Oligomycin effects on lipolysis and the oxidative metabolism of brown fat cells
1. Oligomycin inhibited the respiration of rat brown fat cells incubated in the absence but not in the presence of 10 mM glucose.2. Oligomycin increased the conversion of glucose to CO"2 in brown fat cells. In white fat cells oligomycin diminished the conversion of glucose to CO"2.3. m-Chl...
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Englisch |
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1970 |
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Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Biochimica et Biophysica Acta (BBA)/Bioenergetics - Amsterdam : Elsevier, 197(1970), 1, Seite 40-48 |
| Übergeordnetes Werk: |
volume:197 ; year:1970 ; number:1 ; pages:40-48 |
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| 520 | |a 1. Oligomycin inhibited the respiration of rat brown fat cells incubated in the absence but not in the presence of 10 mM glucose.2. Oligomycin increased the conversion of glucose to CO"2 in brown fat cells. In white fat cells oligomycin diminished the conversion of glucose to CO"2.3. m-Chloro(carbonyl cyanide)phenylhydrazone doubled respiration by brown fat cells and markedly increased the conversion of glucose to CO"2 over a 2-h period in the presence of glucose. In the absence of glucose, m-chloro(carbonyl cyanide)phenylhydrazone reduced respiration of brown fat cells by over 50%.4. Octanoic acid (0.9 mM) increased O"2 consumption of brown fat cells over 10-fold in the presence of glucose and 4-fold in the absence of glucose. Oligomycin had only a small effect on octanoate conversion to CO"2 or octanoate-induced respiration of brown fat cells in the presence of glucose, but in the absence of glucose oligomycin markedly inhibited these parameters.5. Oligomycin blocked the lipolytic response of both brown and white fat cells to epinephrine and theophylline if the antibiotic was added prior to the lipolytic agents.6. These data indicate that in the presence of glucose both basal and fatty acid-stimulated respiration in brown fat cells is largely oligomycin insensitive under conditions in which hormonal activation of lipolysis is blocked by oligomycin. | ||
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(DE-627)NLEJ185649238 (DE-599)GBVNLZ185649238 DE-627 ger DE-627 rakwb eng Oligomycin effects on lipolysis and the oxidative metabolism of brown fat cells 1970 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Oligomycin inhibited the respiration of rat brown fat cells incubated in the absence but not in the presence of 10 mM glucose.2. Oligomycin increased the conversion of glucose to CO"2 in brown fat cells. In white fat cells oligomycin diminished the conversion of glucose to CO"2.3. m-Chloro(carbonyl cyanide)phenylhydrazone doubled respiration by brown fat cells and markedly increased the conversion of glucose to CO"2 over a 2-h period in the presence of glucose. In the absence of glucose, m-chloro(carbonyl cyanide)phenylhydrazone reduced respiration of brown fat cells by over 50%.4. Octanoic acid (0.9 mM) increased O"2 consumption of brown fat cells over 10-fold in the presence of glucose and 4-fold in the absence of glucose. Oligomycin had only a small effect on octanoate conversion to CO"2 or octanoate-induced respiration of brown fat cells in the presence of glucose, but in the absence of glucose oligomycin markedly inhibited these parameters.5. Oligomycin blocked the lipolytic response of both brown and white fat cells to epinephrine and theophylline if the antibiotic was added prior to the lipolytic agents.6. These data indicate that in the presence of glucose both basal and fatty acid-stimulated respiration in brown fat cells is largely oligomycin insensitive under conditions in which hormonal activation of lipolysis is blocked by oligomycin. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Fain, J.N. oth Loken, S.C. oth Czech, M.P. oth in Biochimica et Biophysica Acta (BBA)/Bioenergetics Amsterdam : Elsevier 197(1970), 1, Seite 40-48 (DE-627)NLEJ177198850 (DE-600)2209370-9 0005-2728 nnns volume:197 year:1970 number:1 pages:40-48 http://linkinghub.elsevier.com/retrieve/pii/0005-2728(70)90006-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 197 1970 1 40-48 |
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(DE-627)NLEJ185649238 (DE-599)GBVNLZ185649238 DE-627 ger DE-627 rakwb eng Oligomycin effects on lipolysis and the oxidative metabolism of brown fat cells 1970 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Oligomycin inhibited the respiration of rat brown fat cells incubated in the absence but not in the presence of 10 mM glucose.2. Oligomycin increased the conversion of glucose to CO"2 in brown fat cells. In white fat cells oligomycin diminished the conversion of glucose to CO"2.3. m-Chloro(carbonyl cyanide)phenylhydrazone doubled respiration by brown fat cells and markedly increased the conversion of glucose to CO"2 over a 2-h period in the presence of glucose. In the absence of glucose, m-chloro(carbonyl cyanide)phenylhydrazone reduced respiration of brown fat cells by over 50%.4. Octanoic acid (0.9 mM) increased O"2 consumption of brown fat cells over 10-fold in the presence of glucose and 4-fold in the absence of glucose. Oligomycin had only a small effect on octanoate conversion to CO"2 or octanoate-induced respiration of brown fat cells in the presence of glucose, but in the absence of glucose oligomycin markedly inhibited these parameters.5. Oligomycin blocked the lipolytic response of both brown and white fat cells to epinephrine and theophylline if the antibiotic was added prior to the lipolytic agents.6. These data indicate that in the presence of glucose both basal and fatty acid-stimulated respiration in brown fat cells is largely oligomycin insensitive under conditions in which hormonal activation of lipolysis is blocked by oligomycin. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Fain, J.N. oth Loken, S.C. oth Czech, M.P. oth in Biochimica et Biophysica Acta (BBA)/Bioenergetics Amsterdam : Elsevier 197(1970), 1, Seite 40-48 (DE-627)NLEJ177198850 (DE-600)2209370-9 0005-2728 nnns volume:197 year:1970 number:1 pages:40-48 http://linkinghub.elsevier.com/retrieve/pii/0005-2728(70)90006-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 197 1970 1 40-48 |
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(DE-627)NLEJ185649238 (DE-599)GBVNLZ185649238 DE-627 ger DE-627 rakwb eng Oligomycin effects on lipolysis and the oxidative metabolism of brown fat cells 1970 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Oligomycin inhibited the respiration of rat brown fat cells incubated in the absence but not in the presence of 10 mM glucose.2. Oligomycin increased the conversion of glucose to CO"2 in brown fat cells. In white fat cells oligomycin diminished the conversion of glucose to CO"2.3. m-Chloro(carbonyl cyanide)phenylhydrazone doubled respiration by brown fat cells and markedly increased the conversion of glucose to CO"2 over a 2-h period in the presence of glucose. In the absence of glucose, m-chloro(carbonyl cyanide)phenylhydrazone reduced respiration of brown fat cells by over 50%.4. Octanoic acid (0.9 mM) increased O"2 consumption of brown fat cells over 10-fold in the presence of glucose and 4-fold in the absence of glucose. Oligomycin had only a small effect on octanoate conversion to CO"2 or octanoate-induced respiration of brown fat cells in the presence of glucose, but in the absence of glucose oligomycin markedly inhibited these parameters.5. Oligomycin blocked the lipolytic response of both brown and white fat cells to epinephrine and theophylline if the antibiotic was added prior to the lipolytic agents.6. These data indicate that in the presence of glucose both basal and fatty acid-stimulated respiration in brown fat cells is largely oligomycin insensitive under conditions in which hormonal activation of lipolysis is blocked by oligomycin. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Fain, J.N. oth Loken, S.C. oth Czech, M.P. oth in Biochimica et Biophysica Acta (BBA)/Bioenergetics Amsterdam : Elsevier 197(1970), 1, Seite 40-48 (DE-627)NLEJ177198850 (DE-600)2209370-9 0005-2728 nnns volume:197 year:1970 number:1 pages:40-48 http://linkinghub.elsevier.com/retrieve/pii/0005-2728(70)90006-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 197 1970 1 40-48 |
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(DE-627)NLEJ185649238 (DE-599)GBVNLZ185649238 DE-627 ger DE-627 rakwb eng Oligomycin effects on lipolysis and the oxidative metabolism of brown fat cells 1970 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Oligomycin inhibited the respiration of rat brown fat cells incubated in the absence but not in the presence of 10 mM glucose.2. Oligomycin increased the conversion of glucose to CO"2 in brown fat cells. In white fat cells oligomycin diminished the conversion of glucose to CO"2.3. m-Chloro(carbonyl cyanide)phenylhydrazone doubled respiration by brown fat cells and markedly increased the conversion of glucose to CO"2 over a 2-h period in the presence of glucose. In the absence of glucose, m-chloro(carbonyl cyanide)phenylhydrazone reduced respiration of brown fat cells by over 50%.4. Octanoic acid (0.9 mM) increased O"2 consumption of brown fat cells over 10-fold in the presence of glucose and 4-fold in the absence of glucose. Oligomycin had only a small effect on octanoate conversion to CO"2 or octanoate-induced respiration of brown fat cells in the presence of glucose, but in the absence of glucose oligomycin markedly inhibited these parameters.5. Oligomycin blocked the lipolytic response of both brown and white fat cells to epinephrine and theophylline if the antibiotic was added prior to the lipolytic agents.6. These data indicate that in the presence of glucose both basal and fatty acid-stimulated respiration in brown fat cells is largely oligomycin insensitive under conditions in which hormonal activation of lipolysis is blocked by oligomycin. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Fain, J.N. oth Loken, S.C. oth Czech, M.P. oth in Biochimica et Biophysica Acta (BBA)/Bioenergetics Amsterdam : Elsevier 197(1970), 1, Seite 40-48 (DE-627)NLEJ177198850 (DE-600)2209370-9 0005-2728 nnns volume:197 year:1970 number:1 pages:40-48 http://linkinghub.elsevier.com/retrieve/pii/0005-2728(70)90006-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 197 1970 1 40-48 |
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(DE-627)NLEJ185649238 (DE-599)GBVNLZ185649238 DE-627 ger DE-627 rakwb eng Oligomycin effects on lipolysis and the oxidative metabolism of brown fat cells 1970 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Oligomycin inhibited the respiration of rat brown fat cells incubated in the absence but not in the presence of 10 mM glucose.2. Oligomycin increased the conversion of glucose to CO"2 in brown fat cells. In white fat cells oligomycin diminished the conversion of glucose to CO"2.3. m-Chloro(carbonyl cyanide)phenylhydrazone doubled respiration by brown fat cells and markedly increased the conversion of glucose to CO"2 over a 2-h period in the presence of glucose. In the absence of glucose, m-chloro(carbonyl cyanide)phenylhydrazone reduced respiration of brown fat cells by over 50%.4. Octanoic acid (0.9 mM) increased O"2 consumption of brown fat cells over 10-fold in the presence of glucose and 4-fold in the absence of glucose. Oligomycin had only a small effect on octanoate conversion to CO"2 or octanoate-induced respiration of brown fat cells in the presence of glucose, but in the absence of glucose oligomycin markedly inhibited these parameters.5. Oligomycin blocked the lipolytic response of both brown and white fat cells to epinephrine and theophylline if the antibiotic was added prior to the lipolytic agents.6. These data indicate that in the presence of glucose both basal and fatty acid-stimulated respiration in brown fat cells is largely oligomycin insensitive under conditions in which hormonal activation of lipolysis is blocked by oligomycin. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Fain, J.N. oth Loken, S.C. oth Czech, M.P. oth in Biochimica et Biophysica Acta (BBA)/Bioenergetics Amsterdam : Elsevier 197(1970), 1, Seite 40-48 (DE-627)NLEJ177198850 (DE-600)2209370-9 0005-2728 nnns volume:197 year:1970 number:1 pages:40-48 http://linkinghub.elsevier.com/retrieve/pii/0005-2728(70)90006-X GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 197 1970 1 40-48 |
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Oligomycin effects on lipolysis and the oxidative metabolism of brown fat cells |
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1. Oligomycin inhibited the respiration of rat brown fat cells incubated in the absence but not in the presence of 10 mM glucose.2. Oligomycin increased the conversion of glucose to CO"2 in brown fat cells. In white fat cells oligomycin diminished the conversion of glucose to CO"2.3. m-Chloro(carbonyl cyanide)phenylhydrazone doubled respiration by brown fat cells and markedly increased the conversion of glucose to CO"2 over a 2-h period in the presence of glucose. In the absence of glucose, m-chloro(carbonyl cyanide)phenylhydrazone reduced respiration of brown fat cells by over 50%.4. Octanoic acid (0.9 mM) increased O"2 consumption of brown fat cells over 10-fold in the presence of glucose and 4-fold in the absence of glucose. Oligomycin had only a small effect on octanoate conversion to CO"2 or octanoate-induced respiration of brown fat cells in the presence of glucose, but in the absence of glucose oligomycin markedly inhibited these parameters.5. Oligomycin blocked the lipolytic response of both brown and white fat cells to epinephrine and theophylline if the antibiotic was added prior to the lipolytic agents.6. These data indicate that in the presence of glucose both basal and fatty acid-stimulated respiration in brown fat cells is largely oligomycin insensitive under conditions in which hormonal activation of lipolysis is blocked by oligomycin. |
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1. Oligomycin inhibited the respiration of rat brown fat cells incubated in the absence but not in the presence of 10 mM glucose.2. Oligomycin increased the conversion of glucose to CO"2 in brown fat cells. In white fat cells oligomycin diminished the conversion of glucose to CO"2.3. m-Chloro(carbonyl cyanide)phenylhydrazone doubled respiration by brown fat cells and markedly increased the conversion of glucose to CO"2 over a 2-h period in the presence of glucose. In the absence of glucose, m-chloro(carbonyl cyanide)phenylhydrazone reduced respiration of brown fat cells by over 50%.4. Octanoic acid (0.9 mM) increased O"2 consumption of brown fat cells over 10-fold in the presence of glucose and 4-fold in the absence of glucose. Oligomycin had only a small effect on octanoate conversion to CO"2 or octanoate-induced respiration of brown fat cells in the presence of glucose, but in the absence of glucose oligomycin markedly inhibited these parameters.5. Oligomycin blocked the lipolytic response of both brown and white fat cells to epinephrine and theophylline if the antibiotic was added prior to the lipolytic agents.6. These data indicate that in the presence of glucose both basal and fatty acid-stimulated respiration in brown fat cells is largely oligomycin insensitive under conditions in which hormonal activation of lipolysis is blocked by oligomycin. |
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1. Oligomycin inhibited the respiration of rat brown fat cells incubated in the absence but not in the presence of 10 mM glucose.2. Oligomycin increased the conversion of glucose to CO"2 in brown fat cells. In white fat cells oligomycin diminished the conversion of glucose to CO"2.3. m-Chloro(carbonyl cyanide)phenylhydrazone doubled respiration by brown fat cells and markedly increased the conversion of glucose to CO"2 over a 2-h period in the presence of glucose. In the absence of glucose, m-chloro(carbonyl cyanide)phenylhydrazone reduced respiration of brown fat cells by over 50%.4. Octanoic acid (0.9 mM) increased O"2 consumption of brown fat cells over 10-fold in the presence of glucose and 4-fold in the absence of glucose. Oligomycin had only a small effect on octanoate conversion to CO"2 or octanoate-induced respiration of brown fat cells in the presence of glucose, but in the absence of glucose oligomycin markedly inhibited these parameters.5. Oligomycin blocked the lipolytic response of both brown and white fat cells to epinephrine and theophylline if the antibiotic was added prior to the lipolytic agents.6. These data indicate that in the presence of glucose both basal and fatty acid-stimulated respiration in brown fat cells is largely oligomycin insensitive under conditions in which hormonal activation of lipolysis is blocked by oligomycin. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ185649238</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707023037.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070506s1970 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ185649238</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ185649238</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Oligomycin effects on lipolysis and the oxidative metabolism of brown fat cells</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1970</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">1. Oligomycin inhibited the respiration of rat brown fat cells incubated in the absence but not in the presence of 10 mM glucose.2. Oligomycin increased the conversion of glucose to CO"2 in brown fat cells. In white fat cells oligomycin diminished the conversion of glucose to CO"2.3. m-Chloro(carbonyl cyanide)phenylhydrazone doubled respiration by brown fat cells and markedly increased the conversion of glucose to CO"2 over a 2-h period in the presence of glucose. In the absence of glucose, m-chloro(carbonyl cyanide)phenylhydrazone reduced respiration of brown fat cells by over 50%.4. Octanoic acid (0.9 mM) increased O"2 consumption of brown fat cells over 10-fold in the presence of glucose and 4-fold in the absence of glucose. Oligomycin had only a small effect on octanoate conversion to CO"2 or octanoate-induced respiration of brown fat cells in the presence of glucose, but in the absence of glucose oligomycin markedly inhibited these parameters.5. Oligomycin blocked the lipolytic response of both brown and white fat cells to epinephrine and theophylline if the antibiotic was added prior to the lipolytic agents.6. These data indicate that in the presence of glucose both basal and fatty acid-stimulated respiration in brown fat cells is largely oligomycin insensitive under conditions in which hormonal activation of lipolysis is blocked by oligomycin.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fain, J.N.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Loken, S.C.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Czech, M.P.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Biochimica et Biophysica Acta (BBA)/Bioenergetics</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">197(1970), 1, Seite 40-48</subfield><subfield code="w">(DE-627)NLEJ177198850</subfield><subfield code="w">(DE-600)2209370-9</subfield><subfield code="x">0005-2728</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:197</subfield><subfield code="g">year:1970</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:40-48</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://linkinghub.elsevier.com/retrieve/pii/0005-2728(70)90006-X</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">197</subfield><subfield code="j">1970</subfield><subfield code="e">1</subfield><subfield code="h">40-48</subfield></datafield></record></collection>
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