Anti-histone antibodies in subacute sensory neuropathy
Summary We investigated the levels of anti-histone antibodies in the sera of 7 patients with subacute sense neuropathy. IgG antibodies to histones HI and H3 were significantly elevated in 4 of these patients. The ai H1 antibodies reacted mainly with determinants located in the central globular and t...
Ausführliche Beschreibung
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1991 |
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| Umfang: |
5 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Journal of neuro-oncology - 1983, 11(1991) vom: Jan., Seite 71-75 |
| Übergeordnetes Werk: |
volume:11 ; year:1991 ; month:01 ; pages:71-75 ; extent:5 |
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| 520 | |a Summary We investigated the levels of anti-histone antibodies in the sera of 7 patients with subacute sense neuropathy. IgG antibodies to histones HI and H3 were significantly elevated in 4 of these patients. The ai H1 antibodies reacted mainly with determinants located in the central globular and the carboxy-termi domain of the H1 molecule. We also observed reactivity of these sera with histone H1°, a variant founc terminally-differentiated cells such as neurons. This study suggests a potential for histones to serve autoantigens in humorally-mediated paraneoplastic diseases. | ||
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| 700 | 1 | |a Monestier, Marc |4 oth | |
| 700 | 1 | |a Fasy, Thomas M. |4 oth | |
| 700 | 1 | |a Bohm, Lothar |4 oth | |
| 700 | 1 | |a Lieberman, Frank S. |4 oth | |
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(DE-627)NLEJ198181272 DE-627 ger DE-627 rakwb eng Anti-histone antibodies in subacute sensory neuropathy 1991 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We investigated the levels of anti-histone antibodies in the sera of 7 patients with subacute sense neuropathy. IgG antibodies to histones HI and H3 were significantly elevated in 4 of these patients. The ai H1 antibodies reacted mainly with determinants located in the central globular and the carboxy-termi domain of the H1 molecule. We also observed reactivity of these sera with histone H1°, a variant founc terminally-differentiated cells such as neurons. This study suggests a potential for histones to serve autoantigens in humorally-mediated paraneoplastic diseases. Springer Online Journal Archives 1860-2002 Monestier, Marc oth Fasy, Thomas M. oth Bohm, Lothar oth Lieberman, Frank S. oth in Journal of neuro-oncology 1983 11(1991) vom: Jan., Seite 71-75 (DE-627)NLEJ188986960 (DE-600)2007293-4 1573-7373 nnns volume:11 year:1991 month:01 pages:71-75 extent:5 http://dx.doi.org/10.1007/BF00167000 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 11 1991 1 71-75 5 |
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(DE-627)NLEJ198181272 DE-627 ger DE-627 rakwb eng Anti-histone antibodies in subacute sensory neuropathy 1991 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We investigated the levels of anti-histone antibodies in the sera of 7 patients with subacute sense neuropathy. IgG antibodies to histones HI and H3 were significantly elevated in 4 of these patients. The ai H1 antibodies reacted mainly with determinants located in the central globular and the carboxy-termi domain of the H1 molecule. We also observed reactivity of these sera with histone H1°, a variant founc terminally-differentiated cells such as neurons. This study suggests a potential for histones to serve autoantigens in humorally-mediated paraneoplastic diseases. Springer Online Journal Archives 1860-2002 Monestier, Marc oth Fasy, Thomas M. oth Bohm, Lothar oth Lieberman, Frank S. oth in Journal of neuro-oncology 1983 11(1991) vom: Jan., Seite 71-75 (DE-627)NLEJ188986960 (DE-600)2007293-4 1573-7373 nnns volume:11 year:1991 month:01 pages:71-75 extent:5 http://dx.doi.org/10.1007/BF00167000 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 11 1991 1 71-75 5 |
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(DE-627)NLEJ198181272 DE-627 ger DE-627 rakwb eng Anti-histone antibodies in subacute sensory neuropathy 1991 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We investigated the levels of anti-histone antibodies in the sera of 7 patients with subacute sense neuropathy. IgG antibodies to histones HI and H3 were significantly elevated in 4 of these patients. The ai H1 antibodies reacted mainly with determinants located in the central globular and the carboxy-termi domain of the H1 molecule. We also observed reactivity of these sera with histone H1°, a variant founc terminally-differentiated cells such as neurons. This study suggests a potential for histones to serve autoantigens in humorally-mediated paraneoplastic diseases. Springer Online Journal Archives 1860-2002 Monestier, Marc oth Fasy, Thomas M. oth Bohm, Lothar oth Lieberman, Frank S. oth in Journal of neuro-oncology 1983 11(1991) vom: Jan., Seite 71-75 (DE-627)NLEJ188986960 (DE-600)2007293-4 1573-7373 nnns volume:11 year:1991 month:01 pages:71-75 extent:5 http://dx.doi.org/10.1007/BF00167000 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 11 1991 1 71-75 5 |
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(DE-627)NLEJ198181272 DE-627 ger DE-627 rakwb eng Anti-histone antibodies in subacute sensory neuropathy 1991 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We investigated the levels of anti-histone antibodies in the sera of 7 patients with subacute sense neuropathy. IgG antibodies to histones HI and H3 were significantly elevated in 4 of these patients. The ai H1 antibodies reacted mainly with determinants located in the central globular and the carboxy-termi domain of the H1 molecule. We also observed reactivity of these sera with histone H1°, a variant founc terminally-differentiated cells such as neurons. This study suggests a potential for histones to serve autoantigens in humorally-mediated paraneoplastic diseases. Springer Online Journal Archives 1860-2002 Monestier, Marc oth Fasy, Thomas M. oth Bohm, Lothar oth Lieberman, Frank S. oth in Journal of neuro-oncology 1983 11(1991) vom: Jan., Seite 71-75 (DE-627)NLEJ188986960 (DE-600)2007293-4 1573-7373 nnns volume:11 year:1991 month:01 pages:71-75 extent:5 http://dx.doi.org/10.1007/BF00167000 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 11 1991 1 71-75 5 |
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(DE-627)NLEJ198181272 DE-627 ger DE-627 rakwb eng Anti-histone antibodies in subacute sensory neuropathy 1991 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary We investigated the levels of anti-histone antibodies in the sera of 7 patients with subacute sense neuropathy. IgG antibodies to histones HI and H3 were significantly elevated in 4 of these patients. The ai H1 antibodies reacted mainly with determinants located in the central globular and the carboxy-termi domain of the H1 molecule. We also observed reactivity of these sera with histone H1°, a variant founc terminally-differentiated cells such as neurons. This study suggests a potential for histones to serve autoantigens in humorally-mediated paraneoplastic diseases. Springer Online Journal Archives 1860-2002 Monestier, Marc oth Fasy, Thomas M. oth Bohm, Lothar oth Lieberman, Frank S. oth in Journal of neuro-oncology 1983 11(1991) vom: Jan., Seite 71-75 (DE-627)NLEJ188986960 (DE-600)2007293-4 1573-7373 nnns volume:11 year:1991 month:01 pages:71-75 extent:5 http://dx.doi.org/10.1007/BF00167000 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 11 1991 1 71-75 5 |
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Summary We investigated the levels of anti-histone antibodies in the sera of 7 patients with subacute sense neuropathy. IgG antibodies to histones HI and H3 were significantly elevated in 4 of these patients. The ai H1 antibodies reacted mainly with determinants located in the central globular and the carboxy-termi domain of the H1 molecule. We also observed reactivity of these sera with histone H1°, a variant founc terminally-differentiated cells such as neurons. This study suggests a potential for histones to serve autoantigens in humorally-mediated paraneoplastic diseases. |
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Summary We investigated the levels of anti-histone antibodies in the sera of 7 patients with subacute sense neuropathy. IgG antibodies to histones HI and H3 were significantly elevated in 4 of these patients. The ai H1 antibodies reacted mainly with determinants located in the central globular and the carboxy-termi domain of the H1 molecule. We also observed reactivity of these sera with histone H1°, a variant founc terminally-differentiated cells such as neurons. This study suggests a potential for histones to serve autoantigens in humorally-mediated paraneoplastic diseases. |
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Summary We investigated the levels of anti-histone antibodies in the sera of 7 patients with subacute sense neuropathy. IgG antibodies to histones HI and H3 were significantly elevated in 4 of these patients. The ai H1 antibodies reacted mainly with determinants located in the central globular and the carboxy-termi domain of the H1 molecule. We also observed reactivity of these sera with histone H1°, a variant founc terminally-differentiated cells such as neurons. This study suggests a potential for histones to serve autoantigens in humorally-mediated paraneoplastic diseases. |
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