Automated high-performance liquid chromatographic method for the determination of mianserin in plasma using electrochemical detection
An automated high-performance liquid chromatographic method for the determination of mianserin in plasma is described. Extraction and injection of the samples were automatically done by the Gilson ASPEC system using C"8, 100-mg Supelclean solid-phase extraction columns. The extracts were chroma...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1992 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Journal of Chromatography B: Biomedical Sciences and Applications - Amsterdam : Elsevier, 582(1992), 1-2, Seite 268-272 |
| Übergeordnetes Werk: |
volume:582 ; year:1992 ; number:1-2 ; pages:268-272 |
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NLEJ188307281 |
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| 520 | |a An automated high-performance liquid chromatographic method for the determination of mianserin in plasma is described. Extraction and injection of the samples were automatically done by the Gilson ASPEC system using C"8, 100-mg Supelclean solid-phase extraction columns. The extracts were chromatographed on a reversed-phase C"1"8 column (150 mm x 3.9 mm I.D.) with a phosphate buffer-acetonitrile-methanol mobile phase and the analytes detected electrochemically. Calibration curves were linear to at least 53.7 ng/ml at which the between-day relative standard deviation was 5% and the recovery 101%. The limit of quantification was 1.67 ng/ml at which the between-day relative standard deviation was 9% and the recovery 92% using a sample volume of 0.5 ml. The method was applied to the determination of mianserin in the plasma of normal human volunteers participating in a comparative bioavailability study. | ||
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| 700 | 1 | |a Swart, K.J. |4 oth | |
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(DE-627)NLEJ188307281 (DE-599)GBVNLZ188307281 DE-627 ger DE-627 rakwb eng Automated high-performance liquid chromatographic method for the determination of mianserin in plasma using electrochemical detection 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier An automated high-performance liquid chromatographic method for the determination of mianserin in plasma is described. Extraction and injection of the samples were automatically done by the Gilson ASPEC system using C"8, 100-mg Supelclean solid-phase extraction columns. The extracts were chromatographed on a reversed-phase C"1"8 column (150 mm x 3.9 mm I.D.) with a phosphate buffer-acetonitrile-methanol mobile phase and the analytes detected electrochemically. Calibration curves were linear to at least 53.7 ng/ml at which the between-day relative standard deviation was 5% and the recovery 101%. The limit of quantification was 1.67 ng/ml at which the between-day relative standard deviation was 9% and the recovery 92% using a sample volume of 0.5 ml. The method was applied to the determination of mianserin in the plasma of normal human volunteers participating in a comparative bioavailability study. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brown, L.W. oth Hundt, H.K.L. oth Swart, K.J. oth in Journal of Chromatography B: Biomedical Sciences and Applications Amsterdam : Elsevier 582(1992), 1-2, Seite 268-272 (DE-627)NLEJ177261676 (DE-600)1491259-4 0378-4347 nnns volume:582 year:1992 number:1-2 pages:268-272 http://linkinghub.elsevier.com/retrieve/pii/0378-4347(92)80332-K GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 582 1992 1-2 268-272 |
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(DE-627)NLEJ188307281 (DE-599)GBVNLZ188307281 DE-627 ger DE-627 rakwb eng Automated high-performance liquid chromatographic method for the determination of mianserin in plasma using electrochemical detection 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier An automated high-performance liquid chromatographic method for the determination of mianserin in plasma is described. Extraction and injection of the samples were automatically done by the Gilson ASPEC system using C"8, 100-mg Supelclean solid-phase extraction columns. The extracts were chromatographed on a reversed-phase C"1"8 column (150 mm x 3.9 mm I.D.) with a phosphate buffer-acetonitrile-methanol mobile phase and the analytes detected electrochemically. Calibration curves were linear to at least 53.7 ng/ml at which the between-day relative standard deviation was 5% and the recovery 101%. The limit of quantification was 1.67 ng/ml at which the between-day relative standard deviation was 9% and the recovery 92% using a sample volume of 0.5 ml. The method was applied to the determination of mianserin in the plasma of normal human volunteers participating in a comparative bioavailability study. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brown, L.W. oth Hundt, H.K.L. oth Swart, K.J. oth in Journal of Chromatography B: Biomedical Sciences and Applications Amsterdam : Elsevier 582(1992), 1-2, Seite 268-272 (DE-627)NLEJ177261676 (DE-600)1491259-4 0378-4347 nnns volume:582 year:1992 number:1-2 pages:268-272 http://linkinghub.elsevier.com/retrieve/pii/0378-4347(92)80332-K GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 582 1992 1-2 268-272 |
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(DE-627)NLEJ188307281 (DE-599)GBVNLZ188307281 DE-627 ger DE-627 rakwb eng Automated high-performance liquid chromatographic method for the determination of mianserin in plasma using electrochemical detection 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier An automated high-performance liquid chromatographic method for the determination of mianserin in plasma is described. Extraction and injection of the samples were automatically done by the Gilson ASPEC system using C"8, 100-mg Supelclean solid-phase extraction columns. The extracts were chromatographed on a reversed-phase C"1"8 column (150 mm x 3.9 mm I.D.) with a phosphate buffer-acetonitrile-methanol mobile phase and the analytes detected electrochemically. Calibration curves were linear to at least 53.7 ng/ml at which the between-day relative standard deviation was 5% and the recovery 101%. The limit of quantification was 1.67 ng/ml at which the between-day relative standard deviation was 9% and the recovery 92% using a sample volume of 0.5 ml. The method was applied to the determination of mianserin in the plasma of normal human volunteers participating in a comparative bioavailability study. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brown, L.W. oth Hundt, H.K.L. oth Swart, K.J. oth in Journal of Chromatography B: Biomedical Sciences and Applications Amsterdam : Elsevier 582(1992), 1-2, Seite 268-272 (DE-627)NLEJ177261676 (DE-600)1491259-4 0378-4347 nnns volume:582 year:1992 number:1-2 pages:268-272 http://linkinghub.elsevier.com/retrieve/pii/0378-4347(92)80332-K GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 582 1992 1-2 268-272 |
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(DE-627)NLEJ188307281 (DE-599)GBVNLZ188307281 DE-627 ger DE-627 rakwb eng Automated high-performance liquid chromatographic method for the determination of mianserin in plasma using electrochemical detection 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier An automated high-performance liquid chromatographic method for the determination of mianserin in plasma is described. Extraction and injection of the samples were automatically done by the Gilson ASPEC system using C"8, 100-mg Supelclean solid-phase extraction columns. The extracts were chromatographed on a reversed-phase C"1"8 column (150 mm x 3.9 mm I.D.) with a phosphate buffer-acetonitrile-methanol mobile phase and the analytes detected electrochemically. Calibration curves were linear to at least 53.7 ng/ml at which the between-day relative standard deviation was 5% and the recovery 101%. The limit of quantification was 1.67 ng/ml at which the between-day relative standard deviation was 9% and the recovery 92% using a sample volume of 0.5 ml. The method was applied to the determination of mianserin in the plasma of normal human volunteers participating in a comparative bioavailability study. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brown, L.W. oth Hundt, H.K.L. oth Swart, K.J. oth in Journal of Chromatography B: Biomedical Sciences and Applications Amsterdam : Elsevier 582(1992), 1-2, Seite 268-272 (DE-627)NLEJ177261676 (DE-600)1491259-4 0378-4347 nnns volume:582 year:1992 number:1-2 pages:268-272 http://linkinghub.elsevier.com/retrieve/pii/0378-4347(92)80332-K GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 582 1992 1-2 268-272 |
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(DE-627)NLEJ188307281 (DE-599)GBVNLZ188307281 DE-627 ger DE-627 rakwb eng Automated high-performance liquid chromatographic method for the determination of mianserin in plasma using electrochemical detection 1992 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier An automated high-performance liquid chromatographic method for the determination of mianserin in plasma is described. Extraction and injection of the samples were automatically done by the Gilson ASPEC system using C"8, 100-mg Supelclean solid-phase extraction columns. The extracts were chromatographed on a reversed-phase C"1"8 column (150 mm x 3.9 mm I.D.) with a phosphate buffer-acetonitrile-methanol mobile phase and the analytes detected electrochemically. Calibration curves were linear to at least 53.7 ng/ml at which the between-day relative standard deviation was 5% and the recovery 101%. The limit of quantification was 1.67 ng/ml at which the between-day relative standard deviation was 9% and the recovery 92% using a sample volume of 0.5 ml. The method was applied to the determination of mianserin in the plasma of normal human volunteers participating in a comparative bioavailability study. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Brown, L.W. oth Hundt, H.K.L. oth Swart, K.J. oth in Journal of Chromatography B: Biomedical Sciences and Applications Amsterdam : Elsevier 582(1992), 1-2, Seite 268-272 (DE-627)NLEJ177261676 (DE-600)1491259-4 0378-4347 nnns volume:582 year:1992 number:1-2 pages:268-272 http://linkinghub.elsevier.com/retrieve/pii/0378-4347(92)80332-K GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 582 1992 1-2 268-272 |
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Automated high-performance liquid chromatographic method for the determination of mianserin in plasma using electrochemical detection |
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An automated high-performance liquid chromatographic method for the determination of mianserin in plasma is described. Extraction and injection of the samples were automatically done by the Gilson ASPEC system using C"8, 100-mg Supelclean solid-phase extraction columns. The extracts were chromatographed on a reversed-phase C"1"8 column (150 mm x 3.9 mm I.D.) with a phosphate buffer-acetonitrile-methanol mobile phase and the analytes detected electrochemically. Calibration curves were linear to at least 53.7 ng/ml at which the between-day relative standard deviation was 5% and the recovery 101%. The limit of quantification was 1.67 ng/ml at which the between-day relative standard deviation was 9% and the recovery 92% using a sample volume of 0.5 ml. The method was applied to the determination of mianserin in the plasma of normal human volunteers participating in a comparative bioavailability study. |
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An automated high-performance liquid chromatographic method for the determination of mianserin in plasma is described. Extraction and injection of the samples were automatically done by the Gilson ASPEC system using C"8, 100-mg Supelclean solid-phase extraction columns. The extracts were chromatographed on a reversed-phase C"1"8 column (150 mm x 3.9 mm I.D.) with a phosphate buffer-acetonitrile-methanol mobile phase and the analytes detected electrochemically. Calibration curves were linear to at least 53.7 ng/ml at which the between-day relative standard deviation was 5% and the recovery 101%. The limit of quantification was 1.67 ng/ml at which the between-day relative standard deviation was 9% and the recovery 92% using a sample volume of 0.5 ml. The method was applied to the determination of mianserin in the plasma of normal human volunteers participating in a comparative bioavailability study. |
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An automated high-performance liquid chromatographic method for the determination of mianserin in plasma is described. Extraction and injection of the samples were automatically done by the Gilson ASPEC system using C"8, 100-mg Supelclean solid-phase extraction columns. The extracts were chromatographed on a reversed-phase C"1"8 column (150 mm x 3.9 mm I.D.) with a phosphate buffer-acetonitrile-methanol mobile phase and the analytes detected electrochemically. Calibration curves were linear to at least 53.7 ng/ml at which the between-day relative standard deviation was 5% and the recovery 101%. The limit of quantification was 1.67 ng/ml at which the between-day relative standard deviation was 9% and the recovery 92% using a sample volume of 0.5 ml. The method was applied to the determination of mianserin in the plasma of normal human volunteers participating in a comparative bioavailability study. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ188307281</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707095002.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070506s1992 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ188307281</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ188307281</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Automated high-performance liquid chromatographic method for the determination of mianserin in plasma using electrochemical detection</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1992</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">An automated high-performance liquid chromatographic method for the determination of mianserin in plasma is described. Extraction and injection of the samples were automatically done by the Gilson ASPEC system using C"8, 100-mg Supelclean solid-phase extraction columns. The extracts were chromatographed on a reversed-phase C"1"8 column (150 mm x 3.9 mm I.D.) with a phosphate buffer-acetonitrile-methanol mobile phase and the analytes detected electrochemically. Calibration curves were linear to at least 53.7 ng/ml at which the between-day relative standard deviation was 5% and the recovery 101%. The limit of quantification was 1.67 ng/ml at which the between-day relative standard deviation was 9% and the recovery 92% using a sample volume of 0.5 ml. The method was applied to the determination of mianserin in the plasma of normal human volunteers participating in a comparative bioavailability study.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Brown, L.W.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hundt, H.K.L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Swart, K.J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Journal of Chromatography B: Biomedical Sciences and Applications</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">582(1992), 1-2, Seite 268-272</subfield><subfield code="w">(DE-627)NLEJ177261676</subfield><subfield code="w">(DE-600)1491259-4</subfield><subfield code="x">0378-4347</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:582</subfield><subfield code="g">year:1992</subfield><subfield code="g">number:1-2</subfield><subfield code="g">pages:268-272</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://linkinghub.elsevier.com/retrieve/pii/0378-4347(92)80332-K</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">582</subfield><subfield code="j">1992</subfield><subfield code="e">1-2</subfield><subfield code="h">268-272</subfield></datafield></record></collection>
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7.4011383 |