Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM)
For evaluation of the degree of senescence in SAM-P, accelerated senescence prone mouse, formerly called SAM or prone series or P-series, consisting of SAM-P/1, SAM-P/2, SAM-P/3 and SAM-P/4 corresponding to P-1, P-2, P-3 and P-4 series, respectively, in the previous reports, and in SAM-R, accelerate...
Ausführliche Beschreibung
Autor*in: |
---|
Format: |
E-Artikel |
---|---|
Sprache: |
Englisch |
Erschienen: |
1984 |
---|
Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
---|---|
Übergeordnetes Werk: |
in: Mechanisms of Ageing and Development - Amsterdam : Elsevier, 26(1984), 1, Seite 91-102 |
Übergeordnetes Werk: |
volume:26 ; year:1984 ; number:1 ; pages:91-102 |
Links: |
---|
Katalog-ID: |
NLEJ186550499 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLEJ186550499 | ||
003 | DE-627 | ||
005 | 20210707051402.0 | ||
007 | cr uuu---uuuuu | ||
008 | 070506s1984 xx |||||o 00| ||eng c | ||
035 | |a (DE-627)NLEJ186550499 | ||
035 | |a (DE-599)GBVNLZ186550499 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
245 | 1 | 0 | |a Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM) |
264 | 1 | |c 1984 | |
336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
337 | |a nicht spezifiziert |b z |2 rdamedia | ||
338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
520 | |a For evaluation of the degree of senescence in SAM-P, accelerated senescence prone mouse, formerly called SAM or prone series or P-series, consisting of SAM-P/1, SAM-P/2, SAM-P/3 and SAM-P/4 corresponding to P-1, P-2, P-3 and P-4 series, respectively, in the previous reports, and in SAM-R, accelerated senescence resistant mouse, formerly called resistant series or R-series, consisting of SAM-R/1, SAM-R/2 and SAM-R/3 corresponding to R-1, R-2 and R-3 series, respectively, in the previous reports, the grading score system was adopted. The items to be examined in this system include 11 categories selected from the clinical signs and gross lesions considered to be associated with the aging process. The degree of the senescence in each category was graded from 0 to 4 according to the detailed criteria devised in our laboratory. After 8 months of age each mouse was examined every 4 months, and some of the mice were examined after 2 months of age.In almost all categories, the grading score and incidence began to increase from 4 or 6 months of age and continued to increase with advancing age in both SAM-P and SAM-R. The increase, however, was more marked in SAM-P than in SAM-R. The slow but steady increase in the SAM-R levelled out at 24 months of age and was comparable to that of 12 months of age in SAM-P. In both SAM-P/1 at 8 months of age and SAM-R/2 at 12 months of age, there was a significant reverse correlation between total score of this grading score system and length of residual life after examination.Systematic and extensive studies using the grading score system showed that if the validity of the system is, based on ''irreversibility'' and ''universality'' of the changes in | ||
533 | |f Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 | ||
700 | 1 | |a Hosokawa, M. |4 oth | |
700 | 1 | |a Kasai, R. |4 oth | |
700 | 1 | |a Higuchi, K. |4 oth | |
700 | 1 | |a Takeshita, S. |4 oth | |
700 | 1 | |a Shimizu, K. |4 oth | |
700 | 1 | |a Hamamoto, H. |4 oth | |
700 | 1 | |a Honma, A. |4 oth | |
700 | 1 | |a Irino, M. |4 oth | |
700 | 1 | |a Toda, K. |4 oth | |
700 | 1 | |a Matsumura, A. |4 oth | |
700 | 1 | |a Matsushita, M. |4 oth | |
700 | 1 | |a Takeda, T. |4 oth | |
773 | 0 | 8 | |i in |t Mechanisms of Ageing and Development |d Amsterdam : Elsevier |g 26(1984), 1, Seite 91-102 |w (DE-627)NLEJ176932682 |w (DE-600)1502520-2 |x 0047-6374 |7 nnns |
773 | 1 | 8 | |g volume:26 |g year:1984 |g number:1 |g pages:91-102 |
856 | 4 | 0 | |u http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90168-4 |
912 | |a GBV_USEFLAG_H | ||
912 | |a ZDB-1-SDJ | ||
912 | |a GBV_NL_ARTICLE | ||
951 | |a AR | ||
952 | |d 26 |j 1984 |e 1 |h 91-102 |
matchkey_str |
article:00476374:1984----::rdnsoeytmmtofrvlainfhdgeosnsecisns |
---|---|
hierarchy_sort_str |
1984 |
publishDate |
1984 |
allfields |
(DE-627)NLEJ186550499 (DE-599)GBVNLZ186550499 DE-627 ger DE-627 rakwb eng Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM) 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For evaluation of the degree of senescence in SAM-P, accelerated senescence prone mouse, formerly called SAM or prone series or P-series, consisting of SAM-P/1, SAM-P/2, SAM-P/3 and SAM-P/4 corresponding to P-1, P-2, P-3 and P-4 series, respectively, in the previous reports, and in SAM-R, accelerated senescence resistant mouse, formerly called resistant series or R-series, consisting of SAM-R/1, SAM-R/2 and SAM-R/3 corresponding to R-1, R-2 and R-3 series, respectively, in the previous reports, the grading score system was adopted. The items to be examined in this system include 11 categories selected from the clinical signs and gross lesions considered to be associated with the aging process. The degree of the senescence in each category was graded from 0 to 4 according to the detailed criteria devised in our laboratory. After 8 months of age each mouse was examined every 4 months, and some of the mice were examined after 2 months of age.In almost all categories, the grading score and incidence began to increase from 4 or 6 months of age and continued to increase with advancing age in both SAM-P and SAM-R. The increase, however, was more marked in SAM-P than in SAM-R. The slow but steady increase in the SAM-R levelled out at 24 months of age and was comparable to that of 12 months of age in SAM-P. In both SAM-P/1 at 8 months of age and SAM-R/2 at 12 months of age, there was a significant reverse correlation between total score of this grading score system and length of residual life after examination.Systematic and extensive studies using the grading score system showed that if the validity of the system is, based on ''irreversibility'' and ''universality'' of the changes in Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Hosokawa, M. oth Kasai, R. oth Higuchi, K. oth Takeshita, S. oth Shimizu, K. oth Hamamoto, H. oth Honma, A. oth Irino, M. oth Toda, K. oth Matsumura, A. oth Matsushita, M. oth Takeda, T. oth in Mechanisms of Ageing and Development Amsterdam : Elsevier 26(1984), 1, Seite 91-102 (DE-627)NLEJ176932682 (DE-600)1502520-2 0047-6374 nnns volume:26 year:1984 number:1 pages:91-102 http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90168-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 26 1984 1 91-102 |
spelling |
(DE-627)NLEJ186550499 (DE-599)GBVNLZ186550499 DE-627 ger DE-627 rakwb eng Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM) 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For evaluation of the degree of senescence in SAM-P, accelerated senescence prone mouse, formerly called SAM or prone series or P-series, consisting of SAM-P/1, SAM-P/2, SAM-P/3 and SAM-P/4 corresponding to P-1, P-2, P-3 and P-4 series, respectively, in the previous reports, and in SAM-R, accelerated senescence resistant mouse, formerly called resistant series or R-series, consisting of SAM-R/1, SAM-R/2 and SAM-R/3 corresponding to R-1, R-2 and R-3 series, respectively, in the previous reports, the grading score system was adopted. The items to be examined in this system include 11 categories selected from the clinical signs and gross lesions considered to be associated with the aging process. The degree of the senescence in each category was graded from 0 to 4 according to the detailed criteria devised in our laboratory. After 8 months of age each mouse was examined every 4 months, and some of the mice were examined after 2 months of age.In almost all categories, the grading score and incidence began to increase from 4 or 6 months of age and continued to increase with advancing age in both SAM-P and SAM-R. The increase, however, was more marked in SAM-P than in SAM-R. The slow but steady increase in the SAM-R levelled out at 24 months of age and was comparable to that of 12 months of age in SAM-P. In both SAM-P/1 at 8 months of age and SAM-R/2 at 12 months of age, there was a significant reverse correlation between total score of this grading score system and length of residual life after examination.Systematic and extensive studies using the grading score system showed that if the validity of the system is, based on ''irreversibility'' and ''universality'' of the changes in Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Hosokawa, M. oth Kasai, R. oth Higuchi, K. oth Takeshita, S. oth Shimizu, K. oth Hamamoto, H. oth Honma, A. oth Irino, M. oth Toda, K. oth Matsumura, A. oth Matsushita, M. oth Takeda, T. oth in Mechanisms of Ageing and Development Amsterdam : Elsevier 26(1984), 1, Seite 91-102 (DE-627)NLEJ176932682 (DE-600)1502520-2 0047-6374 nnns volume:26 year:1984 number:1 pages:91-102 http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90168-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 26 1984 1 91-102 |
allfields_unstemmed |
(DE-627)NLEJ186550499 (DE-599)GBVNLZ186550499 DE-627 ger DE-627 rakwb eng Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM) 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For evaluation of the degree of senescence in SAM-P, accelerated senescence prone mouse, formerly called SAM or prone series or P-series, consisting of SAM-P/1, SAM-P/2, SAM-P/3 and SAM-P/4 corresponding to P-1, P-2, P-3 and P-4 series, respectively, in the previous reports, and in SAM-R, accelerated senescence resistant mouse, formerly called resistant series or R-series, consisting of SAM-R/1, SAM-R/2 and SAM-R/3 corresponding to R-1, R-2 and R-3 series, respectively, in the previous reports, the grading score system was adopted. The items to be examined in this system include 11 categories selected from the clinical signs and gross lesions considered to be associated with the aging process. The degree of the senescence in each category was graded from 0 to 4 according to the detailed criteria devised in our laboratory. After 8 months of age each mouse was examined every 4 months, and some of the mice were examined after 2 months of age.In almost all categories, the grading score and incidence began to increase from 4 or 6 months of age and continued to increase with advancing age in both SAM-P and SAM-R. The increase, however, was more marked in SAM-P than in SAM-R. The slow but steady increase in the SAM-R levelled out at 24 months of age and was comparable to that of 12 months of age in SAM-P. In both SAM-P/1 at 8 months of age and SAM-R/2 at 12 months of age, there was a significant reverse correlation between total score of this grading score system and length of residual life after examination.Systematic and extensive studies using the grading score system showed that if the validity of the system is, based on ''irreversibility'' and ''universality'' of the changes in Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Hosokawa, M. oth Kasai, R. oth Higuchi, K. oth Takeshita, S. oth Shimizu, K. oth Hamamoto, H. oth Honma, A. oth Irino, M. oth Toda, K. oth Matsumura, A. oth Matsushita, M. oth Takeda, T. oth in Mechanisms of Ageing and Development Amsterdam : Elsevier 26(1984), 1, Seite 91-102 (DE-627)NLEJ176932682 (DE-600)1502520-2 0047-6374 nnns volume:26 year:1984 number:1 pages:91-102 http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90168-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 26 1984 1 91-102 |
allfieldsGer |
(DE-627)NLEJ186550499 (DE-599)GBVNLZ186550499 DE-627 ger DE-627 rakwb eng Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM) 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For evaluation of the degree of senescence in SAM-P, accelerated senescence prone mouse, formerly called SAM or prone series or P-series, consisting of SAM-P/1, SAM-P/2, SAM-P/3 and SAM-P/4 corresponding to P-1, P-2, P-3 and P-4 series, respectively, in the previous reports, and in SAM-R, accelerated senescence resistant mouse, formerly called resistant series or R-series, consisting of SAM-R/1, SAM-R/2 and SAM-R/3 corresponding to R-1, R-2 and R-3 series, respectively, in the previous reports, the grading score system was adopted. The items to be examined in this system include 11 categories selected from the clinical signs and gross lesions considered to be associated with the aging process. The degree of the senescence in each category was graded from 0 to 4 according to the detailed criteria devised in our laboratory. After 8 months of age each mouse was examined every 4 months, and some of the mice were examined after 2 months of age.In almost all categories, the grading score and incidence began to increase from 4 or 6 months of age and continued to increase with advancing age in both SAM-P and SAM-R. The increase, however, was more marked in SAM-P than in SAM-R. The slow but steady increase in the SAM-R levelled out at 24 months of age and was comparable to that of 12 months of age in SAM-P. In both SAM-P/1 at 8 months of age and SAM-R/2 at 12 months of age, there was a significant reverse correlation between total score of this grading score system and length of residual life after examination.Systematic and extensive studies using the grading score system showed that if the validity of the system is, based on ''irreversibility'' and ''universality'' of the changes in Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Hosokawa, M. oth Kasai, R. oth Higuchi, K. oth Takeshita, S. oth Shimizu, K. oth Hamamoto, H. oth Honma, A. oth Irino, M. oth Toda, K. oth Matsumura, A. oth Matsushita, M. oth Takeda, T. oth in Mechanisms of Ageing and Development Amsterdam : Elsevier 26(1984), 1, Seite 91-102 (DE-627)NLEJ176932682 (DE-600)1502520-2 0047-6374 nnns volume:26 year:1984 number:1 pages:91-102 http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90168-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 26 1984 1 91-102 |
allfieldsSound |
(DE-627)NLEJ186550499 (DE-599)GBVNLZ186550499 DE-627 ger DE-627 rakwb eng Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM) 1984 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier For evaluation of the degree of senescence in SAM-P, accelerated senescence prone mouse, formerly called SAM or prone series or P-series, consisting of SAM-P/1, SAM-P/2, SAM-P/3 and SAM-P/4 corresponding to P-1, P-2, P-3 and P-4 series, respectively, in the previous reports, and in SAM-R, accelerated senescence resistant mouse, formerly called resistant series or R-series, consisting of SAM-R/1, SAM-R/2 and SAM-R/3 corresponding to R-1, R-2 and R-3 series, respectively, in the previous reports, the grading score system was adopted. The items to be examined in this system include 11 categories selected from the clinical signs and gross lesions considered to be associated with the aging process. The degree of the senescence in each category was graded from 0 to 4 according to the detailed criteria devised in our laboratory. After 8 months of age each mouse was examined every 4 months, and some of the mice were examined after 2 months of age.In almost all categories, the grading score and incidence began to increase from 4 or 6 months of age and continued to increase with advancing age in both SAM-P and SAM-R. The increase, however, was more marked in SAM-P than in SAM-R. The slow but steady increase in the SAM-R levelled out at 24 months of age and was comparable to that of 12 months of age in SAM-P. In both SAM-P/1 at 8 months of age and SAM-R/2 at 12 months of age, there was a significant reverse correlation between total score of this grading score system and length of residual life after examination.Systematic and extensive studies using the grading score system showed that if the validity of the system is, based on ''irreversibility'' and ''universality'' of the changes in Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Hosokawa, M. oth Kasai, R. oth Higuchi, K. oth Takeshita, S. oth Shimizu, K. oth Hamamoto, H. oth Honma, A. oth Irino, M. oth Toda, K. oth Matsumura, A. oth Matsushita, M. oth Takeda, T. oth in Mechanisms of Ageing and Development Amsterdam : Elsevier 26(1984), 1, Seite 91-102 (DE-627)NLEJ176932682 (DE-600)1502520-2 0047-6374 nnns volume:26 year:1984 number:1 pages:91-102 http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90168-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 26 1984 1 91-102 |
language |
English |
source |
in Mechanisms of Ageing and Development 26(1984), 1, Seite 91-102 volume:26 year:1984 number:1 pages:91-102 |
sourceStr |
in Mechanisms of Ageing and Development 26(1984), 1, Seite 91-102 volume:26 year:1984 number:1 pages:91-102 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
isfreeaccess_bool |
false |
container_title |
Mechanisms of Ageing and Development |
authorswithroles_txt_mv |
Hosokawa, M. @@oth@@ Kasai, R. @@oth@@ Higuchi, K. @@oth@@ Takeshita, S. @@oth@@ Shimizu, K. @@oth@@ Hamamoto, H. @@oth@@ Honma, A. @@oth@@ Irino, M. @@oth@@ Toda, K. @@oth@@ Matsumura, A. @@oth@@ Matsushita, M. @@oth@@ Takeda, T. @@oth@@ |
publishDateDaySort_date |
1984-01-01T00:00:00Z |
hierarchy_top_id |
NLEJ176932682 |
id |
NLEJ186550499 |
language_de |
englisch |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ186550499</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707051402.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070506s1984 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ186550499</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ186550499</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1984</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">For evaluation of the degree of senescence in SAM-P, accelerated senescence prone mouse, formerly called SAM or prone series or P-series, consisting of SAM-P/1, SAM-P/2, SAM-P/3 and SAM-P/4 corresponding to P-1, P-2, P-3 and P-4 series, respectively, in the previous reports, and in SAM-R, accelerated senescence resistant mouse, formerly called resistant series or R-series, consisting of SAM-R/1, SAM-R/2 and SAM-R/3 corresponding to R-1, R-2 and R-3 series, respectively, in the previous reports, the grading score system was adopted. The items to be examined in this system include 11 categories selected from the clinical signs and gross lesions considered to be associated with the aging process. The degree of the senescence in each category was graded from 0 to 4 according to the detailed criteria devised in our laboratory. After 8 months of age each mouse was examined every 4 months, and some of the mice were examined after 2 months of age.In almost all categories, the grading score and incidence began to increase from 4 or 6 months of age and continued to increase with advancing age in both SAM-P and SAM-R. The increase, however, was more marked in SAM-P than in SAM-R. The slow but steady increase in the SAM-R levelled out at 24 months of age and was comparable to that of 12 months of age in SAM-P. In both SAM-P/1 at 8 months of age and SAM-R/2 at 12 months of age, there was a significant reverse correlation between total score of this grading score system and length of residual life after examination.Systematic and extensive studies using the grading score system showed that if the validity of the system is, based on ''irreversibility'' and ''universality'' of the changes in</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hosokawa, M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kasai, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Higuchi, K.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takeshita, S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shimizu, K.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hamamoto, H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Honma, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Irino, M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Toda, K.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Matsumura, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Matsushita, M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takeda, T.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Mechanisms of Ageing and Development</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">26(1984), 1, Seite 91-102</subfield><subfield code="w">(DE-627)NLEJ176932682</subfield><subfield code="w">(DE-600)1502520-2</subfield><subfield code="x">0047-6374</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:26</subfield><subfield code="g">year:1984</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:91-102</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90168-4</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">26</subfield><subfield code="j">1984</subfield><subfield code="e">1</subfield><subfield code="h">91-102</subfield></datafield></record></collection>
|
series2 |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ176932682 |
format |
electronic Article |
delete_txt_mv |
keep |
collection |
NL |
remote_str |
true |
illustrated |
Not Illustrated |
issn |
0047-6374 |
topic_title |
Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM) |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
zu |
author2_variant |
m h mh r k rk k h kh s t st k s ks h h hh a h ah m i mi k t kt a m am m m mm t t tt |
hierarchy_parent_title |
Mechanisms of Ageing and Development |
hierarchy_parent_id |
NLEJ176932682 |
hierarchy_top_title |
Mechanisms of Ageing and Development |
isfreeaccess_txt |
false |
familylinks_str_mv |
(DE-627)NLEJ176932682 (DE-600)1502520-2 |
title |
Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM) |
spellingShingle |
Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM) |
ctrlnum |
(DE-627)NLEJ186550499 (DE-599)GBVNLZ186550499 |
title_full |
Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM) |
journal |
Mechanisms of Ageing and Development |
journalStr |
Mechanisms of Ageing and Development |
lang_code |
eng |
isOA_bool |
false |
recordtype |
marc |
publishDateSort |
1984 |
contenttype_str_mv |
zzz |
container_start_page |
91 |
container_volume |
26 |
format_se |
Elektronische Aufsätze |
title_sort |
grading score system: a method for evaluation of the degree of senescence in senescence accelerated mouse (sam) |
title_auth |
Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM) |
abstract |
For evaluation of the degree of senescence in SAM-P, accelerated senescence prone mouse, formerly called SAM or prone series or P-series, consisting of SAM-P/1, SAM-P/2, SAM-P/3 and SAM-P/4 corresponding to P-1, P-2, P-3 and P-4 series, respectively, in the previous reports, and in SAM-R, accelerated senescence resistant mouse, formerly called resistant series or R-series, consisting of SAM-R/1, SAM-R/2 and SAM-R/3 corresponding to R-1, R-2 and R-3 series, respectively, in the previous reports, the grading score system was adopted. The items to be examined in this system include 11 categories selected from the clinical signs and gross lesions considered to be associated with the aging process. The degree of the senescence in each category was graded from 0 to 4 according to the detailed criteria devised in our laboratory. After 8 months of age each mouse was examined every 4 months, and some of the mice were examined after 2 months of age.In almost all categories, the grading score and incidence began to increase from 4 or 6 months of age and continued to increase with advancing age in both SAM-P and SAM-R. The increase, however, was more marked in SAM-P than in SAM-R. The slow but steady increase in the SAM-R levelled out at 24 months of age and was comparable to that of 12 months of age in SAM-P. In both SAM-P/1 at 8 months of age and SAM-R/2 at 12 months of age, there was a significant reverse correlation between total score of this grading score system and length of residual life after examination.Systematic and extensive studies using the grading score system showed that if the validity of the system is, based on ''irreversibility'' and ''universality'' of the changes in |
abstractGer |
For evaluation of the degree of senescence in SAM-P, accelerated senescence prone mouse, formerly called SAM or prone series or P-series, consisting of SAM-P/1, SAM-P/2, SAM-P/3 and SAM-P/4 corresponding to P-1, P-2, P-3 and P-4 series, respectively, in the previous reports, and in SAM-R, accelerated senescence resistant mouse, formerly called resistant series or R-series, consisting of SAM-R/1, SAM-R/2 and SAM-R/3 corresponding to R-1, R-2 and R-3 series, respectively, in the previous reports, the grading score system was adopted. The items to be examined in this system include 11 categories selected from the clinical signs and gross lesions considered to be associated with the aging process. The degree of the senescence in each category was graded from 0 to 4 according to the detailed criteria devised in our laboratory. After 8 months of age each mouse was examined every 4 months, and some of the mice were examined after 2 months of age.In almost all categories, the grading score and incidence began to increase from 4 or 6 months of age and continued to increase with advancing age in both SAM-P and SAM-R. The increase, however, was more marked in SAM-P than in SAM-R. The slow but steady increase in the SAM-R levelled out at 24 months of age and was comparable to that of 12 months of age in SAM-P. In both SAM-P/1 at 8 months of age and SAM-R/2 at 12 months of age, there was a significant reverse correlation between total score of this grading score system and length of residual life after examination.Systematic and extensive studies using the grading score system showed that if the validity of the system is, based on ''irreversibility'' and ''universality'' of the changes in |
abstract_unstemmed |
For evaluation of the degree of senescence in SAM-P, accelerated senescence prone mouse, formerly called SAM or prone series or P-series, consisting of SAM-P/1, SAM-P/2, SAM-P/3 and SAM-P/4 corresponding to P-1, P-2, P-3 and P-4 series, respectively, in the previous reports, and in SAM-R, accelerated senescence resistant mouse, formerly called resistant series or R-series, consisting of SAM-R/1, SAM-R/2 and SAM-R/3 corresponding to R-1, R-2 and R-3 series, respectively, in the previous reports, the grading score system was adopted. The items to be examined in this system include 11 categories selected from the clinical signs and gross lesions considered to be associated with the aging process. The degree of the senescence in each category was graded from 0 to 4 according to the detailed criteria devised in our laboratory. After 8 months of age each mouse was examined every 4 months, and some of the mice were examined after 2 months of age.In almost all categories, the grading score and incidence began to increase from 4 or 6 months of age and continued to increase with advancing age in both SAM-P and SAM-R. The increase, however, was more marked in SAM-P than in SAM-R. The slow but steady increase in the SAM-R levelled out at 24 months of age and was comparable to that of 12 months of age in SAM-P. In both SAM-P/1 at 8 months of age and SAM-R/2 at 12 months of age, there was a significant reverse correlation between total score of this grading score system and length of residual life after examination.Systematic and extensive studies using the grading score system showed that if the validity of the system is, based on ''irreversibility'' and ''universality'' of the changes in |
collection_details |
GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE |
container_issue |
1 |
title_short |
Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM) |
url |
http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90168-4 |
remote_bool |
true |
author2 |
Hosokawa, M. Kasai, R. Higuchi, K. Takeshita, S. Shimizu, K. Hamamoto, H. Honma, A. Irino, M. Toda, K. Matsumura, A. Matsushita, M. Takeda, T. |
author2Str |
Hosokawa, M. Kasai, R. Higuchi, K. Takeshita, S. Shimizu, K. Hamamoto, H. Honma, A. Irino, M. Toda, K. Matsumura, A. Matsushita, M. Takeda, T. |
ppnlink |
NLEJ176932682 |
mediatype_str_mv |
z |
isOA_txt |
false |
hochschulschrift_bool |
false |
author2_role |
oth oth oth oth oth oth oth oth oth oth oth oth |
up_date |
2024-07-06T07:14:00.705Z |
_version_ |
1803812906684383232 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ186550499</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707051402.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070506s1984 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ186550499</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ186550499</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1984</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">For evaluation of the degree of senescence in SAM-P, accelerated senescence prone mouse, formerly called SAM or prone series or P-series, consisting of SAM-P/1, SAM-P/2, SAM-P/3 and SAM-P/4 corresponding to P-1, P-2, P-3 and P-4 series, respectively, in the previous reports, and in SAM-R, accelerated senescence resistant mouse, formerly called resistant series or R-series, consisting of SAM-R/1, SAM-R/2 and SAM-R/3 corresponding to R-1, R-2 and R-3 series, respectively, in the previous reports, the grading score system was adopted. The items to be examined in this system include 11 categories selected from the clinical signs and gross lesions considered to be associated with the aging process. The degree of the senescence in each category was graded from 0 to 4 according to the detailed criteria devised in our laboratory. After 8 months of age each mouse was examined every 4 months, and some of the mice were examined after 2 months of age.In almost all categories, the grading score and incidence began to increase from 4 or 6 months of age and continued to increase with advancing age in both SAM-P and SAM-R. The increase, however, was more marked in SAM-P than in SAM-R. The slow but steady increase in the SAM-R levelled out at 24 months of age and was comparable to that of 12 months of age in SAM-P. In both SAM-P/1 at 8 months of age and SAM-R/2 at 12 months of age, there was a significant reverse correlation between total score of this grading score system and length of residual life after examination.Systematic and extensive studies using the grading score system showed that if the validity of the system is, based on ''irreversibility'' and ''universality'' of the changes in</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hosokawa, M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kasai, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Higuchi, K.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takeshita, S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shimizu, K.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hamamoto, H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Honma, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Irino, M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Toda, K.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Matsumura, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Matsushita, M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takeda, T.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Mechanisms of Ageing and Development</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">26(1984), 1, Seite 91-102</subfield><subfield code="w">(DE-627)NLEJ176932682</subfield><subfield code="w">(DE-600)1502520-2</subfield><subfield code="x">0047-6374</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:26</subfield><subfield code="g">year:1984</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:91-102</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://linkinghub.elsevier.com/retrieve/pii/0047-6374(84)90168-4</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">26</subfield><subfield code="j">1984</subfield><subfield code="e">1</subfield><subfield code="h">91-102</subfield></datafield></record></collection>
|
score |
7.399453 |