Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on basal metabolic rate in obese Finns
Summary The polymorphisms in the uncoupling protein 1 (UCP1, A to G) and β 3-adrenergic receptor (β 3-AR, Trp64Arg) genes have been suggested to be associated with an increased tendency to gain weight. We investigated the frequency of the A to G polymorphism of the UCP1 gene and its effect on basal...
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1998 |
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| Umfang: |
5 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Diabetologia - 1965, 41(1998) vom: März, Seite 357-361 |
| Übergeordnetes Werk: |
volume:41 ; year:1998 ; month:03 ; pages:357-361 ; extent:5 |
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NLEJ199943990 |
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| 245 | 1 | 0 | |a Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on basal metabolic rate in obese Finns |
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| 520 | |a Summary The polymorphisms in the uncoupling protein 1 (UCP1, A to G) and β 3-adrenergic receptor (β 3-AR, Trp64Arg) genes have been suggested to be associated with an increased tendency to gain weight. We investigated the frequency of the A to G polymorphism of the UCP1 gene and its effect on basal metabolic rate (BMR) among obese Finns. We also examined the effects of the simultaneous occurrence of the polymorphisms in the UCP1 and β 3-AR genes on BMR. Altogether 170 obese subjects (29 men, 141 women, BMI 34.7 ± 3.8 kg/m2, age 43 ± 8 years, mean ± SD) participated in the study. The A to G substitution of the UCP1 gene was verified by digestion of the PCR product with Bcl I. The frequency of the A to G polymorphism of the UCP1 gene in obese subjects did not differ significantly from the population-based control subjects (5 vs 1 % for homozygotes (GG) and 35 vs 42 % for heterozygotes (AG), p = 0.077, for trend). BMR adjusted for lean body mass, age and sex (adjBMR) was similar among the three UCP1 gene genotypes of obese subjects (AA n = 90, AG n = 72 or GG n = 8). However, the subjects with the polymorphisms in both UCP1 and β 3-AR genes (n = 18) had a 79 kcal/day (95 % CI 30–128) lower adjBMR than the subjects without these polymorphisms (n = 76) (1551 ± 77 vs 1629 ± 141 kcal/day, p = 0.002). Furthermore, adjBMR was 63 kcal/day (95 % CI 7–118 kcal/day) lower in the subjects with both polymorphisms (n = 18) compared with the subjects (n = 14) who had only the polymorphism in the β 3-AR gene (1551 ± 77 vs 1613 ± 76 kcal/day, p = 0.028). The A to G polymorphism of the UCP1 gene did not have an independent effect on BMR, but its simultaneous existence with the Trp64Arg polymorphism of the β 3-AR gene resulted in more lowered BMR than the Trp64Arg polymorphism of β 3-AR gene alone. [Diabetologia (1998) 41: 357–361] | ||
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(DE-627)NLEJ199943990 DE-627 ger DE-627 rakwb eng Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on basal metabolic rate in obese Finns 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The polymorphisms in the uncoupling protein 1 (UCP1, A to G) and β 3-adrenergic receptor (β 3-AR, Trp64Arg) genes have been suggested to be associated with an increased tendency to gain weight. We investigated the frequency of the A to G polymorphism of the UCP1 gene and its effect on basal metabolic rate (BMR) among obese Finns. We also examined the effects of the simultaneous occurrence of the polymorphisms in the UCP1 and β 3-AR genes on BMR. Altogether 170 obese subjects (29 men, 141 women, BMI 34.7 ± 3.8 kg/m2, age 43 ± 8 years, mean ± SD) participated in the study. The A to G substitution of the UCP1 gene was verified by digestion of the PCR product with Bcl I. The frequency of the A to G polymorphism of the UCP1 gene in obese subjects did not differ significantly from the population-based control subjects (5 vs 1 % for homozygotes (GG) and 35 vs 42 % for heterozygotes (AG), p = 0.077, for trend). BMR adjusted for lean body mass, age and sex (adjBMR) was similar among the three UCP1 gene genotypes of obese subjects (AA n = 90, AG n = 72 or GG n = 8). However, the subjects with the polymorphisms in both UCP1 and β 3-AR genes (n = 18) had a 79 kcal/day (95 % CI 30–128) lower adjBMR than the subjects without these polymorphisms (n = 76) (1551 ± 77 vs 1629 ± 141 kcal/day, p = 0.002). Furthermore, adjBMR was 63 kcal/day (95 % CI 7–118 kcal/day) lower in the subjects with both polymorphisms (n = 18) compared with the subjects (n = 14) who had only the polymorphism in the β 3-AR gene (1551 ± 77 vs 1613 ± 76 kcal/day, p = 0.028). The A to G polymorphism of the UCP1 gene did not have an independent effect on BMR, but its simultaneous existence with the Trp64Arg polymorphism of the β 3-AR gene resulted in more lowered BMR than the Trp64Arg polymorphism of β 3-AR gene alone. [Diabetologia (1998) 41: 357–361] Springer Online Journal Archives 1860-2002 Valve, R. oth Heikkinen, S. oth Rissanen, A. oth Laakso, M. oth Uusitupa, M. oth in Diabetologia 1965 41(1998) vom: März, Seite 357-361 (DE-627)NLEJ188984526 (DE-600)1458993-x 1432-0428 nnns volume:41 year:1998 month:03 pages:357-361 extent:5 http://dx.doi.org/10.1007/s001250050915 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 41 1998 3 357-361 5 |
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(DE-627)NLEJ199943990 DE-627 ger DE-627 rakwb eng Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on basal metabolic rate in obese Finns 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The polymorphisms in the uncoupling protein 1 (UCP1, A to G) and β 3-adrenergic receptor (β 3-AR, Trp64Arg) genes have been suggested to be associated with an increased tendency to gain weight. We investigated the frequency of the A to G polymorphism of the UCP1 gene and its effect on basal metabolic rate (BMR) among obese Finns. We also examined the effects of the simultaneous occurrence of the polymorphisms in the UCP1 and β 3-AR genes on BMR. Altogether 170 obese subjects (29 men, 141 women, BMI 34.7 ± 3.8 kg/m2, age 43 ± 8 years, mean ± SD) participated in the study. The A to G substitution of the UCP1 gene was verified by digestion of the PCR product with Bcl I. The frequency of the A to G polymorphism of the UCP1 gene in obese subjects did not differ significantly from the population-based control subjects (5 vs 1 % for homozygotes (GG) and 35 vs 42 % for heterozygotes (AG), p = 0.077, for trend). BMR adjusted for lean body mass, age and sex (adjBMR) was similar among the three UCP1 gene genotypes of obese subjects (AA n = 90, AG n = 72 or GG n = 8). However, the subjects with the polymorphisms in both UCP1 and β 3-AR genes (n = 18) had a 79 kcal/day (95 % CI 30–128) lower adjBMR than the subjects without these polymorphisms (n = 76) (1551 ± 77 vs 1629 ± 141 kcal/day, p = 0.002). Furthermore, adjBMR was 63 kcal/day (95 % CI 7–118 kcal/day) lower in the subjects with both polymorphisms (n = 18) compared with the subjects (n = 14) who had only the polymorphism in the β 3-AR gene (1551 ± 77 vs 1613 ± 76 kcal/day, p = 0.028). The A to G polymorphism of the UCP1 gene did not have an independent effect on BMR, but its simultaneous existence with the Trp64Arg polymorphism of the β 3-AR gene resulted in more lowered BMR than the Trp64Arg polymorphism of β 3-AR gene alone. [Diabetologia (1998) 41: 357–361] Springer Online Journal Archives 1860-2002 Valve, R. oth Heikkinen, S. oth Rissanen, A. oth Laakso, M. oth Uusitupa, M. oth in Diabetologia 1965 41(1998) vom: März, Seite 357-361 (DE-627)NLEJ188984526 (DE-600)1458993-x 1432-0428 nnns volume:41 year:1998 month:03 pages:357-361 extent:5 http://dx.doi.org/10.1007/s001250050915 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 41 1998 3 357-361 5 |
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(DE-627)NLEJ199943990 DE-627 ger DE-627 rakwb eng Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on basal metabolic rate in obese Finns 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The polymorphisms in the uncoupling protein 1 (UCP1, A to G) and β 3-adrenergic receptor (β 3-AR, Trp64Arg) genes have been suggested to be associated with an increased tendency to gain weight. We investigated the frequency of the A to G polymorphism of the UCP1 gene and its effect on basal metabolic rate (BMR) among obese Finns. We also examined the effects of the simultaneous occurrence of the polymorphisms in the UCP1 and β 3-AR genes on BMR. Altogether 170 obese subjects (29 men, 141 women, BMI 34.7 ± 3.8 kg/m2, age 43 ± 8 years, mean ± SD) participated in the study. The A to G substitution of the UCP1 gene was verified by digestion of the PCR product with Bcl I. The frequency of the A to G polymorphism of the UCP1 gene in obese subjects did not differ significantly from the population-based control subjects (5 vs 1 % for homozygotes (GG) and 35 vs 42 % for heterozygotes (AG), p = 0.077, for trend). BMR adjusted for lean body mass, age and sex (adjBMR) was similar among the three UCP1 gene genotypes of obese subjects (AA n = 90, AG n = 72 or GG n = 8). However, the subjects with the polymorphisms in both UCP1 and β 3-AR genes (n = 18) had a 79 kcal/day (95 % CI 30–128) lower adjBMR than the subjects without these polymorphisms (n = 76) (1551 ± 77 vs 1629 ± 141 kcal/day, p = 0.002). Furthermore, adjBMR was 63 kcal/day (95 % CI 7–118 kcal/day) lower in the subjects with both polymorphisms (n = 18) compared with the subjects (n = 14) who had only the polymorphism in the β 3-AR gene (1551 ± 77 vs 1613 ± 76 kcal/day, p = 0.028). The A to G polymorphism of the UCP1 gene did not have an independent effect on BMR, but its simultaneous existence with the Trp64Arg polymorphism of the β 3-AR gene resulted in more lowered BMR than the Trp64Arg polymorphism of β 3-AR gene alone. [Diabetologia (1998) 41: 357–361] Springer Online Journal Archives 1860-2002 Valve, R. oth Heikkinen, S. oth Rissanen, A. oth Laakso, M. oth Uusitupa, M. oth in Diabetologia 1965 41(1998) vom: März, Seite 357-361 (DE-627)NLEJ188984526 (DE-600)1458993-x 1432-0428 nnns volume:41 year:1998 month:03 pages:357-361 extent:5 http://dx.doi.org/10.1007/s001250050915 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 41 1998 3 357-361 5 |
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(DE-627)NLEJ199943990 DE-627 ger DE-627 rakwb eng Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on basal metabolic rate in obese Finns 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The polymorphisms in the uncoupling protein 1 (UCP1, A to G) and β 3-adrenergic receptor (β 3-AR, Trp64Arg) genes have been suggested to be associated with an increased tendency to gain weight. We investigated the frequency of the A to G polymorphism of the UCP1 gene and its effect on basal metabolic rate (BMR) among obese Finns. We also examined the effects of the simultaneous occurrence of the polymorphisms in the UCP1 and β 3-AR genes on BMR. Altogether 170 obese subjects (29 men, 141 women, BMI 34.7 ± 3.8 kg/m2, age 43 ± 8 years, mean ± SD) participated in the study. The A to G substitution of the UCP1 gene was verified by digestion of the PCR product with Bcl I. The frequency of the A to G polymorphism of the UCP1 gene in obese subjects did not differ significantly from the population-based control subjects (5 vs 1 % for homozygotes (GG) and 35 vs 42 % for heterozygotes (AG), p = 0.077, for trend). BMR adjusted for lean body mass, age and sex (adjBMR) was similar among the three UCP1 gene genotypes of obese subjects (AA n = 90, AG n = 72 or GG n = 8). However, the subjects with the polymorphisms in both UCP1 and β 3-AR genes (n = 18) had a 79 kcal/day (95 % CI 30–128) lower adjBMR than the subjects without these polymorphisms (n = 76) (1551 ± 77 vs 1629 ± 141 kcal/day, p = 0.002). Furthermore, adjBMR was 63 kcal/day (95 % CI 7–118 kcal/day) lower in the subjects with both polymorphisms (n = 18) compared with the subjects (n = 14) who had only the polymorphism in the β 3-AR gene (1551 ± 77 vs 1613 ± 76 kcal/day, p = 0.028). The A to G polymorphism of the UCP1 gene did not have an independent effect on BMR, but its simultaneous existence with the Trp64Arg polymorphism of the β 3-AR gene resulted in more lowered BMR than the Trp64Arg polymorphism of β 3-AR gene alone. [Diabetologia (1998) 41: 357–361] Springer Online Journal Archives 1860-2002 Valve, R. oth Heikkinen, S. oth Rissanen, A. oth Laakso, M. oth Uusitupa, M. oth in Diabetologia 1965 41(1998) vom: März, Seite 357-361 (DE-627)NLEJ188984526 (DE-600)1458993-x 1432-0428 nnns volume:41 year:1998 month:03 pages:357-361 extent:5 http://dx.doi.org/10.1007/s001250050915 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 41 1998 3 357-361 5 |
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(DE-627)NLEJ199943990 DE-627 ger DE-627 rakwb eng Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on basal metabolic rate in obese Finns 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary The polymorphisms in the uncoupling protein 1 (UCP1, A to G) and β 3-adrenergic receptor (β 3-AR, Trp64Arg) genes have been suggested to be associated with an increased tendency to gain weight. We investigated the frequency of the A to G polymorphism of the UCP1 gene and its effect on basal metabolic rate (BMR) among obese Finns. We also examined the effects of the simultaneous occurrence of the polymorphisms in the UCP1 and β 3-AR genes on BMR. Altogether 170 obese subjects (29 men, 141 women, BMI 34.7 ± 3.8 kg/m2, age 43 ± 8 years, mean ± SD) participated in the study. The A to G substitution of the UCP1 gene was verified by digestion of the PCR product with Bcl I. The frequency of the A to G polymorphism of the UCP1 gene in obese subjects did not differ significantly from the population-based control subjects (5 vs 1 % for homozygotes (GG) and 35 vs 42 % for heterozygotes (AG), p = 0.077, for trend). BMR adjusted for lean body mass, age and sex (adjBMR) was similar among the three UCP1 gene genotypes of obese subjects (AA n = 90, AG n = 72 or GG n = 8). However, the subjects with the polymorphisms in both UCP1 and β 3-AR genes (n = 18) had a 79 kcal/day (95 % CI 30–128) lower adjBMR than the subjects without these polymorphisms (n = 76) (1551 ± 77 vs 1629 ± 141 kcal/day, p = 0.002). Furthermore, adjBMR was 63 kcal/day (95 % CI 7–118 kcal/day) lower in the subjects with both polymorphisms (n = 18) compared with the subjects (n = 14) who had only the polymorphism in the β 3-AR gene (1551 ± 77 vs 1613 ± 76 kcal/day, p = 0.028). The A to G polymorphism of the UCP1 gene did not have an independent effect on BMR, but its simultaneous existence with the Trp64Arg polymorphism of the β 3-AR gene resulted in more lowered BMR than the Trp64Arg polymorphism of β 3-AR gene alone. [Diabetologia (1998) 41: 357–361] Springer Online Journal Archives 1860-2002 Valve, R. oth Heikkinen, S. oth Rissanen, A. oth Laakso, M. oth Uusitupa, M. oth in Diabetologia 1965 41(1998) vom: März, Seite 357-361 (DE-627)NLEJ188984526 (DE-600)1458993-x 1432-0428 nnns volume:41 year:1998 month:03 pages:357-361 extent:5 http://dx.doi.org/10.1007/s001250050915 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 41 1998 3 357-361 5 |
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We investigated the frequency of the A to G polymorphism of the UCP1 gene and its effect on basal metabolic rate (BMR) among obese Finns. We also examined the effects of the simultaneous occurrence of the polymorphisms in the UCP1 and β 3-AR genes on BMR. Altogether 170 obese subjects (29 men, 141 women, BMI 34.7 ± 3.8 kg/m2, age 43 ± 8 years, mean ± SD) participated in the study. The A to G substitution of the UCP1 gene was verified by digestion of the PCR product with Bcl I. The frequency of the A to G polymorphism of the UCP1 gene in obese subjects did not differ significantly from the population-based control subjects (5 vs 1 % for homozygotes (GG) and 35 vs 42 % for heterozygotes (AG), p = 0.077, for trend). BMR adjusted for lean body mass, age and sex (adjBMR) was similar among the three UCP1 gene genotypes of obese subjects (AA n = 90, AG n = 72 or GG n = 8). 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synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on basal metabolic rate in obese finns |
| title_auth |
Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on basal metabolic rate in obese Finns |
| abstract |
Summary The polymorphisms in the uncoupling protein 1 (UCP1, A to G) and β 3-adrenergic receptor (β 3-AR, Trp64Arg) genes have been suggested to be associated with an increased tendency to gain weight. We investigated the frequency of the A to G polymorphism of the UCP1 gene and its effect on basal metabolic rate (BMR) among obese Finns. We also examined the effects of the simultaneous occurrence of the polymorphisms in the UCP1 and β 3-AR genes on BMR. Altogether 170 obese subjects (29 men, 141 women, BMI 34.7 ± 3.8 kg/m2, age 43 ± 8 years, mean ± SD) participated in the study. The A to G substitution of the UCP1 gene was verified by digestion of the PCR product with Bcl I. The frequency of the A to G polymorphism of the UCP1 gene in obese subjects did not differ significantly from the population-based control subjects (5 vs 1 % for homozygotes (GG) and 35 vs 42 % for heterozygotes (AG), p = 0.077, for trend). BMR adjusted for lean body mass, age and sex (adjBMR) was similar among the three UCP1 gene genotypes of obese subjects (AA n = 90, AG n = 72 or GG n = 8). However, the subjects with the polymorphisms in both UCP1 and β 3-AR genes (n = 18) had a 79 kcal/day (95 % CI 30–128) lower adjBMR than the subjects without these polymorphisms (n = 76) (1551 ± 77 vs 1629 ± 141 kcal/day, p = 0.002). Furthermore, adjBMR was 63 kcal/day (95 % CI 7–118 kcal/day) lower in the subjects with both polymorphisms (n = 18) compared with the subjects (n = 14) who had only the polymorphism in the β 3-AR gene (1551 ± 77 vs 1613 ± 76 kcal/day, p = 0.028). The A to G polymorphism of the UCP1 gene did not have an independent effect on BMR, but its simultaneous existence with the Trp64Arg polymorphism of the β 3-AR gene resulted in more lowered BMR than the Trp64Arg polymorphism of β 3-AR gene alone. [Diabetologia (1998) 41: 357–361] |
| abstractGer |
Summary The polymorphisms in the uncoupling protein 1 (UCP1, A to G) and β 3-adrenergic receptor (β 3-AR, Trp64Arg) genes have been suggested to be associated with an increased tendency to gain weight. We investigated the frequency of the A to G polymorphism of the UCP1 gene and its effect on basal metabolic rate (BMR) among obese Finns. We also examined the effects of the simultaneous occurrence of the polymorphisms in the UCP1 and β 3-AR genes on BMR. Altogether 170 obese subjects (29 men, 141 women, BMI 34.7 ± 3.8 kg/m2, age 43 ± 8 years, mean ± SD) participated in the study. The A to G substitution of the UCP1 gene was verified by digestion of the PCR product with Bcl I. The frequency of the A to G polymorphism of the UCP1 gene in obese subjects did not differ significantly from the population-based control subjects (5 vs 1 % for homozygotes (GG) and 35 vs 42 % for heterozygotes (AG), p = 0.077, for trend). BMR adjusted for lean body mass, age and sex (adjBMR) was similar among the three UCP1 gene genotypes of obese subjects (AA n = 90, AG n = 72 or GG n = 8). However, the subjects with the polymorphisms in both UCP1 and β 3-AR genes (n = 18) had a 79 kcal/day (95 % CI 30–128) lower adjBMR than the subjects without these polymorphisms (n = 76) (1551 ± 77 vs 1629 ± 141 kcal/day, p = 0.002). Furthermore, adjBMR was 63 kcal/day (95 % CI 7–118 kcal/day) lower in the subjects with both polymorphisms (n = 18) compared with the subjects (n = 14) who had only the polymorphism in the β 3-AR gene (1551 ± 77 vs 1613 ± 76 kcal/day, p = 0.028). The A to G polymorphism of the UCP1 gene did not have an independent effect on BMR, but its simultaneous existence with the Trp64Arg polymorphism of the β 3-AR gene resulted in more lowered BMR than the Trp64Arg polymorphism of β 3-AR gene alone. [Diabetologia (1998) 41: 357–361] |
| abstract_unstemmed |
Summary The polymorphisms in the uncoupling protein 1 (UCP1, A to G) and β 3-adrenergic receptor (β 3-AR, Trp64Arg) genes have been suggested to be associated with an increased tendency to gain weight. We investigated the frequency of the A to G polymorphism of the UCP1 gene and its effect on basal metabolic rate (BMR) among obese Finns. We also examined the effects of the simultaneous occurrence of the polymorphisms in the UCP1 and β 3-AR genes on BMR. Altogether 170 obese subjects (29 men, 141 women, BMI 34.7 ± 3.8 kg/m2, age 43 ± 8 years, mean ± SD) participated in the study. The A to G substitution of the UCP1 gene was verified by digestion of the PCR product with Bcl I. The frequency of the A to G polymorphism of the UCP1 gene in obese subjects did not differ significantly from the population-based control subjects (5 vs 1 % for homozygotes (GG) and 35 vs 42 % for heterozygotes (AG), p = 0.077, for trend). BMR adjusted for lean body mass, age and sex (adjBMR) was similar among the three UCP1 gene genotypes of obese subjects (AA n = 90, AG n = 72 or GG n = 8). However, the subjects with the polymorphisms in both UCP1 and β 3-AR genes (n = 18) had a 79 kcal/day (95 % CI 30–128) lower adjBMR than the subjects without these polymorphisms (n = 76) (1551 ± 77 vs 1629 ± 141 kcal/day, p = 0.002). Furthermore, adjBMR was 63 kcal/day (95 % CI 7–118 kcal/day) lower in the subjects with both polymorphisms (n = 18) compared with the subjects (n = 14) who had only the polymorphism in the β 3-AR gene (1551 ± 77 vs 1613 ± 76 kcal/day, p = 0.028). The A to G polymorphism of the UCP1 gene did not have an independent effect on BMR, but its simultaneous existence with the Trp64Arg polymorphism of the β 3-AR gene resulted in more lowered BMR than the Trp64Arg polymorphism of β 3-AR gene alone. [Diabetologia (1998) 41: 357–361] |
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| title_short |
Synergistic effect of polymorphisms in uncoupling protein 1 and β3-adrenergic receptor genes on basal metabolic rate in obese Finns |
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http://dx.doi.org/10.1007/s001250050915 |
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Valve, R. Heikkinen, S. Rissanen, A. Laakso, M. Uusitupa, M. |
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