogens or incubation of homogenates from lymphoblasts with fresh lymphocyte extracts does not generate the new isozyme. This system provides, for the first time, an invivo method for studying the molecular basis and factors regulating the expression of the different isozymes of human triosephosphate isomerase. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Kester, M.V. oth Gracy, R.W. oth in Biochemical and Biophysical Research Communications Amsterdam : Elsevier 65(1975), 4, Seite 1270-1277 (DE-627)NLEJ176855645 (DE-600)1461396-7 0006-291X nnns volume:65 year:1975 number:4 pages:1270-1277 http://dx.doi.org/10.1016/S0006-291X(75)80367-6 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 65 1975 4 1270-1277 |
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alteration of human lymphocyte triosephosphate isomerase isozymes during blastogenesis |
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Alteration of human lymphocyte triosephosphate isomerase isozymes during blastogenesis |
| abstract |
Human lymphocytes contain a single isozyme of triosephosphate isomerase (pI=5.6). However, when induced to undergo blastogenesis by culturing in the presense of mitogens, a more acidic isozyme (pI=5.2) is also produced concomitant with DNA replication. Culturing of lymphocytes in the absence of mitogens or incubation of homogenates from lymphoblasts with fresh lymphocyte extracts does not generate the new isozyme. This system provides, for the first time, an invivo method for studying the molecular basis and factors regulating the expression of the different isozymes of human triosephosphate isomerase. |
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Human lymphocytes contain a single isozyme of triosephosphate isomerase (pI=5.6). However, when induced to undergo blastogenesis by culturing in the presense of mitogens, a more acidic isozyme (pI=5.2) is also produced concomitant with DNA replication. Culturing of lymphocytes in the absence of mitogens or incubation of homogenates from lymphoblasts with fresh lymphocyte extracts does not generate the new isozyme. This system provides, for the first time, an invivo method for studying the molecular basis and factors regulating the expression of the different isozymes of human triosephosphate isomerase. |
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Human lymphocytes contain a single isozyme of triosephosphate isomerase (pI=5.6). However, when induced to undergo blastogenesis by culturing in the presense of mitogens, a more acidic isozyme (pI=5.2) is also produced concomitant with DNA replication. Culturing of lymphocytes in the absence of mitogens or incubation of homogenates from lymphoblasts with fresh lymphocyte extracts does not generate the new isozyme. This system provides, for the first time, an invivo method for studying the molecular basis and factors regulating the expression of the different isozymes of human triosephosphate isomerase. |
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Alteration of human lymphocyte triosephosphate isomerase isozymes during blastogenesis |
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