Age-related changes of serum apoprotein SAS"S"A"M, apoprotein A-I and low-density lipoprotein levels in senescence accelerated mouse (SAM)
Age-related changes of serum concentration of apo SAS"S"A"M, an apoprotein of high density lipoprotein (HDL) which cross-reacts with antiserum against murine senile amyloid fibril protein (AS"S"A"M) were estimated in senescence accelerated mouse (SAM-P) and in senescenc...
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1984 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Mechanisms of Ageing and Development - Amsterdam : Elsevier, 26(1984), 2-3, Seite 311-326 |
| Übergeordnetes Werk: |
volume:26 ; year:1984 ; number:2-3 ; pages:311-326 |
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NLEJ18654345X |
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| 245 | 1 | 0 | |a Age-related changes of serum apoprotein SAS"S"A"M, apoprotein A-I and low-density lipoprotein levels in senescence accelerated mouse (SAM) |
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| 520 | |a Age-related changes of serum concentration of apo SAS"S"A"M, an apoprotein of high density lipoprotein (HDL) which cross-reacts with antiserum against murine senile amyloid fibril protein (AS"S"A"M) were estimated in senescence accelerated mouse (SAM-P) and in senescence resistant series (SAM-R), as a control, using a single radial immuno fxdiffusion technique. Serum concentrations of apo A-I, a major apoprotein of HDL, and low density lipoprotein (LDL) were also measured.In SAM-P (SAM-P/1 and SAM-P/2) with a high incidence of senile systemic amyloidosis, we observed age-associated decreases in serum apo SAS"S"A"M levels. The concentrations of apo SAS"S"A"M at 16 months of age were below 40% of the concentration at 2 months of age, regardless of the sex. In contrast with SAM-P, we observed no age-associated decrease of serum apo SAS"S"A"M levels in SAM-R (SAM-R/1 and SAM-R/2) with a low incidence of amyloidosis. Serum apo SAS"S"A"M concentration was higher in SAM-R/1 than in any other strain of mice observed.Serum apo A-1 concentration was highly and significantly correlated with the serum concentration of apo SAS"S"A"M and decreased with advancing age in SAM-P but not in SAM-R. Age-related changes of LDL were not observed in any strain, but the concentration was lower in the females.In old SAM-P (16 months' old), the concentration of apo SAS"S"A"M decreased to one-third of that in the young SAM-P (4 months' old) and the serum concentrations of albumin and total protein did not decrease, compared with those in the young mice. All these findings taken together suggest that abnormality of metabolism in apo SAS"S"A"M, putative precursor of AS"S"A"M, might occur in SAM-P. | ||
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| 700 | 1 | |a Matsushita, M. |4 oth | |
| 700 | 1 | |a Yonezu, T. |4 oth | |
| 700 | 1 | |a Hosokawa, M. |4 oth | |
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(DE-627)NLEJ18654345X (DE-599)GBVNLZ18654345X DE-627 ger DE-627 rakwb eng Age-related changes of serum apoprotein SAS"S"A"M, apoprotein A-I and low-density lipoprotein levels in senescence accelerated mouse (SAM) 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Age-related changes of serum concentration of apo SAS"S"A"M, an apoprotein of high density lipoprotein (HDL) which cross-reacts with antiserum against murine senile amyloid fibril protein (AS"S"A"M) were estimated in senescence accelerated mouse (SAM-P) and in senescence resistant series (SAM-R), as a control, using a single radial immuno fxdiffusion technique. Serum concentrations of apo A-I, a major apoprotein of HDL, and low density lipoprotein (LDL) were also measured.In SAM-P (SAM-P/1 and SAM-P/2) with a high incidence of senile systemic amyloidosis, we observed age-associated decreases in serum apo SAS"S"A"M levels. The concentrations of apo SAS"S"A"M at 16 months of age were below 40% of the concentration at 2 months of age, regardless of the sex. In contrast with SAM-P, we observed no age-associated decrease of serum apo SAS"S"A"M levels in SAM-R (SAM-R/1 and SAM-R/2) with a low incidence of amyloidosis. Serum apo SAS"S"A"M concentration was higher in SAM-R/1 than in any other strain of mice observed.Serum apo A-1 concentration was highly and significantly correlated with the serum concentration of apo SAS"S"A"M and decreased with advancing age in SAM-P but not in SAM-R. Age-related changes of LDL were not observed in any strain, but the concentration was lower in the females.In old SAM-P (16 months' old), the concentration of apo SAS"S"A"M decreased to one-third of that in the young SAM-P (4 months' old) and the serum concentrations of albumin and total protein did not decrease, compared with those in the young mice. All these findings taken together suggest that abnormality of metabolism in apo SAS"S"A"M, putative precursor of AS"S"A"M, might occur in SAM-P. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Higuchi, K. oth Matsumura, A. oth Honma, A. oth Toda, K. oth Takeshita, S. oth Matsushita, M. oth Yonezu, T. oth Hosokawa, M. oth Takeda, T. oth in Mechanisms of Ageing and Development Amsterdam : Elsevier 26(1984), 2-3, Seite 311-326 (DE-627)NLEJ176932682 (DE-600)1502520-2 0047-6374 nnns volume:26 year:1984 number:2-3 pages:311-326 http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90103-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 26 1984 2-3 311-326 |
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(DE-627)NLEJ18654345X (DE-599)GBVNLZ18654345X DE-627 ger DE-627 rakwb eng Age-related changes of serum apoprotein SAS"S"A"M, apoprotein A-I and low-density lipoprotein levels in senescence accelerated mouse (SAM) 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Age-related changes of serum concentration of apo SAS"S"A"M, an apoprotein of high density lipoprotein (HDL) which cross-reacts with antiserum against murine senile amyloid fibril protein (AS"S"A"M) were estimated in senescence accelerated mouse (SAM-P) and in senescence resistant series (SAM-R), as a control, using a single radial immuno fxdiffusion technique. Serum concentrations of apo A-I, a major apoprotein of HDL, and low density lipoprotein (LDL) were also measured.In SAM-P (SAM-P/1 and SAM-P/2) with a high incidence of senile systemic amyloidosis, we observed age-associated decreases in serum apo SAS"S"A"M levels. The concentrations of apo SAS"S"A"M at 16 months of age were below 40% of the concentration at 2 months of age, regardless of the sex. In contrast with SAM-P, we observed no age-associated decrease of serum apo SAS"S"A"M levels in SAM-R (SAM-R/1 and SAM-R/2) with a low incidence of amyloidosis. Serum apo SAS"S"A"M concentration was higher in SAM-R/1 than in any other strain of mice observed.Serum apo A-1 concentration was highly and significantly correlated with the serum concentration of apo SAS"S"A"M and decreased with advancing age in SAM-P but not in SAM-R. Age-related changes of LDL were not observed in any strain, but the concentration was lower in the females.In old SAM-P (16 months' old), the concentration of apo SAS"S"A"M decreased to one-third of that in the young SAM-P (4 months' old) and the serum concentrations of albumin and total protein did not decrease, compared with those in the young mice. All these findings taken together suggest that abnormality of metabolism in apo SAS"S"A"M, putative precursor of AS"S"A"M, might occur in SAM-P. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Higuchi, K. oth Matsumura, A. oth Honma, A. oth Toda, K. oth Takeshita, S. oth Matsushita, M. oth Yonezu, T. oth Hosokawa, M. oth Takeda, T. oth in Mechanisms of Ageing and Development Amsterdam : Elsevier 26(1984), 2-3, Seite 311-326 (DE-627)NLEJ176932682 (DE-600)1502520-2 0047-6374 nnns volume:26 year:1984 number:2-3 pages:311-326 http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90103-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 26 1984 2-3 311-326 |
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(DE-627)NLEJ18654345X (DE-599)GBVNLZ18654345X DE-627 ger DE-627 rakwb eng Age-related changes of serum apoprotein SAS"S"A"M, apoprotein A-I and low-density lipoprotein levels in senescence accelerated mouse (SAM) 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Age-related changes of serum concentration of apo SAS"S"A"M, an apoprotein of high density lipoprotein (HDL) which cross-reacts with antiserum against murine senile amyloid fibril protein (AS"S"A"M) were estimated in senescence accelerated mouse (SAM-P) and in senescence resistant series (SAM-R), as a control, using a single radial immuno fxdiffusion technique. Serum concentrations of apo A-I, a major apoprotein of HDL, and low density lipoprotein (LDL) were also measured.In SAM-P (SAM-P/1 and SAM-P/2) with a high incidence of senile systemic amyloidosis, we observed age-associated decreases in serum apo SAS"S"A"M levels. The concentrations of apo SAS"S"A"M at 16 months of age were below 40% of the concentration at 2 months of age, regardless of the sex. In contrast with SAM-P, we observed no age-associated decrease of serum apo SAS"S"A"M levels in SAM-R (SAM-R/1 and SAM-R/2) with a low incidence of amyloidosis. Serum apo SAS"S"A"M concentration was higher in SAM-R/1 than in any other strain of mice observed.Serum apo A-1 concentration was highly and significantly correlated with the serum concentration of apo SAS"S"A"M and decreased with advancing age in SAM-P but not in SAM-R. Age-related changes of LDL were not observed in any strain, but the concentration was lower in the females.In old SAM-P (16 months' old), the concentration of apo SAS"S"A"M decreased to one-third of that in the young SAM-P (4 months' old) and the serum concentrations of albumin and total protein did not decrease, compared with those in the young mice. All these findings taken together suggest that abnormality of metabolism in apo SAS"S"A"M, putative precursor of AS"S"A"M, might occur in SAM-P. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Higuchi, K. oth Matsumura, A. oth Honma, A. oth Toda, K. oth Takeshita, S. oth Matsushita, M. oth Yonezu, T. oth Hosokawa, M. oth Takeda, T. oth in Mechanisms of Ageing and Development Amsterdam : Elsevier 26(1984), 2-3, Seite 311-326 (DE-627)NLEJ176932682 (DE-600)1502520-2 0047-6374 nnns volume:26 year:1984 number:2-3 pages:311-326 http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90103-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 26 1984 2-3 311-326 |
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(DE-627)NLEJ18654345X (DE-599)GBVNLZ18654345X DE-627 ger DE-627 rakwb eng Age-related changes of serum apoprotein SAS"S"A"M, apoprotein A-I and low-density lipoprotein levels in senescence accelerated mouse (SAM) 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Age-related changes of serum concentration of apo SAS"S"A"M, an apoprotein of high density lipoprotein (HDL) which cross-reacts with antiserum against murine senile amyloid fibril protein (AS"S"A"M) were estimated in senescence accelerated mouse (SAM-P) and in senescence resistant series (SAM-R), as a control, using a single radial immuno fxdiffusion technique. Serum concentrations of apo A-I, a major apoprotein of HDL, and low density lipoprotein (LDL) were also measured.In SAM-P (SAM-P/1 and SAM-P/2) with a high incidence of senile systemic amyloidosis, we observed age-associated decreases in serum apo SAS"S"A"M levels. The concentrations of apo SAS"S"A"M at 16 months of age were below 40% of the concentration at 2 months of age, regardless of the sex. In contrast with SAM-P, we observed no age-associated decrease of serum apo SAS"S"A"M levels in SAM-R (SAM-R/1 and SAM-R/2) with a low incidence of amyloidosis. Serum apo SAS"S"A"M concentration was higher in SAM-R/1 than in any other strain of mice observed.Serum apo A-1 concentration was highly and significantly correlated with the serum concentration of apo SAS"S"A"M and decreased with advancing age in SAM-P but not in SAM-R. Age-related changes of LDL were not observed in any strain, but the concentration was lower in the females.In old SAM-P (16 months' old), the concentration of apo SAS"S"A"M decreased to one-third of that in the young SAM-P (4 months' old) and the serum concentrations of albumin and total protein did not decrease, compared with those in the young mice. All these findings taken together suggest that abnormality of metabolism in apo SAS"S"A"M, putative precursor of AS"S"A"M, might occur in SAM-P. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Higuchi, K. oth Matsumura, A. oth Honma, A. oth Toda, K. oth Takeshita, S. oth Matsushita, M. oth Yonezu, T. oth Hosokawa, M. oth Takeda, T. oth in Mechanisms of Ageing and Development Amsterdam : Elsevier 26(1984), 2-3, Seite 311-326 (DE-627)NLEJ176932682 (DE-600)1502520-2 0047-6374 nnns volume:26 year:1984 number:2-3 pages:311-326 http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90103-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 26 1984 2-3 311-326 |
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(DE-627)NLEJ18654345X (DE-599)GBVNLZ18654345X DE-627 ger DE-627 rakwb eng Age-related changes of serum apoprotein SAS"S"A"M, apoprotein A-I and low-density lipoprotein levels in senescence accelerated mouse (SAM) 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Age-related changes of serum concentration of apo SAS"S"A"M, an apoprotein of high density lipoprotein (HDL) which cross-reacts with antiserum against murine senile amyloid fibril protein (AS"S"A"M) were estimated in senescence accelerated mouse (SAM-P) and in senescence resistant series (SAM-R), as a control, using a single radial immuno fxdiffusion technique. Serum concentrations of apo A-I, a major apoprotein of HDL, and low density lipoprotein (LDL) were also measured.In SAM-P (SAM-P/1 and SAM-P/2) with a high incidence of senile systemic amyloidosis, we observed age-associated decreases in serum apo SAS"S"A"M levels. The concentrations of apo SAS"S"A"M at 16 months of age were below 40% of the concentration at 2 months of age, regardless of the sex. In contrast with SAM-P, we observed no age-associated decrease of serum apo SAS"S"A"M levels in SAM-R (SAM-R/1 and SAM-R/2) with a low incidence of amyloidosis. Serum apo SAS"S"A"M concentration was higher in SAM-R/1 than in any other strain of mice observed.Serum apo A-1 concentration was highly and significantly correlated with the serum concentration of apo SAS"S"A"M and decreased with advancing age in SAM-P but not in SAM-R. Age-related changes of LDL were not observed in any strain, but the concentration was lower in the females.In old SAM-P (16 months' old), the concentration of apo SAS"S"A"M decreased to one-third of that in the young SAM-P (4 months' old) and the serum concentrations of albumin and total protein did not decrease, compared with those in the young mice. All these findings taken together suggest that abnormality of metabolism in apo SAS"S"A"M, putative precursor of AS"S"A"M, might occur in SAM-P. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Higuchi, K. oth Matsumura, A. oth Honma, A. oth Toda, K. oth Takeshita, S. oth Matsushita, M. oth Yonezu, T. oth Hosokawa, M. oth Takeda, T. oth in Mechanisms of Ageing and Development Amsterdam : Elsevier 26(1984), 2-3, Seite 311-326 (DE-627)NLEJ176932682 (DE-600)1502520-2 0047-6374 nnns volume:26 year:1984 number:2-3 pages:311-326 http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90103-9 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 26 1984 2-3 311-326 |
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Age-related changes of serum apoprotein SAS"S"A"M, apoprotein A-I and low-density lipoprotein levels in senescence accelerated mouse (SAM) |
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Age-related changes of serum apoprotein SAS"S"A"M, apoprotein A-I and low-density lipoprotein levels in senescence accelerated mouse (SAM) |
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| title_full |
Age-related changes of serum apoprotein SAS"S"A"M, apoprotein A-I and low-density lipoprotein levels in senescence accelerated mouse (SAM) |
| journal |
Mechanisms of Ageing and Development |
| journalStr |
Mechanisms of Ageing and Development |
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eng |
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1984 |
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Elektronische Aufsätze |
| title_sort |
age-related changes of serum apoprotein sas"s"a"m, apoprotein a-i and low-density lipoprotein levels in senescence accelerated mouse (sam) |
| title_auth |
Age-related changes of serum apoprotein SAS"S"A"M, apoprotein A-I and low-density lipoprotein levels in senescence accelerated mouse (SAM) |
| abstract |
Age-related changes of serum concentration of apo SAS"S"A"M, an apoprotein of high density lipoprotein (HDL) which cross-reacts with antiserum against murine senile amyloid fibril protein (AS"S"A"M) were estimated in senescence accelerated mouse (SAM-P) and in senescence resistant series (SAM-R), as a control, using a single radial immuno fxdiffusion technique. Serum concentrations of apo A-I, a major apoprotein of HDL, and low density lipoprotein (LDL) were also measured.In SAM-P (SAM-P/1 and SAM-P/2) with a high incidence of senile systemic amyloidosis, we observed age-associated decreases in serum apo SAS"S"A"M levels. The concentrations of apo SAS"S"A"M at 16 months of age were below 40% of the concentration at 2 months of age, regardless of the sex. In contrast with SAM-P, we observed no age-associated decrease of serum apo SAS"S"A"M levels in SAM-R (SAM-R/1 and SAM-R/2) with a low incidence of amyloidosis. Serum apo SAS"S"A"M concentration was higher in SAM-R/1 than in any other strain of mice observed.Serum apo A-1 concentration was highly and significantly correlated with the serum concentration of apo SAS"S"A"M and decreased with advancing age in SAM-P but not in SAM-R. Age-related changes of LDL were not observed in any strain, but the concentration was lower in the females.In old SAM-P (16 months' old), the concentration of apo SAS"S"A"M decreased to one-third of that in the young SAM-P (4 months' old) and the serum concentrations of albumin and total protein did not decrease, compared with those in the young mice. All these findings taken together suggest that abnormality of metabolism in apo SAS"S"A"M, putative precursor of AS"S"A"M, might occur in SAM-P. |
| abstractGer |
Age-related changes of serum concentration of apo SAS"S"A"M, an apoprotein of high density lipoprotein (HDL) which cross-reacts with antiserum against murine senile amyloid fibril protein (AS"S"A"M) were estimated in senescence accelerated mouse (SAM-P) and in senescence resistant series (SAM-R), as a control, using a single radial immuno fxdiffusion technique. Serum concentrations of apo A-I, a major apoprotein of HDL, and low density lipoprotein (LDL) were also measured.In SAM-P (SAM-P/1 and SAM-P/2) with a high incidence of senile systemic amyloidosis, we observed age-associated decreases in serum apo SAS"S"A"M levels. The concentrations of apo SAS"S"A"M at 16 months of age were below 40% of the concentration at 2 months of age, regardless of the sex. In contrast with SAM-P, we observed no age-associated decrease of serum apo SAS"S"A"M levels in SAM-R (SAM-R/1 and SAM-R/2) with a low incidence of amyloidosis. Serum apo SAS"S"A"M concentration was higher in SAM-R/1 than in any other strain of mice observed.Serum apo A-1 concentration was highly and significantly correlated with the serum concentration of apo SAS"S"A"M and decreased with advancing age in SAM-P but not in SAM-R. Age-related changes of LDL were not observed in any strain, but the concentration was lower in the females.In old SAM-P (16 months' old), the concentration of apo SAS"S"A"M decreased to one-third of that in the young SAM-P (4 months' old) and the serum concentrations of albumin and total protein did not decrease, compared with those in the young mice. All these findings taken together suggest that abnormality of metabolism in apo SAS"S"A"M, putative precursor of AS"S"A"M, might occur in SAM-P. |
| abstract_unstemmed |
Age-related changes of serum concentration of apo SAS"S"A"M, an apoprotein of high density lipoprotein (HDL) which cross-reacts with antiserum against murine senile amyloid fibril protein (AS"S"A"M) were estimated in senescence accelerated mouse (SAM-P) and in senescence resistant series (SAM-R), as a control, using a single radial immuno fxdiffusion technique. Serum concentrations of apo A-I, a major apoprotein of HDL, and low density lipoprotein (LDL) were also measured.In SAM-P (SAM-P/1 and SAM-P/2) with a high incidence of senile systemic amyloidosis, we observed age-associated decreases in serum apo SAS"S"A"M levels. The concentrations of apo SAS"S"A"M at 16 months of age were below 40% of the concentration at 2 months of age, regardless of the sex. In contrast with SAM-P, we observed no age-associated decrease of serum apo SAS"S"A"M levels in SAM-R (SAM-R/1 and SAM-R/2) with a low incidence of amyloidosis. Serum apo SAS"S"A"M concentration was higher in SAM-R/1 than in any other strain of mice observed.Serum apo A-1 concentration was highly and significantly correlated with the serum concentration of apo SAS"S"A"M and decreased with advancing age in SAM-P but not in SAM-R. Age-related changes of LDL were not observed in any strain, but the concentration was lower in the females.In old SAM-P (16 months' old), the concentration of apo SAS"S"A"M decreased to one-third of that in the young SAM-P (4 months' old) and the serum concentrations of albumin and total protein did not decrease, compared with those in the young mice. All these findings taken together suggest that abnormality of metabolism in apo SAS"S"A"M, putative precursor of AS"S"A"M, might occur in SAM-P. |
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| title_short |
Age-related changes of serum apoprotein SAS"S"A"M, apoprotein A-I and low-density lipoprotein levels in senescence accelerated mouse (SAM) |
| url |
http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90103-9 |
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| author2 |
Higuchi, K. Matsumura, A. Honma, A. Toda, K. Takeshita, S. Matsushita, M. Yonezu, T. Hosokawa, M. Takeda, T. |
| author2Str |
Higuchi, K. Matsumura, A. Honma, A. Toda, K. Takeshita, S. Matsushita, M. Yonezu, T. Hosokawa, M. Takeda, T. |
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2024-07-06T07:12:48.722Z |
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