The antibiotic viomycin as a model peptide for the origin of the co-evolution of RNA and proteins
Abstract Viomycin is an RNA-binding peptide antibiotic which inhibits prokaryotic protein synthesis and group I intron self-splicing. This antibiotic enhances the activity of the ribozyme derived from the Neurospora crassa VS RNA, and at sub-inhibitory concentrations it induces the formation of grou...
Ausführliche Beschreibung
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1999 |
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| Umfang: |
14 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
|---|---|
| Übergeordnetes Werk: |
in: Origins of life and evolution of the biospheres - 1968, 29(1999) vom: Apr., Seite 391-404 |
| Übergeordnetes Werk: |
volume:29 ; year:1999 ; month:04 ; pages:391-404 ; extent:14 |
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NLEJ19540162X |
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| 245 | 1 | 0 | |a The antibiotic viomycin as a model peptide for the origin of the co-evolution of RNA and proteins |
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| 520 | |a Abstract Viomycin is an RNA-binding peptide antibiotic which inhibits prokaryotic protein synthesis and group I intron self-splicing. This antibiotic enhances the activity of the ribozyme derived from the Neurospora crassa VS RNA, and at sub-inhibitory concentrations it induces the formation of group I intron oligomers. Here, we address the question whether viomycin exerts specificity in the promotion of RNA-RNA interactions. In an in vitro selection experiment we tested the ability of viomycin to specifically select molecules out of an RNA pool. Group I intron RNA was incubated with a pool of random sequence RNA, or with a pool of RNA molecules which had previously been enriched for viomycin-binding RNAs. Viomycin was added in order to select viomycin-binding RNAs and to guide their interaction with the intron RNA resulting in recombinant molecules. Viomycin was indeed capable of specifically selecting RNA molecules which contain viomycin-binding sites promoting recombination. These results suggest that small peptides are able to play the role of selector molecules in a putative ‘RNA World’ launching the co-evolution of RNA and proteins into an ‘RNA-protein World’. | ||
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| 700 | 1 | |a Schroeder, Renée |4 oth | |
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(DE-627)NLEJ19540162X DE-627 ger DE-627 rakwb eng The antibiotic viomycin as a model peptide for the origin of the co-evolution of RNA and proteins 1999 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Viomycin is an RNA-binding peptide antibiotic which inhibits prokaryotic protein synthesis and group I intron self-splicing. This antibiotic enhances the activity of the ribozyme derived from the Neurospora crassa VS RNA, and at sub-inhibitory concentrations it induces the formation of group I intron oligomers. Here, we address the question whether viomycin exerts specificity in the promotion of RNA-RNA interactions. In an in vitro selection experiment we tested the ability of viomycin to specifically select molecules out of an RNA pool. Group I intron RNA was incubated with a pool of random sequence RNA, or with a pool of RNA molecules which had previously been enriched for viomycin-binding RNAs. Viomycin was added in order to select viomycin-binding RNAs and to guide their interaction with the intron RNA resulting in recombinant molecules. Viomycin was indeed capable of specifically selecting RNA molecules which contain viomycin-binding sites promoting recombination. These results suggest that small peptides are able to play the role of selector molecules in a putative ‘RNA World’ launching the co-evolution of RNA and proteins into an ‘RNA-protein World’. Springer Online Journal Archives 1860-2002 Wank, Herbert oth Clodi, Elisabeth oth Wallis, Mary G. oth Schroeder, Renée oth in Origins of life and evolution of the biospheres 1968 29(1999) vom: Apr., Seite 391-404 (DE-627)NLEJ188986243 (DE-600)2018578-9 1573-0875 nnns volume:29 year:1999 month:04 pages:391-404 extent:14 http://dx.doi.org/10.1023/A:1006572028643 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1999 4 391-404 14 |
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(DE-627)NLEJ19540162X DE-627 ger DE-627 rakwb eng The antibiotic viomycin as a model peptide for the origin of the co-evolution of RNA and proteins 1999 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Viomycin is an RNA-binding peptide antibiotic which inhibits prokaryotic protein synthesis and group I intron self-splicing. This antibiotic enhances the activity of the ribozyme derived from the Neurospora crassa VS RNA, and at sub-inhibitory concentrations it induces the formation of group I intron oligomers. Here, we address the question whether viomycin exerts specificity in the promotion of RNA-RNA interactions. In an in vitro selection experiment we tested the ability of viomycin to specifically select molecules out of an RNA pool. Group I intron RNA was incubated with a pool of random sequence RNA, or with a pool of RNA molecules which had previously been enriched for viomycin-binding RNAs. Viomycin was added in order to select viomycin-binding RNAs and to guide their interaction with the intron RNA resulting in recombinant molecules. Viomycin was indeed capable of specifically selecting RNA molecules which contain viomycin-binding sites promoting recombination. These results suggest that small peptides are able to play the role of selector molecules in a putative ‘RNA World’ launching the co-evolution of RNA and proteins into an ‘RNA-protein World’. Springer Online Journal Archives 1860-2002 Wank, Herbert oth Clodi, Elisabeth oth Wallis, Mary G. oth Schroeder, Renée oth in Origins of life and evolution of the biospheres 1968 29(1999) vom: Apr., Seite 391-404 (DE-627)NLEJ188986243 (DE-600)2018578-9 1573-0875 nnns volume:29 year:1999 month:04 pages:391-404 extent:14 http://dx.doi.org/10.1023/A:1006572028643 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1999 4 391-404 14 |
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(DE-627)NLEJ19540162X DE-627 ger DE-627 rakwb eng The antibiotic viomycin as a model peptide for the origin of the co-evolution of RNA and proteins 1999 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Viomycin is an RNA-binding peptide antibiotic which inhibits prokaryotic protein synthesis and group I intron self-splicing. This antibiotic enhances the activity of the ribozyme derived from the Neurospora crassa VS RNA, and at sub-inhibitory concentrations it induces the formation of group I intron oligomers. Here, we address the question whether viomycin exerts specificity in the promotion of RNA-RNA interactions. In an in vitro selection experiment we tested the ability of viomycin to specifically select molecules out of an RNA pool. Group I intron RNA was incubated with a pool of random sequence RNA, or with a pool of RNA molecules which had previously been enriched for viomycin-binding RNAs. Viomycin was added in order to select viomycin-binding RNAs and to guide their interaction with the intron RNA resulting in recombinant molecules. Viomycin was indeed capable of specifically selecting RNA molecules which contain viomycin-binding sites promoting recombination. These results suggest that small peptides are able to play the role of selector molecules in a putative ‘RNA World’ launching the co-evolution of RNA and proteins into an ‘RNA-protein World’. Springer Online Journal Archives 1860-2002 Wank, Herbert oth Clodi, Elisabeth oth Wallis, Mary G. oth Schroeder, Renée oth in Origins of life and evolution of the biospheres 1968 29(1999) vom: Apr., Seite 391-404 (DE-627)NLEJ188986243 (DE-600)2018578-9 1573-0875 nnns volume:29 year:1999 month:04 pages:391-404 extent:14 http://dx.doi.org/10.1023/A:1006572028643 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1999 4 391-404 14 |
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(DE-627)NLEJ19540162X DE-627 ger DE-627 rakwb eng The antibiotic viomycin as a model peptide for the origin of the co-evolution of RNA and proteins 1999 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Viomycin is an RNA-binding peptide antibiotic which inhibits prokaryotic protein synthesis and group I intron self-splicing. This antibiotic enhances the activity of the ribozyme derived from the Neurospora crassa VS RNA, and at sub-inhibitory concentrations it induces the formation of group I intron oligomers. Here, we address the question whether viomycin exerts specificity in the promotion of RNA-RNA interactions. In an in vitro selection experiment we tested the ability of viomycin to specifically select molecules out of an RNA pool. Group I intron RNA was incubated with a pool of random sequence RNA, or with a pool of RNA molecules which had previously been enriched for viomycin-binding RNAs. Viomycin was added in order to select viomycin-binding RNAs and to guide their interaction with the intron RNA resulting in recombinant molecules. Viomycin was indeed capable of specifically selecting RNA molecules which contain viomycin-binding sites promoting recombination. These results suggest that small peptides are able to play the role of selector molecules in a putative ‘RNA World’ launching the co-evolution of RNA and proteins into an ‘RNA-protein World’. Springer Online Journal Archives 1860-2002 Wank, Herbert oth Clodi, Elisabeth oth Wallis, Mary G. oth Schroeder, Renée oth in Origins of life and evolution of the biospheres 1968 29(1999) vom: Apr., Seite 391-404 (DE-627)NLEJ188986243 (DE-600)2018578-9 1573-0875 nnns volume:29 year:1999 month:04 pages:391-404 extent:14 http://dx.doi.org/10.1023/A:1006572028643 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1999 4 391-404 14 |
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(DE-627)NLEJ19540162X DE-627 ger DE-627 rakwb eng The antibiotic viomycin as a model peptide for the origin of the co-evolution of RNA and proteins 1999 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Viomycin is an RNA-binding peptide antibiotic which inhibits prokaryotic protein synthesis and group I intron self-splicing. This antibiotic enhances the activity of the ribozyme derived from the Neurospora crassa VS RNA, and at sub-inhibitory concentrations it induces the formation of group I intron oligomers. Here, we address the question whether viomycin exerts specificity in the promotion of RNA-RNA interactions. In an in vitro selection experiment we tested the ability of viomycin to specifically select molecules out of an RNA pool. Group I intron RNA was incubated with a pool of random sequence RNA, or with a pool of RNA molecules which had previously been enriched for viomycin-binding RNAs. Viomycin was added in order to select viomycin-binding RNAs and to guide their interaction with the intron RNA resulting in recombinant molecules. Viomycin was indeed capable of specifically selecting RNA molecules which contain viomycin-binding sites promoting recombination. These results suggest that small peptides are able to play the role of selector molecules in a putative ‘RNA World’ launching the co-evolution of RNA and proteins into an ‘RNA-protein World’. Springer Online Journal Archives 1860-2002 Wank, Herbert oth Clodi, Elisabeth oth Wallis, Mary G. oth Schroeder, Renée oth in Origins of life and evolution of the biospheres 1968 29(1999) vom: Apr., Seite 391-404 (DE-627)NLEJ188986243 (DE-600)2018578-9 1573-0875 nnns volume:29 year:1999 month:04 pages:391-404 extent:14 http://dx.doi.org/10.1023/A:1006572028643 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1999 4 391-404 14 |
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The antibiotic viomycin as a model peptide for the origin of the co-evolution of RNA and proteins |
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Abstract Viomycin is an RNA-binding peptide antibiotic which inhibits prokaryotic protein synthesis and group I intron self-splicing. This antibiotic enhances the activity of the ribozyme derived from the Neurospora crassa VS RNA, and at sub-inhibitory concentrations it induces the formation of group I intron oligomers. Here, we address the question whether viomycin exerts specificity in the promotion of RNA-RNA interactions. In an in vitro selection experiment we tested the ability of viomycin to specifically select molecules out of an RNA pool. Group I intron RNA was incubated with a pool of random sequence RNA, or with a pool of RNA molecules which had previously been enriched for viomycin-binding RNAs. Viomycin was added in order to select viomycin-binding RNAs and to guide their interaction with the intron RNA resulting in recombinant molecules. Viomycin was indeed capable of specifically selecting RNA molecules which contain viomycin-binding sites promoting recombination. These results suggest that small peptides are able to play the role of selector molecules in a putative ‘RNA World’ launching the co-evolution of RNA and proteins into an ‘RNA-protein World’. |
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Abstract Viomycin is an RNA-binding peptide antibiotic which inhibits prokaryotic protein synthesis and group I intron self-splicing. This antibiotic enhances the activity of the ribozyme derived from the Neurospora crassa VS RNA, and at sub-inhibitory concentrations it induces the formation of group I intron oligomers. Here, we address the question whether viomycin exerts specificity in the promotion of RNA-RNA interactions. In an in vitro selection experiment we tested the ability of viomycin to specifically select molecules out of an RNA pool. Group I intron RNA was incubated with a pool of random sequence RNA, or with a pool of RNA molecules which had previously been enriched for viomycin-binding RNAs. Viomycin was added in order to select viomycin-binding RNAs and to guide their interaction with the intron RNA resulting in recombinant molecules. Viomycin was indeed capable of specifically selecting RNA molecules which contain viomycin-binding sites promoting recombination. These results suggest that small peptides are able to play the role of selector molecules in a putative ‘RNA World’ launching the co-evolution of RNA and proteins into an ‘RNA-protein World’. |
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Abstract Viomycin is an RNA-binding peptide antibiotic which inhibits prokaryotic protein synthesis and group I intron self-splicing. This antibiotic enhances the activity of the ribozyme derived from the Neurospora crassa VS RNA, and at sub-inhibitory concentrations it induces the formation of group I intron oligomers. Here, we address the question whether viomycin exerts specificity in the promotion of RNA-RNA interactions. In an in vitro selection experiment we tested the ability of viomycin to specifically select molecules out of an RNA pool. Group I intron RNA was incubated with a pool of random sequence RNA, or with a pool of RNA molecules which had previously been enriched for viomycin-binding RNAs. Viomycin was added in order to select viomycin-binding RNAs and to guide their interaction with the intron RNA resulting in recombinant molecules. Viomycin was indeed capable of specifically selecting RNA molecules which contain viomycin-binding sites promoting recombination. These results suggest that small peptides are able to play the role of selector molecules in a putative ‘RNA World’ launching the co-evolution of RNA and proteins into an ‘RNA-protein World’. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ19540162X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210708005907.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070526s1999 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ19540162X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The antibiotic viomycin as a model peptide for the origin of the co-evolution of RNA and proteins</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1999</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">14</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Viomycin is an RNA-binding peptide antibiotic which inhibits prokaryotic protein synthesis and group I intron self-splicing. This antibiotic enhances the activity of the ribozyme derived from the Neurospora crassa VS RNA, and at sub-inhibitory concentrations it induces the formation of group I intron oligomers. Here, we address the question whether viomycin exerts specificity in the promotion of RNA-RNA interactions. In an in vitro selection experiment we tested the ability of viomycin to specifically select molecules out of an RNA pool. Group I intron RNA was incubated with a pool of random sequence RNA, or with a pool of RNA molecules which had previously been enriched for viomycin-binding RNAs. Viomycin was added in order to select viomycin-binding RNAs and to guide their interaction with the intron RNA resulting in recombinant molecules. Viomycin was indeed capable of specifically selecting RNA molecules which contain viomycin-binding sites promoting recombination. These results suggest that small peptides are able to play the role of selector molecules in a putative ‘RNA World’ launching the co-evolution of RNA and proteins into an ‘RNA-protein World’.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wank, Herbert</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Clodi, Elisabeth</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wallis, Mary G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schroeder, Renée</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Origins of life and evolution of the biospheres</subfield><subfield code="d">1968</subfield><subfield code="g">29(1999) vom: Apr., Seite 391-404</subfield><subfield code="w">(DE-627)NLEJ188986243</subfield><subfield code="w">(DE-600)2018578-9</subfield><subfield code="x">1573-0875</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:29</subfield><subfield code="g">year:1999</subfield><subfield code="g">month:04</subfield><subfield code="g">pages:391-404</subfield><subfield code="g">extent:14</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1023/A:1006572028643</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">29</subfield><subfield code="j">1999</subfield><subfield code="c">4</subfield><subfield code="h">391-404</subfield><subfield code="g">14</subfield></datafield></record></collection>
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