Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein
Abstract We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELI...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1992 |
|---|
| Umfang: |
9 |
|---|
| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
|---|---|
| Übergeordnetes Werk: |
in: Journal of clinical immunology - 1981, 12(1992) vom: Jan., Seite 27-35 |
| Übergeordnetes Werk: |
volume:12 ; year:1992 ; month:01 ; pages:27-35 ; extent:9 |
| Links: |
|---|
| Katalog-ID: |
NLEJ197582362 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ197582362 | ||
| 003 | DE-627 | ||
| 005 | 20210705220835.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 070527s1992 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)NLEJ197582362 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 245 | 1 | 0 | |a Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein |
| 264 | 1 | |c 1992 | |
| 300 | |a 9 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Abstract We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL binding to phospholipid but no inhibition of PAP I-phospholipid binding by aPL. aPL and PAP I interact additively in anticoagulant activity inin vitro clotting systems and compete for phospholipid in ELISA system. These data support the hypotheses that aPL and PAP I may recognize similar phospholipid epitopes and thatin vivo interaction may occur. | ||
| 533 | |f Springer Online Journal Archives 1860-2002 | ||
| 700 | 1 | |a Sammaritano, Lisa R. |4 oth | |
| 700 | 1 | |a Gharavi, Azzudin E. |4 oth | |
| 700 | 1 | |a Soberano, Consolacion |4 oth | |
| 700 | 1 | |a Levy, Roger A. |4 oth | |
| 700 | 1 | |a Lockshin, Michael D. |4 oth | |
| 773 | 0 | 8 | |i in |t Journal of clinical immunology |d 1981 |g 12(1992) vom: Jan., Seite 27-35 |w (DE-627)NLEJ188988572 |w (DE-600)2016755-6 |x 1573-2592 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:1992 |g month:01 |g pages:27-35 |g extent:9 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/BF00918270 |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-SOJ | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 1992 |c 1 |h 27-35 |g 9 | ||
| matchkey_str |
article:15732592:1992----::hshlpdidnoatpopoiiatbdeadlcn |
|---|---|
| hierarchy_sort_str |
1992 |
| publishDate |
1992 |
| allfields |
(DE-627)NLEJ197582362 DE-627 ger DE-627 rakwb eng Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein 1992 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL binding to phospholipid but no inhibition of PAP I-phospholipid binding by aPL. aPL and PAP I interact additively in anticoagulant activity inin vitro clotting systems and compete for phospholipid in ELISA system. These data support the hypotheses that aPL and PAP I may recognize similar phospholipid epitopes and thatin vivo interaction may occur. Springer Online Journal Archives 1860-2002 Sammaritano, Lisa R. oth Gharavi, Azzudin E. oth Soberano, Consolacion oth Levy, Roger A. oth Lockshin, Michael D. oth in Journal of clinical immunology 1981 12(1992) vom: Jan., Seite 27-35 (DE-627)NLEJ188988572 (DE-600)2016755-6 1573-2592 nnns volume:12 year:1992 month:01 pages:27-35 extent:9 http://dx.doi.org/10.1007/BF00918270 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 12 1992 1 27-35 9 |
| spelling |
(DE-627)NLEJ197582362 DE-627 ger DE-627 rakwb eng Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein 1992 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL binding to phospholipid but no inhibition of PAP I-phospholipid binding by aPL. aPL and PAP I interact additively in anticoagulant activity inin vitro clotting systems and compete for phospholipid in ELISA system. These data support the hypotheses that aPL and PAP I may recognize similar phospholipid epitopes and thatin vivo interaction may occur. Springer Online Journal Archives 1860-2002 Sammaritano, Lisa R. oth Gharavi, Azzudin E. oth Soberano, Consolacion oth Levy, Roger A. oth Lockshin, Michael D. oth in Journal of clinical immunology 1981 12(1992) vom: Jan., Seite 27-35 (DE-627)NLEJ188988572 (DE-600)2016755-6 1573-2592 nnns volume:12 year:1992 month:01 pages:27-35 extent:9 http://dx.doi.org/10.1007/BF00918270 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 12 1992 1 27-35 9 |
| allfields_unstemmed |
(DE-627)NLEJ197582362 DE-627 ger DE-627 rakwb eng Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein 1992 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL binding to phospholipid but no inhibition of PAP I-phospholipid binding by aPL. aPL and PAP I interact additively in anticoagulant activity inin vitro clotting systems and compete for phospholipid in ELISA system. These data support the hypotheses that aPL and PAP I may recognize similar phospholipid epitopes and thatin vivo interaction may occur. Springer Online Journal Archives 1860-2002 Sammaritano, Lisa R. oth Gharavi, Azzudin E. oth Soberano, Consolacion oth Levy, Roger A. oth Lockshin, Michael D. oth in Journal of clinical immunology 1981 12(1992) vom: Jan., Seite 27-35 (DE-627)NLEJ188988572 (DE-600)2016755-6 1573-2592 nnns volume:12 year:1992 month:01 pages:27-35 extent:9 http://dx.doi.org/10.1007/BF00918270 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 12 1992 1 27-35 9 |
| allfieldsGer |
(DE-627)NLEJ197582362 DE-627 ger DE-627 rakwb eng Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein 1992 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL binding to phospholipid but no inhibition of PAP I-phospholipid binding by aPL. aPL and PAP I interact additively in anticoagulant activity inin vitro clotting systems and compete for phospholipid in ELISA system. These data support the hypotheses that aPL and PAP I may recognize similar phospholipid epitopes and thatin vivo interaction may occur. Springer Online Journal Archives 1860-2002 Sammaritano, Lisa R. oth Gharavi, Azzudin E. oth Soberano, Consolacion oth Levy, Roger A. oth Lockshin, Michael D. oth in Journal of clinical immunology 1981 12(1992) vom: Jan., Seite 27-35 (DE-627)NLEJ188988572 (DE-600)2016755-6 1573-2592 nnns volume:12 year:1992 month:01 pages:27-35 extent:9 http://dx.doi.org/10.1007/BF00918270 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 12 1992 1 27-35 9 |
| allfieldsSound |
(DE-627)NLEJ197582362 DE-627 ger DE-627 rakwb eng Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein 1992 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL binding to phospholipid but no inhibition of PAP I-phospholipid binding by aPL. aPL and PAP I interact additively in anticoagulant activity inin vitro clotting systems and compete for phospholipid in ELISA system. These data support the hypotheses that aPL and PAP I may recognize similar phospholipid epitopes and thatin vivo interaction may occur. Springer Online Journal Archives 1860-2002 Sammaritano, Lisa R. oth Gharavi, Azzudin E. oth Soberano, Consolacion oth Levy, Roger A. oth Lockshin, Michael D. oth in Journal of clinical immunology 1981 12(1992) vom: Jan., Seite 27-35 (DE-627)NLEJ188988572 (DE-600)2016755-6 1573-2592 nnns volume:12 year:1992 month:01 pages:27-35 extent:9 http://dx.doi.org/10.1007/BF00918270 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 12 1992 1 27-35 9 |
| language |
English |
| source |
in Journal of clinical immunology 12(1992) vom: Jan., Seite 27-35 volume:12 year:1992 month:01 pages:27-35 extent:9 |
| sourceStr |
in Journal of clinical immunology 12(1992) vom: Jan., Seite 27-35 volume:12 year:1992 month:01 pages:27-35 extent:9 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Journal of clinical immunology |
| authorswithroles_txt_mv |
Sammaritano, Lisa R. @@oth@@ Gharavi, Azzudin E. @@oth@@ Soberano, Consolacion @@oth@@ Levy, Roger A. @@oth@@ Lockshin, Michael D. @@oth@@ |
| publishDateDaySort_date |
1992-01-01T00:00:00Z |
| hierarchy_top_id |
NLEJ188988572 |
| id |
NLEJ197582362 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ197582362</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210705220835.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1992 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ197582362</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1992</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">9</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL binding to phospholipid but no inhibition of PAP I-phospholipid binding by aPL. aPL and PAP I interact additively in anticoagulant activity inin vitro clotting systems and compete for phospholipid in ELISA system. These data support the hypotheses that aPL and PAP I may recognize similar phospholipid epitopes and thatin vivo interaction may occur.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sammaritano, Lisa R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gharavi, Azzudin E.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Soberano, Consolacion</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Levy, Roger A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lockshin, Michael D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Journal of clinical immunology</subfield><subfield code="d">1981</subfield><subfield code="g">12(1992) vom: Jan., Seite 27-35</subfield><subfield code="w">(DE-627)NLEJ188988572</subfield><subfield code="w">(DE-600)2016755-6</subfield><subfield code="x">1573-2592</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:1992</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:27-35</subfield><subfield code="g">extent:9</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00918270</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">1992</subfield><subfield code="c">1</subfield><subfield code="h">27-35</subfield><subfield code="g">9</subfield></datafield></record></collection>
|
| series2 |
Springer Online Journal Archives 1860-2002 |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ188988572 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| collection |
NL |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1573-2592 |
| topic_title |
Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
l r s lr lrs a e g ae aeg c s cs r a l ra ral m d l md mdl |
| hierarchy_parent_title |
Journal of clinical immunology |
| hierarchy_parent_id |
NLEJ188988572 |
| hierarchy_top_title |
Journal of clinical immunology |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ188988572 (DE-600)2016755-6 |
| title |
Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein |
| spellingShingle |
Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein |
| ctrlnum |
(DE-627)NLEJ197582362 |
| title_full |
Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein |
| journal |
Journal of clinical immunology |
| journalStr |
Journal of clinical immunology |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1992 |
| contenttype_str_mv |
zzz |
| container_start_page |
27 |
| container_volume |
12 |
| physical |
9 |
| format_se |
Elektronische Aufsätze |
| title_sort |
phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein |
| title_auth |
Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein |
| abstract |
Abstract We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL binding to phospholipid but no inhibition of PAP I-phospholipid binding by aPL. aPL and PAP I interact additively in anticoagulant activity inin vitro clotting systems and compete for phospholipid in ELISA system. These data support the hypotheses that aPL and PAP I may recognize similar phospholipid epitopes and thatin vivo interaction may occur. |
| abstractGer |
Abstract We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL binding to phospholipid but no inhibition of PAP I-phospholipid binding by aPL. aPL and PAP I interact additively in anticoagulant activity inin vitro clotting systems and compete for phospholipid in ELISA system. These data support the hypotheses that aPL and PAP I may recognize similar phospholipid epitopes and thatin vivo interaction may occur. |
| abstract_unstemmed |
Abstract We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL binding to phospholipid but no inhibition of PAP I-phospholipid binding by aPL. aPL and PAP I interact additively in anticoagulant activity inin vitro clotting systems and compete for phospholipid in ELISA system. These data support the hypotheses that aPL and PAP I may recognize similar phospholipid epitopes and thatin vivo interaction may occur. |
| collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
| title_short |
Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein |
| url |
http://dx.doi.org/10.1007/BF00918270 |
| remote_bool |
true |
| author2 |
Sammaritano, Lisa R. Gharavi, Azzudin E. Soberano, Consolacion Levy, Roger A. Lockshin, Michael D. |
| author2Str |
Sammaritano, Lisa R. Gharavi, Azzudin E. Soberano, Consolacion Levy, Roger A. Lockshin, Michael D. |
| ppnlink |
NLEJ188988572 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth |
| up_date |
2024-07-06T09:17:35.142Z |
| _version_ |
1803820681285074944 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ197582362</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210705220835.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1992 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ197582362</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Phospholipid binding of antiphospholipid antibodies and placental anticoagulant protein</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1992</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">9</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract We evaluated the interaction of antiphospholipid antibodies (aPL) with placental anticoagulant protein I (PAP I), a calcium-dependent phospholipid binding protein which may act as a natural anticoagulant. Clotting assays showed additive prolongation of clotting times with aPL and PAP I. ELISA and vesicle phospholipid binding studies showed PAP I inhibition of aPL binding to phospholipid but no inhibition of PAP I-phospholipid binding by aPL. aPL and PAP I interact additively in anticoagulant activity inin vitro clotting systems and compete for phospholipid in ELISA system. These data support the hypotheses that aPL and PAP I may recognize similar phospholipid epitopes and thatin vivo interaction may occur.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sammaritano, Lisa R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gharavi, Azzudin E.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Soberano, Consolacion</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Levy, Roger A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lockshin, Michael D.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Journal of clinical immunology</subfield><subfield code="d">1981</subfield><subfield code="g">12(1992) vom: Jan., Seite 27-35</subfield><subfield code="w">(DE-627)NLEJ188988572</subfield><subfield code="w">(DE-600)2016755-6</subfield><subfield code="x">1573-2592</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:1992</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:27-35</subfield><subfield code="g">extent:9</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00918270</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">1992</subfield><subfield code="c">1</subfield><subfield code="h">27-35</subfield><subfield code="g">9</subfield></datafield></record></collection>
|
| score |
7.401078 |