To the problem of biologically active conformation of enkephalin
Summary A semi-rigid structural analog of [Leu5] enkephalin, possessing the azo-bridge between Tyr1 and Phe4 residues, was synthesized, along with two other linear enkephalin analogs: [4′-amino Phe4] enkephalin and [4′hydroxyphenyl/-azo Phe4] enkephalin. The results of the determination of the analg...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1981 |
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| Umfang: |
7 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Molecular and cellular biochemistry - 1973, 34(1981) vom: Jan., Seite 23-29 |
| Übergeordnetes Werk: |
volume:34 ; year:1981 ; month:01 ; pages:23-29 ; extent:7 |
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NLEJ198058071 |
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| 520 | |a Summary A semi-rigid structural analog of [Leu5] enkephalin, possessing the azo-bridge between Tyr1 and Phe4 residues, was synthesized, along with two other linear enkephalin analogs: [4′-amino Phe4] enkephalin and [4′hydroxyphenyl/-azo Phe4] enkephalin. The results of the determination of the analgesic activity of the synthesized compounds suggest that the biologically active conformation of the enkephalin molecule should be such that both aromatic rings, Tyr1 and Phe4, are situated in close proximity. | ||
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| 700 | 1 | |a Siemion, Ignacy Z. |4 oth | |
| 700 | 1 | |a Szewczuk, Zbigniew |4 oth | |
| 700 | 1 | |a Herman, Zbigniew S. |4 oth | |
| 700 | 1 | |a Stachura, Zdzislaw |4 oth | |
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(DE-627)NLEJ198058071 DE-627 ger DE-627 rakwb eng To the problem of biologically active conformation of enkephalin 1981 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A semi-rigid structural analog of [Leu5] enkephalin, possessing the azo-bridge between Tyr1 and Phe4 residues, was synthesized, along with two other linear enkephalin analogs: [4′-amino Phe4] enkephalin and [4′hydroxyphenyl/-azo Phe4] enkephalin. The results of the determination of the analgesic activity of the synthesized compounds suggest that the biologically active conformation of the enkephalin molecule should be such that both aromatic rings, Tyr1 and Phe4, are situated in close proximity. Springer Online Journal Archives 1860-2002 Siemion, Ignacy Z. oth Szewczuk, Zbigniew oth Herman, Zbigniew S. oth Stachura, Zdzislaw oth in Molecular and cellular biochemistry 1973 34(1981) vom: Jan., Seite 23-29 (DE-627)NLEJ188989099 (DE-600)2003615-2 1573-4919 nnns volume:34 year:1981 month:01 pages:23-29 extent:7 http://dx.doi.org/10.1007/BF02354848 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 34 1981 1 23-29 7 |
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(DE-627)NLEJ198058071 DE-627 ger DE-627 rakwb eng To the problem of biologically active conformation of enkephalin 1981 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A semi-rigid structural analog of [Leu5] enkephalin, possessing the azo-bridge between Tyr1 and Phe4 residues, was synthesized, along with two other linear enkephalin analogs: [4′-amino Phe4] enkephalin and [4′hydroxyphenyl/-azo Phe4] enkephalin. The results of the determination of the analgesic activity of the synthesized compounds suggest that the biologically active conformation of the enkephalin molecule should be such that both aromatic rings, Tyr1 and Phe4, are situated in close proximity. Springer Online Journal Archives 1860-2002 Siemion, Ignacy Z. oth Szewczuk, Zbigniew oth Herman, Zbigniew S. oth Stachura, Zdzislaw oth in Molecular and cellular biochemistry 1973 34(1981) vom: Jan., Seite 23-29 (DE-627)NLEJ188989099 (DE-600)2003615-2 1573-4919 nnns volume:34 year:1981 month:01 pages:23-29 extent:7 http://dx.doi.org/10.1007/BF02354848 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 34 1981 1 23-29 7 |
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(DE-627)NLEJ198058071 DE-627 ger DE-627 rakwb eng To the problem of biologically active conformation of enkephalin 1981 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A semi-rigid structural analog of [Leu5] enkephalin, possessing the azo-bridge between Tyr1 and Phe4 residues, was synthesized, along with two other linear enkephalin analogs: [4′-amino Phe4] enkephalin and [4′hydroxyphenyl/-azo Phe4] enkephalin. The results of the determination of the analgesic activity of the synthesized compounds suggest that the biologically active conformation of the enkephalin molecule should be such that both aromatic rings, Tyr1 and Phe4, are situated in close proximity. Springer Online Journal Archives 1860-2002 Siemion, Ignacy Z. oth Szewczuk, Zbigniew oth Herman, Zbigniew S. oth Stachura, Zdzislaw oth in Molecular and cellular biochemistry 1973 34(1981) vom: Jan., Seite 23-29 (DE-627)NLEJ188989099 (DE-600)2003615-2 1573-4919 nnns volume:34 year:1981 month:01 pages:23-29 extent:7 http://dx.doi.org/10.1007/BF02354848 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 34 1981 1 23-29 7 |
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(DE-627)NLEJ198058071 DE-627 ger DE-627 rakwb eng To the problem of biologically active conformation of enkephalin 1981 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A semi-rigid structural analog of [Leu5] enkephalin, possessing the azo-bridge between Tyr1 and Phe4 residues, was synthesized, along with two other linear enkephalin analogs: [4′-amino Phe4] enkephalin and [4′hydroxyphenyl/-azo Phe4] enkephalin. The results of the determination of the analgesic activity of the synthesized compounds suggest that the biologically active conformation of the enkephalin molecule should be such that both aromatic rings, Tyr1 and Phe4, are situated in close proximity. Springer Online Journal Archives 1860-2002 Siemion, Ignacy Z. oth Szewczuk, Zbigniew oth Herman, Zbigniew S. oth Stachura, Zdzislaw oth in Molecular and cellular biochemistry 1973 34(1981) vom: Jan., Seite 23-29 (DE-627)NLEJ188989099 (DE-600)2003615-2 1573-4919 nnns volume:34 year:1981 month:01 pages:23-29 extent:7 http://dx.doi.org/10.1007/BF02354848 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 34 1981 1 23-29 7 |
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(DE-627)NLEJ198058071 DE-627 ger DE-627 rakwb eng To the problem of biologically active conformation of enkephalin 1981 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary A semi-rigid structural analog of [Leu5] enkephalin, possessing the azo-bridge between Tyr1 and Phe4 residues, was synthesized, along with two other linear enkephalin analogs: [4′-amino Phe4] enkephalin and [4′hydroxyphenyl/-azo Phe4] enkephalin. The results of the determination of the analgesic activity of the synthesized compounds suggest that the biologically active conformation of the enkephalin molecule should be such that both aromatic rings, Tyr1 and Phe4, are situated in close proximity. Springer Online Journal Archives 1860-2002 Siemion, Ignacy Z. oth Szewczuk, Zbigniew oth Herman, Zbigniew S. oth Stachura, Zdzislaw oth in Molecular and cellular biochemistry 1973 34(1981) vom: Jan., Seite 23-29 (DE-627)NLEJ188989099 (DE-600)2003615-2 1573-4919 nnns volume:34 year:1981 month:01 pages:23-29 extent:7 http://dx.doi.org/10.1007/BF02354848 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 34 1981 1 23-29 7 |
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to the problem of biologically active conformation of enkephalin |
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To the problem of biologically active conformation of enkephalin |
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Summary A semi-rigid structural analog of [Leu5] enkephalin, possessing the azo-bridge between Tyr1 and Phe4 residues, was synthesized, along with two other linear enkephalin analogs: [4′-amino Phe4] enkephalin and [4′hydroxyphenyl/-azo Phe4] enkephalin. The results of the determination of the analgesic activity of the synthesized compounds suggest that the biologically active conformation of the enkephalin molecule should be such that both aromatic rings, Tyr1 and Phe4, are situated in close proximity. |
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Summary A semi-rigid structural analog of [Leu5] enkephalin, possessing the azo-bridge between Tyr1 and Phe4 residues, was synthesized, along with two other linear enkephalin analogs: [4′-amino Phe4] enkephalin and [4′hydroxyphenyl/-azo Phe4] enkephalin. The results of the determination of the analgesic activity of the synthesized compounds suggest that the biologically active conformation of the enkephalin molecule should be such that both aromatic rings, Tyr1 and Phe4, are situated in close proximity. |
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Summary A semi-rigid structural analog of [Leu5] enkephalin, possessing the azo-bridge between Tyr1 and Phe4 residues, was synthesized, along with two other linear enkephalin analogs: [4′-amino Phe4] enkephalin and [4′hydroxyphenyl/-azo Phe4] enkephalin. The results of the determination of the analgesic activity of the synthesized compounds suggest that the biologically active conformation of the enkephalin molecule should be such that both aromatic rings, Tyr1 and Phe4, are situated in close proximity. |
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