Hepatocyte growth factor/scatter factor—Met signaling in tumorigenicity and invasion/metastasis
Abstract Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular processes, this signaling pathway has also been implicated in the generation and m...
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1996 |
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| Umfang: |
9 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Journal of molecular medicine - 1922, 74(1996) vom: Sept., Seite 505-513 |
| Übergeordnetes Werk: |
volume:74 ; year:1996 ; month:09 ; pages:505-513 ; extent:9 |
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| 520 | |a Abstract Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular processes, this signaling pathway has also been implicated in the generation and metastatic spread of tumors. This review discusses in detail several model systems that have been developed to investigate the role of HGF/SF-Met signaling in malignancy and describes additional data regarding the expression of these molecules in human tumors. Collectively the findings support a role for this receptor-ligand pair in human malignancy. | ||
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| 700 | 1 | |a Woude, George F. |4 oth | |
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(DE-627)NLEJ199406782 DE-627 ger DE-627 rakwb eng Hepatocyte growth factor/scatter factor—Met signaling in tumorigenicity and invasion/metastasis 1996 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular processes, this signaling pathway has also been implicated in the generation and metastatic spread of tumors. This review discusses in detail several model systems that have been developed to investigate the role of HGF/SF-Met signaling in malignancy and describes additional data regarding the expression of these molecules in human tumors. Collectively the findings support a role for this receptor-ligand pair in human malignancy. Springer Online Journal Archives 1860-2002 Jeffers, Michael oth Rong, Sing oth Woude, George F. oth in Journal of molecular medicine 1922 74(1996) vom: Sept., Seite 505-513 (DE-627)NLEJ188988254 (DE-600)1462132-0 1432-1440 nnns volume:74 year:1996 month:09 pages:505-513 extent:9 http://dx.doi.org/10.1007/BF00204976 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 74 1996 9 505-513 9 |
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(DE-627)NLEJ199406782 DE-627 ger DE-627 rakwb eng Hepatocyte growth factor/scatter factor—Met signaling in tumorigenicity and invasion/metastasis 1996 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular processes, this signaling pathway has also been implicated in the generation and metastatic spread of tumors. This review discusses in detail several model systems that have been developed to investigate the role of HGF/SF-Met signaling in malignancy and describes additional data regarding the expression of these molecules in human tumors. Collectively the findings support a role for this receptor-ligand pair in human malignancy. Springer Online Journal Archives 1860-2002 Jeffers, Michael oth Rong, Sing oth Woude, George F. oth in Journal of molecular medicine 1922 74(1996) vom: Sept., Seite 505-513 (DE-627)NLEJ188988254 (DE-600)1462132-0 1432-1440 nnns volume:74 year:1996 month:09 pages:505-513 extent:9 http://dx.doi.org/10.1007/BF00204976 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 74 1996 9 505-513 9 |
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(DE-627)NLEJ199406782 DE-627 ger DE-627 rakwb eng Hepatocyte growth factor/scatter factor—Met signaling in tumorigenicity and invasion/metastasis 1996 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular processes, this signaling pathway has also been implicated in the generation and metastatic spread of tumors. This review discusses in detail several model systems that have been developed to investigate the role of HGF/SF-Met signaling in malignancy and describes additional data regarding the expression of these molecules in human tumors. Collectively the findings support a role for this receptor-ligand pair in human malignancy. Springer Online Journal Archives 1860-2002 Jeffers, Michael oth Rong, Sing oth Woude, George F. oth in Journal of molecular medicine 1922 74(1996) vom: Sept., Seite 505-513 (DE-627)NLEJ188988254 (DE-600)1462132-0 1432-1440 nnns volume:74 year:1996 month:09 pages:505-513 extent:9 http://dx.doi.org/10.1007/BF00204976 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 74 1996 9 505-513 9 |
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(DE-627)NLEJ199406782 DE-627 ger DE-627 rakwb eng Hepatocyte growth factor/scatter factor—Met signaling in tumorigenicity and invasion/metastasis 1996 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular processes, this signaling pathway has also been implicated in the generation and metastatic spread of tumors. This review discusses in detail several model systems that have been developed to investigate the role of HGF/SF-Met signaling in malignancy and describes additional data regarding the expression of these molecules in human tumors. Collectively the findings support a role for this receptor-ligand pair in human malignancy. Springer Online Journal Archives 1860-2002 Jeffers, Michael oth Rong, Sing oth Woude, George F. oth in Journal of molecular medicine 1922 74(1996) vom: Sept., Seite 505-513 (DE-627)NLEJ188988254 (DE-600)1462132-0 1432-1440 nnns volume:74 year:1996 month:09 pages:505-513 extent:9 http://dx.doi.org/10.1007/BF00204976 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 74 1996 9 505-513 9 |
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Hepatocyte growth factor/scatter factor—Met signaling in tumorigenicity and invasion/metastasis |
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Abstract Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular processes, this signaling pathway has also been implicated in the generation and metastatic spread of tumors. This review discusses in detail several model systems that have been developed to investigate the role of HGF/SF-Met signaling in malignancy and describes additional data regarding the expression of these molecules in human tumors. Collectively the findings support a role for this receptor-ligand pair in human malignancy. |
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Abstract Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular processes, this signaling pathway has also been implicated in the generation and metastatic spread of tumors. This review discusses in detail several model systems that have been developed to investigate the role of HGF/SF-Met signaling in malignancy and describes additional data regarding the expression of these molecules in human tumors. Collectively the findings support a role for this receptor-ligand pair in human malignancy. |
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Abstract Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular processes, this signaling pathway has also been implicated in the generation and metastatic spread of tumors. This review discusses in detail several model systems that have been developed to investigate the role of HGF/SF-Met signaling in malignancy and describes additional data regarding the expression of these molecules in human tumors. Collectively the findings support a role for this receptor-ligand pair in human malignancy. |
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