Pulmonary sarcoidosis: Assessment of disease activity by lung lymphocyte subpopulations
Summary The aim of this study was to determine the value of the destination of T-lymphocyte subpopulations in bronchoalveolar lavage (BAL) fluid for the assessment of disease activity in pulmonary sarcoidosis in comparison with other tests of activity, i.e., lung function tests, angiotensin-converti...
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1983 |
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| Umfang: |
8 |
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Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Journal of molecular medicine - 1922, 61(1983) vom: Juli, Seite 349-356 |
| Übergeordnetes Werk: |
volume:61 ; year:1983 ; month:07 ; pages:349-356 ; extent:8 |
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NLEJ199367221 |
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| 520 | |a Summary The aim of this study was to determine the value of the destination of T-lymphocyte subpopulations in bronchoalveolar lavage (BAL) fluid for the assessment of disease activity in pulmonary sarcoidosis in comparison with other tests of activity, i.e., lung function tests, angiotensin-converting enzyme (ACE), and gallium lung scan. According to clinical and roentgenographic data, 20 patients with biopsy-proven sarcoidosis were classified as having either active (nine patients) or inactive (11 patients) disease. Helper and suppressor T-lymphocyte subsets in BAL were identified by the peroxidase-antiperoxidase method performed on glass slides using murine monoclonal antibodies (OKT 3 for pan T-, OKT 4 for helper, and OKT 8 for suppressor T-lymphocytes). Patients with active sarcoidosis had significantly higher proportions of lung helper cells (90±5% of T-lymphocytes) than did patients with inactive sarcoidosis (65±11%) or control patients (63±7%),P<0.001. The proportion of lung helper cells correlated significantly with vital capacity (r=−0.72,P<0.001), with total lung capacity (r=−0.60,P<0.01), with PaO2 at rest (r=−0.46,P<0.05) and during exercise (r=−0.54,P<0.05), and with CO-diffusing capacity/1 lung volume (r=−0.53,P<0.05). There was, however, no correlation between lung lymphocyte subsets and serum ACE or gallium lung scan, nor between ACE and gallium scan. Although ACE and gallium uptake were higher in active sarcoidosis than in inactive disease, considerable overlap existed between groups, and the difference was not significant. Thus, the proportion of helper cells in BAL fluid appears to be a most useful parameter to assess activity of pulmonary sarcoidosis. | ||
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(DE-627)NLEJ199367221 DE-627 ger DE-627 rakwb eng Pulmonary sarcoidosis: Assessment of disease activity by lung lymphocyte subpopulations 1983 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The aim of this study was to determine the value of the destination of T-lymphocyte subpopulations in bronchoalveolar lavage (BAL) fluid for the assessment of disease activity in pulmonary sarcoidosis in comparison with other tests of activity, i.e., lung function tests, angiotensin-converting enzyme (ACE), and gallium lung scan. According to clinical and roentgenographic data, 20 patients with biopsy-proven sarcoidosis were classified as having either active (nine patients) or inactive (11 patients) disease. Helper and suppressor T-lymphocyte subsets in BAL were identified by the peroxidase-antiperoxidase method performed on glass slides using murine monoclonal antibodies (OKT 3 for pan T-, OKT 4 for helper, and OKT 8 for suppressor T-lymphocytes). Patients with active sarcoidosis had significantly higher proportions of lung helper cells (90±5% of T-lymphocytes) than did patients with inactive sarcoidosis (65±11%) or control patients (63±7%),P<0.001. The proportion of lung helper cells correlated significantly with vital capacity (r=−0.72,P<0.001), with total lung capacity (r=−0.60,P<0.01), with PaO2 at rest (r=−0.46,P<0.05) and during exercise (r=−0.54,P<0.05), and with CO-diffusing capacity/1 lung volume (r=−0.53,P<0.05). There was, however, no correlation between lung lymphocyte subsets and serum ACE or gallium lung scan, nor between ACE and gallium scan. Although ACE and gallium uptake were higher in active sarcoidosis than in inactive disease, considerable overlap existed between groups, and the difference was not significant. Thus, the proportion of helper cells in BAL fluid appears to be a most useful parameter to assess activity of pulmonary sarcoidosis. Springer Online Journal Archives 1860-2002 Costabel, U. oth Bross, K. J. oth Matthys, H. oth in Journal of molecular medicine 1922 61(1983) vom: Juli, Seite 349-356 (DE-627)NLEJ188988254 (DE-600)1462132-0 1432-1440 nnns volume:61 year:1983 month:07 pages:349-356 extent:8 http://dx.doi.org/10.1007/BF01485026 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 61 1983 7 349-356 8 |
| spelling |
(DE-627)NLEJ199367221 DE-627 ger DE-627 rakwb eng Pulmonary sarcoidosis: Assessment of disease activity by lung lymphocyte subpopulations 1983 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The aim of this study was to determine the value of the destination of T-lymphocyte subpopulations in bronchoalveolar lavage (BAL) fluid for the assessment of disease activity in pulmonary sarcoidosis in comparison with other tests of activity, i.e., lung function tests, angiotensin-converting enzyme (ACE), and gallium lung scan. According to clinical and roentgenographic data, 20 patients with biopsy-proven sarcoidosis were classified as having either active (nine patients) or inactive (11 patients) disease. Helper and suppressor T-lymphocyte subsets in BAL were identified by the peroxidase-antiperoxidase method performed on glass slides using murine monoclonal antibodies (OKT 3 for pan T-, OKT 4 for helper, and OKT 8 for suppressor T-lymphocytes). Patients with active sarcoidosis had significantly higher proportions of lung helper cells (90±5% of T-lymphocytes) than did patients with inactive sarcoidosis (65±11%) or control patients (63±7%),P<0.001. The proportion of lung helper cells correlated significantly with vital capacity (r=−0.72,P<0.001), with total lung capacity (r=−0.60,P<0.01), with PaO2 at rest (r=−0.46,P<0.05) and during exercise (r=−0.54,P<0.05), and with CO-diffusing capacity/1 lung volume (r=−0.53,P<0.05). There was, however, no correlation between lung lymphocyte subsets and serum ACE or gallium lung scan, nor between ACE and gallium scan. Although ACE and gallium uptake were higher in active sarcoidosis than in inactive disease, considerable overlap existed between groups, and the difference was not significant. Thus, the proportion of helper cells in BAL fluid appears to be a most useful parameter to assess activity of pulmonary sarcoidosis. Springer Online Journal Archives 1860-2002 Costabel, U. oth Bross, K. J. oth Matthys, H. oth in Journal of molecular medicine 1922 61(1983) vom: Juli, Seite 349-356 (DE-627)NLEJ188988254 (DE-600)1462132-0 1432-1440 nnns volume:61 year:1983 month:07 pages:349-356 extent:8 http://dx.doi.org/10.1007/BF01485026 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 61 1983 7 349-356 8 |
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(DE-627)NLEJ199367221 DE-627 ger DE-627 rakwb eng Pulmonary sarcoidosis: Assessment of disease activity by lung lymphocyte subpopulations 1983 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The aim of this study was to determine the value of the destination of T-lymphocyte subpopulations in bronchoalveolar lavage (BAL) fluid for the assessment of disease activity in pulmonary sarcoidosis in comparison with other tests of activity, i.e., lung function tests, angiotensin-converting enzyme (ACE), and gallium lung scan. According to clinical and roentgenographic data, 20 patients with biopsy-proven sarcoidosis were classified as having either active (nine patients) or inactive (11 patients) disease. Helper and suppressor T-lymphocyte subsets in BAL were identified by the peroxidase-antiperoxidase method performed on glass slides using murine monoclonal antibodies (OKT 3 for pan T-, OKT 4 for helper, and OKT 8 for suppressor T-lymphocytes). Patients with active sarcoidosis had significantly higher proportions of lung helper cells (90±5% of T-lymphocytes) than did patients with inactive sarcoidosis (65±11%) or control patients (63±7%),P<0.001. The proportion of lung helper cells correlated significantly with vital capacity (r=−0.72,P<0.001), with total lung capacity (r=−0.60,P<0.01), with PaO2 at rest (r=−0.46,P<0.05) and during exercise (r=−0.54,P<0.05), and with CO-diffusing capacity/1 lung volume (r=−0.53,P<0.05). There was, however, no correlation between lung lymphocyte subsets and serum ACE or gallium lung scan, nor between ACE and gallium scan. Although ACE and gallium uptake were higher in active sarcoidosis than in inactive disease, considerable overlap existed between groups, and the difference was not significant. Thus, the proportion of helper cells in BAL fluid appears to be a most useful parameter to assess activity of pulmonary sarcoidosis. Springer Online Journal Archives 1860-2002 Costabel, U. oth Bross, K. J. oth Matthys, H. oth in Journal of molecular medicine 1922 61(1983) vom: Juli, Seite 349-356 (DE-627)NLEJ188988254 (DE-600)1462132-0 1432-1440 nnns volume:61 year:1983 month:07 pages:349-356 extent:8 http://dx.doi.org/10.1007/BF01485026 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 61 1983 7 349-356 8 |
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(DE-627)NLEJ199367221 DE-627 ger DE-627 rakwb eng Pulmonary sarcoidosis: Assessment of disease activity by lung lymphocyte subpopulations 1983 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The aim of this study was to determine the value of the destination of T-lymphocyte subpopulations in bronchoalveolar lavage (BAL) fluid for the assessment of disease activity in pulmonary sarcoidosis in comparison with other tests of activity, i.e., lung function tests, angiotensin-converting enzyme (ACE), and gallium lung scan. According to clinical and roentgenographic data, 20 patients with biopsy-proven sarcoidosis were classified as having either active (nine patients) or inactive (11 patients) disease. Helper and suppressor T-lymphocyte subsets in BAL were identified by the peroxidase-antiperoxidase method performed on glass slides using murine monoclonal antibodies (OKT 3 for pan T-, OKT 4 for helper, and OKT 8 for suppressor T-lymphocytes). Patients with active sarcoidosis had significantly higher proportions of lung helper cells (90±5% of T-lymphocytes) than did patients with inactive sarcoidosis (65±11%) or control patients (63±7%),P<0.001. The proportion of lung helper cells correlated significantly with vital capacity (r=−0.72,P<0.001), with total lung capacity (r=−0.60,P<0.01), with PaO2 at rest (r=−0.46,P<0.05) and during exercise (r=−0.54,P<0.05), and with CO-diffusing capacity/1 lung volume (r=−0.53,P<0.05). There was, however, no correlation between lung lymphocyte subsets and serum ACE or gallium lung scan, nor between ACE and gallium scan. Although ACE and gallium uptake were higher in active sarcoidosis than in inactive disease, considerable overlap existed between groups, and the difference was not significant. Thus, the proportion of helper cells in BAL fluid appears to be a most useful parameter to assess activity of pulmonary sarcoidosis. Springer Online Journal Archives 1860-2002 Costabel, U. oth Bross, K. J. oth Matthys, H. oth in Journal of molecular medicine 1922 61(1983) vom: Juli, Seite 349-356 (DE-627)NLEJ188988254 (DE-600)1462132-0 1432-1440 nnns volume:61 year:1983 month:07 pages:349-356 extent:8 http://dx.doi.org/10.1007/BF01485026 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 61 1983 7 349-356 8 |
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(DE-627)NLEJ199367221 DE-627 ger DE-627 rakwb eng Pulmonary sarcoidosis: Assessment of disease activity by lung lymphocyte subpopulations 1983 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The aim of this study was to determine the value of the destination of T-lymphocyte subpopulations in bronchoalveolar lavage (BAL) fluid for the assessment of disease activity in pulmonary sarcoidosis in comparison with other tests of activity, i.e., lung function tests, angiotensin-converting enzyme (ACE), and gallium lung scan. According to clinical and roentgenographic data, 20 patients with biopsy-proven sarcoidosis were classified as having either active (nine patients) or inactive (11 patients) disease. Helper and suppressor T-lymphocyte subsets in BAL were identified by the peroxidase-antiperoxidase method performed on glass slides using murine monoclonal antibodies (OKT 3 for pan T-, OKT 4 for helper, and OKT 8 for suppressor T-lymphocytes). Patients with active sarcoidosis had significantly higher proportions of lung helper cells (90±5% of T-lymphocytes) than did patients with inactive sarcoidosis (65±11%) or control patients (63±7%),P<0.001. The proportion of lung helper cells correlated significantly with vital capacity (r=−0.72,P<0.001), with total lung capacity (r=−0.60,P<0.01), with PaO2 at rest (r=−0.46,P<0.05) and during exercise (r=−0.54,P<0.05), and with CO-diffusing capacity/1 lung volume (r=−0.53,P<0.05). There was, however, no correlation between lung lymphocyte subsets and serum ACE or gallium lung scan, nor between ACE and gallium scan. Although ACE and gallium uptake were higher in active sarcoidosis than in inactive disease, considerable overlap existed between groups, and the difference was not significant. Thus, the proportion of helper cells in BAL fluid appears to be a most useful parameter to assess activity of pulmonary sarcoidosis. Springer Online Journal Archives 1860-2002 Costabel, U. oth Bross, K. J. oth Matthys, H. oth in Journal of molecular medicine 1922 61(1983) vom: Juli, Seite 349-356 (DE-627)NLEJ188988254 (DE-600)1462132-0 1432-1440 nnns volume:61 year:1983 month:07 pages:349-356 extent:8 http://dx.doi.org/10.1007/BF01485026 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 61 1983 7 349-356 8 |
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pulmonary sarcoidosis: assessment of disease activity by lung lymphocyte subpopulations |
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Pulmonary sarcoidosis: Assessment of disease activity by lung lymphocyte subpopulations |
| abstract |
Summary The aim of this study was to determine the value of the destination of T-lymphocyte subpopulations in bronchoalveolar lavage (BAL) fluid for the assessment of disease activity in pulmonary sarcoidosis in comparison with other tests of activity, i.e., lung function tests, angiotensin-converting enzyme (ACE), and gallium lung scan. According to clinical and roentgenographic data, 20 patients with biopsy-proven sarcoidosis were classified as having either active (nine patients) or inactive (11 patients) disease. Helper and suppressor T-lymphocyte subsets in BAL were identified by the peroxidase-antiperoxidase method performed on glass slides using murine monoclonal antibodies (OKT 3 for pan T-, OKT 4 for helper, and OKT 8 for suppressor T-lymphocytes). Patients with active sarcoidosis had significantly higher proportions of lung helper cells (90±5% of T-lymphocytes) than did patients with inactive sarcoidosis (65±11%) or control patients (63±7%),P<0.001. The proportion of lung helper cells correlated significantly with vital capacity (r=−0.72,P<0.001), with total lung capacity (r=−0.60,P<0.01), with PaO2 at rest (r=−0.46,P<0.05) and during exercise (r=−0.54,P<0.05), and with CO-diffusing capacity/1 lung volume (r=−0.53,P<0.05). There was, however, no correlation between lung lymphocyte subsets and serum ACE or gallium lung scan, nor between ACE and gallium scan. Although ACE and gallium uptake were higher in active sarcoidosis than in inactive disease, considerable overlap existed between groups, and the difference was not significant. Thus, the proportion of helper cells in BAL fluid appears to be a most useful parameter to assess activity of pulmonary sarcoidosis. |
| abstractGer |
Summary The aim of this study was to determine the value of the destination of T-lymphocyte subpopulations in bronchoalveolar lavage (BAL) fluid for the assessment of disease activity in pulmonary sarcoidosis in comparison with other tests of activity, i.e., lung function tests, angiotensin-converting enzyme (ACE), and gallium lung scan. According to clinical and roentgenographic data, 20 patients with biopsy-proven sarcoidosis were classified as having either active (nine patients) or inactive (11 patients) disease. Helper and suppressor T-lymphocyte subsets in BAL were identified by the peroxidase-antiperoxidase method performed on glass slides using murine monoclonal antibodies (OKT 3 for pan T-, OKT 4 for helper, and OKT 8 for suppressor T-lymphocytes). Patients with active sarcoidosis had significantly higher proportions of lung helper cells (90±5% of T-lymphocytes) than did patients with inactive sarcoidosis (65±11%) or control patients (63±7%),P<0.001. The proportion of lung helper cells correlated significantly with vital capacity (r=−0.72,P<0.001), with total lung capacity (r=−0.60,P<0.01), with PaO2 at rest (r=−0.46,P<0.05) and during exercise (r=−0.54,P<0.05), and with CO-diffusing capacity/1 lung volume (r=−0.53,P<0.05). There was, however, no correlation between lung lymphocyte subsets and serum ACE or gallium lung scan, nor between ACE and gallium scan. Although ACE and gallium uptake were higher in active sarcoidosis than in inactive disease, considerable overlap existed between groups, and the difference was not significant. Thus, the proportion of helper cells in BAL fluid appears to be a most useful parameter to assess activity of pulmonary sarcoidosis. |
| abstract_unstemmed |
Summary The aim of this study was to determine the value of the destination of T-lymphocyte subpopulations in bronchoalveolar lavage (BAL) fluid for the assessment of disease activity in pulmonary sarcoidosis in comparison with other tests of activity, i.e., lung function tests, angiotensin-converting enzyme (ACE), and gallium lung scan. According to clinical and roentgenographic data, 20 patients with biopsy-proven sarcoidosis were classified as having either active (nine patients) or inactive (11 patients) disease. Helper and suppressor T-lymphocyte subsets in BAL were identified by the peroxidase-antiperoxidase method performed on glass slides using murine monoclonal antibodies (OKT 3 for pan T-, OKT 4 for helper, and OKT 8 for suppressor T-lymphocytes). Patients with active sarcoidosis had significantly higher proportions of lung helper cells (90±5% of T-lymphocytes) than did patients with inactive sarcoidosis (65±11%) or control patients (63±7%),P<0.001. The proportion of lung helper cells correlated significantly with vital capacity (r=−0.72,P<0.001), with total lung capacity (r=−0.60,P<0.01), with PaO2 at rest (r=−0.46,P<0.05) and during exercise (r=−0.54,P<0.05), and with CO-diffusing capacity/1 lung volume (r=−0.53,P<0.05). There was, however, no correlation between lung lymphocyte subsets and serum ACE or gallium lung scan, nor between ACE and gallium scan. Although ACE and gallium uptake were higher in active sarcoidosis than in inactive disease, considerable overlap existed between groups, and the difference was not significant. Thus, the proportion of helper cells in BAL fluid appears to be a most useful parameter to assess activity of pulmonary sarcoidosis. |
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Pulmonary sarcoidosis: Assessment of disease activity by lung lymphocyte subpopulations |
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