Recombinational DNA repair and sister chromatid exchanges
We show that a recombinational repair mechanism for DNA lesions can be expected to produce exactly the types of exceptions to the usually observed semiconservative segregation of newly synthetized DNA that have been reported in the literature. This removes the obstacles their occurrence appearance t...
Ausführliche Beschreibung
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1974 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
|---|---|
| Übergeordnetes Werk: |
in: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis - Amsterdam : Elsevier, 24(1974), 2, Seite 117-123 |
| Übergeordnetes Werk: |
volume:24 ; year:1974 ; number:2 ; pages:117-123 |
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| 520 | |a We show that a recombinational repair mechanism for DNA lesions can be expected to produce exactly the types of exceptions to the usually observed semiconservative segregation of newly synthetized DNA that have been reported in the literature. This removes the obstacles their occurrence appearance to present to the interpretation that the eukaryote chromosome is mononeme, containing but a single DNA double helix prior to replication. We further note that such a recombinational repair system would generate single sister chromatid exchange (SCE) events but not twin SCE events. This, along with other factors, complicates the interpretation of single: twin ratios in terms of any particular model of eukaryote chromosome structure. | ||
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| 700 | 1 | |a Gaston Griggs, H. |4 oth | |
| 700 | 1 | |a Bedford, J.S. |4 oth | |
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(DE-627)NLEJ186445415 (DE-599)GBVNLZ186445415 DE-627 ger DE-627 rakwb eng Recombinational DNA repair and sister chromatid exchanges 1974 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We show that a recombinational repair mechanism for DNA lesions can be expected to produce exactly the types of exceptions to the usually observed semiconservative segregation of newly synthetized DNA that have been reported in the literature. This removes the obstacles their occurrence appearance to present to the interpretation that the eukaryote chromosome is mononeme, containing but a single DNA double helix prior to replication. We further note that such a recombinational repair system would generate single sister chromatid exchange (SCE) events but not twin SCE events. This, along with other factors, complicates the interpretation of single: twin ratios in terms of any particular model of eukaryote chromosome structure. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Bender, M.A. oth Gaston Griggs, H. oth Bedford, J.S. oth in Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Amsterdam : Elsevier 24(1974), 2, Seite 117-123 (DE-627)NLEJ177212004 (DE-600)1491099-8 0027-5107 nnns volume:24 year:1974 number:2 pages:117-123 http://linkinghub.elsevier.com/retrieve/pii/0027-5107(74)90125-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 24 1974 2 117-123 |
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(DE-627)NLEJ186445415 (DE-599)GBVNLZ186445415 DE-627 ger DE-627 rakwb eng Recombinational DNA repair and sister chromatid exchanges 1974 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We show that a recombinational repair mechanism for DNA lesions can be expected to produce exactly the types of exceptions to the usually observed semiconservative segregation of newly synthetized DNA that have been reported in the literature. This removes the obstacles their occurrence appearance to present to the interpretation that the eukaryote chromosome is mononeme, containing but a single DNA double helix prior to replication. We further note that such a recombinational repair system would generate single sister chromatid exchange (SCE) events but not twin SCE events. This, along with other factors, complicates the interpretation of single: twin ratios in terms of any particular model of eukaryote chromosome structure. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Bender, M.A. oth Gaston Griggs, H. oth Bedford, J.S. oth in Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Amsterdam : Elsevier 24(1974), 2, Seite 117-123 (DE-627)NLEJ177212004 (DE-600)1491099-8 0027-5107 nnns volume:24 year:1974 number:2 pages:117-123 http://linkinghub.elsevier.com/retrieve/pii/0027-5107(74)90125-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 24 1974 2 117-123 |
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(DE-627)NLEJ186445415 (DE-599)GBVNLZ186445415 DE-627 ger DE-627 rakwb eng Recombinational DNA repair and sister chromatid exchanges 1974 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We show that a recombinational repair mechanism for DNA lesions can be expected to produce exactly the types of exceptions to the usually observed semiconservative segregation of newly synthetized DNA that have been reported in the literature. This removes the obstacles their occurrence appearance to present to the interpretation that the eukaryote chromosome is mononeme, containing but a single DNA double helix prior to replication. We further note that such a recombinational repair system would generate single sister chromatid exchange (SCE) events but not twin SCE events. This, along with other factors, complicates the interpretation of single: twin ratios in terms of any particular model of eukaryote chromosome structure. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Bender, M.A. oth Gaston Griggs, H. oth Bedford, J.S. oth in Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Amsterdam : Elsevier 24(1974), 2, Seite 117-123 (DE-627)NLEJ177212004 (DE-600)1491099-8 0027-5107 nnns volume:24 year:1974 number:2 pages:117-123 http://linkinghub.elsevier.com/retrieve/pii/0027-5107(74)90125-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 24 1974 2 117-123 |
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(DE-627)NLEJ186445415 (DE-599)GBVNLZ186445415 DE-627 ger DE-627 rakwb eng Recombinational DNA repair and sister chromatid exchanges 1974 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We show that a recombinational repair mechanism for DNA lesions can be expected to produce exactly the types of exceptions to the usually observed semiconservative segregation of newly synthetized DNA that have been reported in the literature. This removes the obstacles their occurrence appearance to present to the interpretation that the eukaryote chromosome is mononeme, containing but a single DNA double helix prior to replication. We further note that such a recombinational repair system would generate single sister chromatid exchange (SCE) events but not twin SCE events. This, along with other factors, complicates the interpretation of single: twin ratios in terms of any particular model of eukaryote chromosome structure. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Bender, M.A. oth Gaston Griggs, H. oth Bedford, J.S. oth in Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Amsterdam : Elsevier 24(1974), 2, Seite 117-123 (DE-627)NLEJ177212004 (DE-600)1491099-8 0027-5107 nnns volume:24 year:1974 number:2 pages:117-123 http://linkinghub.elsevier.com/retrieve/pii/0027-5107(74)90125-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 24 1974 2 117-123 |
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(DE-627)NLEJ186445415 (DE-599)GBVNLZ186445415 DE-627 ger DE-627 rakwb eng Recombinational DNA repair and sister chromatid exchanges 1974 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We show that a recombinational repair mechanism for DNA lesions can be expected to produce exactly the types of exceptions to the usually observed semiconservative segregation of newly synthetized DNA that have been reported in the literature. This removes the obstacles their occurrence appearance to present to the interpretation that the eukaryote chromosome is mononeme, containing but a single DNA double helix prior to replication. We further note that such a recombinational repair system would generate single sister chromatid exchange (SCE) events but not twin SCE events. This, along with other factors, complicates the interpretation of single: twin ratios in terms of any particular model of eukaryote chromosome structure. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Bender, M.A. oth Gaston Griggs, H. oth Bedford, J.S. oth in Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis Amsterdam : Elsevier 24(1974), 2, Seite 117-123 (DE-627)NLEJ177212004 (DE-600)1491099-8 0027-5107 nnns volume:24 year:1974 number:2 pages:117-123 http://linkinghub.elsevier.com/retrieve/pii/0027-5107(74)90125-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 24 1974 2 117-123 |
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We show that a recombinational repair mechanism for DNA lesions can be expected to produce exactly the types of exceptions to the usually observed semiconservative segregation of newly synthetized DNA that have been reported in the literature. This removes the obstacles their occurrence appearance to present to the interpretation that the eukaryote chromosome is mononeme, containing but a single DNA double helix prior to replication. We further note that such a recombinational repair system would generate single sister chromatid exchange (SCE) events but not twin SCE events. This, along with other factors, complicates the interpretation of single: twin ratios in terms of any particular model of eukaryote chromosome structure. |
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We show that a recombinational repair mechanism for DNA lesions can be expected to produce exactly the types of exceptions to the usually observed semiconservative segregation of newly synthetized DNA that have been reported in the literature. This removes the obstacles their occurrence appearance to present to the interpretation that the eukaryote chromosome is mononeme, containing but a single DNA double helix prior to replication. We further note that such a recombinational repair system would generate single sister chromatid exchange (SCE) events but not twin SCE events. This, along with other factors, complicates the interpretation of single: twin ratios in terms of any particular model of eukaryote chromosome structure. |
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We show that a recombinational repair mechanism for DNA lesions can be expected to produce exactly the types of exceptions to the usually observed semiconservative segregation of newly synthetized DNA that have been reported in the literature. This removes the obstacles their occurrence appearance to present to the interpretation that the eukaryote chromosome is mononeme, containing but a single DNA double helix prior to replication. We further note that such a recombinational repair system would generate single sister chromatid exchange (SCE) events but not twin SCE events. This, along with other factors, complicates the interpretation of single: twin ratios in terms of any particular model of eukaryote chromosome structure. |
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