Determinants of survival after forebrain ischemia in Mongolian gerbils
Abstract Mongolian gerbils were exposed to 15 min of cerebral ischemia. Quantitative histology was used to establish neuronal damage in the CA1, CA2/3, and CA3 sectors of the hippocampus 2 weeks after the insult. Seven moribund animals were sacrificed earlier to examine whether there is a correlatio...
Ausführliche Beschreibung
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1988 |
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| Umfang: |
9 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Metabolic brain disease - 1986, 3(1988) vom: Apr., Seite 247-255 |
| Übergeordnetes Werk: |
volume:3 ; year:1988 ; month:04 ; pages:247-255 ; extent:9 |
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| 520 | |a Abstract Mongolian gerbils were exposed to 15 min of cerebral ischemia. Quantitative histology was used to establish neuronal damage in the CA1, CA2/3, and CA3 sectors of the hippocampus 2 weeks after the insult. Seven moribund animals were sacrificed earlier to examine whether there is a correlation between hippocampal damage and mortality. Surviving animals had a 86.6% loss of CA1 neurons. In the CA2/3 and CA3 sectors 62.7 and 72.6% of the neurons were preserved. Moribund animals had a further dramatic loss of nerve cells in these sectors, to 14.8 and 20.3%, respectively. The reduction of CA2/3 neurons and survival time were correlated. In addition, gerbils which would later become moribund were found to have a significant increase in plasma osmolarity from 319 to 342 mosm/liter and of hematocrit from 47.4 to 53.9 at day 4 after ischemia. | ||
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| 700 | 1 | |a Kempski, O. |4 oth | |
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(DE-627)NLEJ198074425 DE-627 ger DE-627 rakwb eng Determinants of survival after forebrain ischemia in Mongolian gerbils 1988 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Mongolian gerbils were exposed to 15 min of cerebral ischemia. Quantitative histology was used to establish neuronal damage in the CA1, CA2/3, and CA3 sectors of the hippocampus 2 weeks after the insult. Seven moribund animals were sacrificed earlier to examine whether there is a correlation between hippocampal damage and mortality. Surviving animals had a 86.6% loss of CA1 neurons. In the CA2/3 and CA3 sectors 62.7 and 72.6% of the neurons were preserved. Moribund animals had a further dramatic loss of nerve cells in these sectors, to 14.8 and 20.3%, respectively. The reduction of CA2/3 neurons and survival time were correlated. In addition, gerbils which would later become moribund were found to have a significant increase in plasma osmolarity from 319 to 342 mosm/liter and of hematocrit from 47.4 to 53.9 at day 4 after ischemia. Springer Online Journal Archives 1860-2002 Weber, K. oth Baethmann, A. oth Kempski, O. oth in Metabolic brain disease 1986 3(1988) vom: Apr., Seite 247-255 (DE-627)NLEJ188990275 (DE-600)2018067-6 1573-7365 nnns volume:3 year:1988 month:04 pages:247-255 extent:9 http://dx.doi.org/10.1007/BF00999534 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 3 1988 4 247-255 9 |
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(DE-627)NLEJ198074425 DE-627 ger DE-627 rakwb eng Determinants of survival after forebrain ischemia in Mongolian gerbils 1988 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Mongolian gerbils were exposed to 15 min of cerebral ischemia. Quantitative histology was used to establish neuronal damage in the CA1, CA2/3, and CA3 sectors of the hippocampus 2 weeks after the insult. Seven moribund animals were sacrificed earlier to examine whether there is a correlation between hippocampal damage and mortality. Surviving animals had a 86.6% loss of CA1 neurons. In the CA2/3 and CA3 sectors 62.7 and 72.6% of the neurons were preserved. Moribund animals had a further dramatic loss of nerve cells in these sectors, to 14.8 and 20.3%, respectively. The reduction of CA2/3 neurons and survival time were correlated. In addition, gerbils which would later become moribund were found to have a significant increase in plasma osmolarity from 319 to 342 mosm/liter and of hematocrit from 47.4 to 53.9 at day 4 after ischemia. Springer Online Journal Archives 1860-2002 Weber, K. oth Baethmann, A. oth Kempski, O. oth in Metabolic brain disease 1986 3(1988) vom: Apr., Seite 247-255 (DE-627)NLEJ188990275 (DE-600)2018067-6 1573-7365 nnns volume:3 year:1988 month:04 pages:247-255 extent:9 http://dx.doi.org/10.1007/BF00999534 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 3 1988 4 247-255 9 |
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(DE-627)NLEJ198074425 DE-627 ger DE-627 rakwb eng Determinants of survival after forebrain ischemia in Mongolian gerbils 1988 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Mongolian gerbils were exposed to 15 min of cerebral ischemia. Quantitative histology was used to establish neuronal damage in the CA1, CA2/3, and CA3 sectors of the hippocampus 2 weeks after the insult. Seven moribund animals were sacrificed earlier to examine whether there is a correlation between hippocampal damage and mortality. Surviving animals had a 86.6% loss of CA1 neurons. In the CA2/3 and CA3 sectors 62.7 and 72.6% of the neurons were preserved. Moribund animals had a further dramatic loss of nerve cells in these sectors, to 14.8 and 20.3%, respectively. The reduction of CA2/3 neurons and survival time were correlated. In addition, gerbils which would later become moribund were found to have a significant increase in plasma osmolarity from 319 to 342 mosm/liter and of hematocrit from 47.4 to 53.9 at day 4 after ischemia. Springer Online Journal Archives 1860-2002 Weber, K. oth Baethmann, A. oth Kempski, O. oth in Metabolic brain disease 1986 3(1988) vom: Apr., Seite 247-255 (DE-627)NLEJ188990275 (DE-600)2018067-6 1573-7365 nnns volume:3 year:1988 month:04 pages:247-255 extent:9 http://dx.doi.org/10.1007/BF00999534 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 3 1988 4 247-255 9 |
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(DE-627)NLEJ198074425 DE-627 ger DE-627 rakwb eng Determinants of survival after forebrain ischemia in Mongolian gerbils 1988 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Mongolian gerbils were exposed to 15 min of cerebral ischemia. Quantitative histology was used to establish neuronal damage in the CA1, CA2/3, and CA3 sectors of the hippocampus 2 weeks after the insult. Seven moribund animals were sacrificed earlier to examine whether there is a correlation between hippocampal damage and mortality. Surviving animals had a 86.6% loss of CA1 neurons. In the CA2/3 and CA3 sectors 62.7 and 72.6% of the neurons were preserved. Moribund animals had a further dramatic loss of nerve cells in these sectors, to 14.8 and 20.3%, respectively. The reduction of CA2/3 neurons and survival time were correlated. In addition, gerbils which would later become moribund were found to have a significant increase in plasma osmolarity from 319 to 342 mosm/liter and of hematocrit from 47.4 to 53.9 at day 4 after ischemia. Springer Online Journal Archives 1860-2002 Weber, K. oth Baethmann, A. oth Kempski, O. oth in Metabolic brain disease 1986 3(1988) vom: Apr., Seite 247-255 (DE-627)NLEJ188990275 (DE-600)2018067-6 1573-7365 nnns volume:3 year:1988 month:04 pages:247-255 extent:9 http://dx.doi.org/10.1007/BF00999534 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 3 1988 4 247-255 9 |
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(DE-627)NLEJ198074425 DE-627 ger DE-627 rakwb eng Determinants of survival after forebrain ischemia in Mongolian gerbils 1988 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Mongolian gerbils were exposed to 15 min of cerebral ischemia. Quantitative histology was used to establish neuronal damage in the CA1, CA2/3, and CA3 sectors of the hippocampus 2 weeks after the insult. Seven moribund animals were sacrificed earlier to examine whether there is a correlation between hippocampal damage and mortality. Surviving animals had a 86.6% loss of CA1 neurons. In the CA2/3 and CA3 sectors 62.7 and 72.6% of the neurons were preserved. Moribund animals had a further dramatic loss of nerve cells in these sectors, to 14.8 and 20.3%, respectively. The reduction of CA2/3 neurons and survival time were correlated. In addition, gerbils which would later become moribund were found to have a significant increase in plasma osmolarity from 319 to 342 mosm/liter and of hematocrit from 47.4 to 53.9 at day 4 after ischemia. Springer Online Journal Archives 1860-2002 Weber, K. oth Baethmann, A. oth Kempski, O. oth in Metabolic brain disease 1986 3(1988) vom: Apr., Seite 247-255 (DE-627)NLEJ188990275 (DE-600)2018067-6 1573-7365 nnns volume:3 year:1988 month:04 pages:247-255 extent:9 http://dx.doi.org/10.1007/BF00999534 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 3 1988 4 247-255 9 |
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Determinants of survival after forebrain ischemia in Mongolian gerbils |
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Abstract Mongolian gerbils were exposed to 15 min of cerebral ischemia. Quantitative histology was used to establish neuronal damage in the CA1, CA2/3, and CA3 sectors of the hippocampus 2 weeks after the insult. Seven moribund animals were sacrificed earlier to examine whether there is a correlation between hippocampal damage and mortality. Surviving animals had a 86.6% loss of CA1 neurons. In the CA2/3 and CA3 sectors 62.7 and 72.6% of the neurons were preserved. Moribund animals had a further dramatic loss of nerve cells in these sectors, to 14.8 and 20.3%, respectively. The reduction of CA2/3 neurons and survival time were correlated. In addition, gerbils which would later become moribund were found to have a significant increase in plasma osmolarity from 319 to 342 mosm/liter and of hematocrit from 47.4 to 53.9 at day 4 after ischemia. |
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Abstract Mongolian gerbils were exposed to 15 min of cerebral ischemia. Quantitative histology was used to establish neuronal damage in the CA1, CA2/3, and CA3 sectors of the hippocampus 2 weeks after the insult. Seven moribund animals were sacrificed earlier to examine whether there is a correlation between hippocampal damage and mortality. Surviving animals had a 86.6% loss of CA1 neurons. In the CA2/3 and CA3 sectors 62.7 and 72.6% of the neurons were preserved. Moribund animals had a further dramatic loss of nerve cells in these sectors, to 14.8 and 20.3%, respectively. The reduction of CA2/3 neurons and survival time were correlated. In addition, gerbils which would later become moribund were found to have a significant increase in plasma osmolarity from 319 to 342 mosm/liter and of hematocrit from 47.4 to 53.9 at day 4 after ischemia. |
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Abstract Mongolian gerbils were exposed to 15 min of cerebral ischemia. Quantitative histology was used to establish neuronal damage in the CA1, CA2/3, and CA3 sectors of the hippocampus 2 weeks after the insult. Seven moribund animals were sacrificed earlier to examine whether there is a correlation between hippocampal damage and mortality. Surviving animals had a 86.6% loss of CA1 neurons. In the CA2/3 and CA3 sectors 62.7 and 72.6% of the neurons were preserved. Moribund animals had a further dramatic loss of nerve cells in these sectors, to 14.8 and 20.3%, respectively. The reduction of CA2/3 neurons and survival time were correlated. In addition, gerbils which would later become moribund were found to have a significant increase in plasma osmolarity from 319 to 342 mosm/liter and of hematocrit from 47.4 to 53.9 at day 4 after ischemia. |
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