Comparison of conventional partitioning systems used for studying the hydrophobicity of polar organic compounds
An analysis of published partition coefficients measured in various two-phase systems for homologous series of fatty acids, aliphatic alcohols and amines was performed in order to clarify the physical meaning of the constants in the so-called solvent regression equation: ln K"i = a"i ln K&...
Ausführliche Beschreibung
Gespeichert in:
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1981 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Journal of Chromatography A - Amsterdam : Elsevier, 216(1981), Seite 103-113 |
| Übergeordnetes Werk: |
volume:216 ; year:1981 ; pages:103-113 |
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| 520 | |a An analysis of published partition coefficients measured in various two-phase systems for homologous series of fatty acids, aliphatic alcohols and amines was performed in order to clarify the physical meaning of the constants in the so-called solvent regression equation: ln K"i = a"i ln K"0 + b"i, where K"i and K"0 are the partition coefficients for a given solute determined in the partitioning system in question and in that chosen as the reference, respectively, and a"i and b"i are constants. The difference in the relative hydrophobicities of two phases of a given partitioning system is expressed in terms of the free energy of transfer of a CH"2 group from the non-aqueous to the aqueous phase of the system (Δg"i^C^H^2). It is shown that a"i is related to the Δg"i^C^H^2 and Δg"0^C^H^2 values by the equation a"i = Δg"i^C^H^2/Δg"0^C^H^2. The term b"i appears to account for the specific solute-water (and/or solute-solvent) interactions characteristic of a polar group contained by the solute molecule.The analysis of literature data indicates that the difference in the relative hydrophobicities between any two groups depends on the choice of partitioning system. The physical meaning of the relative hydrophobicity of a chemical compound is discussed, and it is concluded that an aqueous two-phase system should be used as the reference. The aqueous two-phase polymeric system Ficoll-dextran is proposed for this purpose and its advantages are briefly considered. | ||
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(DE-627)NLEJ188533788 (DE-599)GBVNLZ188533788 DE-627 ger DE-627 rakwb eng Comparison of conventional partitioning systems used for studying the hydrophobicity of polar organic compounds 1981 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier An analysis of published partition coefficients measured in various two-phase systems for homologous series of fatty acids, aliphatic alcohols and amines was performed in order to clarify the physical meaning of the constants in the so-called solvent regression equation: ln K"i = a"i ln K"0 + b"i, where K"i and K"0 are the partition coefficients for a given solute determined in the partitioning system in question and in that chosen as the reference, respectively, and a"i and b"i are constants. The difference in the relative hydrophobicities of two phases of a given partitioning system is expressed in terms of the free energy of transfer of a CH"2 group from the non-aqueous to the aqueous phase of the system (Δg"i^C^H^2). It is shown that a"i is related to the Δg"i^C^H^2 and Δg"0^C^H^2 values by the equation a"i = Δg"i^C^H^2/Δg"0^C^H^2. The term b"i appears to account for the specific solute-water (and/or solute-solvent) interactions characteristic of a polar group contained by the solute molecule.The analysis of literature data indicates that the difference in the relative hydrophobicities between any two groups depends on the choice of partitioning system. The physical meaning of the relative hydrophobicity of a chemical compound is discussed, and it is concluded that an aqueous two-phase system should be used as the reference. The aqueous two-phase polymeric system Ficoll-dextran is proposed for this purpose and its advantages are briefly considered. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Zaslavsky, B.Y. oth Miheeva, L.M. oth Rogozhin, S.V. oth in Journal of Chromatography A Amsterdam : Elsevier 216(1981), Seite 103-113 (DE-627)NLEJ17403282X (DE-600)1491247-8 0021-9673 nnns volume:216 year:1981 pages:103-113 http://dx.doi.org/10.1016/S0021-9673(00)82339-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 216 1981 103-113 |
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(DE-627)NLEJ188533788 (DE-599)GBVNLZ188533788 DE-627 ger DE-627 rakwb eng Comparison of conventional partitioning systems used for studying the hydrophobicity of polar organic compounds 1981 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier An analysis of published partition coefficients measured in various two-phase systems for homologous series of fatty acids, aliphatic alcohols and amines was performed in order to clarify the physical meaning of the constants in the so-called solvent regression equation: ln K"i = a"i ln K"0 + b"i, where K"i and K"0 are the partition coefficients for a given solute determined in the partitioning system in question and in that chosen as the reference, respectively, and a"i and b"i are constants. The difference in the relative hydrophobicities of two phases of a given partitioning system is expressed in terms of the free energy of transfer of a CH"2 group from the non-aqueous to the aqueous phase of the system (Δg"i^C^H^2). It is shown that a"i is related to the Δg"i^C^H^2 and Δg"0^C^H^2 values by the equation a"i = Δg"i^C^H^2/Δg"0^C^H^2. The term b"i appears to account for the specific solute-water (and/or solute-solvent) interactions characteristic of a polar group contained by the solute molecule.The analysis of literature data indicates that the difference in the relative hydrophobicities between any two groups depends on the choice of partitioning system. The physical meaning of the relative hydrophobicity of a chemical compound is discussed, and it is concluded that an aqueous two-phase system should be used as the reference. The aqueous two-phase polymeric system Ficoll-dextran is proposed for this purpose and its advantages are briefly considered. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Zaslavsky, B.Y. oth Miheeva, L.M. oth Rogozhin, S.V. oth in Journal of Chromatography A Amsterdam : Elsevier 216(1981), Seite 103-113 (DE-627)NLEJ17403282X (DE-600)1491247-8 0021-9673 nnns volume:216 year:1981 pages:103-113 http://dx.doi.org/10.1016/S0021-9673(00)82339-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 216 1981 103-113 |
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(DE-627)NLEJ188533788 (DE-599)GBVNLZ188533788 DE-627 ger DE-627 rakwb eng Comparison of conventional partitioning systems used for studying the hydrophobicity of polar organic compounds 1981 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier An analysis of published partition coefficients measured in various two-phase systems for homologous series of fatty acids, aliphatic alcohols and amines was performed in order to clarify the physical meaning of the constants in the so-called solvent regression equation: ln K"i = a"i ln K"0 + b"i, where K"i and K"0 are the partition coefficients for a given solute determined in the partitioning system in question and in that chosen as the reference, respectively, and a"i and b"i are constants. The difference in the relative hydrophobicities of two phases of a given partitioning system is expressed in terms of the free energy of transfer of a CH"2 group from the non-aqueous to the aqueous phase of the system (Δg"i^C^H^2). It is shown that a"i is related to the Δg"i^C^H^2 and Δg"0^C^H^2 values by the equation a"i = Δg"i^C^H^2/Δg"0^C^H^2. The term b"i appears to account for the specific solute-water (and/or solute-solvent) interactions characteristic of a polar group contained by the solute molecule.The analysis of literature data indicates that the difference in the relative hydrophobicities between any two groups depends on the choice of partitioning system. The physical meaning of the relative hydrophobicity of a chemical compound is discussed, and it is concluded that an aqueous two-phase system should be used as the reference. The aqueous two-phase polymeric system Ficoll-dextran is proposed for this purpose and its advantages are briefly considered. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Zaslavsky, B.Y. oth Miheeva, L.M. oth Rogozhin, S.V. oth in Journal of Chromatography A Amsterdam : Elsevier 216(1981), Seite 103-113 (DE-627)NLEJ17403282X (DE-600)1491247-8 0021-9673 nnns volume:216 year:1981 pages:103-113 http://dx.doi.org/10.1016/S0021-9673(00)82339-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 216 1981 103-113 |
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(DE-627)NLEJ188533788 (DE-599)GBVNLZ188533788 DE-627 ger DE-627 rakwb eng Comparison of conventional partitioning systems used for studying the hydrophobicity of polar organic compounds 1981 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier An analysis of published partition coefficients measured in various two-phase systems for homologous series of fatty acids, aliphatic alcohols and amines was performed in order to clarify the physical meaning of the constants in the so-called solvent regression equation: ln K"i = a"i ln K"0 + b"i, where K"i and K"0 are the partition coefficients for a given solute determined in the partitioning system in question and in that chosen as the reference, respectively, and a"i and b"i are constants. The difference in the relative hydrophobicities of two phases of a given partitioning system is expressed in terms of the free energy of transfer of a CH"2 group from the non-aqueous to the aqueous phase of the system (Δg"i^C^H^2). It is shown that a"i is related to the Δg"i^C^H^2 and Δg"0^C^H^2 values by the equation a"i = Δg"i^C^H^2/Δg"0^C^H^2. The term b"i appears to account for the specific solute-water (and/or solute-solvent) interactions characteristic of a polar group contained by the solute molecule.The analysis of literature data indicates that the difference in the relative hydrophobicities between any two groups depends on the choice of partitioning system. The physical meaning of the relative hydrophobicity of a chemical compound is discussed, and it is concluded that an aqueous two-phase system should be used as the reference. The aqueous two-phase polymeric system Ficoll-dextran is proposed for this purpose and its advantages are briefly considered. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Zaslavsky, B.Y. oth Miheeva, L.M. oth Rogozhin, S.V. oth in Journal of Chromatography A Amsterdam : Elsevier 216(1981), Seite 103-113 (DE-627)NLEJ17403282X (DE-600)1491247-8 0021-9673 nnns volume:216 year:1981 pages:103-113 http://dx.doi.org/10.1016/S0021-9673(00)82339-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 216 1981 103-113 |
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(DE-627)NLEJ188533788 (DE-599)GBVNLZ188533788 DE-627 ger DE-627 rakwb eng Comparison of conventional partitioning systems used for studying the hydrophobicity of polar organic compounds 1981 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier An analysis of published partition coefficients measured in various two-phase systems for homologous series of fatty acids, aliphatic alcohols and amines was performed in order to clarify the physical meaning of the constants in the so-called solvent regression equation: ln K"i = a"i ln K"0 + b"i, where K"i and K"0 are the partition coefficients for a given solute determined in the partitioning system in question and in that chosen as the reference, respectively, and a"i and b"i are constants. The difference in the relative hydrophobicities of two phases of a given partitioning system is expressed in terms of the free energy of transfer of a CH"2 group from the non-aqueous to the aqueous phase of the system (Δg"i^C^H^2). It is shown that a"i is related to the Δg"i^C^H^2 and Δg"0^C^H^2 values by the equation a"i = Δg"i^C^H^2/Δg"0^C^H^2. The term b"i appears to account for the specific solute-water (and/or solute-solvent) interactions characteristic of a polar group contained by the solute molecule.The analysis of literature data indicates that the difference in the relative hydrophobicities between any two groups depends on the choice of partitioning system. The physical meaning of the relative hydrophobicity of a chemical compound is discussed, and it is concluded that an aqueous two-phase system should be used as the reference. The aqueous two-phase polymeric system Ficoll-dextran is proposed for this purpose and its advantages are briefly considered. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Zaslavsky, B.Y. oth Miheeva, L.M. oth Rogozhin, S.V. oth in Journal of Chromatography A Amsterdam : Elsevier 216(1981), Seite 103-113 (DE-627)NLEJ17403282X (DE-600)1491247-8 0021-9673 nnns volume:216 year:1981 pages:103-113 http://dx.doi.org/10.1016/S0021-9673(00)82339-0 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 216 1981 103-113 |
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comparison of conventional partitioning systems used for studying the hydrophobicity of polar organic compounds |
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Comparison of conventional partitioning systems used for studying the hydrophobicity of polar organic compounds |
| abstract |
An analysis of published partition coefficients measured in various two-phase systems for homologous series of fatty acids, aliphatic alcohols and amines was performed in order to clarify the physical meaning of the constants in the so-called solvent regression equation: ln K"i = a"i ln K"0 + b"i, where K"i and K"0 are the partition coefficients for a given solute determined in the partitioning system in question and in that chosen as the reference, respectively, and a"i and b"i are constants. The difference in the relative hydrophobicities of two phases of a given partitioning system is expressed in terms of the free energy of transfer of a CH"2 group from the non-aqueous to the aqueous phase of the system (Δg"i^C^H^2). It is shown that a"i is related to the Δg"i^C^H^2 and Δg"0^C^H^2 values by the equation a"i = Δg"i^C^H^2/Δg"0^C^H^2. The term b"i appears to account for the specific solute-water (and/or solute-solvent) interactions characteristic of a polar group contained by the solute molecule.The analysis of literature data indicates that the difference in the relative hydrophobicities between any two groups depends on the choice of partitioning system. The physical meaning of the relative hydrophobicity of a chemical compound is discussed, and it is concluded that an aqueous two-phase system should be used as the reference. The aqueous two-phase polymeric system Ficoll-dextran is proposed for this purpose and its advantages are briefly considered. |
| abstractGer |
An analysis of published partition coefficients measured in various two-phase systems for homologous series of fatty acids, aliphatic alcohols and amines was performed in order to clarify the physical meaning of the constants in the so-called solvent regression equation: ln K"i = a"i ln K"0 + b"i, where K"i and K"0 are the partition coefficients for a given solute determined in the partitioning system in question and in that chosen as the reference, respectively, and a"i and b"i are constants. The difference in the relative hydrophobicities of two phases of a given partitioning system is expressed in terms of the free energy of transfer of a CH"2 group from the non-aqueous to the aqueous phase of the system (Δg"i^C^H^2). It is shown that a"i is related to the Δg"i^C^H^2 and Δg"0^C^H^2 values by the equation a"i = Δg"i^C^H^2/Δg"0^C^H^2. The term b"i appears to account for the specific solute-water (and/or solute-solvent) interactions characteristic of a polar group contained by the solute molecule.The analysis of literature data indicates that the difference in the relative hydrophobicities between any two groups depends on the choice of partitioning system. The physical meaning of the relative hydrophobicity of a chemical compound is discussed, and it is concluded that an aqueous two-phase system should be used as the reference. The aqueous two-phase polymeric system Ficoll-dextran is proposed for this purpose and its advantages are briefly considered. |
| abstract_unstemmed |
An analysis of published partition coefficients measured in various two-phase systems for homologous series of fatty acids, aliphatic alcohols and amines was performed in order to clarify the physical meaning of the constants in the so-called solvent regression equation: ln K"i = a"i ln K"0 + b"i, where K"i and K"0 are the partition coefficients for a given solute determined in the partitioning system in question and in that chosen as the reference, respectively, and a"i and b"i are constants. The difference in the relative hydrophobicities of two phases of a given partitioning system is expressed in terms of the free energy of transfer of a CH"2 group from the non-aqueous to the aqueous phase of the system (Δg"i^C^H^2). It is shown that a"i is related to the Δg"i^C^H^2 and Δg"0^C^H^2 values by the equation a"i = Δg"i^C^H^2/Δg"0^C^H^2. The term b"i appears to account for the specific solute-water (and/or solute-solvent) interactions characteristic of a polar group contained by the solute molecule.The analysis of literature data indicates that the difference in the relative hydrophobicities between any two groups depends on the choice of partitioning system. The physical meaning of the relative hydrophobicity of a chemical compound is discussed, and it is concluded that an aqueous two-phase system should be used as the reference. The aqueous two-phase polymeric system Ficoll-dextran is proposed for this purpose and its advantages are briefly considered. |
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2024-07-05T22:18:07.553Z |
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1803779191660871680 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ188533788</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707102316.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070506s1981 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ188533788</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ188533788</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Comparison of conventional partitioning systems used for studying the hydrophobicity of polar organic compounds</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1981</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">An analysis of published partition coefficients measured in various two-phase systems for homologous series of fatty acids, aliphatic alcohols and amines was performed in order to clarify the physical meaning of the constants in the so-called solvent regression equation: ln K"i = a"i ln K"0 + b"i, where K"i and K"0 are the partition coefficients for a given solute determined in the partitioning system in question and in that chosen as the reference, respectively, and a"i and b"i are constants. The difference in the relative hydrophobicities of two phases of a given partitioning system is expressed in terms of the free energy of transfer of a CH"2 group from the non-aqueous to the aqueous phase of the system (Δg"i^C^H^2). It is shown that a"i is related to the Δg"i^C^H^2 and Δg"0^C^H^2 values by the equation a"i = Δg"i^C^H^2/Δg"0^C^H^2. The term b"i appears to account for the specific solute-water (and/or solute-solvent) interactions characteristic of a polar group contained by the solute molecule.The analysis of literature data indicates that the difference in the relative hydrophobicities between any two groups depends on the choice of partitioning system. The physical meaning of the relative hydrophobicity of a chemical compound is discussed, and it is concluded that an aqueous two-phase system should be used as the reference. The aqueous two-phase polymeric system Ficoll-dextran is proposed for this purpose and its advantages are briefly considered.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zaslavsky, B.Y.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Miheeva, L.M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rogozhin, S.V.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Journal of Chromatography A</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">216(1981), Seite 103-113</subfield><subfield code="w">(DE-627)NLEJ17403282X</subfield><subfield code="w">(DE-600)1491247-8</subfield><subfield code="x">0021-9673</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:216</subfield><subfield code="g">year:1981</subfield><subfield code="g">pages:103-113</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1016/S0021-9673(00)82339-0</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">216</subfield><subfield code="j">1981</subfield><subfield code="h">103-113</subfield></datafield></record></collection>
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