Cardiac function and coronary arteriography in asymptomatic Type 1 (insulin-dependent) diabetic patients: Evidence for a specific diabetic heart disease
Summary Cardiac function was examined in 63 asymptomatic Type 1 (insulin-dependent) diabetic patients, aged 30–50 years, using radionuclide ventriculography and exercise electrocardiography to investigate the possible existence of a specific diabetic heart disease. Comparisons were made with 45 age-...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1986 |
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| Umfang: |
7 |
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Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Diabetologia - 1965, 29(1986) vom: Okt., Seite 706-712 |
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volume:29 ; year:1986 ; month:10 ; pages:706-712 ; extent:7 |
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| 245 | 1 | 0 | |a Cardiac function and coronary arteriography in asymptomatic Type 1 (insulin-dependent) diabetic patients: Evidence for a specific diabetic heart disease |
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| 520 | |a Summary Cardiac function was examined in 63 asymptomatic Type 1 (insulin-dependent) diabetic patients, aged 30–50 years, using radionuclide ventriculography and exercise electrocardiography to investigate the possible existence of a specific diabetic heart disease. Comparisons were made with 45 age- and sex-matched non-diabetic controls. Radionuclide ventriculography was performed at rest and during the physiological stresses of isometric exercise, cold-pressor testing and dynamic exercise. Scans were technically satisfactory in 56 of the diabetic patients and 38 of the control subjects. The resting left ventricular ejection fractions and the responses to isometric exercise and cold-pressor testing were similar in the diabetic patients and controls. A smaller rise in the left ventricular ejection fraction during dynamic exercise was observed in male diabetic patients compared with male control subjects (9±1% (mean±SEM) vs 14±1% (p< 0.005)). A similar trend was observed in female diabetic patients, with a rise of 5±1% on dynamic exercise compared with a rise of 8 ± 1 % in the control group. Sixteen diabetic patients (29%) demonstrated an abnormal response to dynamic exercise, and 5 of these had an abnormal exercise electrocardiogram. Cardiac catheterisation and coronary arteriography were performed in eight of these 16 patients, and all 8 had normal coronary arteries. Endomyocardial biopsy revealed arteriolar thickening and interstitial fibrosis in 5 patients, and in 2 patients basement membrane thickening was conspicuous. Thus, in diabetic patients cardiac function may be abnormal without evidence of coronary heart disease, and some patients appear to have the histological changes consistent with a diabetic microangiopathy involving the heart. | ||
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(DE-627)NLEJ199910057 DE-627 ger DE-627 rakwb eng Cardiac function and coronary arteriography in asymptomatic Type 1 (insulin-dependent) diabetic patients: Evidence for a specific diabetic heart disease 1986 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Cardiac function was examined in 63 asymptomatic Type 1 (insulin-dependent) diabetic patients, aged 30–50 years, using radionuclide ventriculography and exercise electrocardiography to investigate the possible existence of a specific diabetic heart disease. Comparisons were made with 45 age- and sex-matched non-diabetic controls. Radionuclide ventriculography was performed at rest and during the physiological stresses of isometric exercise, cold-pressor testing and dynamic exercise. Scans were technically satisfactory in 56 of the diabetic patients and 38 of the control subjects. The resting left ventricular ejection fractions and the responses to isometric exercise and cold-pressor testing were similar in the diabetic patients and controls. A smaller rise in the left ventricular ejection fraction during dynamic exercise was observed in male diabetic patients compared with male control subjects (9±1% (mean±SEM) vs 14±1% (p< 0.005)). A similar trend was observed in female diabetic patients, with a rise of 5±1% on dynamic exercise compared with a rise of 8 ± 1 % in the control group. Sixteen diabetic patients (29%) demonstrated an abnormal response to dynamic exercise, and 5 of these had an abnormal exercise electrocardiogram. Cardiac catheterisation and coronary arteriography were performed in eight of these 16 patients, and all 8 had normal coronary arteries. Endomyocardial biopsy revealed arteriolar thickening and interstitial fibrosis in 5 patients, and in 2 patients basement membrane thickening was conspicuous. Thus, in diabetic patients cardiac function may be abnormal without evidence of coronary heart disease, and some patients appear to have the histological changes consistent with a diabetic microangiopathy involving the heart. Springer Online Journal Archives 1860-2002 Fisher, B. M. oth Gillen, G. oth Lindop, G. B. M. oth Dargie, H. J. oth Frier, B. M. oth in Diabetologia 1965 29(1986) vom: Okt., Seite 706-712 (DE-627)NLEJ188984526 (DE-600)1458993-x 1432-0428 nnns volume:29 year:1986 month:10 pages:706-712 extent:7 http://dx.doi.org/10.1007/BF00870280 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1986 10 706-712 7 |
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(DE-627)NLEJ199910057 DE-627 ger DE-627 rakwb eng Cardiac function and coronary arteriography in asymptomatic Type 1 (insulin-dependent) diabetic patients: Evidence for a specific diabetic heart disease 1986 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Cardiac function was examined in 63 asymptomatic Type 1 (insulin-dependent) diabetic patients, aged 30–50 years, using radionuclide ventriculography and exercise electrocardiography to investigate the possible existence of a specific diabetic heart disease. Comparisons were made with 45 age- and sex-matched non-diabetic controls. Radionuclide ventriculography was performed at rest and during the physiological stresses of isometric exercise, cold-pressor testing and dynamic exercise. Scans were technically satisfactory in 56 of the diabetic patients and 38 of the control subjects. The resting left ventricular ejection fractions and the responses to isometric exercise and cold-pressor testing were similar in the diabetic patients and controls. A smaller rise in the left ventricular ejection fraction during dynamic exercise was observed in male diabetic patients compared with male control subjects (9±1% (mean±SEM) vs 14±1% (p< 0.005)). A similar trend was observed in female diabetic patients, with a rise of 5±1% on dynamic exercise compared with a rise of 8 ± 1 % in the control group. Sixteen diabetic patients (29%) demonstrated an abnormal response to dynamic exercise, and 5 of these had an abnormal exercise electrocardiogram. Cardiac catheterisation and coronary arteriography were performed in eight of these 16 patients, and all 8 had normal coronary arteries. Endomyocardial biopsy revealed arteriolar thickening and interstitial fibrosis in 5 patients, and in 2 patients basement membrane thickening was conspicuous. Thus, in diabetic patients cardiac function may be abnormal without evidence of coronary heart disease, and some patients appear to have the histological changes consistent with a diabetic microangiopathy involving the heart. Springer Online Journal Archives 1860-2002 Fisher, B. M. oth Gillen, G. oth Lindop, G. B. M. oth Dargie, H. J. oth Frier, B. M. oth in Diabetologia 1965 29(1986) vom: Okt., Seite 706-712 (DE-627)NLEJ188984526 (DE-600)1458993-x 1432-0428 nnns volume:29 year:1986 month:10 pages:706-712 extent:7 http://dx.doi.org/10.1007/BF00870280 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1986 10 706-712 7 |
| allfields_unstemmed |
(DE-627)NLEJ199910057 DE-627 ger DE-627 rakwb eng Cardiac function and coronary arteriography in asymptomatic Type 1 (insulin-dependent) diabetic patients: Evidence for a specific diabetic heart disease 1986 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Cardiac function was examined in 63 asymptomatic Type 1 (insulin-dependent) diabetic patients, aged 30–50 years, using radionuclide ventriculography and exercise electrocardiography to investigate the possible existence of a specific diabetic heart disease. Comparisons were made with 45 age- and sex-matched non-diabetic controls. Radionuclide ventriculography was performed at rest and during the physiological stresses of isometric exercise, cold-pressor testing and dynamic exercise. Scans were technically satisfactory in 56 of the diabetic patients and 38 of the control subjects. The resting left ventricular ejection fractions and the responses to isometric exercise and cold-pressor testing were similar in the diabetic patients and controls. A smaller rise in the left ventricular ejection fraction during dynamic exercise was observed in male diabetic patients compared with male control subjects (9±1% (mean±SEM) vs 14±1% (p< 0.005)). A similar trend was observed in female diabetic patients, with a rise of 5±1% on dynamic exercise compared with a rise of 8 ± 1 % in the control group. Sixteen diabetic patients (29%) demonstrated an abnormal response to dynamic exercise, and 5 of these had an abnormal exercise electrocardiogram. Cardiac catheterisation and coronary arteriography were performed in eight of these 16 patients, and all 8 had normal coronary arteries. Endomyocardial biopsy revealed arteriolar thickening and interstitial fibrosis in 5 patients, and in 2 patients basement membrane thickening was conspicuous. Thus, in diabetic patients cardiac function may be abnormal without evidence of coronary heart disease, and some patients appear to have the histological changes consistent with a diabetic microangiopathy involving the heart. Springer Online Journal Archives 1860-2002 Fisher, B. M. oth Gillen, G. oth Lindop, G. B. M. oth Dargie, H. J. oth Frier, B. M. oth in Diabetologia 1965 29(1986) vom: Okt., Seite 706-712 (DE-627)NLEJ188984526 (DE-600)1458993-x 1432-0428 nnns volume:29 year:1986 month:10 pages:706-712 extent:7 http://dx.doi.org/10.1007/BF00870280 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1986 10 706-712 7 |
| allfieldsGer |
(DE-627)NLEJ199910057 DE-627 ger DE-627 rakwb eng Cardiac function and coronary arteriography in asymptomatic Type 1 (insulin-dependent) diabetic patients: Evidence for a specific diabetic heart disease 1986 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Cardiac function was examined in 63 asymptomatic Type 1 (insulin-dependent) diabetic patients, aged 30–50 years, using radionuclide ventriculography and exercise electrocardiography to investigate the possible existence of a specific diabetic heart disease. Comparisons were made with 45 age- and sex-matched non-diabetic controls. Radionuclide ventriculography was performed at rest and during the physiological stresses of isometric exercise, cold-pressor testing and dynamic exercise. Scans were technically satisfactory in 56 of the diabetic patients and 38 of the control subjects. The resting left ventricular ejection fractions and the responses to isometric exercise and cold-pressor testing were similar in the diabetic patients and controls. A smaller rise in the left ventricular ejection fraction during dynamic exercise was observed in male diabetic patients compared with male control subjects (9±1% (mean±SEM) vs 14±1% (p< 0.005)). A similar trend was observed in female diabetic patients, with a rise of 5±1% on dynamic exercise compared with a rise of 8 ± 1 % in the control group. Sixteen diabetic patients (29%) demonstrated an abnormal response to dynamic exercise, and 5 of these had an abnormal exercise electrocardiogram. Cardiac catheterisation and coronary arteriography were performed in eight of these 16 patients, and all 8 had normal coronary arteries. Endomyocardial biopsy revealed arteriolar thickening and interstitial fibrosis in 5 patients, and in 2 patients basement membrane thickening was conspicuous. Thus, in diabetic patients cardiac function may be abnormal without evidence of coronary heart disease, and some patients appear to have the histological changes consistent with a diabetic microangiopathy involving the heart. Springer Online Journal Archives 1860-2002 Fisher, B. M. oth Gillen, G. oth Lindop, G. B. M. oth Dargie, H. J. oth Frier, B. M. oth in Diabetologia 1965 29(1986) vom: Okt., Seite 706-712 (DE-627)NLEJ188984526 (DE-600)1458993-x 1432-0428 nnns volume:29 year:1986 month:10 pages:706-712 extent:7 http://dx.doi.org/10.1007/BF00870280 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1986 10 706-712 7 |
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(DE-627)NLEJ199910057 DE-627 ger DE-627 rakwb eng Cardiac function and coronary arteriography in asymptomatic Type 1 (insulin-dependent) diabetic patients: Evidence for a specific diabetic heart disease 1986 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Cardiac function was examined in 63 asymptomatic Type 1 (insulin-dependent) diabetic patients, aged 30–50 years, using radionuclide ventriculography and exercise electrocardiography to investigate the possible existence of a specific diabetic heart disease. Comparisons were made with 45 age- and sex-matched non-diabetic controls. Radionuclide ventriculography was performed at rest and during the physiological stresses of isometric exercise, cold-pressor testing and dynamic exercise. Scans were technically satisfactory in 56 of the diabetic patients and 38 of the control subjects. The resting left ventricular ejection fractions and the responses to isometric exercise and cold-pressor testing were similar in the diabetic patients and controls. A smaller rise in the left ventricular ejection fraction during dynamic exercise was observed in male diabetic patients compared with male control subjects (9±1% (mean±SEM) vs 14±1% (p< 0.005)). A similar trend was observed in female diabetic patients, with a rise of 5±1% on dynamic exercise compared with a rise of 8 ± 1 % in the control group. Sixteen diabetic patients (29%) demonstrated an abnormal response to dynamic exercise, and 5 of these had an abnormal exercise electrocardiogram. Cardiac catheterisation and coronary arteriography were performed in eight of these 16 patients, and all 8 had normal coronary arteries. Endomyocardial biopsy revealed arteriolar thickening and interstitial fibrosis in 5 patients, and in 2 patients basement membrane thickening was conspicuous. Thus, in diabetic patients cardiac function may be abnormal without evidence of coronary heart disease, and some patients appear to have the histological changes consistent with a diabetic microangiopathy involving the heart. Springer Online Journal Archives 1860-2002 Fisher, B. M. oth Gillen, G. oth Lindop, G. B. M. oth Dargie, H. J. oth Frier, B. M. oth in Diabetologia 1965 29(1986) vom: Okt., Seite 706-712 (DE-627)NLEJ188984526 (DE-600)1458993-x 1432-0428 nnns volume:29 year:1986 month:10 pages:706-712 extent:7 http://dx.doi.org/10.1007/BF00870280 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 29 1986 10 706-712 7 |
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Comparisons were made with 45 age- and sex-matched non-diabetic controls. Radionuclide ventriculography was performed at rest and during the physiological stresses of isometric exercise, cold-pressor testing and dynamic exercise. Scans were technically satisfactory in 56 of the diabetic patients and 38 of the control subjects. The resting left ventricular ejection fractions and the responses to isometric exercise and cold-pressor testing were similar in the diabetic patients and controls. A smaller rise in the left ventricular ejection fraction during dynamic exercise was observed in male diabetic patients compared with male control subjects (9±1% (mean±SEM) vs 14±1% (p< 0.005)). A similar trend was observed in female diabetic patients, with a rise of 5±1% on dynamic exercise compared with a rise of 8 ± 1 % in the control group. Sixteen diabetic patients (29%) demonstrated an abnormal response to dynamic exercise, and 5 of these had an abnormal exercise electrocardiogram. 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cardiac function and coronary arteriography in asymptomatic type 1 (insulin-dependent) diabetic patients: evidence for a specific diabetic heart disease |
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Cardiac function and coronary arteriography in asymptomatic Type 1 (insulin-dependent) diabetic patients: Evidence for a specific diabetic heart disease |
| abstract |
Summary Cardiac function was examined in 63 asymptomatic Type 1 (insulin-dependent) diabetic patients, aged 30–50 years, using radionuclide ventriculography and exercise electrocardiography to investigate the possible existence of a specific diabetic heart disease. Comparisons were made with 45 age- and sex-matched non-diabetic controls. Radionuclide ventriculography was performed at rest and during the physiological stresses of isometric exercise, cold-pressor testing and dynamic exercise. Scans were technically satisfactory in 56 of the diabetic patients and 38 of the control subjects. The resting left ventricular ejection fractions and the responses to isometric exercise and cold-pressor testing were similar in the diabetic patients and controls. A smaller rise in the left ventricular ejection fraction during dynamic exercise was observed in male diabetic patients compared with male control subjects (9±1% (mean±SEM) vs 14±1% (p< 0.005)). A similar trend was observed in female diabetic patients, with a rise of 5±1% on dynamic exercise compared with a rise of 8 ± 1 % in the control group. Sixteen diabetic patients (29%) demonstrated an abnormal response to dynamic exercise, and 5 of these had an abnormal exercise electrocardiogram. Cardiac catheterisation and coronary arteriography were performed in eight of these 16 patients, and all 8 had normal coronary arteries. Endomyocardial biopsy revealed arteriolar thickening and interstitial fibrosis in 5 patients, and in 2 patients basement membrane thickening was conspicuous. Thus, in diabetic patients cardiac function may be abnormal without evidence of coronary heart disease, and some patients appear to have the histological changes consistent with a diabetic microangiopathy involving the heart. |
| abstractGer |
Summary Cardiac function was examined in 63 asymptomatic Type 1 (insulin-dependent) diabetic patients, aged 30–50 years, using radionuclide ventriculography and exercise electrocardiography to investigate the possible existence of a specific diabetic heart disease. Comparisons were made with 45 age- and sex-matched non-diabetic controls. Radionuclide ventriculography was performed at rest and during the physiological stresses of isometric exercise, cold-pressor testing and dynamic exercise. Scans were technically satisfactory in 56 of the diabetic patients and 38 of the control subjects. The resting left ventricular ejection fractions and the responses to isometric exercise and cold-pressor testing were similar in the diabetic patients and controls. A smaller rise in the left ventricular ejection fraction during dynamic exercise was observed in male diabetic patients compared with male control subjects (9±1% (mean±SEM) vs 14±1% (p< 0.005)). A similar trend was observed in female diabetic patients, with a rise of 5±1% on dynamic exercise compared with a rise of 8 ± 1 % in the control group. Sixteen diabetic patients (29%) demonstrated an abnormal response to dynamic exercise, and 5 of these had an abnormal exercise electrocardiogram. Cardiac catheterisation and coronary arteriography were performed in eight of these 16 patients, and all 8 had normal coronary arteries. Endomyocardial biopsy revealed arteriolar thickening and interstitial fibrosis in 5 patients, and in 2 patients basement membrane thickening was conspicuous. Thus, in diabetic patients cardiac function may be abnormal without evidence of coronary heart disease, and some patients appear to have the histological changes consistent with a diabetic microangiopathy involving the heart. |
| abstract_unstemmed |
Summary Cardiac function was examined in 63 asymptomatic Type 1 (insulin-dependent) diabetic patients, aged 30–50 years, using radionuclide ventriculography and exercise electrocardiography to investigate the possible existence of a specific diabetic heart disease. Comparisons were made with 45 age- and sex-matched non-diabetic controls. Radionuclide ventriculography was performed at rest and during the physiological stresses of isometric exercise, cold-pressor testing and dynamic exercise. Scans were technically satisfactory in 56 of the diabetic patients and 38 of the control subjects. The resting left ventricular ejection fractions and the responses to isometric exercise and cold-pressor testing were similar in the diabetic patients and controls. A smaller rise in the left ventricular ejection fraction during dynamic exercise was observed in male diabetic patients compared with male control subjects (9±1% (mean±SEM) vs 14±1% (p< 0.005)). A similar trend was observed in female diabetic patients, with a rise of 5±1% on dynamic exercise compared with a rise of 8 ± 1 % in the control group. Sixteen diabetic patients (29%) demonstrated an abnormal response to dynamic exercise, and 5 of these had an abnormal exercise electrocardiogram. Cardiac catheterisation and coronary arteriography were performed in eight of these 16 patients, and all 8 had normal coronary arteries. Endomyocardial biopsy revealed arteriolar thickening and interstitial fibrosis in 5 patients, and in 2 patients basement membrane thickening was conspicuous. Thus, in diabetic patients cardiac function may be abnormal without evidence of coronary heart disease, and some patients appear to have the histological changes consistent with a diabetic microangiopathy involving the heart. |
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Cardiac function and coronary arteriography in asymptomatic Type 1 (insulin-dependent) diabetic patients: Evidence for a specific diabetic heart disease |
| url |
http://dx.doi.org/10.1007/BF00870280 |
| remote_bool |
true |
| author2 |
Fisher, B. M. Gillen, G. Lindop, G. B. M. Dargie, H. J. Frier, B. M. |
| author2Str |
Fisher, B. M. Gillen, G. Lindop, G. B. M. Dargie, H. J. Frier, B. M. |
| ppnlink |
NLEJ188984526 |
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z |
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false |
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oth oth oth oth oth |
| up_date |
2024-07-06T01:19:01.079Z |
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1803790572407750656 |
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Comparisons were made with 45 age- and sex-matched non-diabetic controls. Radionuclide ventriculography was performed at rest and during the physiological stresses of isometric exercise, cold-pressor testing and dynamic exercise. Scans were technically satisfactory in 56 of the diabetic patients and 38 of the control subjects. The resting left ventricular ejection fractions and the responses to isometric exercise and cold-pressor testing were similar in the diabetic patients and controls. A smaller rise in the left ventricular ejection fraction during dynamic exercise was observed in male diabetic patients compared with male control subjects (9±1% (mean±SEM) vs 14±1% (p< 0.005)). A similar trend was observed in female diabetic patients, with a rise of 5±1% on dynamic exercise compared with a rise of 8 ± 1 % in the control group. Sixteen diabetic patients (29%) demonstrated an abnormal response to dynamic exercise, and 5 of these had an abnormal exercise electrocardiogram. Cardiac catheterisation and coronary arteriography were performed in eight of these 16 patients, and all 8 had normal coronary arteries. Endomyocardial biopsy revealed arteriolar thickening and interstitial fibrosis in 5 patients, and in 2 patients basement membrane thickening was conspicuous. Thus, in diabetic patients cardiac function may be abnormal without evidence of coronary heart disease, and some patients appear to have the histological changes consistent with a diabetic microangiopathy involving the heart.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fisher, B. M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gillen, G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lindop, G. B. 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M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Diabetologia</subfield><subfield code="d">1965</subfield><subfield code="g">29(1986) vom: Okt., Seite 706-712</subfield><subfield code="w">(DE-627)NLEJ188984526</subfield><subfield code="w">(DE-600)1458993-x</subfield><subfield code="x">1432-0428</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:29</subfield><subfield code="g">year:1986</subfield><subfield code="g">month:10</subfield><subfield code="g">pages:706-712</subfield><subfield code="g">extent:7</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00870280</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">29</subfield><subfield code="j">1986</subfield><subfield code="c">10</subfield><subfield code="h">706-712</subfield><subfield code="g">7</subfield></datafield></record></collection>
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7.4012547 |