Uptake and metabolism of nicotine by the CNS of a nicotine-resistant insect, the tobacco hornworm (Manduca sexta)
Penetration of the CNS by nicotine occurred equally rapidly in the nicotine-insensitive Manduca cord and the nicotine-sensitive Periplaneta cord, ruling out the possibility that lowered permeability renders Manduca insensitive. Although a saturable concentrative component of nicotine uptake was foun...
Ausführliche Beschreibung
Gespeichert in:
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1983 |
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| Reproduktion: |
Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 |
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| Übergeordnetes Werk: |
in: Journal of Insect Physiology - Amsterdam : Elsevier, 29(1983), 11, Seite 807-817 |
| Übergeordnetes Werk: |
volume:29 ; year:1983 ; number:11 ; pages:807-817 |
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| 245 | 1 | 0 | |a Uptake and metabolism of nicotine by the CNS of a nicotine-resistant insect, the tobacco hornworm (Manduca sexta) |
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| 520 | |a Penetration of the CNS by nicotine occurred equally rapidly in the nicotine-insensitive Manduca cord and the nicotine-sensitive Periplaneta cord, ruling out the possibility that lowered permeability renders Manduca insensitive. Although a saturable concentrative component of nicotine uptake was found in the Manduca cord, it was difficult to examine this component rigorously, because, except at high concentrations, the CNS metabolises the bulk of the nicotine that is taken up. The CNS metabolites of nicotine are water-soluble compounds. They are special first by virtue of the fact that they are formed in the CNS itself and secondly because their chromatographic characteristics are different from mammalian nicotine metabolites (which are not formed by nervous tissue). When subjected to hydrolysis, the metabolites acted like conjugates. Periplaneta CNS also metabolised nicotine, but much less extensively than Manduca. It is speculated that enzymic detoxification of dietary neurotoxins may be a necessary function of the insect CNS, since insects have no anatomical equivalent of a hepatic-portal system for detoxifying ingested compounds before they reach the blood-brain interface. | ||
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(DE-627)NLEJ188618031 (DE-599)GBVNLZ188618031 DE-627 ger DE-627 rakwb eng Uptake and metabolism of nicotine by the CNS of a nicotine-resistant insect, the tobacco hornworm (Manduca sexta) 1983 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Penetration of the CNS by nicotine occurred equally rapidly in the nicotine-insensitive Manduca cord and the nicotine-sensitive Periplaneta cord, ruling out the possibility that lowered permeability renders Manduca insensitive. Although a saturable concentrative component of nicotine uptake was found in the Manduca cord, it was difficult to examine this component rigorously, because, except at high concentrations, the CNS metabolises the bulk of the nicotine that is taken up. The CNS metabolites of nicotine are water-soluble compounds. They are special first by virtue of the fact that they are formed in the CNS itself and secondly because their chromatographic characteristics are different from mammalian nicotine metabolites (which are not formed by nervous tissue). When subjected to hydrolysis, the metabolites acted like conjugates. Periplaneta CNS also metabolised nicotine, but much less extensively than Manduca. It is speculated that enzymic detoxification of dietary neurotoxins may be a necessary function of the insect CNS, since insects have no anatomical equivalent of a hepatic-portal system for detoxifying ingested compounds before they reach the blood-brain interface. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Morris, C.E. oth in Journal of Insect Physiology Amsterdam : Elsevier 29(1983), 11, Seite 807-817 (DE-627)NLEJ188565949 (DE-600)1482429-2 0022-1910 nnns volume:29 year:1983 number:11 pages:807-817 http://dx.doi.org/10.1016/0022-1910(83)90146-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 29 1983 11 807-817 |
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(DE-627)NLEJ188618031 (DE-599)GBVNLZ188618031 DE-627 ger DE-627 rakwb eng Uptake and metabolism of nicotine by the CNS of a nicotine-resistant insect, the tobacco hornworm (Manduca sexta) 1983 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Penetration of the CNS by nicotine occurred equally rapidly in the nicotine-insensitive Manduca cord and the nicotine-sensitive Periplaneta cord, ruling out the possibility that lowered permeability renders Manduca insensitive. Although a saturable concentrative component of nicotine uptake was found in the Manduca cord, it was difficult to examine this component rigorously, because, except at high concentrations, the CNS metabolises the bulk of the nicotine that is taken up. The CNS metabolites of nicotine are water-soluble compounds. They are special first by virtue of the fact that they are formed in the CNS itself and secondly because their chromatographic characteristics are different from mammalian nicotine metabolites (which are not formed by nervous tissue). When subjected to hydrolysis, the metabolites acted like conjugates. Periplaneta CNS also metabolised nicotine, but much less extensively than Manduca. It is speculated that enzymic detoxification of dietary neurotoxins may be a necessary function of the insect CNS, since insects have no anatomical equivalent of a hepatic-portal system for detoxifying ingested compounds before they reach the blood-brain interface. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Morris, C.E. oth in Journal of Insect Physiology Amsterdam : Elsevier 29(1983), 11, Seite 807-817 (DE-627)NLEJ188565949 (DE-600)1482429-2 0022-1910 nnns volume:29 year:1983 number:11 pages:807-817 http://dx.doi.org/10.1016/0022-1910(83)90146-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 29 1983 11 807-817 |
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(DE-627)NLEJ188618031 (DE-599)GBVNLZ188618031 DE-627 ger DE-627 rakwb eng Uptake and metabolism of nicotine by the CNS of a nicotine-resistant insect, the tobacco hornworm (Manduca sexta) 1983 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Penetration of the CNS by nicotine occurred equally rapidly in the nicotine-insensitive Manduca cord and the nicotine-sensitive Periplaneta cord, ruling out the possibility that lowered permeability renders Manduca insensitive. Although a saturable concentrative component of nicotine uptake was found in the Manduca cord, it was difficult to examine this component rigorously, because, except at high concentrations, the CNS metabolises the bulk of the nicotine that is taken up. The CNS metabolites of nicotine are water-soluble compounds. They are special first by virtue of the fact that they are formed in the CNS itself and secondly because their chromatographic characteristics are different from mammalian nicotine metabolites (which are not formed by nervous tissue). When subjected to hydrolysis, the metabolites acted like conjugates. Periplaneta CNS also metabolised nicotine, but much less extensively than Manduca. It is speculated that enzymic detoxification of dietary neurotoxins may be a necessary function of the insect CNS, since insects have no anatomical equivalent of a hepatic-portal system for detoxifying ingested compounds before they reach the blood-brain interface. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Morris, C.E. oth in Journal of Insect Physiology Amsterdam : Elsevier 29(1983), 11, Seite 807-817 (DE-627)NLEJ188565949 (DE-600)1482429-2 0022-1910 nnns volume:29 year:1983 number:11 pages:807-817 http://dx.doi.org/10.1016/0022-1910(83)90146-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 29 1983 11 807-817 |
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(DE-627)NLEJ188618031 (DE-599)GBVNLZ188618031 DE-627 ger DE-627 rakwb eng Uptake and metabolism of nicotine by the CNS of a nicotine-resistant insect, the tobacco hornworm (Manduca sexta) 1983 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Penetration of the CNS by nicotine occurred equally rapidly in the nicotine-insensitive Manduca cord and the nicotine-sensitive Periplaneta cord, ruling out the possibility that lowered permeability renders Manduca insensitive. Although a saturable concentrative component of nicotine uptake was found in the Manduca cord, it was difficult to examine this component rigorously, because, except at high concentrations, the CNS metabolises the bulk of the nicotine that is taken up. The CNS metabolites of nicotine are water-soluble compounds. They are special first by virtue of the fact that they are formed in the CNS itself and secondly because their chromatographic characteristics are different from mammalian nicotine metabolites (which are not formed by nervous tissue). When subjected to hydrolysis, the metabolites acted like conjugates. Periplaneta CNS also metabolised nicotine, but much less extensively than Manduca. It is speculated that enzymic detoxification of dietary neurotoxins may be a necessary function of the insect CNS, since insects have no anatomical equivalent of a hepatic-portal system for detoxifying ingested compounds before they reach the blood-brain interface. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Morris, C.E. oth in Journal of Insect Physiology Amsterdam : Elsevier 29(1983), 11, Seite 807-817 (DE-627)NLEJ188565949 (DE-600)1482429-2 0022-1910 nnns volume:29 year:1983 number:11 pages:807-817 http://dx.doi.org/10.1016/0022-1910(83)90146-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 29 1983 11 807-817 |
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(DE-627)NLEJ188618031 (DE-599)GBVNLZ188618031 DE-627 ger DE-627 rakwb eng Uptake and metabolism of nicotine by the CNS of a nicotine-resistant insect, the tobacco hornworm (Manduca sexta) 1983 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Penetration of the CNS by nicotine occurred equally rapidly in the nicotine-insensitive Manduca cord and the nicotine-sensitive Periplaneta cord, ruling out the possibility that lowered permeability renders Manduca insensitive. Although a saturable concentrative component of nicotine uptake was found in the Manduca cord, it was difficult to examine this component rigorously, because, except at high concentrations, the CNS metabolises the bulk of the nicotine that is taken up. The CNS metabolites of nicotine are water-soluble compounds. They are special first by virtue of the fact that they are formed in the CNS itself and secondly because their chromatographic characteristics are different from mammalian nicotine metabolites (which are not formed by nervous tissue). When subjected to hydrolysis, the metabolites acted like conjugates. Periplaneta CNS also metabolised nicotine, but much less extensively than Manduca. It is speculated that enzymic detoxification of dietary neurotoxins may be a necessary function of the insect CNS, since insects have no anatomical equivalent of a hepatic-portal system for detoxifying ingested compounds before they reach the blood-brain interface. Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 Morris, C.E. oth in Journal of Insect Physiology Amsterdam : Elsevier 29(1983), 11, Seite 807-817 (DE-627)NLEJ188565949 (DE-600)1482429-2 0022-1910 nnns volume:29 year:1983 number:11 pages:807-817 http://dx.doi.org/10.1016/0022-1910(83)90146-4 GBV_USEFLAG_H ZDB-1-SDJ GBV_NL_ARTICLE AR 29 1983 11 807-817 |
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Uptake and metabolism of nicotine by the CNS of a nicotine-resistant insect, the tobacco hornworm (Manduca sexta) |
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uptake and metabolism of nicotine by the cns of a nicotine-resistant insect, the tobacco hornworm (manduca sexta) |
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Uptake and metabolism of nicotine by the CNS of a nicotine-resistant insect, the tobacco hornworm (Manduca sexta) |
| abstract |
Penetration of the CNS by nicotine occurred equally rapidly in the nicotine-insensitive Manduca cord and the nicotine-sensitive Periplaneta cord, ruling out the possibility that lowered permeability renders Manduca insensitive. Although a saturable concentrative component of nicotine uptake was found in the Manduca cord, it was difficult to examine this component rigorously, because, except at high concentrations, the CNS metabolises the bulk of the nicotine that is taken up. The CNS metabolites of nicotine are water-soluble compounds. They are special first by virtue of the fact that they are formed in the CNS itself and secondly because their chromatographic characteristics are different from mammalian nicotine metabolites (which are not formed by nervous tissue). When subjected to hydrolysis, the metabolites acted like conjugates. Periplaneta CNS also metabolised nicotine, but much less extensively than Manduca. It is speculated that enzymic detoxification of dietary neurotoxins may be a necessary function of the insect CNS, since insects have no anatomical equivalent of a hepatic-portal system for detoxifying ingested compounds before they reach the blood-brain interface. |
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Penetration of the CNS by nicotine occurred equally rapidly in the nicotine-insensitive Manduca cord and the nicotine-sensitive Periplaneta cord, ruling out the possibility that lowered permeability renders Manduca insensitive. Although a saturable concentrative component of nicotine uptake was found in the Manduca cord, it was difficult to examine this component rigorously, because, except at high concentrations, the CNS metabolises the bulk of the nicotine that is taken up. The CNS metabolites of nicotine are water-soluble compounds. They are special first by virtue of the fact that they are formed in the CNS itself and secondly because their chromatographic characteristics are different from mammalian nicotine metabolites (which are not formed by nervous tissue). When subjected to hydrolysis, the metabolites acted like conjugates. Periplaneta CNS also metabolised nicotine, but much less extensively than Manduca. It is speculated that enzymic detoxification of dietary neurotoxins may be a necessary function of the insect CNS, since insects have no anatomical equivalent of a hepatic-portal system for detoxifying ingested compounds before they reach the blood-brain interface. |
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Penetration of the CNS by nicotine occurred equally rapidly in the nicotine-insensitive Manduca cord and the nicotine-sensitive Periplaneta cord, ruling out the possibility that lowered permeability renders Manduca insensitive. Although a saturable concentrative component of nicotine uptake was found in the Manduca cord, it was difficult to examine this component rigorously, because, except at high concentrations, the CNS metabolises the bulk of the nicotine that is taken up. The CNS metabolites of nicotine are water-soluble compounds. They are special first by virtue of the fact that they are formed in the CNS itself and secondly because their chromatographic characteristics are different from mammalian nicotine metabolites (which are not formed by nervous tissue). When subjected to hydrolysis, the metabolites acted like conjugates. Periplaneta CNS also metabolised nicotine, but much less extensively than Manduca. It is speculated that enzymic detoxification of dietary neurotoxins may be a necessary function of the insect CNS, since insects have no anatomical equivalent of a hepatic-portal system for detoxifying ingested compounds before they reach the blood-brain interface. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ188618031</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707103602.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070506s1983 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ188618031</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVNLZ188618031</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Uptake and metabolism of nicotine by the CNS of a nicotine-resistant insect, the tobacco hornworm (Manduca sexta)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1983</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Penetration of the CNS by nicotine occurred equally rapidly in the nicotine-insensitive Manduca cord and the nicotine-sensitive Periplaneta cord, ruling out the possibility that lowered permeability renders Manduca insensitive. Although a saturable concentrative component of nicotine uptake was found in the Manduca cord, it was difficult to examine this component rigorously, because, except at high concentrations, the CNS metabolises the bulk of the nicotine that is taken up. The CNS metabolites of nicotine are water-soluble compounds. They are special first by virtue of the fact that they are formed in the CNS itself and secondly because their chromatographic characteristics are different from mammalian nicotine metabolites (which are not formed by nervous tissue). When subjected to hydrolysis, the metabolites acted like conjugates. Periplaneta CNS also metabolised nicotine, but much less extensively than Manduca. It is speculated that enzymic detoxification of dietary neurotoxins may be a necessary function of the insect CNS, since insects have no anatomical equivalent of a hepatic-portal system for detoxifying ingested compounds before they reach the blood-brain interface.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Elsevier Journal Backfiles on ScienceDirect 1907 - 2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Morris, C.E.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Journal of Insect Physiology</subfield><subfield code="d">Amsterdam : Elsevier</subfield><subfield code="g">29(1983), 11, Seite 807-817</subfield><subfield code="w">(DE-627)NLEJ188565949</subfield><subfield code="w">(DE-600)1482429-2</subfield><subfield code="x">0022-1910</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:29</subfield><subfield code="g">year:1983</subfield><subfield code="g">number:11</subfield><subfield code="g">pages:807-817</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1016/0022-1910(83)90146-4</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_H</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SDJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">29</subfield><subfield code="j">1983</subfield><subfield code="e">11</subfield><subfield code="h">807-817</subfield></datafield></record></collection>
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7.401886 |