Detection and separation of the anthrapyrazole CI-941 and its metabolites in serum and urine by high-performance liquid chromatography
A high-performance liquid chromatographic method using ion-pairing chromatography on reversed-phase C"1"8 material with a mobile phase of acetonitrile-water (19:81, v/v) containing 5 mM 1-pentanesulfonic acid was developed for the detection and separation of the anthrapyrazole CI-941 (I) a...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1994 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Journal of Chromatography B: Biomedical Sciences and Applications - Amsterdam : Elsevier, 658(1994), 2, Seite 349-353 |
| Übergeordnetes Werk: |
volume:658 ; year:1994 ; number:2 ; pages:349-353 |
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| 520 | |a A high-performance liquid chromatographic method using ion-pairing chromatography on reversed-phase C"1"8 material with a mobile phase of acetonitrile-water (19:81, v/v) containing 5 mM 1-pentanesulfonic acid was developed for the detection and separation of the anthrapyrazole CI-941 (I) and its metabolites. After sample clean-up with solid-phase extraction, I and its metabolites were measurable at a wavelength of 491 nm. A detection limit of 5 ng/ml was achievable for I. The dicarboxylic acid derivative and the isomers of the monocarboxylic acid derivative could be separated. Application of the method to a human pharmacokinetic study showed two and four metabolites of I in serum and urine respectively. | ||
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(DE-627)NLEJ188312161 (DE-599)GBVNLZ188312161 DE-627 ger DE-627 rakwb eng Detection and separation of the anthrapyrazole CI-941 and its metabolites in serum and urine by high-performance liquid chromatography 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A high-performance liquid chromatographic method using ion-pairing chromatography on reversed-phase C"1"8 material with a mobile phase of acetonitrile-water (19:81, v/v) containing 5 mM 1-pentanesulfonic acid was developed for the detection and separation of the anthrapyrazole CI-941 (I) and its metabolites. After sample clean-up with solid-phase extraction, I and its metabolites were measurable at a wavelength of 491 nm. A detection limit of 5 ng/ml was achievable for I. The dicarboxylic acid derivative and the isomers of the monocarboxylic acid derivative could be separated. Application of the method to a human pharmacokinetic study showed two and four metabolites of I in serum and urine respectively. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Proksch, B. oth Blanz, J. oth Zeller, K.-P. oth Ehninger, G. oth in Journal of Chromatography B: Biomedical Sciences and Applications Amsterdam : Elsevier 658(1994), 2, Seite 349-353 (DE-627)NLEJ177261676 (DE-600)1491259-4 0378-4347 nnns volume:658 year:1994 number:2 pages:349-353 http://linkinghub.elsevier.com/retrieve/pii/0378-4347(94)00235-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 658 1994 2 349-353 |
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(DE-627)NLEJ188312161 (DE-599)GBVNLZ188312161 DE-627 ger DE-627 rakwb eng Detection and separation of the anthrapyrazole CI-941 and its metabolites in serum and urine by high-performance liquid chromatography 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A high-performance liquid chromatographic method using ion-pairing chromatography on reversed-phase C"1"8 material with a mobile phase of acetonitrile-water (19:81, v/v) containing 5 mM 1-pentanesulfonic acid was developed for the detection and separation of the anthrapyrazole CI-941 (I) and its metabolites. After sample clean-up with solid-phase extraction, I and its metabolites were measurable at a wavelength of 491 nm. A detection limit of 5 ng/ml was achievable for I. The dicarboxylic acid derivative and the isomers of the monocarboxylic acid derivative could be separated. Application of the method to a human pharmacokinetic study showed two and four metabolites of I in serum and urine respectively. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Proksch, B. oth Blanz, J. oth Zeller, K.-P. oth Ehninger, G. oth in Journal of Chromatography B: Biomedical Sciences and Applications Amsterdam : Elsevier 658(1994), 2, Seite 349-353 (DE-627)NLEJ177261676 (DE-600)1491259-4 0378-4347 nnns volume:658 year:1994 number:2 pages:349-353 http://linkinghub.elsevier.com/retrieve/pii/0378-4347(94)00235-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 658 1994 2 349-353 |
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(DE-627)NLEJ188312161 (DE-599)GBVNLZ188312161 DE-627 ger DE-627 rakwb eng Detection and separation of the anthrapyrazole CI-941 and its metabolites in serum and urine by high-performance liquid chromatography 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A high-performance liquid chromatographic method using ion-pairing chromatography on reversed-phase C"1"8 material with a mobile phase of acetonitrile-water (19:81, v/v) containing 5 mM 1-pentanesulfonic acid was developed for the detection and separation of the anthrapyrazole CI-941 (I) and its metabolites. After sample clean-up with solid-phase extraction, I and its metabolites were measurable at a wavelength of 491 nm. A detection limit of 5 ng/ml was achievable for I. The dicarboxylic acid derivative and the isomers of the monocarboxylic acid derivative could be separated. Application of the method to a human pharmacokinetic study showed two and four metabolites of I in serum and urine respectively. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Proksch, B. oth Blanz, J. oth Zeller, K.-P. oth Ehninger, G. oth in Journal of Chromatography B: Biomedical Sciences and Applications Amsterdam : Elsevier 658(1994), 2, Seite 349-353 (DE-627)NLEJ177261676 (DE-600)1491259-4 0378-4347 nnns volume:658 year:1994 number:2 pages:349-353 http://linkinghub.elsevier.com/retrieve/pii/0378-4347(94)00235-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 658 1994 2 349-353 |
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(DE-627)NLEJ188312161 (DE-599)GBVNLZ188312161 DE-627 ger DE-627 rakwb eng Detection and separation of the anthrapyrazole CI-941 and its metabolites in serum and urine by high-performance liquid chromatography 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A high-performance liquid chromatographic method using ion-pairing chromatography on reversed-phase C"1"8 material with a mobile phase of acetonitrile-water (19:81, v/v) containing 5 mM 1-pentanesulfonic acid was developed for the detection and separation of the anthrapyrazole CI-941 (I) and its metabolites. After sample clean-up with solid-phase extraction, I and its metabolites were measurable at a wavelength of 491 nm. A detection limit of 5 ng/ml was achievable for I. The dicarboxylic acid derivative and the isomers of the monocarboxylic acid derivative could be separated. Application of the method to a human pharmacokinetic study showed two and four metabolites of I in serum and urine respectively. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Proksch, B. oth Blanz, J. oth Zeller, K.-P. oth Ehninger, G. oth in Journal of Chromatography B: Biomedical Sciences and Applications Amsterdam : Elsevier 658(1994), 2, Seite 349-353 (DE-627)NLEJ177261676 (DE-600)1491259-4 0378-4347 nnns volume:658 year:1994 number:2 pages:349-353 http://linkinghub.elsevier.com/retrieve/pii/0378-4347(94)00235-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 658 1994 2 349-353 |
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(DE-627)NLEJ188312161 (DE-599)GBVNLZ188312161 DE-627 ger DE-627 rakwb eng Detection and separation of the anthrapyrazole CI-941 and its metabolites in serum and urine by high-performance liquid chromatography 1994 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A high-performance liquid chromatographic method using ion-pairing chromatography on reversed-phase C"1"8 material with a mobile phase of acetonitrile-water (19:81, v/v) containing 5 mM 1-pentanesulfonic acid was developed for the detection and separation of the anthrapyrazole CI-941 (I) and its metabolites. After sample clean-up with solid-phase extraction, I and its metabolites were measurable at a wavelength of 491 nm. A detection limit of 5 ng/ml was achievable for I. The dicarboxylic acid derivative and the isomers of the monocarboxylic acid derivative could be separated. Application of the method to a human pharmacokinetic study showed two and four metabolites of I in serum and urine respectively. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Proksch, B. oth Blanz, J. oth Zeller, K.-P. oth Ehninger, G. oth in Journal of Chromatography B: Biomedical Sciences and Applications Amsterdam : Elsevier 658(1994), 2, Seite 349-353 (DE-627)NLEJ177261676 (DE-600)1491259-4 0378-4347 nnns volume:658 year:1994 number:2 pages:349-353 http://linkinghub.elsevier.com/retrieve/pii/0378-4347(94)00235-5 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 658 1994 2 349-353 |
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Detection and separation of the anthrapyrazole CI-941 and its metabolites in serum and urine by high-performance liquid chromatography |
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A high-performance liquid chromatographic method using ion-pairing chromatography on reversed-phase C"1"8 material with a mobile phase of acetonitrile-water (19:81, v/v) containing 5 mM 1-pentanesulfonic acid was developed for the detection and separation of the anthrapyrazole CI-941 (I) and its metabolites. After sample clean-up with solid-phase extraction, I and its metabolites were measurable at a wavelength of 491 nm. A detection limit of 5 ng/ml was achievable for I. The dicarboxylic acid derivative and the isomers of the monocarboxylic acid derivative could be separated. Application of the method to a human pharmacokinetic study showed two and four metabolites of I in serum and urine respectively. |
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A high-performance liquid chromatographic method using ion-pairing chromatography on reversed-phase C"1"8 material with a mobile phase of acetonitrile-water (19:81, v/v) containing 5 mM 1-pentanesulfonic acid was developed for the detection and separation of the anthrapyrazole CI-941 (I) and its metabolites. After sample clean-up with solid-phase extraction, I and its metabolites were measurable at a wavelength of 491 nm. A detection limit of 5 ng/ml was achievable for I. The dicarboxylic acid derivative and the isomers of the monocarboxylic acid derivative could be separated. Application of the method to a human pharmacokinetic study showed two and four metabolites of I in serum and urine respectively. |
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A high-performance liquid chromatographic method using ion-pairing chromatography on reversed-phase C"1"8 material with a mobile phase of acetonitrile-water (19:81, v/v) containing 5 mM 1-pentanesulfonic acid was developed for the detection and separation of the anthrapyrazole CI-941 (I) and its metabolites. After sample clean-up with solid-phase extraction, I and its metabolites were measurable at a wavelength of 491 nm. A detection limit of 5 ng/ml was achievable for I. The dicarboxylic acid derivative and the isomers of the monocarboxylic acid derivative could be separated. Application of the method to a human pharmacokinetic study showed two and four metabolites of I in serum and urine respectively. |
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