Cytokines and the hypothalamic-pituitary-adrenal axis
After administration of the cytokines interleukin 1 (IL1), tumor necrosis factor (TNF), interleukin 2 and interleukin 6 to laboratory animals or humans, plasma levels of glucocorticoids are elevated. This effect is mediated by activation of the hypothalamic-pituitary unit. IL1 and TNF inhibit aldost...
Ausführliche Beschreibung
Autor*in: |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
1990 |
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Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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Übergeordnetes Werk: |
in: The Journal of Steroid Biochemistry and Molecular Biology - Amsterdam : Elsevier, 37(1990), 6, Seite 867-871 |
Übergeordnetes Werk: |
volume:37 ; year:1990 ; number:6 ; pages:867-871 |
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520 | |a After administration of the cytokines interleukin 1 (IL1), tumor necrosis factor (TNF), interleukin 2 and interleukin 6 to laboratory animals or humans, plasma levels of glucocorticoids are elevated. This effect is mediated by activation of the hypothalamic-pituitary unit. IL1 and TNF inhibit aldosterone production by rat adrenocortical cells in vitro and stimulate renin release by rat renal cortical cells. Administration of IL1 or TNF in rats suppresses hypothalamic-pituitary-thyroid function, whereas IL1 acts at the level of the brain and the gonads to interfere with gonadotropin and sex steroid secretion.During stimulation of the immune system (e.g. during infectious diseases), peculiar alterations in hormone secretion occur (hypercortisolism, hyperreninemic hypoaldosteronism, euthyroid sick syndrome, hypogonadism). The role of cytokines in these alterations remains to be established. | ||
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(DE-627)NLEJ187418306 (DE-599)GBVNLZ187418306 DE-627 ger DE-627 rakwb eng Cytokines and the hypothalamic-pituitary-adrenal axis 1990 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier After administration of the cytokines interleukin 1 (IL1), tumor necrosis factor (TNF), interleukin 2 and interleukin 6 to laboratory animals or humans, plasma levels of glucocorticoids are elevated. This effect is mediated by activation of the hypothalamic-pituitary unit. IL1 and TNF inhibit aldosterone production by rat adrenocortical cells in vitro and stimulate renin release by rat renal cortical cells. Administration of IL1 or TNF in rats suppresses hypothalamic-pituitary-thyroid function, whereas IL1 acts at the level of the brain and the gonads to interfere with gonadotropin and sex steroid secretion.During stimulation of the immune system (e.g. during infectious diseases), peculiar alterations in hormone secretion occur (hypercortisolism, hyperreninemic hypoaldosteronism, euthyroid sick syndrome, hypogonadism). The role of cytokines in these alterations remains to be established. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Hermus, A.R.M.M. oth Sweep, C.G.J. oth in The Journal of Steroid Biochemistry and Molecular Biology Amsterdam : Elsevier 37(1990), 6, Seite 867-871 (DE-627)NLEJ18741422X (DE-600)1482780-3 0960-0760 nnns volume:37 year:1990 number:6 pages:867-871 http://linkinghub.elsevier.com/retrieve/pii/0960-0760(90)90434-M GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 37 1990 6 867-871 |
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(DE-627)NLEJ187418306 (DE-599)GBVNLZ187418306 DE-627 ger DE-627 rakwb eng Cytokines and the hypothalamic-pituitary-adrenal axis 1990 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier After administration of the cytokines interleukin 1 (IL1), tumor necrosis factor (TNF), interleukin 2 and interleukin 6 to laboratory animals or humans, plasma levels of glucocorticoids are elevated. This effect is mediated by activation of the hypothalamic-pituitary unit. IL1 and TNF inhibit aldosterone production by rat adrenocortical cells in vitro and stimulate renin release by rat renal cortical cells. Administration of IL1 or TNF in rats suppresses hypothalamic-pituitary-thyroid function, whereas IL1 acts at the level of the brain and the gonads to interfere with gonadotropin and sex steroid secretion.During stimulation of the immune system (e.g. during infectious diseases), peculiar alterations in hormone secretion occur (hypercortisolism, hyperreninemic hypoaldosteronism, euthyroid sick syndrome, hypogonadism). The role of cytokines in these alterations remains to be established. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Hermus, A.R.M.M. oth Sweep, C.G.J. oth in The Journal of Steroid Biochemistry and Molecular Biology Amsterdam : Elsevier 37(1990), 6, Seite 867-871 (DE-627)NLEJ18741422X (DE-600)1482780-3 0960-0760 nnns volume:37 year:1990 number:6 pages:867-871 http://linkinghub.elsevier.com/retrieve/pii/0960-0760(90)90434-M GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 37 1990 6 867-871 |
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(DE-627)NLEJ187418306 (DE-599)GBVNLZ187418306 DE-627 ger DE-627 rakwb eng Cytokines and the hypothalamic-pituitary-adrenal axis 1990 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier After administration of the cytokines interleukin 1 (IL1), tumor necrosis factor (TNF), interleukin 2 and interleukin 6 to laboratory animals or humans, plasma levels of glucocorticoids are elevated. This effect is mediated by activation of the hypothalamic-pituitary unit. IL1 and TNF inhibit aldosterone production by rat adrenocortical cells in vitro and stimulate renin release by rat renal cortical cells. Administration of IL1 or TNF in rats suppresses hypothalamic-pituitary-thyroid function, whereas IL1 acts at the level of the brain and the gonads to interfere with gonadotropin and sex steroid secretion.During stimulation of the immune system (e.g. during infectious diseases), peculiar alterations in hormone secretion occur (hypercortisolism, hyperreninemic hypoaldosteronism, euthyroid sick syndrome, hypogonadism). The role of cytokines in these alterations remains to be established. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Hermus, A.R.M.M. oth Sweep, C.G.J. oth in The Journal of Steroid Biochemistry and Molecular Biology Amsterdam : Elsevier 37(1990), 6, Seite 867-871 (DE-627)NLEJ18741422X (DE-600)1482780-3 0960-0760 nnns volume:37 year:1990 number:6 pages:867-871 http://linkinghub.elsevier.com/retrieve/pii/0960-0760(90)90434-M GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 37 1990 6 867-871 |
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(DE-627)NLEJ187418306 (DE-599)GBVNLZ187418306 DE-627 ger DE-627 rakwb eng Cytokines and the hypothalamic-pituitary-adrenal axis 1990 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier After administration of the cytokines interleukin 1 (IL1), tumor necrosis factor (TNF), interleukin 2 and interleukin 6 to laboratory animals or humans, plasma levels of glucocorticoids are elevated. This effect is mediated by activation of the hypothalamic-pituitary unit. IL1 and TNF inhibit aldosterone production by rat adrenocortical cells in vitro and stimulate renin release by rat renal cortical cells. Administration of IL1 or TNF in rats suppresses hypothalamic-pituitary-thyroid function, whereas IL1 acts at the level of the brain and the gonads to interfere with gonadotropin and sex steroid secretion.During stimulation of the immune system (e.g. during infectious diseases), peculiar alterations in hormone secretion occur (hypercortisolism, hyperreninemic hypoaldosteronism, euthyroid sick syndrome, hypogonadism). The role of cytokines in these alterations remains to be established. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Hermus, A.R.M.M. oth Sweep, C.G.J. oth in The Journal of Steroid Biochemistry and Molecular Biology Amsterdam : Elsevier 37(1990), 6, Seite 867-871 (DE-627)NLEJ18741422X (DE-600)1482780-3 0960-0760 nnns volume:37 year:1990 number:6 pages:867-871 http://linkinghub.elsevier.com/retrieve/pii/0960-0760(90)90434-M GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 37 1990 6 867-871 |
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(DE-627)NLEJ187418306 (DE-599)GBVNLZ187418306 DE-627 ger DE-627 rakwb eng Cytokines and the hypothalamic-pituitary-adrenal axis 1990 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier After administration of the cytokines interleukin 1 (IL1), tumor necrosis factor (TNF), interleukin 2 and interleukin 6 to laboratory animals or humans, plasma levels of glucocorticoids are elevated. This effect is mediated by activation of the hypothalamic-pituitary unit. IL1 and TNF inhibit aldosterone production by rat adrenocortical cells in vitro and stimulate renin release by rat renal cortical cells. Administration of IL1 or TNF in rats suppresses hypothalamic-pituitary-thyroid function, whereas IL1 acts at the level of the brain and the gonads to interfere with gonadotropin and sex steroid secretion.During stimulation of the immune system (e.g. during infectious diseases), peculiar alterations in hormone secretion occur (hypercortisolism, hyperreninemic hypoaldosteronism, euthyroid sick syndrome, hypogonadism). The role of cytokines in these alterations remains to be established. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Hermus, A.R.M.M. oth Sweep, C.G.J. oth in The Journal of Steroid Biochemistry and Molecular Biology Amsterdam : Elsevier 37(1990), 6, Seite 867-871 (DE-627)NLEJ18741422X (DE-600)1482780-3 0960-0760 nnns volume:37 year:1990 number:6 pages:867-871 http://linkinghub.elsevier.com/retrieve/pii/0960-0760(90)90434-M GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 37 1990 6 867-871 |
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Cytokines and the hypothalamic-pituitary-adrenal axis |
abstract |
After administration of the cytokines interleukin 1 (IL1), tumor necrosis factor (TNF), interleukin 2 and interleukin 6 to laboratory animals or humans, plasma levels of glucocorticoids are elevated. This effect is mediated by activation of the hypothalamic-pituitary unit. IL1 and TNF inhibit aldosterone production by rat adrenocortical cells in vitro and stimulate renin release by rat renal cortical cells. Administration of IL1 or TNF in rats suppresses hypothalamic-pituitary-thyroid function, whereas IL1 acts at the level of the brain and the gonads to interfere with gonadotropin and sex steroid secretion.During stimulation of the immune system (e.g. during infectious diseases), peculiar alterations in hormone secretion occur (hypercortisolism, hyperreninemic hypoaldosteronism, euthyroid sick syndrome, hypogonadism). The role of cytokines in these alterations remains to be established. |
abstractGer |
After administration of the cytokines interleukin 1 (IL1), tumor necrosis factor (TNF), interleukin 2 and interleukin 6 to laboratory animals or humans, plasma levels of glucocorticoids are elevated. This effect is mediated by activation of the hypothalamic-pituitary unit. IL1 and TNF inhibit aldosterone production by rat adrenocortical cells in vitro and stimulate renin release by rat renal cortical cells. Administration of IL1 or TNF in rats suppresses hypothalamic-pituitary-thyroid function, whereas IL1 acts at the level of the brain and the gonads to interfere with gonadotropin and sex steroid secretion.During stimulation of the immune system (e.g. during infectious diseases), peculiar alterations in hormone secretion occur (hypercortisolism, hyperreninemic hypoaldosteronism, euthyroid sick syndrome, hypogonadism). The role of cytokines in these alterations remains to be established. |
abstract_unstemmed |
After administration of the cytokines interleukin 1 (IL1), tumor necrosis factor (TNF), interleukin 2 and interleukin 6 to laboratory animals or humans, plasma levels of glucocorticoids are elevated. This effect is mediated by activation of the hypothalamic-pituitary unit. IL1 and TNF inhibit aldosterone production by rat adrenocortical cells in vitro and stimulate renin release by rat renal cortical cells. Administration of IL1 or TNF in rats suppresses hypothalamic-pituitary-thyroid function, whereas IL1 acts at the level of the brain and the gonads to interfere with gonadotropin and sex steroid secretion.During stimulation of the immune system (e.g. during infectious diseases), peculiar alterations in hormone secretion occur (hypercortisolism, hyperreninemic hypoaldosteronism, euthyroid sick syndrome, hypogonadism). The role of cytokines in these alterations remains to be established. |
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