Platelet and Thrombin Activity Following Cardiac Catheterization Despite Treatment with Aspirin
Abstract Thromboembolic complications are reported to occur in up to 0.5–2% of left cardiac catheterizations and angiographies. Activation of the hemostatic system may contribute to their onset. To prevent platelet and thrombin activity during catheterization, aspirin or systemic heparin are often u...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1998 |
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| Umfang: |
5 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Journal of thrombosis and thrombolysis - 1994, 6(1998) vom: Feb., Seite 141-145 |
| Übergeordnetes Werk: |
volume:6 ; year:1998 ; month:02 ; pages:141-145 ; extent:5 |
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NLEJ189973005 |
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| 520 | |a Abstract Thromboembolic complications are reported to occur in up to 0.5–2% of left cardiac catheterizations and angiographies. Activation of the hemostatic system may contribute to their onset. To prevent platelet and thrombin activity during catheterization, aspirin or systemic heparin are often used in addition to heparinized flush solutions. We investigated whether aspirin alone can prevent platelet and thrombin activity induced by catheterization in ten consecutive patients (nine males, mean 50 ± 8 years) undergoing elective left cardiac catheterization after at least 5 days of oral aspirin (75–300 mg/d). Anticoagulant drugs were not given. Peripheral venous samples were drawn before, immediately after (time 0), and at 15, 60, and 180 minutes after the procedure for measurement of thrombin–antithrombin (TAT), prothrombin fragment 1.2 (F 1.2), fibrinopeptide A (FPA), and β-thromboglobulin (β-TG). TAT, F1.2, and FPA increased significantly at time 0 compared with both before and 180 minutes after the procedure (P < 0.04); β-TG values were higher at time 0 compared with 180 minutes later (P = 0.01). TAT levels were related to those of FPA (r = 0.66; P = 0.0003), F1.2 (r = 0.35; P = 0.01), and β-TG (r = 0.37; p = 0.04). Thus, routine left cardiac catheterization is associated with transient, systematically detectable, activation of coagulation and platelets, despite aspirin therapy. Newer antiplatelet agents may be more effective in preventing hemostatic activation induced by catheterization. | ||
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| 700 | 1 | |a Crake, Tom |4 oth | |
| 700 | 1 | |a Maseri, Attilio |4 oth | |
| 700 | 1 | |a Marco, Eugenia |4 oth | |
| 700 | 1 | |a Davies, Graham J. |4 oth | |
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(DE-627)NLEJ189973005 DE-627 ger DE-627 rakwb eng Platelet and Thrombin Activity Following Cardiac Catheterization Despite Treatment with Aspirin 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Thromboembolic complications are reported to occur in up to 0.5–2% of left cardiac catheterizations and angiographies. Activation of the hemostatic system may contribute to their onset. To prevent platelet and thrombin activity during catheterization, aspirin or systemic heparin are often used in addition to heparinized flush solutions. We investigated whether aspirin alone can prevent platelet and thrombin activity induced by catheterization in ten consecutive patients (nine males, mean 50 ± 8 years) undergoing elective left cardiac catheterization after at least 5 days of oral aspirin (75–300 mg/d). Anticoagulant drugs were not given. Peripheral venous samples were drawn before, immediately after (time 0), and at 15, 60, and 180 minutes after the procedure for measurement of thrombin–antithrombin (TAT), prothrombin fragment 1.2 (F 1.2), fibrinopeptide A (FPA), and β-thromboglobulin (β-TG). TAT, F1.2, and FPA increased significantly at time 0 compared with both before and 180 minutes after the procedure (P < 0.04); β-TG values were higher at time 0 compared with 180 minutes later (P = 0.01). TAT levels were related to those of FPA (r = 0.66; P = 0.0003), F1.2 (r = 0.35; P = 0.01), and β-TG (r = 0.37; p = 0.04). Thus, routine left cardiac catheterization is associated with transient, systematically detectable, activation of coagulation and platelets, despite aspirin therapy. Newer antiplatelet agents may be more effective in preventing hemostatic activation induced by catheterization. Springer Online Journal Archives 1860-2002 Andreotti, Felicita oth Lefroy, David C. oth Sciahbasi, Alessandro oth Crake, Tom oth Maseri, Attilio oth Marco, Eugenia oth Davies, Graham J. oth in Journal of thrombosis and thrombolysis 1994 6(1998) vom: Feb., Seite 141-145 (DE-627)NLEJ188996028 (DE-600)2017305-2 1573-742X nnns volume:6 year:1998 month:02 pages:141-145 extent:5 http://dx.doi.org/10.1023/A:1008805823198 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1998 2 141-145 5 |
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(DE-627)NLEJ189973005 DE-627 ger DE-627 rakwb eng Platelet and Thrombin Activity Following Cardiac Catheterization Despite Treatment with Aspirin 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Thromboembolic complications are reported to occur in up to 0.5–2% of left cardiac catheterizations and angiographies. Activation of the hemostatic system may contribute to their onset. To prevent platelet and thrombin activity during catheterization, aspirin or systemic heparin are often used in addition to heparinized flush solutions. We investigated whether aspirin alone can prevent platelet and thrombin activity induced by catheterization in ten consecutive patients (nine males, mean 50 ± 8 years) undergoing elective left cardiac catheterization after at least 5 days of oral aspirin (75–300 mg/d). Anticoagulant drugs were not given. Peripheral venous samples were drawn before, immediately after (time 0), and at 15, 60, and 180 minutes after the procedure for measurement of thrombin–antithrombin (TAT), prothrombin fragment 1.2 (F 1.2), fibrinopeptide A (FPA), and β-thromboglobulin (β-TG). TAT, F1.2, and FPA increased significantly at time 0 compared with both before and 180 minutes after the procedure (P < 0.04); β-TG values were higher at time 0 compared with 180 minutes later (P = 0.01). TAT levels were related to those of FPA (r = 0.66; P = 0.0003), F1.2 (r = 0.35; P = 0.01), and β-TG (r = 0.37; p = 0.04). Thus, routine left cardiac catheterization is associated with transient, systematically detectable, activation of coagulation and platelets, despite aspirin therapy. Newer antiplatelet agents may be more effective in preventing hemostatic activation induced by catheterization. Springer Online Journal Archives 1860-2002 Andreotti, Felicita oth Lefroy, David C. oth Sciahbasi, Alessandro oth Crake, Tom oth Maseri, Attilio oth Marco, Eugenia oth Davies, Graham J. oth in Journal of thrombosis and thrombolysis 1994 6(1998) vom: Feb., Seite 141-145 (DE-627)NLEJ188996028 (DE-600)2017305-2 1573-742X nnns volume:6 year:1998 month:02 pages:141-145 extent:5 http://dx.doi.org/10.1023/A:1008805823198 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1998 2 141-145 5 |
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(DE-627)NLEJ189973005 DE-627 ger DE-627 rakwb eng Platelet and Thrombin Activity Following Cardiac Catheterization Despite Treatment with Aspirin 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Thromboembolic complications are reported to occur in up to 0.5–2% of left cardiac catheterizations and angiographies. Activation of the hemostatic system may contribute to their onset. To prevent platelet and thrombin activity during catheterization, aspirin or systemic heparin are often used in addition to heparinized flush solutions. We investigated whether aspirin alone can prevent platelet and thrombin activity induced by catheterization in ten consecutive patients (nine males, mean 50 ± 8 years) undergoing elective left cardiac catheterization after at least 5 days of oral aspirin (75–300 mg/d). Anticoagulant drugs were not given. Peripheral venous samples were drawn before, immediately after (time 0), and at 15, 60, and 180 minutes after the procedure for measurement of thrombin–antithrombin (TAT), prothrombin fragment 1.2 (F 1.2), fibrinopeptide A (FPA), and β-thromboglobulin (β-TG). TAT, F1.2, and FPA increased significantly at time 0 compared with both before and 180 minutes after the procedure (P < 0.04); β-TG values were higher at time 0 compared with 180 minutes later (P = 0.01). TAT levels were related to those of FPA (r = 0.66; P = 0.0003), F1.2 (r = 0.35; P = 0.01), and β-TG (r = 0.37; p = 0.04). Thus, routine left cardiac catheterization is associated with transient, systematically detectable, activation of coagulation and platelets, despite aspirin therapy. Newer antiplatelet agents may be more effective in preventing hemostatic activation induced by catheterization. Springer Online Journal Archives 1860-2002 Andreotti, Felicita oth Lefroy, David C. oth Sciahbasi, Alessandro oth Crake, Tom oth Maseri, Attilio oth Marco, Eugenia oth Davies, Graham J. oth in Journal of thrombosis and thrombolysis 1994 6(1998) vom: Feb., Seite 141-145 (DE-627)NLEJ188996028 (DE-600)2017305-2 1573-742X nnns volume:6 year:1998 month:02 pages:141-145 extent:5 http://dx.doi.org/10.1023/A:1008805823198 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1998 2 141-145 5 |
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(DE-627)NLEJ189973005 DE-627 ger DE-627 rakwb eng Platelet and Thrombin Activity Following Cardiac Catheterization Despite Treatment with Aspirin 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Thromboembolic complications are reported to occur in up to 0.5–2% of left cardiac catheterizations and angiographies. Activation of the hemostatic system may contribute to their onset. To prevent platelet and thrombin activity during catheterization, aspirin or systemic heparin are often used in addition to heparinized flush solutions. We investigated whether aspirin alone can prevent platelet and thrombin activity induced by catheterization in ten consecutive patients (nine males, mean 50 ± 8 years) undergoing elective left cardiac catheterization after at least 5 days of oral aspirin (75–300 mg/d). Anticoagulant drugs were not given. Peripheral venous samples were drawn before, immediately after (time 0), and at 15, 60, and 180 minutes after the procedure for measurement of thrombin–antithrombin (TAT), prothrombin fragment 1.2 (F 1.2), fibrinopeptide A (FPA), and β-thromboglobulin (β-TG). TAT, F1.2, and FPA increased significantly at time 0 compared with both before and 180 minutes after the procedure (P < 0.04); β-TG values were higher at time 0 compared with 180 minutes later (P = 0.01). TAT levels were related to those of FPA (r = 0.66; P = 0.0003), F1.2 (r = 0.35; P = 0.01), and β-TG (r = 0.37; p = 0.04). Thus, routine left cardiac catheterization is associated with transient, systematically detectable, activation of coagulation and platelets, despite aspirin therapy. Newer antiplatelet agents may be more effective in preventing hemostatic activation induced by catheterization. Springer Online Journal Archives 1860-2002 Andreotti, Felicita oth Lefroy, David C. oth Sciahbasi, Alessandro oth Crake, Tom oth Maseri, Attilio oth Marco, Eugenia oth Davies, Graham J. oth in Journal of thrombosis and thrombolysis 1994 6(1998) vom: Feb., Seite 141-145 (DE-627)NLEJ188996028 (DE-600)2017305-2 1573-742X nnns volume:6 year:1998 month:02 pages:141-145 extent:5 http://dx.doi.org/10.1023/A:1008805823198 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1998 2 141-145 5 |
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(DE-627)NLEJ189973005 DE-627 ger DE-627 rakwb eng Platelet and Thrombin Activity Following Cardiac Catheterization Despite Treatment with Aspirin 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Thromboembolic complications are reported to occur in up to 0.5–2% of left cardiac catheterizations and angiographies. Activation of the hemostatic system may contribute to their onset. To prevent platelet and thrombin activity during catheterization, aspirin or systemic heparin are often used in addition to heparinized flush solutions. We investigated whether aspirin alone can prevent platelet and thrombin activity induced by catheterization in ten consecutive patients (nine males, mean 50 ± 8 years) undergoing elective left cardiac catheterization after at least 5 days of oral aspirin (75–300 mg/d). Anticoagulant drugs were not given. Peripheral venous samples were drawn before, immediately after (time 0), and at 15, 60, and 180 minutes after the procedure for measurement of thrombin–antithrombin (TAT), prothrombin fragment 1.2 (F 1.2), fibrinopeptide A (FPA), and β-thromboglobulin (β-TG). TAT, F1.2, and FPA increased significantly at time 0 compared with both before and 180 minutes after the procedure (P < 0.04); β-TG values were higher at time 0 compared with 180 minutes later (P = 0.01). TAT levels were related to those of FPA (r = 0.66; P = 0.0003), F1.2 (r = 0.35; P = 0.01), and β-TG (r = 0.37; p = 0.04). Thus, routine left cardiac catheterization is associated with transient, systematically detectable, activation of coagulation and platelets, despite aspirin therapy. Newer antiplatelet agents may be more effective in preventing hemostatic activation induced by catheterization. Springer Online Journal Archives 1860-2002 Andreotti, Felicita oth Lefroy, David C. oth Sciahbasi, Alessandro oth Crake, Tom oth Maseri, Attilio oth Marco, Eugenia oth Davies, Graham J. oth in Journal of thrombosis and thrombolysis 1994 6(1998) vom: Feb., Seite 141-145 (DE-627)NLEJ188996028 (DE-600)2017305-2 1573-742X nnns volume:6 year:1998 month:02 pages:141-145 extent:5 http://dx.doi.org/10.1023/A:1008805823198 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1998 2 141-145 5 |
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platelet and thrombin activity following cardiac catheterization despite treatment with aspirin |
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Platelet and Thrombin Activity Following Cardiac Catheterization Despite Treatment with Aspirin |
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Abstract Thromboembolic complications are reported to occur in up to 0.5–2% of left cardiac catheterizations and angiographies. Activation of the hemostatic system may contribute to their onset. To prevent platelet and thrombin activity during catheterization, aspirin or systemic heparin are often used in addition to heparinized flush solutions. We investigated whether aspirin alone can prevent platelet and thrombin activity induced by catheterization in ten consecutive patients (nine males, mean 50 ± 8 years) undergoing elective left cardiac catheterization after at least 5 days of oral aspirin (75–300 mg/d). Anticoagulant drugs were not given. Peripheral venous samples were drawn before, immediately after (time 0), and at 15, 60, and 180 minutes after the procedure for measurement of thrombin–antithrombin (TAT), prothrombin fragment 1.2 (F 1.2), fibrinopeptide A (FPA), and β-thromboglobulin (β-TG). TAT, F1.2, and FPA increased significantly at time 0 compared with both before and 180 minutes after the procedure (P < 0.04); β-TG values were higher at time 0 compared with 180 minutes later (P = 0.01). TAT levels were related to those of FPA (r = 0.66; P = 0.0003), F1.2 (r = 0.35; P = 0.01), and β-TG (r = 0.37; p = 0.04). Thus, routine left cardiac catheterization is associated with transient, systematically detectable, activation of coagulation and platelets, despite aspirin therapy. Newer antiplatelet agents may be more effective in preventing hemostatic activation induced by catheterization. |
| abstractGer |
Abstract Thromboembolic complications are reported to occur in up to 0.5–2% of left cardiac catheterizations and angiographies. Activation of the hemostatic system may contribute to their onset. To prevent platelet and thrombin activity during catheterization, aspirin or systemic heparin are often used in addition to heparinized flush solutions. We investigated whether aspirin alone can prevent platelet and thrombin activity induced by catheterization in ten consecutive patients (nine males, mean 50 ± 8 years) undergoing elective left cardiac catheterization after at least 5 days of oral aspirin (75–300 mg/d). Anticoagulant drugs were not given. Peripheral venous samples were drawn before, immediately after (time 0), and at 15, 60, and 180 minutes after the procedure for measurement of thrombin–antithrombin (TAT), prothrombin fragment 1.2 (F 1.2), fibrinopeptide A (FPA), and β-thromboglobulin (β-TG). TAT, F1.2, and FPA increased significantly at time 0 compared with both before and 180 minutes after the procedure (P < 0.04); β-TG values were higher at time 0 compared with 180 minutes later (P = 0.01). TAT levels were related to those of FPA (r = 0.66; P = 0.0003), F1.2 (r = 0.35; P = 0.01), and β-TG (r = 0.37; p = 0.04). Thus, routine left cardiac catheterization is associated with transient, systematically detectable, activation of coagulation and platelets, despite aspirin therapy. Newer antiplatelet agents may be more effective in preventing hemostatic activation induced by catheterization. |
| abstract_unstemmed |
Abstract Thromboembolic complications are reported to occur in up to 0.5–2% of left cardiac catheterizations and angiographies. Activation of the hemostatic system may contribute to their onset. To prevent platelet and thrombin activity during catheterization, aspirin or systemic heparin are often used in addition to heparinized flush solutions. We investigated whether aspirin alone can prevent platelet and thrombin activity induced by catheterization in ten consecutive patients (nine males, mean 50 ± 8 years) undergoing elective left cardiac catheterization after at least 5 days of oral aspirin (75–300 mg/d). Anticoagulant drugs were not given. Peripheral venous samples were drawn before, immediately after (time 0), and at 15, 60, and 180 minutes after the procedure for measurement of thrombin–antithrombin (TAT), prothrombin fragment 1.2 (F 1.2), fibrinopeptide A (FPA), and β-thromboglobulin (β-TG). TAT, F1.2, and FPA increased significantly at time 0 compared with both before and 180 minutes after the procedure (P < 0.04); β-TG values were higher at time 0 compared with 180 minutes later (P = 0.01). TAT levels were related to those of FPA (r = 0.66; P = 0.0003), F1.2 (r = 0.35; P = 0.01), and β-TG (r = 0.37; p = 0.04). Thus, routine left cardiac catheterization is associated with transient, systematically detectable, activation of coagulation and platelets, despite aspirin therapy. Newer antiplatelet agents may be more effective in preventing hemostatic activation induced by catheterization. |
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Platelet and Thrombin Activity Following Cardiac Catheterization Despite Treatment with Aspirin |
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Andreotti, Felicita Lefroy, David C. Sciahbasi, Alessandro Crake, Tom Maseri, Attilio Marco, Eugenia Davies, Graham J. |
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