Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man
Blood gases, hemodynamics and ventilation were measured in 7 healthy volunteers at baseline while breathing room air (Fi"O"2 0.21), during hypoxia (Fi"O"2 0.125, 15 min) and after nifedipine 20 mg sublingually at Fi"O"2 0.21 (45 min) and at Fi"O"2 (15 min). Di...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1987 |
|---|
| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
|---|---|
| Übergeordnetes Werk: |
in: Respiration Physiology - Amsterdam : Elsevier, 68(1987), 1, Seite 11-27 |
| Übergeordnetes Werk: |
volume:68 ; year:1987 ; number:1 ; pages:11-27 |
| Links: |
|---|
| Katalog-ID: |
NLEJ186461747 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ186461747 | ||
| 003 | DE-627 | ||
| 005 | 20210707045246.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 070506s1987 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)NLEJ186461747 | ||
| 035 | |a (DE-599)GBVNLZ186461747 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 245 | 1 | 0 | |a Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man |
| 264 | 1 | |c 1987 | |
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Blood gases, hemodynamics and ventilation were measured in 7 healthy volunteers at baseline while breathing room air (Fi"O"2 0.21), during hypoxia (Fi"O"2 0.125, 15 min) and after nifedipine 20 mg sublingually at Fi"O"2 0.21 (45 min) and at Fi"O"2 (15 min). Distributions of ventilation-perfusion ratios (Va/Q) were determined, using the multiple inert gas elimination technique, at baseline, during hypoxia, and again during hypoxia after nifedipine intake. Hypoxia was associated with an average increase in pulmonary vascular resistances by 104%, which was partialaly inhibited by nifedipine. The inert gas data showed a mild deterioration in the distribution of Va/Q ratios during hypoxia. However, when blood flow and ventilation were constrained to the baseline normoxic values in the distributions recovered during hypoxia ('normalization procedure') a slight improvement in Va/Q matching could be evidenced, which was blunted during hypoxia after nifedipine. This was interpreted as the functional of hypoxic pulmonary vasoconstriction (HPV). Using the 'normalized' distributions, we computed the relationship between the decrease in compartmental blood flow that occurred during hypoxia and the corresponding alveolar P"O"2, and calculated the gain due to HPV feedback using equations of the control theory. The contribution of HPV to the stability of compartmental Va/Q was greatest for alveolar P"O"2 values around 60 mm Hg, but at best the feedback had only a moderate efficiency. | ||
| 533 | |f Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 | ||
| 700 | 1 | |a Melot, C. |4 oth | |
| 700 | 1 | |a Naeije, R. |4 oth | |
| 700 | 1 | |a Hallemans, R. |4 oth | |
| 700 | 1 | |a Lejeune, P. |4 oth | |
| 700 | 1 | |a Mols, P. |4 oth | |
| 773 | 0 | 8 | |i in |t Respiration Physiology |d Amsterdam : Elsevier |g 68(1987), 1, Seite 11-27 |w (DE-627)NLEJ17704263X |w (DE-600)2010715-8 |x 0034-5687 |7 nnns |
| 773 | 1 | 8 | |g volume:68 |g year:1987 |g number:1 |g pages:11-27 |
| 856 | 4 | 0 | |u http://linkinghub.elsevier.com/retrieve/pii/0034-5687(87)90073-9 |
| 912 | |a GBV_USEFLAG_H | ||
| 912 | |a ZDB-1-SDJ | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 68 |j 1987 |e 1 |h 11-27 | ||
| matchkey_str |
article:00345687:1987----::yoiploayaoosrcinnploayae |
|---|---|
| hierarchy_sort_str |
1987 |
| publishDate |
1987 |
| allfields |
(DE-627)NLEJ186461747 (DE-599)GBVNLZ186461747 DE-627 ger DE-627 rakwb eng Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man 1987 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Blood gases, hemodynamics and ventilation were measured in 7 healthy volunteers at baseline while breathing room air (Fi"O"2 0.21), during hypoxia (Fi"O"2 0.125, 15 min) and after nifedipine 20 mg sublingually at Fi"O"2 0.21 (45 min) and at Fi"O"2 (15 min). Distributions of ventilation-perfusion ratios (Va/Q) were determined, using the multiple inert gas elimination technique, at baseline, during hypoxia, and again during hypoxia after nifedipine intake. Hypoxia was associated with an average increase in pulmonary vascular resistances by 104%, which was partialaly inhibited by nifedipine. The inert gas data showed a mild deterioration in the distribution of Va/Q ratios during hypoxia. However, when blood flow and ventilation were constrained to the baseline normoxic values in the distributions recovered during hypoxia ('normalization procedure') a slight improvement in Va/Q matching could be evidenced, which was blunted during hypoxia after nifedipine. This was interpreted as the functional of hypoxic pulmonary vasoconstriction (HPV). Using the 'normalized' distributions, we computed the relationship between the decrease in compartmental blood flow that occurred during hypoxia and the corresponding alveolar P"O"2, and calculated the gain due to HPV feedback using equations of the control theory. The contribution of HPV to the stability of compartmental Va/Q was greatest for alveolar P"O"2 values around 60 mm Hg, but at best the feedback had only a moderate efficiency. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Melot, C. oth Naeije, R. oth Hallemans, R. oth Lejeune, P. oth Mols, P. oth in Respiration Physiology Amsterdam : Elsevier 68(1987), 1, Seite 11-27 (DE-627)NLEJ17704263X (DE-600)2010715-8 0034-5687 nnns volume:68 year:1987 number:1 pages:11-27 http://linkinghub.elsevier.com/retrieve/pii/0034-5687(87)90073-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 68 1987 1 11-27 |
| spelling |
(DE-627)NLEJ186461747 (DE-599)GBVNLZ186461747 DE-627 ger DE-627 rakwb eng Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man 1987 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Blood gases, hemodynamics and ventilation were measured in 7 healthy volunteers at baseline while breathing room air (Fi"O"2 0.21), during hypoxia (Fi"O"2 0.125, 15 min) and after nifedipine 20 mg sublingually at Fi"O"2 0.21 (45 min) and at Fi"O"2 (15 min). Distributions of ventilation-perfusion ratios (Va/Q) were determined, using the multiple inert gas elimination technique, at baseline, during hypoxia, and again during hypoxia after nifedipine intake. Hypoxia was associated with an average increase in pulmonary vascular resistances by 104%, which was partialaly inhibited by nifedipine. The inert gas data showed a mild deterioration in the distribution of Va/Q ratios during hypoxia. However, when blood flow and ventilation were constrained to the baseline normoxic values in the distributions recovered during hypoxia ('normalization procedure') a slight improvement in Va/Q matching could be evidenced, which was blunted during hypoxia after nifedipine. This was interpreted as the functional of hypoxic pulmonary vasoconstriction (HPV). Using the 'normalized' distributions, we computed the relationship between the decrease in compartmental blood flow that occurred during hypoxia and the corresponding alveolar P"O"2, and calculated the gain due to HPV feedback using equations of the control theory. The contribution of HPV to the stability of compartmental Va/Q was greatest for alveolar P"O"2 values around 60 mm Hg, but at best the feedback had only a moderate efficiency. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Melot, C. oth Naeije, R. oth Hallemans, R. oth Lejeune, P. oth Mols, P. oth in Respiration Physiology Amsterdam : Elsevier 68(1987), 1, Seite 11-27 (DE-627)NLEJ17704263X (DE-600)2010715-8 0034-5687 nnns volume:68 year:1987 number:1 pages:11-27 http://linkinghub.elsevier.com/retrieve/pii/0034-5687(87)90073-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 68 1987 1 11-27 |
| allfields_unstemmed |
(DE-627)NLEJ186461747 (DE-599)GBVNLZ186461747 DE-627 ger DE-627 rakwb eng Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man 1987 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Blood gases, hemodynamics and ventilation were measured in 7 healthy volunteers at baseline while breathing room air (Fi"O"2 0.21), during hypoxia (Fi"O"2 0.125, 15 min) and after nifedipine 20 mg sublingually at Fi"O"2 0.21 (45 min) and at Fi"O"2 (15 min). Distributions of ventilation-perfusion ratios (Va/Q) were determined, using the multiple inert gas elimination technique, at baseline, during hypoxia, and again during hypoxia after nifedipine intake. Hypoxia was associated with an average increase in pulmonary vascular resistances by 104%, which was partialaly inhibited by nifedipine. The inert gas data showed a mild deterioration in the distribution of Va/Q ratios during hypoxia. However, when blood flow and ventilation were constrained to the baseline normoxic values in the distributions recovered during hypoxia ('normalization procedure') a slight improvement in Va/Q matching could be evidenced, which was blunted during hypoxia after nifedipine. This was interpreted as the functional of hypoxic pulmonary vasoconstriction (HPV). Using the 'normalized' distributions, we computed the relationship between the decrease in compartmental blood flow that occurred during hypoxia and the corresponding alveolar P"O"2, and calculated the gain due to HPV feedback using equations of the control theory. The contribution of HPV to the stability of compartmental Va/Q was greatest for alveolar P"O"2 values around 60 mm Hg, but at best the feedback had only a moderate efficiency. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Melot, C. oth Naeije, R. oth Hallemans, R. oth Lejeune, P. oth Mols, P. oth in Respiration Physiology Amsterdam : Elsevier 68(1987), 1, Seite 11-27 (DE-627)NLEJ17704263X (DE-600)2010715-8 0034-5687 nnns volume:68 year:1987 number:1 pages:11-27 http://linkinghub.elsevier.com/retrieve/pii/0034-5687(87)90073-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 68 1987 1 11-27 |
| allfieldsGer |
(DE-627)NLEJ186461747 (DE-599)GBVNLZ186461747 DE-627 ger DE-627 rakwb eng Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man 1987 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Blood gases, hemodynamics and ventilation were measured in 7 healthy volunteers at baseline while breathing room air (Fi"O"2 0.21), during hypoxia (Fi"O"2 0.125, 15 min) and after nifedipine 20 mg sublingually at Fi"O"2 0.21 (45 min) and at Fi"O"2 (15 min). Distributions of ventilation-perfusion ratios (Va/Q) were determined, using the multiple inert gas elimination technique, at baseline, during hypoxia, and again during hypoxia after nifedipine intake. Hypoxia was associated with an average increase in pulmonary vascular resistances by 104%, which was partialaly inhibited by nifedipine. The inert gas data showed a mild deterioration in the distribution of Va/Q ratios during hypoxia. However, when blood flow and ventilation were constrained to the baseline normoxic values in the distributions recovered during hypoxia ('normalization procedure') a slight improvement in Va/Q matching could be evidenced, which was blunted during hypoxia after nifedipine. This was interpreted as the functional of hypoxic pulmonary vasoconstriction (HPV). Using the 'normalized' distributions, we computed the relationship between the decrease in compartmental blood flow that occurred during hypoxia and the corresponding alveolar P"O"2, and calculated the gain due to HPV feedback using equations of the control theory. The contribution of HPV to the stability of compartmental Va/Q was greatest for alveolar P"O"2 values around 60 mm Hg, but at best the feedback had only a moderate efficiency. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Melot, C. oth Naeije, R. oth Hallemans, R. oth Lejeune, P. oth Mols, P. oth in Respiration Physiology Amsterdam : Elsevier 68(1987), 1, Seite 11-27 (DE-627)NLEJ17704263X (DE-600)2010715-8 0034-5687 nnns volume:68 year:1987 number:1 pages:11-27 http://linkinghub.elsevier.com/retrieve/pii/0034-5687(87)90073-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 68 1987 1 11-27 |
| allfieldsSound |
(DE-627)NLEJ186461747 (DE-599)GBVNLZ186461747 DE-627 ger DE-627 rakwb eng Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man 1987 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Blood gases, hemodynamics and ventilation were measured in 7 healthy volunteers at baseline while breathing room air (Fi"O"2 0.21), during hypoxia (Fi"O"2 0.125, 15 min) and after nifedipine 20 mg sublingually at Fi"O"2 0.21 (45 min) and at Fi"O"2 (15 min). Distributions of ventilation-perfusion ratios (Va/Q) were determined, using the multiple inert gas elimination technique, at baseline, during hypoxia, and again during hypoxia after nifedipine intake. Hypoxia was associated with an average increase in pulmonary vascular resistances by 104%, which was partialaly inhibited by nifedipine. The inert gas data showed a mild deterioration in the distribution of Va/Q ratios during hypoxia. However, when blood flow and ventilation were constrained to the baseline normoxic values in the distributions recovered during hypoxia ('normalization procedure') a slight improvement in Va/Q matching could be evidenced, which was blunted during hypoxia after nifedipine. This was interpreted as the functional of hypoxic pulmonary vasoconstriction (HPV). Using the 'normalized' distributions, we computed the relationship between the decrease in compartmental blood flow that occurred during hypoxia and the corresponding alveolar P"O"2, and calculated the gain due to HPV feedback using equations of the control theory. The contribution of HPV to the stability of compartmental Va/Q was greatest for alveolar P"O"2 values around 60 mm Hg, but at best the feedback had only a moderate efficiency. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Melot, C. oth Naeije, R. oth Hallemans, R. oth Lejeune, P. oth Mols, P. oth in Respiration Physiology Amsterdam : Elsevier 68(1987), 1, Seite 11-27 (DE-627)NLEJ17704263X (DE-600)2010715-8 0034-5687 nnns volume:68 year:1987 number:1 pages:11-27 http://linkinghub.elsevier.com/retrieve/pii/0034-5687(87)90073-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 68 1987 1 11-27 |
| language |
English |
| source |
in Respiration Physiology 68(1987), 1, Seite 11-27 volume:68 year:1987 number:1 pages:11-27 |
| sourceStr |
in Respiration Physiology 68(1987), 1, Seite 11-27 volume:68 year:1987 number:1 pages:11-27 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Respiration Physiology |
| authorswithroles_txt_mv |
Melot, C. @@oth@@ Naeije, R. @@oth@@ Hallemans, R. @@oth@@ Lejeune, P. @@oth@@ Mols, P. @@oth@@ |
| publishDateDaySort_date |
1987-01-01T00:00:00Z |
| hierarchy_top_id |
NLEJ17704263X |
| id |
NLEJ186461747 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ186461747</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707045246.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070506s1987 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ186461747</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ186461747</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1987</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Blood gases, hemodynamics and ventilation were measured in 7 healthy volunteers at baseline while breathing room air (Fi"O"2 0.21), during hypoxia (Fi"O"2 0.125, 15 min) and after nifedipine 20 mg sublingually at Fi"O"2 0.21 (45 min) and at Fi"O"2 (15 min). Distributions of ventilation-perfusion ratios (Va/Q) were determined, using the multiple inert gas elimination technique, at baseline, during hypoxia, and again during hypoxia after nifedipine intake. Hypoxia was associated with an average increase in pulmonary vascular resistances by 104%, which was partialaly inhibited by nifedipine. The inert gas data showed a mild deterioration in the distribution of Va/Q ratios during hypoxia. However, when blood flow and ventilation were constrained to the baseline normoxic values in the distributions recovered during hypoxia ('normalization procedure') a slight improvement in Va/Q matching could be evidenced, which was blunted during hypoxia after nifedipine. This was interpreted as the functional of hypoxic pulmonary vasoconstriction (HPV). Using the 'normalized' distributions, we computed the relationship between the decrease in compartmental blood flow that occurred during hypoxia and the corresponding alveolar P"O"2, and calculated the gain due to HPV feedback using equations of the control theory. The contribution of HPV to the stability of compartmental Va/Q was greatest for alveolar P"O"2 values around 60 mm Hg, but at best the feedback had only a moderate efficiency.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Melot, C.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Naeije, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hallemans, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lejeune, P.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mols, P.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Respiration Physiology</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">68(1987), 1, Seite 11-27</subfield><subfield code="w">(DE-627)NLEJ17704263X</subfield><subfield code="w">(DE-600)2010715-8</subfield><subfield code="x">0034-5687</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:68</subfield><subfield code="g">year:1987</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:11-27</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://linkinghub.elsevier.com/retrieve/pii/0034-5687(87)90073-9</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">68</subfield><subfield code="j">1987</subfield><subfield code="e">1</subfield><subfield code="h">11-27</subfield></datafield></record></collection>
|
| series2 |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ17704263X |
| format |
electronic Article |
| delete_txt_mv |
keep |
| collection |
NL |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
0034-5687 |
| topic_title |
Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
c m cm r n rn r h rh p l pl p m pm |
| hierarchy_parent_title |
Respiration Physiology |
| hierarchy_parent_id |
NLEJ17704263X |
| hierarchy_top_title |
Respiration Physiology |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ17704263X (DE-600)2010715-8 |
| title |
Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man |
| spellingShingle |
Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man |
| ctrlnum |
(DE-627)NLEJ186461747 (DE-599)GBVNLZ186461747 |
| title_full |
Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man |
| journal |
Respiration Physiology |
| journalStr |
Respiration Physiology |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1987 |
| contenttype_str_mv |
zzz |
| container_start_page |
11 |
| container_volume |
68 |
| format_se |
Elektronische Aufsätze |
| title_sort |
hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man |
| title_auth |
Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man |
| abstract |
Blood gases, hemodynamics and ventilation were measured in 7 healthy volunteers at baseline while breathing room air (Fi"O"2 0.21), during hypoxia (Fi"O"2 0.125, 15 min) and after nifedipine 20 mg sublingually at Fi"O"2 0.21 (45 min) and at Fi"O"2 (15 min). Distributions of ventilation-perfusion ratios (Va/Q) were determined, using the multiple inert gas elimination technique, at baseline, during hypoxia, and again during hypoxia after nifedipine intake. Hypoxia was associated with an average increase in pulmonary vascular resistances by 104%, which was partialaly inhibited by nifedipine. The inert gas data showed a mild deterioration in the distribution of Va/Q ratios during hypoxia. However, when blood flow and ventilation were constrained to the baseline normoxic values in the distributions recovered during hypoxia ('normalization procedure') a slight improvement in Va/Q matching could be evidenced, which was blunted during hypoxia after nifedipine. This was interpreted as the functional of hypoxic pulmonary vasoconstriction (HPV). Using the 'normalized' distributions, we computed the relationship between the decrease in compartmental blood flow that occurred during hypoxia and the corresponding alveolar P"O"2, and calculated the gain due to HPV feedback using equations of the control theory. The contribution of HPV to the stability of compartmental Va/Q was greatest for alveolar P"O"2 values around 60 mm Hg, but at best the feedback had only a moderate efficiency. |
| abstractGer |
Blood gases, hemodynamics and ventilation were measured in 7 healthy volunteers at baseline while breathing room air (Fi"O"2 0.21), during hypoxia (Fi"O"2 0.125, 15 min) and after nifedipine 20 mg sublingually at Fi"O"2 0.21 (45 min) and at Fi"O"2 (15 min). Distributions of ventilation-perfusion ratios (Va/Q) were determined, using the multiple inert gas elimination technique, at baseline, during hypoxia, and again during hypoxia after nifedipine intake. Hypoxia was associated with an average increase in pulmonary vascular resistances by 104%, which was partialaly inhibited by nifedipine. The inert gas data showed a mild deterioration in the distribution of Va/Q ratios during hypoxia. However, when blood flow and ventilation were constrained to the baseline normoxic values in the distributions recovered during hypoxia ('normalization procedure') a slight improvement in Va/Q matching could be evidenced, which was blunted during hypoxia after nifedipine. This was interpreted as the functional of hypoxic pulmonary vasoconstriction (HPV). Using the 'normalized' distributions, we computed the relationship between the decrease in compartmental blood flow that occurred during hypoxia and the corresponding alveolar P"O"2, and calculated the gain due to HPV feedback using equations of the control theory. The contribution of HPV to the stability of compartmental Va/Q was greatest for alveolar P"O"2 values around 60 mm Hg, but at best the feedback had only a moderate efficiency. |
| abstract_unstemmed |
Blood gases, hemodynamics and ventilation were measured in 7 healthy volunteers at baseline while breathing room air (Fi"O"2 0.21), during hypoxia (Fi"O"2 0.125, 15 min) and after nifedipine 20 mg sublingually at Fi"O"2 0.21 (45 min) and at Fi"O"2 (15 min). Distributions of ventilation-perfusion ratios (Va/Q) were determined, using the multiple inert gas elimination technique, at baseline, during hypoxia, and again during hypoxia after nifedipine intake. Hypoxia was associated with an average increase in pulmonary vascular resistances by 104%, which was partialaly inhibited by nifedipine. The inert gas data showed a mild deterioration in the distribution of Va/Q ratios during hypoxia. However, when blood flow and ventilation were constrained to the baseline normoxic values in the distributions recovered during hypoxia ('normalization procedure') a slight improvement in Va/Q matching could be evidenced, which was blunted during hypoxia after nifedipine. This was interpreted as the functional of hypoxic pulmonary vasoconstriction (HPV). Using the 'normalized' distributions, we computed the relationship between the decrease in compartmental blood flow that occurred during hypoxia and the corresponding alveolar P"O"2, and calculated the gain due to HPV feedback using equations of the control theory. The contribution of HPV to the stability of compartmental Va/Q was greatest for alveolar P"O"2 values around 60 mm Hg, but at best the feedback had only a moderate efficiency. |
| collection_details |
GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE |
| container_issue |
1 |
| title_short |
Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man |
| url |
http://linkinghub.elsevier.com/retrieve/pii/0034-5687(87)90073-9 |
| remote_bool |
true |
| author2 |
Melot, C. Naeije, R. Hallemans, R. Lejeune, P. Mols, P. |
| author2Str |
Melot, C. Naeije, R. Hallemans, R. Lejeune, P. Mols, P. |
| ppnlink |
NLEJ17704263X |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth |
| up_date |
2024-07-06T06:59:49.788Z |
| _version_ |
1803812014432190464 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ186461747</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707045246.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070506s1987 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ186461747</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ186461747</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1987</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Blood gases, hemodynamics and ventilation were measured in 7 healthy volunteers at baseline while breathing room air (Fi"O"2 0.21), during hypoxia (Fi"O"2 0.125, 15 min) and after nifedipine 20 mg sublingually at Fi"O"2 0.21 (45 min) and at Fi"O"2 (15 min). Distributions of ventilation-perfusion ratios (Va/Q) were determined, using the multiple inert gas elimination technique, at baseline, during hypoxia, and again during hypoxia after nifedipine intake. Hypoxia was associated with an average increase in pulmonary vascular resistances by 104%, which was partialaly inhibited by nifedipine. The inert gas data showed a mild deterioration in the distribution of Va/Q ratios during hypoxia. However, when blood flow and ventilation were constrained to the baseline normoxic values in the distributions recovered during hypoxia ('normalization procedure') a slight improvement in Va/Q matching could be evidenced, which was blunted during hypoxia after nifedipine. This was interpreted as the functional of hypoxic pulmonary vasoconstriction (HPV). Using the 'normalized' distributions, we computed the relationship between the decrease in compartmental blood flow that occurred during hypoxia and the corresponding alveolar P"O"2, and calculated the gain due to HPV feedback using equations of the control theory. The contribution of HPV to the stability of compartmental Va/Q was greatest for alveolar P"O"2 values around 60 mm Hg, but at best the feedback had only a moderate efficiency.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Melot, C.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Naeije, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hallemans, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lejeune, P.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mols, P.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Respiration Physiology</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">68(1987), 1, Seite 11-27</subfield><subfield code="w">(DE-627)NLEJ17704263X</subfield><subfield code="w">(DE-600)2010715-8</subfield><subfield code="x">0034-5687</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:68</subfield><subfield code="g">year:1987</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:11-27</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://linkinghub.elsevier.com/retrieve/pii/0034-5687(87)90073-9</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">68</subfield><subfield code="j">1987</subfield><subfield code="e">1</subfield><subfield code="h">11-27</subfield></datafield></record></collection>
|
| score |
7.399996 |