Effect of aging on plasma cholecystokinin secretion and gallbladder emptying
Abstract The present study was undertaken to examine the effect of aging on cholecystokinin (CCK) release, gallbladder emptying and their interrelationships. Therefore, 26 healthy subjects were studied, 13 younger than 40 yr (mean age 31 yr, range 21–39 yr) and 13 older than 40 yr (mean age 64 yr, r...
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Englisch |
| Erschienen: |
1988 |
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5 |
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Springer Online Journal Archives 1860-2002 |
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in: Age - 1978, 11(1988) vom: Apr., Seite 136-140 |
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volume:11 ; year:1988 ; month:04 ; pages:136-140 ; extent:5 |
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| 520 | |a Abstract The present study was undertaken to examine the effect of aging on cholecystokinin (CCK) release, gallbladder emptying and their interrelationships. Therefore, 26 healthy subjects were studied, 13 younger than 40 yr (mean age 31 yr, range 21–39 yr) and 13 older than 40 yr (mean age 64 yr, range 40–78 yr). After intraduodenal administration of 60 ml corn oil, plasma CCK concentration was measured by a sensitive and specific radioimmunoassay and gallbladder emptying by cholescintigraphy. Fasting plasma CCK concentrations were similar in both groups (1.2±0.2 pmol/l in the younger and 1.5 ± 0.3 pmol/l in the older subjects), but the integrated postprandial CCK secretion was significantly (p<0.01) increased in the older subjects (214±21 pmol/l. 60 min) compared to the younger subjects (153±15 pmol/l. 60 min). However, gallbladder emptying was not significantly different between the older and younger subjects (at 60 min 55±7% vs. 61±4%). Gallbladder sensitivity to endogenous CCK was significantly (P<0.02) reduced in the older subjects when compared to the younger subjects. In conclusion, gallbladder sensitivity to CCK is diminished in older subjects but gallbladder emptying remains unchanged due to a significantly increased endogenous CCK secretion. | ||
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(DE-627)NLEJ196258731 DE-627 ger DE-627 rakwb eng Effect of aging on plasma cholecystokinin secretion and gallbladder emptying 1988 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The present study was undertaken to examine the effect of aging on cholecystokinin (CCK) release, gallbladder emptying and their interrelationships. Therefore, 26 healthy subjects were studied, 13 younger than 40 yr (mean age 31 yr, range 21–39 yr) and 13 older than 40 yr (mean age 64 yr, range 40–78 yr). After intraduodenal administration of 60 ml corn oil, plasma CCK concentration was measured by a sensitive and specific radioimmunoassay and gallbladder emptying by cholescintigraphy. Fasting plasma CCK concentrations were similar in both groups (1.2±0.2 pmol/l in the younger and 1.5 ± 0.3 pmol/l in the older subjects), but the integrated postprandial CCK secretion was significantly (p<0.01) increased in the older subjects (214±21 pmol/l. 60 min) compared to the younger subjects (153±15 pmol/l. 60 min). However, gallbladder emptying was not significantly different between the older and younger subjects (at 60 min 55±7% vs. 61±4%). Gallbladder sensitivity to endogenous CCK was significantly (P<0.02) reduced in the older subjects when compared to the younger subjects. In conclusion, gallbladder sensitivity to CCK is diminished in older subjects but gallbladder emptying remains unchanged due to a significantly increased endogenous CCK secretion. Springer Online Journal Archives 1860-2002 Masclee, A. A. M. oth Geuskens, L. M. oth Driessen, W. M. M. oth Jansen, J. B. M. J. oth Lamers, C. B. H. W. oth in Age 1978 11(1988) vom: Apr., Seite 136-140 (DE-627)NLEJ188991581 (DE-600)2201958-3 1574-4647 nnns volume:11 year:1988 month:04 pages:136-140 extent:5 http://dx.doi.org/10.1007/BF02432293 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 11 1988 4 136-140 5 |
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(DE-627)NLEJ196258731 DE-627 ger DE-627 rakwb eng Effect of aging on plasma cholecystokinin secretion and gallbladder emptying 1988 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The present study was undertaken to examine the effect of aging on cholecystokinin (CCK) release, gallbladder emptying and their interrelationships. Therefore, 26 healthy subjects were studied, 13 younger than 40 yr (mean age 31 yr, range 21–39 yr) and 13 older than 40 yr (mean age 64 yr, range 40–78 yr). After intraduodenal administration of 60 ml corn oil, plasma CCK concentration was measured by a sensitive and specific radioimmunoassay and gallbladder emptying by cholescintigraphy. Fasting plasma CCK concentrations were similar in both groups (1.2±0.2 pmol/l in the younger and 1.5 ± 0.3 pmol/l in the older subjects), but the integrated postprandial CCK secretion was significantly (p<0.01) increased in the older subjects (214±21 pmol/l. 60 min) compared to the younger subjects (153±15 pmol/l. 60 min). However, gallbladder emptying was not significantly different between the older and younger subjects (at 60 min 55±7% vs. 61±4%). Gallbladder sensitivity to endogenous CCK was significantly (P<0.02) reduced in the older subjects when compared to the younger subjects. In conclusion, gallbladder sensitivity to CCK is diminished in older subjects but gallbladder emptying remains unchanged due to a significantly increased endogenous CCK secretion. Springer Online Journal Archives 1860-2002 Masclee, A. A. M. oth Geuskens, L. M. oth Driessen, W. M. M. oth Jansen, J. B. M. J. oth Lamers, C. B. H. W. oth in Age 1978 11(1988) vom: Apr., Seite 136-140 (DE-627)NLEJ188991581 (DE-600)2201958-3 1574-4647 nnns volume:11 year:1988 month:04 pages:136-140 extent:5 http://dx.doi.org/10.1007/BF02432293 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 11 1988 4 136-140 5 |
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(DE-627)NLEJ196258731 DE-627 ger DE-627 rakwb eng Effect of aging on plasma cholecystokinin secretion and gallbladder emptying 1988 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The present study was undertaken to examine the effect of aging on cholecystokinin (CCK) release, gallbladder emptying and their interrelationships. Therefore, 26 healthy subjects were studied, 13 younger than 40 yr (mean age 31 yr, range 21–39 yr) and 13 older than 40 yr (mean age 64 yr, range 40–78 yr). After intraduodenal administration of 60 ml corn oil, plasma CCK concentration was measured by a sensitive and specific radioimmunoassay and gallbladder emptying by cholescintigraphy. Fasting plasma CCK concentrations were similar in both groups (1.2±0.2 pmol/l in the younger and 1.5 ± 0.3 pmol/l in the older subjects), but the integrated postprandial CCK secretion was significantly (p<0.01) increased in the older subjects (214±21 pmol/l. 60 min) compared to the younger subjects (153±15 pmol/l. 60 min). However, gallbladder emptying was not significantly different between the older and younger subjects (at 60 min 55±7% vs. 61±4%). Gallbladder sensitivity to endogenous CCK was significantly (P<0.02) reduced in the older subjects when compared to the younger subjects. In conclusion, gallbladder sensitivity to CCK is diminished in older subjects but gallbladder emptying remains unchanged due to a significantly increased endogenous CCK secretion. Springer Online Journal Archives 1860-2002 Masclee, A. A. M. oth Geuskens, L. M. oth Driessen, W. M. M. oth Jansen, J. B. M. J. oth Lamers, C. B. H. W. oth in Age 1978 11(1988) vom: Apr., Seite 136-140 (DE-627)NLEJ188991581 (DE-600)2201958-3 1574-4647 nnns volume:11 year:1988 month:04 pages:136-140 extent:5 http://dx.doi.org/10.1007/BF02432293 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 11 1988 4 136-140 5 |
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(DE-627)NLEJ196258731 DE-627 ger DE-627 rakwb eng Effect of aging on plasma cholecystokinin secretion and gallbladder emptying 1988 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The present study was undertaken to examine the effect of aging on cholecystokinin (CCK) release, gallbladder emptying and their interrelationships. Therefore, 26 healthy subjects were studied, 13 younger than 40 yr (mean age 31 yr, range 21–39 yr) and 13 older than 40 yr (mean age 64 yr, range 40–78 yr). After intraduodenal administration of 60 ml corn oil, plasma CCK concentration was measured by a sensitive and specific radioimmunoassay and gallbladder emptying by cholescintigraphy. Fasting plasma CCK concentrations were similar in both groups (1.2±0.2 pmol/l in the younger and 1.5 ± 0.3 pmol/l in the older subjects), but the integrated postprandial CCK secretion was significantly (p<0.01) increased in the older subjects (214±21 pmol/l. 60 min) compared to the younger subjects (153±15 pmol/l. 60 min). However, gallbladder emptying was not significantly different between the older and younger subjects (at 60 min 55±7% vs. 61±4%). Gallbladder sensitivity to endogenous CCK was significantly (P<0.02) reduced in the older subjects when compared to the younger subjects. In conclusion, gallbladder sensitivity to CCK is diminished in older subjects but gallbladder emptying remains unchanged due to a significantly increased endogenous CCK secretion. Springer Online Journal Archives 1860-2002 Masclee, A. A. M. oth Geuskens, L. M. oth Driessen, W. M. M. oth Jansen, J. B. M. J. oth Lamers, C. B. H. W. oth in Age 1978 11(1988) vom: Apr., Seite 136-140 (DE-627)NLEJ188991581 (DE-600)2201958-3 1574-4647 nnns volume:11 year:1988 month:04 pages:136-140 extent:5 http://dx.doi.org/10.1007/BF02432293 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 11 1988 4 136-140 5 |
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(DE-627)NLEJ196258731 DE-627 ger DE-627 rakwb eng Effect of aging on plasma cholecystokinin secretion and gallbladder emptying 1988 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The present study was undertaken to examine the effect of aging on cholecystokinin (CCK) release, gallbladder emptying and their interrelationships. Therefore, 26 healthy subjects were studied, 13 younger than 40 yr (mean age 31 yr, range 21–39 yr) and 13 older than 40 yr (mean age 64 yr, range 40–78 yr). After intraduodenal administration of 60 ml corn oil, plasma CCK concentration was measured by a sensitive and specific radioimmunoassay and gallbladder emptying by cholescintigraphy. Fasting plasma CCK concentrations were similar in both groups (1.2±0.2 pmol/l in the younger and 1.5 ± 0.3 pmol/l in the older subjects), but the integrated postprandial CCK secretion was significantly (p<0.01) increased in the older subjects (214±21 pmol/l. 60 min) compared to the younger subjects (153±15 pmol/l. 60 min). However, gallbladder emptying was not significantly different between the older and younger subjects (at 60 min 55±7% vs. 61±4%). Gallbladder sensitivity to endogenous CCK was significantly (P<0.02) reduced in the older subjects when compared to the younger subjects. In conclusion, gallbladder sensitivity to CCK is diminished in older subjects but gallbladder emptying remains unchanged due to a significantly increased endogenous CCK secretion. Springer Online Journal Archives 1860-2002 Masclee, A. A. M. oth Geuskens, L. M. oth Driessen, W. M. M. oth Jansen, J. B. M. J. oth Lamers, C. B. H. W. oth in Age 1978 11(1988) vom: Apr., Seite 136-140 (DE-627)NLEJ188991581 (DE-600)2201958-3 1574-4647 nnns volume:11 year:1988 month:04 pages:136-140 extent:5 http://dx.doi.org/10.1007/BF02432293 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 11 1988 4 136-140 5 |
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Effect of aging on plasma cholecystokinin secretion and gallbladder emptying |
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Abstract The present study was undertaken to examine the effect of aging on cholecystokinin (CCK) release, gallbladder emptying and their interrelationships. Therefore, 26 healthy subjects were studied, 13 younger than 40 yr (mean age 31 yr, range 21–39 yr) and 13 older than 40 yr (mean age 64 yr, range 40–78 yr). After intraduodenal administration of 60 ml corn oil, plasma CCK concentration was measured by a sensitive and specific radioimmunoassay and gallbladder emptying by cholescintigraphy. Fasting plasma CCK concentrations were similar in both groups (1.2±0.2 pmol/l in the younger and 1.5 ± 0.3 pmol/l in the older subjects), but the integrated postprandial CCK secretion was significantly (p<0.01) increased in the older subjects (214±21 pmol/l. 60 min) compared to the younger subjects (153±15 pmol/l. 60 min). However, gallbladder emptying was not significantly different between the older and younger subjects (at 60 min 55±7% vs. 61±4%). Gallbladder sensitivity to endogenous CCK was significantly (P<0.02) reduced in the older subjects when compared to the younger subjects. In conclusion, gallbladder sensitivity to CCK is diminished in older subjects but gallbladder emptying remains unchanged due to a significantly increased endogenous CCK secretion. |
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Abstract The present study was undertaken to examine the effect of aging on cholecystokinin (CCK) release, gallbladder emptying and their interrelationships. Therefore, 26 healthy subjects were studied, 13 younger than 40 yr (mean age 31 yr, range 21–39 yr) and 13 older than 40 yr (mean age 64 yr, range 40–78 yr). After intraduodenal administration of 60 ml corn oil, plasma CCK concentration was measured by a sensitive and specific radioimmunoassay and gallbladder emptying by cholescintigraphy. Fasting plasma CCK concentrations were similar in both groups (1.2±0.2 pmol/l in the younger and 1.5 ± 0.3 pmol/l in the older subjects), but the integrated postprandial CCK secretion was significantly (p<0.01) increased in the older subjects (214±21 pmol/l. 60 min) compared to the younger subjects (153±15 pmol/l. 60 min). However, gallbladder emptying was not significantly different between the older and younger subjects (at 60 min 55±7% vs. 61±4%). Gallbladder sensitivity to endogenous CCK was significantly (P<0.02) reduced in the older subjects when compared to the younger subjects. In conclusion, gallbladder sensitivity to CCK is diminished in older subjects but gallbladder emptying remains unchanged due to a significantly increased endogenous CCK secretion. |
| abstract_unstemmed |
Abstract The present study was undertaken to examine the effect of aging on cholecystokinin (CCK) release, gallbladder emptying and their interrelationships. Therefore, 26 healthy subjects were studied, 13 younger than 40 yr (mean age 31 yr, range 21–39 yr) and 13 older than 40 yr (mean age 64 yr, range 40–78 yr). After intraduodenal administration of 60 ml corn oil, plasma CCK concentration was measured by a sensitive and specific radioimmunoassay and gallbladder emptying by cholescintigraphy. Fasting plasma CCK concentrations were similar in both groups (1.2±0.2 pmol/l in the younger and 1.5 ± 0.3 pmol/l in the older subjects), but the integrated postprandial CCK secretion was significantly (p<0.01) increased in the older subjects (214±21 pmol/l. 60 min) compared to the younger subjects (153±15 pmol/l. 60 min). However, gallbladder emptying was not significantly different between the older and younger subjects (at 60 min 55±7% vs. 61±4%). Gallbladder sensitivity to endogenous CCK was significantly (P<0.02) reduced in the older subjects when compared to the younger subjects. In conclusion, gallbladder sensitivity to CCK is diminished in older subjects but gallbladder emptying remains unchanged due to a significantly increased endogenous CCK secretion. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ196258731</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210705185105.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070526s1988 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ196258731</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Effect of aging on plasma cholecystokinin secretion and gallbladder emptying</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1988</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">5</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The present study was undertaken to examine the effect of aging on cholecystokinin (CCK) release, gallbladder emptying and their interrelationships. Therefore, 26 healthy subjects were studied, 13 younger than 40 yr (mean age 31 yr, range 21–39 yr) and 13 older than 40 yr (mean age 64 yr, range 40–78 yr). After intraduodenal administration of 60 ml corn oil, plasma CCK concentration was measured by a sensitive and specific radioimmunoassay and gallbladder emptying by cholescintigraphy. Fasting plasma CCK concentrations were similar in both groups (1.2±0.2 pmol/l in the younger and 1.5 ± 0.3 pmol/l in the older subjects), but the integrated postprandial CCK secretion was significantly (p<0.01) increased in the older subjects (214±21 pmol/l. 60 min) compared to the younger subjects (153±15 pmol/l. 60 min). However, gallbladder emptying was not significantly different between the older and younger subjects (at 60 min 55±7% vs. 61±4%). Gallbladder sensitivity to endogenous CCK was significantly (P<0.02) reduced in the older subjects when compared to the younger subjects. In conclusion, gallbladder sensitivity to CCK is diminished in older subjects but gallbladder emptying remains unchanged due to a significantly increased endogenous CCK secretion.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Masclee, A. A. M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Geuskens, L. M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Driessen, W. M. M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jansen, J. B. M. J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lamers, C. B. H. W.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Age</subfield><subfield code="d">1978</subfield><subfield code="g">11(1988) vom: Apr., Seite 136-140</subfield><subfield code="w">(DE-627)NLEJ188991581</subfield><subfield code="w">(DE-600)2201958-3</subfield><subfield code="x">1574-4647</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:11</subfield><subfield code="g">year:1988</subfield><subfield code="g">month:04</subfield><subfield code="g">pages:136-140</subfield><subfield code="g">extent:5</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF02432293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">11</subfield><subfield code="j">1988</subfield><subfield code="c">4</subfield><subfield code="h">136-140</subfield><subfield code="g">5</subfield></datafield></record></collection>
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7.399872 |