Separate purinoceptors mediate enhancement by adenosine of concanavalin A-induced mediator release and the cyclic AMP response in rat mast cells
Abstract Adenosine caused a concentration-related enhancement of concanavalin A (Con A)-induced 5-hydroxytryptamine (5-HT) release from rat purified peritoneal mast cells. This was accompanied by an enhancement and prolongation of the cyclic AMP response to Con A. The cyclic AMP response but not enh...
Ausführliche Beschreibung
Gespeichert in:
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1986 |
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| Umfang: |
4 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Inflammation research - 1969, 18(1986) vom: Jan./Feb., Seite 81-84 |
| Übergeordnetes Werk: |
volume:18 ; year:1986 ; month:01/02 ; pages:81-84 ; extent:4 |
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NLEJ189095334 |
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| 520 | |a Abstract Adenosine caused a concentration-related enhancement of concanavalin A (Con A)-induced 5-hydroxytryptamine (5-HT) release from rat purified peritoneal mast cells. This was accompanied by an enhancement and prolongation of the cyclic AMP response to Con A. The cyclic AMP response but not enhancement of 5-HT release was blocked by 8-phenyltheophylline suggesting the two events to be unrelated. The effects of AMP and ADP, adenosine analogues and adenosine uptake inhibitors suggest the enhancement of 5-HT release to be mediated by a P1-cell surface purinoceptor which does not show the characteristics of either A1 or A2 subtypes. | ||
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| 700 | 1 | |a Church, Martin K. |4 oth | |
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(DE-627)NLEJ189095334 DE-627 ger DE-627 rakwb eng Separate purinoceptors mediate enhancement by adenosine of concanavalin A-induced mediator release and the cyclic AMP response in rat mast cells 1986 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Adenosine caused a concentration-related enhancement of concanavalin A (Con A)-induced 5-hydroxytryptamine (5-HT) release from rat purified peritoneal mast cells. This was accompanied by an enhancement and prolongation of the cyclic AMP response to Con A. The cyclic AMP response but not enhancement of 5-HT release was blocked by 8-phenyltheophylline suggesting the two events to be unrelated. The effects of AMP and ADP, adenosine analogues and adenosine uptake inhibitors suggest the enhancement of 5-HT release to be mediated by a P1-cell surface purinoceptor which does not show the characteristics of either A1 or A2 subtypes. Springer Online Journal Archives 1860-2002 Hughes, Philip J. oth Church, Martin K. oth in Inflammation research 1969 18(1986) vom: Jan./Feb., Seite 81-84 (DE-627)NLEJ188993533 (DE-600)1459194-7 1420-908X nnns volume:18 year:1986 month:01/02 pages:81-84 extent:4 http://dx.doi.org/10.1007/BF01987989 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 18 1986 1/2 81-84 4 |
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(DE-627)NLEJ189095334 DE-627 ger DE-627 rakwb eng Separate purinoceptors mediate enhancement by adenosine of concanavalin A-induced mediator release and the cyclic AMP response in rat mast cells 1986 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Adenosine caused a concentration-related enhancement of concanavalin A (Con A)-induced 5-hydroxytryptamine (5-HT) release from rat purified peritoneal mast cells. This was accompanied by an enhancement and prolongation of the cyclic AMP response to Con A. The cyclic AMP response but not enhancement of 5-HT release was blocked by 8-phenyltheophylline suggesting the two events to be unrelated. The effects of AMP and ADP, adenosine analogues and adenosine uptake inhibitors suggest the enhancement of 5-HT release to be mediated by a P1-cell surface purinoceptor which does not show the characteristics of either A1 or A2 subtypes. Springer Online Journal Archives 1860-2002 Hughes, Philip J. oth Church, Martin K. oth in Inflammation research 1969 18(1986) vom: Jan./Feb., Seite 81-84 (DE-627)NLEJ188993533 (DE-600)1459194-7 1420-908X nnns volume:18 year:1986 month:01/02 pages:81-84 extent:4 http://dx.doi.org/10.1007/BF01987989 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 18 1986 1/2 81-84 4 |
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(DE-627)NLEJ189095334 DE-627 ger DE-627 rakwb eng Separate purinoceptors mediate enhancement by adenosine of concanavalin A-induced mediator release and the cyclic AMP response in rat mast cells 1986 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Adenosine caused a concentration-related enhancement of concanavalin A (Con A)-induced 5-hydroxytryptamine (5-HT) release from rat purified peritoneal mast cells. This was accompanied by an enhancement and prolongation of the cyclic AMP response to Con A. The cyclic AMP response but not enhancement of 5-HT release was blocked by 8-phenyltheophylline suggesting the two events to be unrelated. The effects of AMP and ADP, adenosine analogues and adenosine uptake inhibitors suggest the enhancement of 5-HT release to be mediated by a P1-cell surface purinoceptor which does not show the characteristics of either A1 or A2 subtypes. Springer Online Journal Archives 1860-2002 Hughes, Philip J. oth Church, Martin K. oth in Inflammation research 1969 18(1986) vom: Jan./Feb., Seite 81-84 (DE-627)NLEJ188993533 (DE-600)1459194-7 1420-908X nnns volume:18 year:1986 month:01/02 pages:81-84 extent:4 http://dx.doi.org/10.1007/BF01987989 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 18 1986 1/2 81-84 4 |
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(DE-627)NLEJ189095334 DE-627 ger DE-627 rakwb eng Separate purinoceptors mediate enhancement by adenosine of concanavalin A-induced mediator release and the cyclic AMP response in rat mast cells 1986 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Adenosine caused a concentration-related enhancement of concanavalin A (Con A)-induced 5-hydroxytryptamine (5-HT) release from rat purified peritoneal mast cells. This was accompanied by an enhancement and prolongation of the cyclic AMP response to Con A. The cyclic AMP response but not enhancement of 5-HT release was blocked by 8-phenyltheophylline suggesting the two events to be unrelated. The effects of AMP and ADP, adenosine analogues and adenosine uptake inhibitors suggest the enhancement of 5-HT release to be mediated by a P1-cell surface purinoceptor which does not show the characteristics of either A1 or A2 subtypes. Springer Online Journal Archives 1860-2002 Hughes, Philip J. oth Church, Martin K. oth in Inflammation research 1969 18(1986) vom: Jan./Feb., Seite 81-84 (DE-627)NLEJ188993533 (DE-600)1459194-7 1420-908X nnns volume:18 year:1986 month:01/02 pages:81-84 extent:4 http://dx.doi.org/10.1007/BF01987989 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 18 1986 1/2 81-84 4 |
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(DE-627)NLEJ189095334 DE-627 ger DE-627 rakwb eng Separate purinoceptors mediate enhancement by adenosine of concanavalin A-induced mediator release and the cyclic AMP response in rat mast cells 1986 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Adenosine caused a concentration-related enhancement of concanavalin A (Con A)-induced 5-hydroxytryptamine (5-HT) release from rat purified peritoneal mast cells. This was accompanied by an enhancement and prolongation of the cyclic AMP response to Con A. The cyclic AMP response but not enhancement of 5-HT release was blocked by 8-phenyltheophylline suggesting the two events to be unrelated. The effects of AMP and ADP, adenosine analogues and adenosine uptake inhibitors suggest the enhancement of 5-HT release to be mediated by a P1-cell surface purinoceptor which does not show the characteristics of either A1 or A2 subtypes. Springer Online Journal Archives 1860-2002 Hughes, Philip J. oth Church, Martin K. oth in Inflammation research 1969 18(1986) vom: Jan./Feb., Seite 81-84 (DE-627)NLEJ188993533 (DE-600)1459194-7 1420-908X nnns volume:18 year:1986 month:01/02 pages:81-84 extent:4 http://dx.doi.org/10.1007/BF01987989 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 18 1986 1/2 81-84 4 |
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Separate purinoceptors mediate enhancement by adenosine of concanavalin A-induced mediator release and the cyclic AMP response in rat mast cells |
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Abstract Adenosine caused a concentration-related enhancement of concanavalin A (Con A)-induced 5-hydroxytryptamine (5-HT) release from rat purified peritoneal mast cells. This was accompanied by an enhancement and prolongation of the cyclic AMP response to Con A. The cyclic AMP response but not enhancement of 5-HT release was blocked by 8-phenyltheophylline suggesting the two events to be unrelated. The effects of AMP and ADP, adenosine analogues and adenosine uptake inhibitors suggest the enhancement of 5-HT release to be mediated by a P1-cell surface purinoceptor which does not show the characteristics of either A1 or A2 subtypes. |
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Abstract Adenosine caused a concentration-related enhancement of concanavalin A (Con A)-induced 5-hydroxytryptamine (5-HT) release from rat purified peritoneal mast cells. This was accompanied by an enhancement and prolongation of the cyclic AMP response to Con A. The cyclic AMP response but not enhancement of 5-HT release was blocked by 8-phenyltheophylline suggesting the two events to be unrelated. The effects of AMP and ADP, adenosine analogues and adenosine uptake inhibitors suggest the enhancement of 5-HT release to be mediated by a P1-cell surface purinoceptor which does not show the characteristics of either A1 or A2 subtypes. |
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Abstract Adenosine caused a concentration-related enhancement of concanavalin A (Con A)-induced 5-hydroxytryptamine (5-HT) release from rat purified peritoneal mast cells. This was accompanied by an enhancement and prolongation of the cyclic AMP response to Con A. The cyclic AMP response but not enhancement of 5-HT release was blocked by 8-phenyltheophylline suggesting the two events to be unrelated. The effects of AMP and ADP, adenosine analogues and adenosine uptake inhibitors suggest the enhancement of 5-HT release to be mediated by a P1-cell surface purinoceptor which does not show the characteristics of either A1 or A2 subtypes. |
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