Relationship between anemia and cholesterol metabolism in 'sex-linked anemic' (gene symbol, sla) mouse
The relationship between hypocholesterolemia and anemia has been recognized in humans. However, no metabolic studies in humans have been reported, nor has an animal model been developed to investigate the effects of anemia on cholesterol metabolism. We have identified an animal model, the 'sex-...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1986 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
|---|---|
| Übergeordnetes Werk: |
in: Biochimica et Biophysica Acta (BBA)/General Subjects - Amsterdam : Elsevier, 883(1986), 2, Seite 242-246 |
| Übergeordnetes Werk: |
volume:883 ; year:1986 ; number:2 ; pages:242-246 |
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NLEJ187037884 |
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| 245 | 1 | 0 | |a Relationship between anemia and cholesterol metabolism in 'sex-linked anemic' (gene symbol, sla) mouse |
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| 520 | |a The relationship between hypocholesterolemia and anemia has been recognized in humans. However, no metabolic studies in humans have been reported, nor has an animal model been developed to investigate the effects of anemia on cholesterol metabolism. We have identified an animal model, the 'sex-linked anemic' (gene symbol, sla) mouse, characterized by iron deficiency anemia, to study the relationship between anemia and cholesterol metabolism. Results from our studies showed that the serum cholesterol was significantly lower in anemic male SLA mice compared to non-anemic littermates. The lower serum cholesterol observed in anemic SLA mice was related to a decreased in vivo hepatic cholesterol synthesis. However, the decreased hepatic cholesterol synthesis in anemic SLA mice was not due to a block at the primary regulatory site, the hydroxymethylglutaryl-CoA reductase, nor at one of the secondary regulatory sites: the acetoacetyl-CoA thiolase and hydroxymethylglutaryl-CoA synthase. | ||
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(DE-627)NLEJ187037884 (DE-599)GBVNLZ187037884 DE-627 ger DE-627 rakwb eng Relationship between anemia and cholesterol metabolism in 'sex-linked anemic' (gene symbol, sla) mouse 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The relationship between hypocholesterolemia and anemia has been recognized in humans. However, no metabolic studies in humans have been reported, nor has an animal model been developed to investigate the effects of anemia on cholesterol metabolism. We have identified an animal model, the 'sex-linked anemic' (gene symbol, sla) mouse, characterized by iron deficiency anemia, to study the relationship between anemia and cholesterol metabolism. Results from our studies showed that the serum cholesterol was significantly lower in anemic male SLA mice compared to non-anemic littermates. The lower serum cholesterol observed in anemic SLA mice was related to a decreased in vivo hepatic cholesterol synthesis. However, the decreased hepatic cholesterol synthesis in anemic SLA mice was not due to a block at the primary regulatory site, the hydroxymethylglutaryl-CoA reductase, nor at one of the secondary regulatory sites: the acetoacetyl-CoA thiolase and hydroxymethylglutaryl-CoA synthase. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Au, Y.P.T. oth Schilling, R.F. oth in Biochimica et Biophysica Acta (BBA)/General Subjects Amsterdam : Elsevier 883(1986), 2, Seite 242-246 (DE-627)NLEJ177008172 (DE-600)2209617-6 0304-4165 nnns volume:883 year:1986 number:2 pages:242-246 http://linkinghub.elsevier.com/retrieve/pii/0304-4165(86)90314-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 883 1986 2 242-246 |
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(DE-627)NLEJ187037884 (DE-599)GBVNLZ187037884 DE-627 ger DE-627 rakwb eng Relationship between anemia and cholesterol metabolism in 'sex-linked anemic' (gene symbol, sla) mouse 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The relationship between hypocholesterolemia and anemia has been recognized in humans. However, no metabolic studies in humans have been reported, nor has an animal model been developed to investigate the effects of anemia on cholesterol metabolism. We have identified an animal model, the 'sex-linked anemic' (gene symbol, sla) mouse, characterized by iron deficiency anemia, to study the relationship between anemia and cholesterol metabolism. Results from our studies showed that the serum cholesterol was significantly lower in anemic male SLA mice compared to non-anemic littermates. The lower serum cholesterol observed in anemic SLA mice was related to a decreased in vivo hepatic cholesterol synthesis. However, the decreased hepatic cholesterol synthesis in anemic SLA mice was not due to a block at the primary regulatory site, the hydroxymethylglutaryl-CoA reductase, nor at one of the secondary regulatory sites: the acetoacetyl-CoA thiolase and hydroxymethylglutaryl-CoA synthase. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Au, Y.P.T. oth Schilling, R.F. oth in Biochimica et Biophysica Acta (BBA)/General Subjects Amsterdam : Elsevier 883(1986), 2, Seite 242-246 (DE-627)NLEJ177008172 (DE-600)2209617-6 0304-4165 nnns volume:883 year:1986 number:2 pages:242-246 http://linkinghub.elsevier.com/retrieve/pii/0304-4165(86)90314-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 883 1986 2 242-246 |
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(DE-627)NLEJ187037884 (DE-599)GBVNLZ187037884 DE-627 ger DE-627 rakwb eng Relationship between anemia and cholesterol metabolism in 'sex-linked anemic' (gene symbol, sla) mouse 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The relationship between hypocholesterolemia and anemia has been recognized in humans. However, no metabolic studies in humans have been reported, nor has an animal model been developed to investigate the effects of anemia on cholesterol metabolism. We have identified an animal model, the 'sex-linked anemic' (gene symbol, sla) mouse, characterized by iron deficiency anemia, to study the relationship between anemia and cholesterol metabolism. Results from our studies showed that the serum cholesterol was significantly lower in anemic male SLA mice compared to non-anemic littermates. The lower serum cholesterol observed in anemic SLA mice was related to a decreased in vivo hepatic cholesterol synthesis. However, the decreased hepatic cholesterol synthesis in anemic SLA mice was not due to a block at the primary regulatory site, the hydroxymethylglutaryl-CoA reductase, nor at one of the secondary regulatory sites: the acetoacetyl-CoA thiolase and hydroxymethylglutaryl-CoA synthase. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Au, Y.P.T. oth Schilling, R.F. oth in Biochimica et Biophysica Acta (BBA)/General Subjects Amsterdam : Elsevier 883(1986), 2, Seite 242-246 (DE-627)NLEJ177008172 (DE-600)2209617-6 0304-4165 nnns volume:883 year:1986 number:2 pages:242-246 http://linkinghub.elsevier.com/retrieve/pii/0304-4165(86)90314-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 883 1986 2 242-246 |
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(DE-627)NLEJ187037884 (DE-599)GBVNLZ187037884 DE-627 ger DE-627 rakwb eng Relationship between anemia and cholesterol metabolism in 'sex-linked anemic' (gene symbol, sla) mouse 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The relationship between hypocholesterolemia and anemia has been recognized in humans. However, no metabolic studies in humans have been reported, nor has an animal model been developed to investigate the effects of anemia on cholesterol metabolism. We have identified an animal model, the 'sex-linked anemic' (gene symbol, sla) mouse, characterized by iron deficiency anemia, to study the relationship between anemia and cholesterol metabolism. Results from our studies showed that the serum cholesterol was significantly lower in anemic male SLA mice compared to non-anemic littermates. The lower serum cholesterol observed in anemic SLA mice was related to a decreased in vivo hepatic cholesterol synthesis. However, the decreased hepatic cholesterol synthesis in anemic SLA mice was not due to a block at the primary regulatory site, the hydroxymethylglutaryl-CoA reductase, nor at one of the secondary regulatory sites: the acetoacetyl-CoA thiolase and hydroxymethylglutaryl-CoA synthase. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Au, Y.P.T. oth Schilling, R.F. oth in Biochimica et Biophysica Acta (BBA)/General Subjects Amsterdam : Elsevier 883(1986), 2, Seite 242-246 (DE-627)NLEJ177008172 (DE-600)2209617-6 0304-4165 nnns volume:883 year:1986 number:2 pages:242-246 http://linkinghub.elsevier.com/retrieve/pii/0304-4165(86)90314-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 883 1986 2 242-246 |
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(DE-627)NLEJ187037884 (DE-599)GBVNLZ187037884 DE-627 ger DE-627 rakwb eng Relationship between anemia and cholesterol metabolism in 'sex-linked anemic' (gene symbol, sla) mouse 1986 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The relationship between hypocholesterolemia and anemia has been recognized in humans. However, no metabolic studies in humans have been reported, nor has an animal model been developed to investigate the effects of anemia on cholesterol metabolism. We have identified an animal model, the 'sex-linked anemic' (gene symbol, sla) mouse, characterized by iron deficiency anemia, to study the relationship between anemia and cholesterol metabolism. Results from our studies showed that the serum cholesterol was significantly lower in anemic male SLA mice compared to non-anemic littermates. The lower serum cholesterol observed in anemic SLA mice was related to a decreased in vivo hepatic cholesterol synthesis. However, the decreased hepatic cholesterol synthesis in anemic SLA mice was not due to a block at the primary regulatory site, the hydroxymethylglutaryl-CoA reductase, nor at one of the secondary regulatory sites: the acetoacetyl-CoA thiolase and hydroxymethylglutaryl-CoA synthase. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Au, Y.P.T. oth Schilling, R.F. oth in Biochimica et Biophysica Acta (BBA)/General Subjects Amsterdam : Elsevier 883(1986), 2, Seite 242-246 (DE-627)NLEJ177008172 (DE-600)2209617-6 0304-4165 nnns volume:883 year:1986 number:2 pages:242-246 http://linkinghub.elsevier.com/retrieve/pii/0304-4165(86)90314-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 883 1986 2 242-246 |
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relationship between anemia and cholesterol metabolism in 'sex-linked anemic' (gene symbol, sla) mouse |
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Relationship between anemia and cholesterol metabolism in 'sex-linked anemic' (gene symbol, sla) mouse |
| abstract |
The relationship between hypocholesterolemia and anemia has been recognized in humans. However, no metabolic studies in humans have been reported, nor has an animal model been developed to investigate the effects of anemia on cholesterol metabolism. We have identified an animal model, the 'sex-linked anemic' (gene symbol, sla) mouse, characterized by iron deficiency anemia, to study the relationship between anemia and cholesterol metabolism. Results from our studies showed that the serum cholesterol was significantly lower in anemic male SLA mice compared to non-anemic littermates. The lower serum cholesterol observed in anemic SLA mice was related to a decreased in vivo hepatic cholesterol synthesis. However, the decreased hepatic cholesterol synthesis in anemic SLA mice was not due to a block at the primary regulatory site, the hydroxymethylglutaryl-CoA reductase, nor at one of the secondary regulatory sites: the acetoacetyl-CoA thiolase and hydroxymethylglutaryl-CoA synthase. |
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The relationship between hypocholesterolemia and anemia has been recognized in humans. However, no metabolic studies in humans have been reported, nor has an animal model been developed to investigate the effects of anemia on cholesterol metabolism. We have identified an animal model, the 'sex-linked anemic' (gene symbol, sla) mouse, characterized by iron deficiency anemia, to study the relationship between anemia and cholesterol metabolism. Results from our studies showed that the serum cholesterol was significantly lower in anemic male SLA mice compared to non-anemic littermates. The lower serum cholesterol observed in anemic SLA mice was related to a decreased in vivo hepatic cholesterol synthesis. However, the decreased hepatic cholesterol synthesis in anemic SLA mice was not due to a block at the primary regulatory site, the hydroxymethylglutaryl-CoA reductase, nor at one of the secondary regulatory sites: the acetoacetyl-CoA thiolase and hydroxymethylglutaryl-CoA synthase. |
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The relationship between hypocholesterolemia and anemia has been recognized in humans. However, no metabolic studies in humans have been reported, nor has an animal model been developed to investigate the effects of anemia on cholesterol metabolism. We have identified an animal model, the 'sex-linked anemic' (gene symbol, sla) mouse, characterized by iron deficiency anemia, to study the relationship between anemia and cholesterol metabolism. Results from our studies showed that the serum cholesterol was significantly lower in anemic male SLA mice compared to non-anemic littermates. The lower serum cholesterol observed in anemic SLA mice was related to a decreased in vivo hepatic cholesterol synthesis. However, the decreased hepatic cholesterol synthesis in anemic SLA mice was not due to a block at the primary regulatory site, the hydroxymethylglutaryl-CoA reductase, nor at one of the secondary regulatory sites: the acetoacetyl-CoA thiolase and hydroxymethylglutaryl-CoA synthase. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ187037884</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707064332.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070506s1986 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ187037884</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ187037884</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Relationship between anemia and cholesterol metabolism in 'sex-linked anemic' (gene symbol, sla) mouse</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1986</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The relationship between hypocholesterolemia and anemia has been recognized in humans. However, no metabolic studies in humans have been reported, nor has an animal model been developed to investigate the effects of anemia on cholesterol metabolism. We have identified an animal model, the 'sex-linked anemic' (gene symbol, sla) mouse, characterized by iron deficiency anemia, to study the relationship between anemia and cholesterol metabolism. Results from our studies showed that the serum cholesterol was significantly lower in anemic male SLA mice compared to non-anemic littermates. The lower serum cholesterol observed in anemic SLA mice was related to a decreased in vivo hepatic cholesterol synthesis. However, the decreased hepatic cholesterol synthesis in anemic SLA mice was not due to a block at the primary regulatory site, the hydroxymethylglutaryl-CoA reductase, nor at one of the secondary regulatory sites: the acetoacetyl-CoA thiolase and hydroxymethylglutaryl-CoA synthase.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Au, Y.P.T.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schilling, R.F.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Biochimica et Biophysica Acta (BBA)/General Subjects</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">883(1986), 2, Seite 242-246</subfield><subfield code="w">(DE-627)NLEJ177008172</subfield><subfield code="w">(DE-600)2209617-6</subfield><subfield code="x">0304-4165</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:883</subfield><subfield code="g">year:1986</subfield><subfield code="g">number:2</subfield><subfield code="g">pages:242-246</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://linkinghub.elsevier.com/retrieve/pii/0304-4165(86)90314-4</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">883</subfield><subfield code="j">1986</subfield><subfield code="e">2</subfield><subfield code="h">242-246</subfield></datafield></record></collection>
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