Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions
Abstract The sodium ion dependency of the uptake of (RS)-nipecotic acid into astrocytes in primary cultures has been studied by performing kinetic analysis at different sodium ion concentrations (16–151 mM).V max of the saturable component of the astroglial (RS-nipecotic acid uptake is clearly affec...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1981 |
|---|
| Umfang: |
10 |
|---|
| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
|---|---|
| Übergeordnetes Werk: |
in: Neurochemical research - 1976, 6(1981) vom: März, Seite 257-266 |
| Übergeordnetes Werk: |
volume:6 ; year:1981 ; month:03 ; pages:257-266 ; extent:10 |
| Links: |
|---|
| Katalog-ID: |
NLEJ198255535 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ198255535 | ||
| 003 | DE-627 | ||
| 005 | 20210705234917.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 070527s1981 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)NLEJ198255535 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 245 | 1 | 0 | |a Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions |
| 264 | 1 | |c 1981 | |
| 300 | |a 10 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Abstract The sodium ion dependency of the uptake of (RS)-nipecotic acid into astrocytes in primary cultures has been studied by performing kinetic analysis at different sodium ion concentrations (16–151 mM).V max of the saturable component of the astroglial (RS-nipecotic acid uptake is clearly affected by the sodium ion concentration whereasK m surprisingly remains unaffected. At high (RS)-nipecotic acid concentrations (≧50 μM), uptake rates as a function of the sodium ion concentration were clearly sigmoid. This sigmoid shape was not obvious at lower concentrations of (RS)-nipecotic acid. The calculated Hill coefficients corresponding to all (RS)-nipecotic acid concentrations studied were approximately two. From these results it is concluded that (RS)-nipecotic acid uptake into astrocytes in primary cultures, like astroglical GABA uptake, requires the binding of at least two sodium ions per (RS)-nipecotic acid molecule transported. | ||
| 533 | |f Springer Online Journal Archives 1860-2002 | ||
| 700 | 1 | |a Larsson, O. M. |4 oth | |
| 700 | 1 | |a Schousboe, A. |4 oth | |
| 773 | 0 | 8 | |i in |t Neurochemical research |d 1976 |g 6(1981) vom: März, Seite 257-266 |w (DE-627)NLEJ188985557 |w (DE-600)2018503-0 |x 1573-6903 |7 nnns |
| 773 | 1 | 8 | |g volume:6 |g year:1981 |g month:03 |g pages:257-266 |g extent:10 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/BF00964041 |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-SOJ | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 6 |j 1981 |c 3 |h 257-266 |g 10 | ||
| matchkey_str |
article:15736903:1981----::oprsnewernpctccdngbtasotnutrdsrcts |
|---|---|
| hierarchy_sort_str |
1981 |
| publishDate |
1981 |
| allfields |
(DE-627)NLEJ198255535 DE-627 ger DE-627 rakwb eng Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions 1981 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The sodium ion dependency of the uptake of (RS)-nipecotic acid into astrocytes in primary cultures has been studied by performing kinetic analysis at different sodium ion concentrations (16–151 mM).V max of the saturable component of the astroglial (RS-nipecotic acid uptake is clearly affected by the sodium ion concentration whereasK m surprisingly remains unaffected. At high (RS)-nipecotic acid concentrations (≧50 μM), uptake rates as a function of the sodium ion concentration were clearly sigmoid. This sigmoid shape was not obvious at lower concentrations of (RS)-nipecotic acid. The calculated Hill coefficients corresponding to all (RS)-nipecotic acid concentrations studied were approximately two. From these results it is concluded that (RS)-nipecotic acid uptake into astrocytes in primary cultures, like astroglical GABA uptake, requires the binding of at least two sodium ions per (RS)-nipecotic acid molecule transported. Springer Online Journal Archives 1860-2002 Larsson, O. M. oth Schousboe, A. oth in Neurochemical research 1976 6(1981) vom: März, Seite 257-266 (DE-627)NLEJ188985557 (DE-600)2018503-0 1573-6903 nnns volume:6 year:1981 month:03 pages:257-266 extent:10 http://dx.doi.org/10.1007/BF00964041 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1981 3 257-266 10 |
| spelling |
(DE-627)NLEJ198255535 DE-627 ger DE-627 rakwb eng Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions 1981 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The sodium ion dependency of the uptake of (RS)-nipecotic acid into astrocytes in primary cultures has been studied by performing kinetic analysis at different sodium ion concentrations (16–151 mM).V max of the saturable component of the astroglial (RS-nipecotic acid uptake is clearly affected by the sodium ion concentration whereasK m surprisingly remains unaffected. At high (RS)-nipecotic acid concentrations (≧50 μM), uptake rates as a function of the sodium ion concentration were clearly sigmoid. This sigmoid shape was not obvious at lower concentrations of (RS)-nipecotic acid. The calculated Hill coefficients corresponding to all (RS)-nipecotic acid concentrations studied were approximately two. From these results it is concluded that (RS)-nipecotic acid uptake into astrocytes in primary cultures, like astroglical GABA uptake, requires the binding of at least two sodium ions per (RS)-nipecotic acid molecule transported. Springer Online Journal Archives 1860-2002 Larsson, O. M. oth Schousboe, A. oth in Neurochemical research 1976 6(1981) vom: März, Seite 257-266 (DE-627)NLEJ188985557 (DE-600)2018503-0 1573-6903 nnns volume:6 year:1981 month:03 pages:257-266 extent:10 http://dx.doi.org/10.1007/BF00964041 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1981 3 257-266 10 |
| allfields_unstemmed |
(DE-627)NLEJ198255535 DE-627 ger DE-627 rakwb eng Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions 1981 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The sodium ion dependency of the uptake of (RS)-nipecotic acid into astrocytes in primary cultures has been studied by performing kinetic analysis at different sodium ion concentrations (16–151 mM).V max of the saturable component of the astroglial (RS-nipecotic acid uptake is clearly affected by the sodium ion concentration whereasK m surprisingly remains unaffected. At high (RS)-nipecotic acid concentrations (≧50 μM), uptake rates as a function of the sodium ion concentration were clearly sigmoid. This sigmoid shape was not obvious at lower concentrations of (RS)-nipecotic acid. The calculated Hill coefficients corresponding to all (RS)-nipecotic acid concentrations studied were approximately two. From these results it is concluded that (RS)-nipecotic acid uptake into astrocytes in primary cultures, like astroglical GABA uptake, requires the binding of at least two sodium ions per (RS)-nipecotic acid molecule transported. Springer Online Journal Archives 1860-2002 Larsson, O. M. oth Schousboe, A. oth in Neurochemical research 1976 6(1981) vom: März, Seite 257-266 (DE-627)NLEJ188985557 (DE-600)2018503-0 1573-6903 nnns volume:6 year:1981 month:03 pages:257-266 extent:10 http://dx.doi.org/10.1007/BF00964041 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1981 3 257-266 10 |
| allfieldsGer |
(DE-627)NLEJ198255535 DE-627 ger DE-627 rakwb eng Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions 1981 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The sodium ion dependency of the uptake of (RS)-nipecotic acid into astrocytes in primary cultures has been studied by performing kinetic analysis at different sodium ion concentrations (16–151 mM).V max of the saturable component of the astroglial (RS-nipecotic acid uptake is clearly affected by the sodium ion concentration whereasK m surprisingly remains unaffected. At high (RS)-nipecotic acid concentrations (≧50 μM), uptake rates as a function of the sodium ion concentration were clearly sigmoid. This sigmoid shape was not obvious at lower concentrations of (RS)-nipecotic acid. The calculated Hill coefficients corresponding to all (RS)-nipecotic acid concentrations studied were approximately two. From these results it is concluded that (RS)-nipecotic acid uptake into astrocytes in primary cultures, like astroglical GABA uptake, requires the binding of at least two sodium ions per (RS)-nipecotic acid molecule transported. Springer Online Journal Archives 1860-2002 Larsson, O. M. oth Schousboe, A. oth in Neurochemical research 1976 6(1981) vom: März, Seite 257-266 (DE-627)NLEJ188985557 (DE-600)2018503-0 1573-6903 nnns volume:6 year:1981 month:03 pages:257-266 extent:10 http://dx.doi.org/10.1007/BF00964041 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1981 3 257-266 10 |
| allfieldsSound |
(DE-627)NLEJ198255535 DE-627 ger DE-627 rakwb eng Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions 1981 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The sodium ion dependency of the uptake of (RS)-nipecotic acid into astrocytes in primary cultures has been studied by performing kinetic analysis at different sodium ion concentrations (16–151 mM).V max of the saturable component of the astroglial (RS-nipecotic acid uptake is clearly affected by the sodium ion concentration whereasK m surprisingly remains unaffected. At high (RS)-nipecotic acid concentrations (≧50 μM), uptake rates as a function of the sodium ion concentration were clearly sigmoid. This sigmoid shape was not obvious at lower concentrations of (RS)-nipecotic acid. The calculated Hill coefficients corresponding to all (RS)-nipecotic acid concentrations studied were approximately two. From these results it is concluded that (RS)-nipecotic acid uptake into astrocytes in primary cultures, like astroglical GABA uptake, requires the binding of at least two sodium ions per (RS)-nipecotic acid molecule transported. Springer Online Journal Archives 1860-2002 Larsson, O. M. oth Schousboe, A. oth in Neurochemical research 1976 6(1981) vom: März, Seite 257-266 (DE-627)NLEJ188985557 (DE-600)2018503-0 1573-6903 nnns volume:6 year:1981 month:03 pages:257-266 extent:10 http://dx.doi.org/10.1007/BF00964041 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 6 1981 3 257-266 10 |
| language |
English |
| source |
in Neurochemical research 6(1981) vom: März, Seite 257-266 volume:6 year:1981 month:03 pages:257-266 extent:10 |
| sourceStr |
in Neurochemical research 6(1981) vom: März, Seite 257-266 volume:6 year:1981 month:03 pages:257-266 extent:10 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Neurochemical research |
| authorswithroles_txt_mv |
Larsson, O. M. @@oth@@ Schousboe, A. @@oth@@ |
| publishDateDaySort_date |
1981-03-01T00:00:00Z |
| hierarchy_top_id |
NLEJ188985557 |
| id |
NLEJ198255535 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ198255535</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210705234917.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1981 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ198255535</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1981</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">10</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The sodium ion dependency of the uptake of (RS)-nipecotic acid into astrocytes in primary cultures has been studied by performing kinetic analysis at different sodium ion concentrations (16–151 mM).V max of the saturable component of the astroglial (RS-nipecotic acid uptake is clearly affected by the sodium ion concentration whereasK m surprisingly remains unaffected. At high (RS)-nipecotic acid concentrations (≧50 μM), uptake rates as a function of the sodium ion concentration were clearly sigmoid. This sigmoid shape was not obvious at lower concentrations of (RS)-nipecotic acid. The calculated Hill coefficients corresponding to all (RS)-nipecotic acid concentrations studied were approximately two. From these results it is concluded that (RS)-nipecotic acid uptake into astrocytes in primary cultures, like astroglical GABA uptake, requires the binding of at least two sodium ions per (RS)-nipecotic acid molecule transported.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Larsson, O. M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schousboe, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Neurochemical research</subfield><subfield code="d">1976</subfield><subfield code="g">6(1981) vom: März, Seite 257-266</subfield><subfield code="w">(DE-627)NLEJ188985557</subfield><subfield code="w">(DE-600)2018503-0</subfield><subfield code="x">1573-6903</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:6</subfield><subfield code="g">year:1981</subfield><subfield code="g">month:03</subfield><subfield code="g">pages:257-266</subfield><subfield code="g">extent:10</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00964041</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">6</subfield><subfield code="j">1981</subfield><subfield code="c">3</subfield><subfield code="h">257-266</subfield><subfield code="g">10</subfield></datafield></record></collection>
|
| series2 |
Springer Online Journal Archives 1860-2002 |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ188985557 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| collection |
NL |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1573-6903 |
| topic_title |
Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
o m l om oml a s as |
| hierarchy_parent_title |
Neurochemical research |
| hierarchy_parent_id |
NLEJ188985557 |
| hierarchy_top_title |
Neurochemical research |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ188985557 (DE-600)2018503-0 |
| title |
Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions |
| spellingShingle |
Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions |
| ctrlnum |
(DE-627)NLEJ198255535 |
| title_full |
Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions |
| journal |
Neurochemical research |
| journalStr |
Neurochemical research |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1981 |
| contenttype_str_mv |
zzz |
| container_start_page |
257 |
| container_volume |
6 |
| physical |
10 |
| format_se |
Elektronische Aufsätze |
| title_sort |
comparison between (rs)-nipecotic acid and gaba transport in cultured astrocytes: coupling with two sodium ions |
| title_auth |
Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions |
| abstract |
Abstract The sodium ion dependency of the uptake of (RS)-nipecotic acid into astrocytes in primary cultures has been studied by performing kinetic analysis at different sodium ion concentrations (16–151 mM).V max of the saturable component of the astroglial (RS-nipecotic acid uptake is clearly affected by the sodium ion concentration whereasK m surprisingly remains unaffected. At high (RS)-nipecotic acid concentrations (≧50 μM), uptake rates as a function of the sodium ion concentration were clearly sigmoid. This sigmoid shape was not obvious at lower concentrations of (RS)-nipecotic acid. The calculated Hill coefficients corresponding to all (RS)-nipecotic acid concentrations studied were approximately two. From these results it is concluded that (RS)-nipecotic acid uptake into astrocytes in primary cultures, like astroglical GABA uptake, requires the binding of at least two sodium ions per (RS)-nipecotic acid molecule transported. |
| abstractGer |
Abstract The sodium ion dependency of the uptake of (RS)-nipecotic acid into astrocytes in primary cultures has been studied by performing kinetic analysis at different sodium ion concentrations (16–151 mM).V max of the saturable component of the astroglial (RS-nipecotic acid uptake is clearly affected by the sodium ion concentration whereasK m surprisingly remains unaffected. At high (RS)-nipecotic acid concentrations (≧50 μM), uptake rates as a function of the sodium ion concentration were clearly sigmoid. This sigmoid shape was not obvious at lower concentrations of (RS)-nipecotic acid. The calculated Hill coefficients corresponding to all (RS)-nipecotic acid concentrations studied were approximately two. From these results it is concluded that (RS)-nipecotic acid uptake into astrocytes in primary cultures, like astroglical GABA uptake, requires the binding of at least two sodium ions per (RS)-nipecotic acid molecule transported. |
| abstract_unstemmed |
Abstract The sodium ion dependency of the uptake of (RS)-nipecotic acid into astrocytes in primary cultures has been studied by performing kinetic analysis at different sodium ion concentrations (16–151 mM).V max of the saturable component of the astroglial (RS-nipecotic acid uptake is clearly affected by the sodium ion concentration whereasK m surprisingly remains unaffected. At high (RS)-nipecotic acid concentrations (≧50 μM), uptake rates as a function of the sodium ion concentration were clearly sigmoid. This sigmoid shape was not obvious at lower concentrations of (RS)-nipecotic acid. The calculated Hill coefficients corresponding to all (RS)-nipecotic acid concentrations studied were approximately two. From these results it is concluded that (RS)-nipecotic acid uptake into astrocytes in primary cultures, like astroglical GABA uptake, requires the binding of at least two sodium ions per (RS)-nipecotic acid molecule transported. |
| collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
| title_short |
Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions |
| url |
http://dx.doi.org/10.1007/BF00964041 |
| remote_bool |
true |
| author2 |
Larsson, O. M. Schousboe, A. |
| author2Str |
Larsson, O. M. Schousboe, A. |
| ppnlink |
NLEJ188985557 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth |
| up_date |
2024-07-06T10:54:34.309Z |
| _version_ |
1803826783121833984 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ198255535</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210705234917.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1981 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ198255535</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1981</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">10</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The sodium ion dependency of the uptake of (RS)-nipecotic acid into astrocytes in primary cultures has been studied by performing kinetic analysis at different sodium ion concentrations (16–151 mM).V max of the saturable component of the astroglial (RS-nipecotic acid uptake is clearly affected by the sodium ion concentration whereasK m surprisingly remains unaffected. At high (RS)-nipecotic acid concentrations (≧50 μM), uptake rates as a function of the sodium ion concentration were clearly sigmoid. This sigmoid shape was not obvious at lower concentrations of (RS)-nipecotic acid. The calculated Hill coefficients corresponding to all (RS)-nipecotic acid concentrations studied were approximately two. From these results it is concluded that (RS)-nipecotic acid uptake into astrocytes in primary cultures, like astroglical GABA uptake, requires the binding of at least two sodium ions per (RS)-nipecotic acid molecule transported.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Larsson, O. M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schousboe, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Neurochemical research</subfield><subfield code="d">1976</subfield><subfield code="g">6(1981) vom: März, Seite 257-266</subfield><subfield code="w">(DE-627)NLEJ188985557</subfield><subfield code="w">(DE-600)2018503-0</subfield><subfield code="x">1573-6903</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:6</subfield><subfield code="g">year:1981</subfield><subfield code="g">month:03</subfield><subfield code="g">pages:257-266</subfield><subfield code="g">extent:10</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00964041</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">6</subfield><subfield code="j">1981</subfield><subfield code="c">3</subfield><subfield code="h">257-266</subfield><subfield code="g">10</subfield></datafield></record></collection>
|
| score |
7.399328 |