Local feedback mechanisms in human breast cancer
Abstract Breast function and development are controlled by a variety of both local and systemic signals. Many of these signals are exerted by hormones and cytokines which are believed to be effectors in autoregulatory feedback loops. Recent studies have also suggested the involvement of such mechani...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2000 |
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| Umfang: |
10 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Breast cancer research and treatment - 1981, 63(2000) vom: Feb., Seite 95-104 |
| Übergeordnetes Werk: |
volume:63 ; year:2000 ; month:02 ; pages:95-104 ; extent:10 |
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| 520 | |a Abstract Breast function and development are controlled by a variety of both local and systemic signals. Many of these signals are exerted by hormones and cytokines which are believed to be effectors in autoregulatory feedback loops. Recent studies have also suggested the involvement of such mechanisms in human breast cancer. For example, the disruption of a negative feedback system by malignant transformation can result in the loss of growth control or in increased malignant behavior of tumor cells. Conversely, pathological positive feedback loops can develop that enhance tumor growth and invasion by excessive release of stimulatory factors. These loops are often located at the site of tumor invasion and involve stromal–epithelial interactions. They can be composed of mutually stimulating or inhibiting cytokines and may include locally expressed sex steroids. Although most studies have concentrated on cell–cell interactions at the site of the primary tumor, a number of observations indicate their importance in metastases as well. A thorough analysis of the regulatory mechansims within a malignant tumor is essential for the understanding of its unique behavior and for the investigation of more specific breast cancer therapies. | ||
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| 700 | 1 | |a Garmroudi, Farideh |4 oth | |
| 700 | 1 | |a Cullen, Kevin J. |4 oth | |
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(DE-627)NLEJ19674444X DE-627 ger DE-627 rakwb eng Local feedback mechanisms in human breast cancer 2000 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Breast function and development are controlled by a variety of both local and systemic signals. Many of these signals are exerted by hormones and cytokines which are believed to be effectors in autoregulatory feedback loops. Recent studies have also suggested the involvement of such mechanisms in human breast cancer. For example, the disruption of a negative feedback system by malignant transformation can result in the loss of growth control or in increased malignant behavior of tumor cells. Conversely, pathological positive feedback loops can develop that enhance tumor growth and invasion by excessive release of stimulatory factors. These loops are often located at the site of tumor invasion and involve stromal–epithelial interactions. They can be composed of mutually stimulating or inhibiting cytokines and may include locally expressed sex steroids. Although most studies have concentrated on cell–cell interactions at the site of the primary tumor, a number of observations indicate their importance in metastases as well. A thorough analysis of the regulatory mechansims within a malignant tumor is essential for the understanding of its unique behavior and for the investigation of more specific breast cancer therapies. Springer Online Journal Archives 1860-2002 Singer, Christian F. oth Kubista, Ernst oth Garmroudi, Farideh oth Cullen, Kevin J. oth in Breast cancer research and treatment 1981 63(2000) vom: Feb., Seite 95-104 (DE-627)NLEJ188984240 (DE-600)2004077-5 1573-7217 nnns volume:63 year:2000 month:02 pages:95-104 extent:10 http://dx.doi.org/10.1023/A:1006430202101 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 63 2000 2 95-104 10 |
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(DE-627)NLEJ19674444X DE-627 ger DE-627 rakwb eng Local feedback mechanisms in human breast cancer 2000 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Breast function and development are controlled by a variety of both local and systemic signals. Many of these signals are exerted by hormones and cytokines which are believed to be effectors in autoregulatory feedback loops. Recent studies have also suggested the involvement of such mechanisms in human breast cancer. For example, the disruption of a negative feedback system by malignant transformation can result in the loss of growth control or in increased malignant behavior of tumor cells. Conversely, pathological positive feedback loops can develop that enhance tumor growth and invasion by excessive release of stimulatory factors. These loops are often located at the site of tumor invasion and involve stromal–epithelial interactions. They can be composed of mutually stimulating or inhibiting cytokines and may include locally expressed sex steroids. Although most studies have concentrated on cell–cell interactions at the site of the primary tumor, a number of observations indicate their importance in metastases as well. A thorough analysis of the regulatory mechansims within a malignant tumor is essential for the understanding of its unique behavior and for the investigation of more specific breast cancer therapies. Springer Online Journal Archives 1860-2002 Singer, Christian F. oth Kubista, Ernst oth Garmroudi, Farideh oth Cullen, Kevin J. oth in Breast cancer research and treatment 1981 63(2000) vom: Feb., Seite 95-104 (DE-627)NLEJ188984240 (DE-600)2004077-5 1573-7217 nnns volume:63 year:2000 month:02 pages:95-104 extent:10 http://dx.doi.org/10.1023/A:1006430202101 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 63 2000 2 95-104 10 |
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(DE-627)NLEJ19674444X DE-627 ger DE-627 rakwb eng Local feedback mechanisms in human breast cancer 2000 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Breast function and development are controlled by a variety of both local and systemic signals. Many of these signals are exerted by hormones and cytokines which are believed to be effectors in autoregulatory feedback loops. Recent studies have also suggested the involvement of such mechanisms in human breast cancer. For example, the disruption of a negative feedback system by malignant transformation can result in the loss of growth control or in increased malignant behavior of tumor cells. Conversely, pathological positive feedback loops can develop that enhance tumor growth and invasion by excessive release of stimulatory factors. These loops are often located at the site of tumor invasion and involve stromal–epithelial interactions. They can be composed of mutually stimulating or inhibiting cytokines and may include locally expressed sex steroids. Although most studies have concentrated on cell–cell interactions at the site of the primary tumor, a number of observations indicate their importance in metastases as well. A thorough analysis of the regulatory mechansims within a malignant tumor is essential for the understanding of its unique behavior and for the investigation of more specific breast cancer therapies. Springer Online Journal Archives 1860-2002 Singer, Christian F. oth Kubista, Ernst oth Garmroudi, Farideh oth Cullen, Kevin J. oth in Breast cancer research and treatment 1981 63(2000) vom: Feb., Seite 95-104 (DE-627)NLEJ188984240 (DE-600)2004077-5 1573-7217 nnns volume:63 year:2000 month:02 pages:95-104 extent:10 http://dx.doi.org/10.1023/A:1006430202101 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 63 2000 2 95-104 10 |
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(DE-627)NLEJ19674444X DE-627 ger DE-627 rakwb eng Local feedback mechanisms in human breast cancer 2000 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Breast function and development are controlled by a variety of both local and systemic signals. Many of these signals are exerted by hormones and cytokines which are believed to be effectors in autoregulatory feedback loops. Recent studies have also suggested the involvement of such mechanisms in human breast cancer. For example, the disruption of a negative feedback system by malignant transformation can result in the loss of growth control or in increased malignant behavior of tumor cells. Conversely, pathological positive feedback loops can develop that enhance tumor growth and invasion by excessive release of stimulatory factors. These loops are often located at the site of tumor invasion and involve stromal–epithelial interactions. They can be composed of mutually stimulating or inhibiting cytokines and may include locally expressed sex steroids. Although most studies have concentrated on cell–cell interactions at the site of the primary tumor, a number of observations indicate their importance in metastases as well. A thorough analysis of the regulatory mechansims within a malignant tumor is essential for the understanding of its unique behavior and for the investigation of more specific breast cancer therapies. Springer Online Journal Archives 1860-2002 Singer, Christian F. oth Kubista, Ernst oth Garmroudi, Farideh oth Cullen, Kevin J. oth in Breast cancer research and treatment 1981 63(2000) vom: Feb., Seite 95-104 (DE-627)NLEJ188984240 (DE-600)2004077-5 1573-7217 nnns volume:63 year:2000 month:02 pages:95-104 extent:10 http://dx.doi.org/10.1023/A:1006430202101 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 63 2000 2 95-104 10 |
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(DE-627)NLEJ19674444X DE-627 ger DE-627 rakwb eng Local feedback mechanisms in human breast cancer 2000 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Breast function and development are controlled by a variety of both local and systemic signals. Many of these signals are exerted by hormones and cytokines which are believed to be effectors in autoregulatory feedback loops. Recent studies have also suggested the involvement of such mechanisms in human breast cancer. For example, the disruption of a negative feedback system by malignant transformation can result in the loss of growth control or in increased malignant behavior of tumor cells. Conversely, pathological positive feedback loops can develop that enhance tumor growth and invasion by excessive release of stimulatory factors. These loops are often located at the site of tumor invasion and involve stromal–epithelial interactions. They can be composed of mutually stimulating or inhibiting cytokines and may include locally expressed sex steroids. Although most studies have concentrated on cell–cell interactions at the site of the primary tumor, a number of observations indicate their importance in metastases as well. A thorough analysis of the regulatory mechansims within a malignant tumor is essential for the understanding of its unique behavior and for the investigation of more specific breast cancer therapies. Springer Online Journal Archives 1860-2002 Singer, Christian F. oth Kubista, Ernst oth Garmroudi, Farideh oth Cullen, Kevin J. oth in Breast cancer research and treatment 1981 63(2000) vom: Feb., Seite 95-104 (DE-627)NLEJ188984240 (DE-600)2004077-5 1573-7217 nnns volume:63 year:2000 month:02 pages:95-104 extent:10 http://dx.doi.org/10.1023/A:1006430202101 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 63 2000 2 95-104 10 |
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Abstract Breast function and development are controlled by a variety of both local and systemic signals. Many of these signals are exerted by hormones and cytokines which are believed to be effectors in autoregulatory feedback loops. Recent studies have also suggested the involvement of such mechanisms in human breast cancer. For example, the disruption of a negative feedback system by malignant transformation can result in the loss of growth control or in increased malignant behavior of tumor cells. Conversely, pathological positive feedback loops can develop that enhance tumor growth and invasion by excessive release of stimulatory factors. These loops are often located at the site of tumor invasion and involve stromal–epithelial interactions. They can be composed of mutually stimulating or inhibiting cytokines and may include locally expressed sex steroids. Although most studies have concentrated on cell–cell interactions at the site of the primary tumor, a number of observations indicate their importance in metastases as well. A thorough analysis of the regulatory mechansims within a malignant tumor is essential for the understanding of its unique behavior and for the investigation of more specific breast cancer therapies. |
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Abstract Breast function and development are controlled by a variety of both local and systemic signals. Many of these signals are exerted by hormones and cytokines which are believed to be effectors in autoregulatory feedback loops. Recent studies have also suggested the involvement of such mechanisms in human breast cancer. For example, the disruption of a negative feedback system by malignant transformation can result in the loss of growth control or in increased malignant behavior of tumor cells. Conversely, pathological positive feedback loops can develop that enhance tumor growth and invasion by excessive release of stimulatory factors. These loops are often located at the site of tumor invasion and involve stromal–epithelial interactions. They can be composed of mutually stimulating or inhibiting cytokines and may include locally expressed sex steroids. Although most studies have concentrated on cell–cell interactions at the site of the primary tumor, a number of observations indicate their importance in metastases as well. A thorough analysis of the regulatory mechansims within a malignant tumor is essential for the understanding of its unique behavior and for the investigation of more specific breast cancer therapies. |
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Abstract Breast function and development are controlled by a variety of both local and systemic signals. Many of these signals are exerted by hormones and cytokines which are believed to be effectors in autoregulatory feedback loops. Recent studies have also suggested the involvement of such mechanisms in human breast cancer. For example, the disruption of a negative feedback system by malignant transformation can result in the loss of growth control or in increased malignant behavior of tumor cells. Conversely, pathological positive feedback loops can develop that enhance tumor growth and invasion by excessive release of stimulatory factors. These loops are often located at the site of tumor invasion and involve stromal–epithelial interactions. They can be composed of mutually stimulating or inhibiting cytokines and may include locally expressed sex steroids. Although most studies have concentrated on cell–cell interactions at the site of the primary tumor, a number of observations indicate their importance in metastases as well. A thorough analysis of the regulatory mechansims within a malignant tumor is essential for the understanding of its unique behavior and for the investigation of more specific breast cancer therapies. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ19674444X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210705195459.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070526s2000 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ19674444X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Local feedback mechanisms in human breast cancer</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2000</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">10</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Breast function and development are controlled by a variety of both local and systemic signals. Many of these signals are exerted by hormones and cytokines which are believed to be effectors in autoregulatory feedback loops. Recent studies have also suggested the involvement of such mechanisms in human breast cancer. For example, the disruption of a negative feedback system by malignant transformation can result in the loss of growth control or in increased malignant behavior of tumor cells. Conversely, pathological positive feedback loops can develop that enhance tumor growth and invasion by excessive release of stimulatory factors. These loops are often located at the site of tumor invasion and involve stromal–epithelial interactions. They can be composed of mutually stimulating or inhibiting cytokines and may include locally expressed sex steroids. Although most studies have concentrated on cell–cell interactions at the site of the primary tumor, a number of observations indicate their importance in metastases as well. A thorough analysis of the regulatory mechansims within a malignant tumor is essential for the understanding of its unique behavior and for the investigation of more specific breast cancer therapies.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Singer, Christian F.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kubista, Ernst</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Garmroudi, Farideh</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cullen, Kevin J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Breast cancer research and treatment</subfield><subfield code="d">1981</subfield><subfield code="g">63(2000) vom: Feb., Seite 95-104</subfield><subfield code="w">(DE-627)NLEJ188984240</subfield><subfield code="w">(DE-600)2004077-5</subfield><subfield code="x">1573-7217</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:63</subfield><subfield code="g">year:2000</subfield><subfield code="g">month:02</subfield><subfield code="g">pages:95-104</subfield><subfield code="g">extent:10</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1023/A:1006430202101</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">63</subfield><subfield code="j">2000</subfield><subfield code="c">2</subfield><subfield code="h">95-104</subfield><subfield code="g">10</subfield></datafield></record></collection>
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