Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit
Abstract Objective To study the effect of selective digestive tract decontamination by erythromycin-base on the incidence of carriage and infection with MREnterobacteriaceae producing an extended spectrum beta-lactamase (ESB). Design After a 10-week prospective survey to ascertain the baseline incid...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1993 |
|---|
| Umfang: |
6 |
|---|
| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
|---|---|
| Übergeordnetes Werk: |
in: Intensive care medicine - 1975, 19(1993) vom: Apr., Seite 191-196 |
| Übergeordnetes Werk: |
volume:19 ; year:1993 ; month:04 ; pages:191-196 ; extent:6 |
| Links: |
|---|
| Katalog-ID: |
NLEJ199998531 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ199998531 | ||
| 003 | DE-627 | ||
| 005 | 20230506111044.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 070527s1993 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)NLEJ199998531 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 245 | 1 | 0 | |a Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit |
| 264 | 1 | |c 1993 | |
| 300 | |a 6 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Abstract Objective To study the effect of selective digestive tract decontamination by erythromycin-base on the incidence of carriage and infection with MREnterobacteriaceae producing an extended spectrum beta-lactamase (ESB). Design After a 10-week prospective survey to ascertain the baseline incidence in two bays (1 and 3) of the same ICU, bay 1 was compared with bay 3 during a further survey of 6 moths. The patients in bya 1. received erythromycin-base. Setting Two non-contiguous bays, 1 and 3, of 4 beds, in the same polyvalent ICU of a university hospital. Patient Consecutive patients with unit stay longer than 2 days; 34 patients were included during the control period, 43 in bay 1 (decontamination) and 46 in bay 3 (control) during the trial period. Intervention Erythromycin-base, 1 g t.i.d. in powder form administered by gastric tube to patients in bay 1 from admission to discharge. Measurements and results Digestive tract carriage was monitored by cultures of gastric and rectal swab specimens, sampled twice a week.Enterobacteriaceae were isolated on Drigalski agar with incorporated ceftazidime (4 mg/l). In bay 1 there was a decrease in ESB producingEnterobacteriaceae (23% vs 10%,p=0.0004) from rectal swab, especially inK. pneumoniae (15% vs 2%,p=10−5), during the decontamination period in comparison to the control period. During the trial period the only differences observed between bays 1 and 3 were in the gastric samples:K. pneumoniae were less often isolated in bay 1 than in bay 3 (0% vs 3%,p=0.03). Intestinal carriage with multiresistantEnterobacteriaceae occurred in 28% patients in bay 1 and 30% patients in bay 3 during the trial period (p=0.79). Erythromycin-base did not delay the carriage by patients in bay 1 (log rank testp=0.42). Conclusion Erythromycin-base was not effective in preventing digestive tract carriage due toEnterobacteriaceae resistant to third generation cephalosporin by production of chromosomal cephalosporinase. The decrease in isolates containingK. pneumoniae in bay 1 cannot be definitively attributed to erythromycin-base, since the number of this species in bay 3 was low. | ||
| 533 | |f Springer Online Journal Archives 1860-2002 | ||
| 700 | 1 | |a Champs, C. L. |4 oth | |
| 700 | 1 | |a Guelon, D. P. |4 oth | |
| 700 | 1 | |a Garnier, R. M. |4 oth | |
| 700 | 1 | |a Poupart, M. C. |4 oth | |
| 700 | 1 | |a Mansoor, O. Y. |4 oth | |
| 700 | 1 | |a Dissait, F. L. |4 oth | |
| 700 | 1 | |a Sirot, J. L. |4 oth | |
| 773 | 0 | 8 | |i in |t Intensive care medicine |d 1975 |g 19(1993) vom: Apr., Seite 191-196 |w (DE-627)NLEJ188995587 |w (DE-600)1459201-0 |x 1432-1238 |7 nnns |
| 773 | 1 | 8 | |g volume:19 |g year:1993 |g month:04 |g pages:191-196 |g extent:6 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/BF01694769 |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-SOJ | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 19 |j 1993 |c 4 |h 191-196 |g 6 | ||
| matchkey_str |
article:14321238:1993----::eetvdgsieeotmntobeyhoyibsiaoya |
|---|---|
| hierarchy_sort_str |
1993 |
| publishDate |
1993 |
| allfields |
(DE-627)NLEJ199998531 DE-627 ger DE-627 rakwb eng Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit 1993 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Objective To study the effect of selective digestive tract decontamination by erythromycin-base on the incidence of carriage and infection with MREnterobacteriaceae producing an extended spectrum beta-lactamase (ESB). Design After a 10-week prospective survey to ascertain the baseline incidence in two bays (1 and 3) of the same ICU, bay 1 was compared with bay 3 during a further survey of 6 moths. The patients in bya 1. received erythromycin-base. Setting Two non-contiguous bays, 1 and 3, of 4 beds, in the same polyvalent ICU of a university hospital. Patient Consecutive patients with unit stay longer than 2 days; 34 patients were included during the control period, 43 in bay 1 (decontamination) and 46 in bay 3 (control) during the trial period. Intervention Erythromycin-base, 1 g t.i.d. in powder form administered by gastric tube to patients in bay 1 from admission to discharge. Measurements and results Digestive tract carriage was monitored by cultures of gastric and rectal swab specimens, sampled twice a week.Enterobacteriaceae were isolated on Drigalski agar with incorporated ceftazidime (4 mg/l). In bay 1 there was a decrease in ESB producingEnterobacteriaceae (23% vs 10%,p=0.0004) from rectal swab, especially inK. pneumoniae (15% vs 2%,p=10−5), during the decontamination period in comparison to the control period. During the trial period the only differences observed between bays 1 and 3 were in the gastric samples:K. pneumoniae were less often isolated in bay 1 than in bay 3 (0% vs 3%,p=0.03). Intestinal carriage with multiresistantEnterobacteriaceae occurred in 28% patients in bay 1 and 30% patients in bay 3 during the trial period (p=0.79). Erythromycin-base did not delay the carriage by patients in bay 1 (log rank testp=0.42). Conclusion Erythromycin-base was not effective in preventing digestive tract carriage due toEnterobacteriaceae resistant to third generation cephalosporin by production of chromosomal cephalosporinase. The decrease in isolates containingK. pneumoniae in bay 1 cannot be definitively attributed to erythromycin-base, since the number of this species in bay 3 was low. Springer Online Journal Archives 1860-2002 Champs, C. L. oth Guelon, D. P. oth Garnier, R. M. oth Poupart, M. C. oth Mansoor, O. Y. oth Dissait, F. L. oth Sirot, J. L. oth in Intensive care medicine 1975 19(1993) vom: Apr., Seite 191-196 (DE-627)NLEJ188995587 (DE-600)1459201-0 1432-1238 nnns volume:19 year:1993 month:04 pages:191-196 extent:6 http://dx.doi.org/10.1007/BF01694769 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 19 1993 4 191-196 6 |
| spelling |
(DE-627)NLEJ199998531 DE-627 ger DE-627 rakwb eng Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit 1993 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Objective To study the effect of selective digestive tract decontamination by erythromycin-base on the incidence of carriage and infection with MREnterobacteriaceae producing an extended spectrum beta-lactamase (ESB). Design After a 10-week prospective survey to ascertain the baseline incidence in two bays (1 and 3) of the same ICU, bay 1 was compared with bay 3 during a further survey of 6 moths. The patients in bya 1. received erythromycin-base. Setting Two non-contiguous bays, 1 and 3, of 4 beds, in the same polyvalent ICU of a university hospital. Patient Consecutive patients with unit stay longer than 2 days; 34 patients were included during the control period, 43 in bay 1 (decontamination) and 46 in bay 3 (control) during the trial period. Intervention Erythromycin-base, 1 g t.i.d. in powder form administered by gastric tube to patients in bay 1 from admission to discharge. Measurements and results Digestive tract carriage was monitored by cultures of gastric and rectal swab specimens, sampled twice a week.Enterobacteriaceae were isolated on Drigalski agar with incorporated ceftazidime (4 mg/l). In bay 1 there was a decrease in ESB producingEnterobacteriaceae (23% vs 10%,p=0.0004) from rectal swab, especially inK. pneumoniae (15% vs 2%,p=10−5), during the decontamination period in comparison to the control period. During the trial period the only differences observed between bays 1 and 3 were in the gastric samples:K. pneumoniae were less often isolated in bay 1 than in bay 3 (0% vs 3%,p=0.03). Intestinal carriage with multiresistantEnterobacteriaceae occurred in 28% patients in bay 1 and 30% patients in bay 3 during the trial period (p=0.79). Erythromycin-base did not delay the carriage by patients in bay 1 (log rank testp=0.42). Conclusion Erythromycin-base was not effective in preventing digestive tract carriage due toEnterobacteriaceae resistant to third generation cephalosporin by production of chromosomal cephalosporinase. The decrease in isolates containingK. pneumoniae in bay 1 cannot be definitively attributed to erythromycin-base, since the number of this species in bay 3 was low. Springer Online Journal Archives 1860-2002 Champs, C. L. oth Guelon, D. P. oth Garnier, R. M. oth Poupart, M. C. oth Mansoor, O. Y. oth Dissait, F. L. oth Sirot, J. L. oth in Intensive care medicine 1975 19(1993) vom: Apr., Seite 191-196 (DE-627)NLEJ188995587 (DE-600)1459201-0 1432-1238 nnns volume:19 year:1993 month:04 pages:191-196 extent:6 http://dx.doi.org/10.1007/BF01694769 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 19 1993 4 191-196 6 |
| allfields_unstemmed |
(DE-627)NLEJ199998531 DE-627 ger DE-627 rakwb eng Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit 1993 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Objective To study the effect of selective digestive tract decontamination by erythromycin-base on the incidence of carriage and infection with MREnterobacteriaceae producing an extended spectrum beta-lactamase (ESB). Design After a 10-week prospective survey to ascertain the baseline incidence in two bays (1 and 3) of the same ICU, bay 1 was compared with bay 3 during a further survey of 6 moths. The patients in bya 1. received erythromycin-base. Setting Two non-contiguous bays, 1 and 3, of 4 beds, in the same polyvalent ICU of a university hospital. Patient Consecutive patients with unit stay longer than 2 days; 34 patients were included during the control period, 43 in bay 1 (decontamination) and 46 in bay 3 (control) during the trial period. Intervention Erythromycin-base, 1 g t.i.d. in powder form administered by gastric tube to patients in bay 1 from admission to discharge. Measurements and results Digestive tract carriage was monitored by cultures of gastric and rectal swab specimens, sampled twice a week.Enterobacteriaceae were isolated on Drigalski agar with incorporated ceftazidime (4 mg/l). In bay 1 there was a decrease in ESB producingEnterobacteriaceae (23% vs 10%,p=0.0004) from rectal swab, especially inK. pneumoniae (15% vs 2%,p=10−5), during the decontamination period in comparison to the control period. During the trial period the only differences observed between bays 1 and 3 were in the gastric samples:K. pneumoniae were less often isolated in bay 1 than in bay 3 (0% vs 3%,p=0.03). Intestinal carriage with multiresistantEnterobacteriaceae occurred in 28% patients in bay 1 and 30% patients in bay 3 during the trial period (p=0.79). Erythromycin-base did not delay the carriage by patients in bay 1 (log rank testp=0.42). Conclusion Erythromycin-base was not effective in preventing digestive tract carriage due toEnterobacteriaceae resistant to third generation cephalosporin by production of chromosomal cephalosporinase. The decrease in isolates containingK. pneumoniae in bay 1 cannot be definitively attributed to erythromycin-base, since the number of this species in bay 3 was low. Springer Online Journal Archives 1860-2002 Champs, C. L. oth Guelon, D. P. oth Garnier, R. M. oth Poupart, M. C. oth Mansoor, O. Y. oth Dissait, F. L. oth Sirot, J. L. oth in Intensive care medicine 1975 19(1993) vom: Apr., Seite 191-196 (DE-627)NLEJ188995587 (DE-600)1459201-0 1432-1238 nnns volume:19 year:1993 month:04 pages:191-196 extent:6 http://dx.doi.org/10.1007/BF01694769 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 19 1993 4 191-196 6 |
| allfieldsGer |
(DE-627)NLEJ199998531 DE-627 ger DE-627 rakwb eng Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit 1993 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Objective To study the effect of selective digestive tract decontamination by erythromycin-base on the incidence of carriage and infection with MREnterobacteriaceae producing an extended spectrum beta-lactamase (ESB). Design After a 10-week prospective survey to ascertain the baseline incidence in two bays (1 and 3) of the same ICU, bay 1 was compared with bay 3 during a further survey of 6 moths. The patients in bya 1. received erythromycin-base. Setting Two non-contiguous bays, 1 and 3, of 4 beds, in the same polyvalent ICU of a university hospital. Patient Consecutive patients with unit stay longer than 2 days; 34 patients were included during the control period, 43 in bay 1 (decontamination) and 46 in bay 3 (control) during the trial period. Intervention Erythromycin-base, 1 g t.i.d. in powder form administered by gastric tube to patients in bay 1 from admission to discharge. Measurements and results Digestive tract carriage was monitored by cultures of gastric and rectal swab specimens, sampled twice a week.Enterobacteriaceae were isolated on Drigalski agar with incorporated ceftazidime (4 mg/l). In bay 1 there was a decrease in ESB producingEnterobacteriaceae (23% vs 10%,p=0.0004) from rectal swab, especially inK. pneumoniae (15% vs 2%,p=10−5), during the decontamination period in comparison to the control period. During the trial period the only differences observed between bays 1 and 3 were in the gastric samples:K. pneumoniae were less often isolated in bay 1 than in bay 3 (0% vs 3%,p=0.03). Intestinal carriage with multiresistantEnterobacteriaceae occurred in 28% patients in bay 1 and 30% patients in bay 3 during the trial period (p=0.79). Erythromycin-base did not delay the carriage by patients in bay 1 (log rank testp=0.42). Conclusion Erythromycin-base was not effective in preventing digestive tract carriage due toEnterobacteriaceae resistant to third generation cephalosporin by production of chromosomal cephalosporinase. The decrease in isolates containingK. pneumoniae in bay 1 cannot be definitively attributed to erythromycin-base, since the number of this species in bay 3 was low. Springer Online Journal Archives 1860-2002 Champs, C. L. oth Guelon, D. P. oth Garnier, R. M. oth Poupart, M. C. oth Mansoor, O. Y. oth Dissait, F. L. oth Sirot, J. L. oth in Intensive care medicine 1975 19(1993) vom: Apr., Seite 191-196 (DE-627)NLEJ188995587 (DE-600)1459201-0 1432-1238 nnns volume:19 year:1993 month:04 pages:191-196 extent:6 http://dx.doi.org/10.1007/BF01694769 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 19 1993 4 191-196 6 |
| allfieldsSound |
(DE-627)NLEJ199998531 DE-627 ger DE-627 rakwb eng Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit 1993 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Objective To study the effect of selective digestive tract decontamination by erythromycin-base on the incidence of carriage and infection with MREnterobacteriaceae producing an extended spectrum beta-lactamase (ESB). Design After a 10-week prospective survey to ascertain the baseline incidence in two bays (1 and 3) of the same ICU, bay 1 was compared with bay 3 during a further survey of 6 moths. The patients in bya 1. received erythromycin-base. Setting Two non-contiguous bays, 1 and 3, of 4 beds, in the same polyvalent ICU of a university hospital. Patient Consecutive patients with unit stay longer than 2 days; 34 patients were included during the control period, 43 in bay 1 (decontamination) and 46 in bay 3 (control) during the trial period. Intervention Erythromycin-base, 1 g t.i.d. in powder form administered by gastric tube to patients in bay 1 from admission to discharge. Measurements and results Digestive tract carriage was monitored by cultures of gastric and rectal swab specimens, sampled twice a week.Enterobacteriaceae were isolated on Drigalski agar with incorporated ceftazidime (4 mg/l). In bay 1 there was a decrease in ESB producingEnterobacteriaceae (23% vs 10%,p=0.0004) from rectal swab, especially inK. pneumoniae (15% vs 2%,p=10−5), during the decontamination period in comparison to the control period. During the trial period the only differences observed between bays 1 and 3 were in the gastric samples:K. pneumoniae were less often isolated in bay 1 than in bay 3 (0% vs 3%,p=0.03). Intestinal carriage with multiresistantEnterobacteriaceae occurred in 28% patients in bay 1 and 30% patients in bay 3 during the trial period (p=0.79). Erythromycin-base did not delay the carriage by patients in bay 1 (log rank testp=0.42). Conclusion Erythromycin-base was not effective in preventing digestive tract carriage due toEnterobacteriaceae resistant to third generation cephalosporin by production of chromosomal cephalosporinase. The decrease in isolates containingK. pneumoniae in bay 1 cannot be definitively attributed to erythromycin-base, since the number of this species in bay 3 was low. Springer Online Journal Archives 1860-2002 Champs, C. L. oth Guelon, D. P. oth Garnier, R. M. oth Poupart, M. C. oth Mansoor, O. Y. oth Dissait, F. L. oth Sirot, J. L. oth in Intensive care medicine 1975 19(1993) vom: Apr., Seite 191-196 (DE-627)NLEJ188995587 (DE-600)1459201-0 1432-1238 nnns volume:19 year:1993 month:04 pages:191-196 extent:6 http://dx.doi.org/10.1007/BF01694769 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 19 1993 4 191-196 6 |
| language |
English |
| source |
in Intensive care medicine 19(1993) vom: Apr., Seite 191-196 volume:19 year:1993 month:04 pages:191-196 extent:6 |
| sourceStr |
in Intensive care medicine 19(1993) vom: Apr., Seite 191-196 volume:19 year:1993 month:04 pages:191-196 extent:6 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Intensive care medicine |
| authorswithroles_txt_mv |
Champs, C. L. @@oth@@ Guelon, D. P. @@oth@@ Garnier, R. M. @@oth@@ Poupart, M. C. @@oth@@ Mansoor, O. Y. @@oth@@ Dissait, F. L. @@oth@@ Sirot, J. L. @@oth@@ |
| publishDateDaySort_date |
1993-04-01T00:00:00Z |
| hierarchy_top_id |
NLEJ188995587 |
| id |
NLEJ199998531 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ199998531</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506111044.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1993 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ199998531</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1993</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">6</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Objective To study the effect of selective digestive tract decontamination by erythromycin-base on the incidence of carriage and infection with MREnterobacteriaceae producing an extended spectrum beta-lactamase (ESB). Design After a 10-week prospective survey to ascertain the baseline incidence in two bays (1 and 3) of the same ICU, bay 1 was compared with bay 3 during a further survey of 6 moths. The patients in bya 1. received erythromycin-base. Setting Two non-contiguous bays, 1 and 3, of 4 beds, in the same polyvalent ICU of a university hospital. Patient Consecutive patients with unit stay longer than 2 days; 34 patients were included during the control period, 43 in bay 1 (decontamination) and 46 in bay 3 (control) during the trial period. Intervention Erythromycin-base, 1 g t.i.d. in powder form administered by gastric tube to patients in bay 1 from admission to discharge. Measurements and results Digestive tract carriage was monitored by cultures of gastric and rectal swab specimens, sampled twice a week.Enterobacteriaceae were isolated on Drigalski agar with incorporated ceftazidime (4 mg/l). In bay 1 there was a decrease in ESB producingEnterobacteriaceae (23% vs 10%,p=0.0004) from rectal swab, especially inK. pneumoniae (15% vs 2%,p=10−5), during the decontamination period in comparison to the control period. During the trial period the only differences observed between bays 1 and 3 were in the gastric samples:K. pneumoniae were less often isolated in bay 1 than in bay 3 (0% vs 3%,p=0.03). Intestinal carriage with multiresistantEnterobacteriaceae occurred in 28% patients in bay 1 and 30% patients in bay 3 during the trial period (p=0.79). Erythromycin-base did not delay the carriage by patients in bay 1 (log rank testp=0.42). Conclusion Erythromycin-base was not effective in preventing digestive tract carriage due toEnterobacteriaceae resistant to third generation cephalosporin by production of chromosomal cephalosporinase. The decrease in isolates containingK. pneumoniae in bay 1 cannot be definitively attributed to erythromycin-base, since the number of this species in bay 3 was low.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Champs, C. L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Guelon, D. P.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Garnier, R. M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Poupart, M. C.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mansoor, O. Y.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dissait, F. L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sirot, J. L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Intensive care medicine</subfield><subfield code="d">1975</subfield><subfield code="g">19(1993) vom: Apr., Seite 191-196</subfield><subfield code="w">(DE-627)NLEJ188995587</subfield><subfield code="w">(DE-600)1459201-0</subfield><subfield code="x">1432-1238</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:19</subfield><subfield code="g">year:1993</subfield><subfield code="g">month:04</subfield><subfield code="g">pages:191-196</subfield><subfield code="g">extent:6</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF01694769</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">19</subfield><subfield code="j">1993</subfield><subfield code="c">4</subfield><subfield code="h">191-196</subfield><subfield code="g">6</subfield></datafield></record></collection>
|
| series2 |
Springer Online Journal Archives 1860-2002 |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ188995587 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| collection |
NL |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1432-1238 |
| topic_title |
Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
c l c cl clc d p g dp dpg r m g rm rmg m c p mc mcp o y m oy oym f l d fl fld j l s jl jls |
| hierarchy_parent_title |
Intensive care medicine |
| hierarchy_parent_id |
NLEJ188995587 |
| hierarchy_top_title |
Intensive care medicine |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ188995587 (DE-600)1459201-0 |
| title |
Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit |
| spellingShingle |
Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit |
| ctrlnum |
(DE-627)NLEJ199998531 |
| title_full |
Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit |
| journal |
Intensive care medicine |
| journalStr |
Intensive care medicine |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1993 |
| contenttype_str_mv |
zzz |
| container_start_page |
191 |
| container_volume |
19 |
| physical |
6 |
| format_se |
Elektronische Aufsätze |
| title_sort |
selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit |
| title_auth |
Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit |
| abstract |
Abstract Objective To study the effect of selective digestive tract decontamination by erythromycin-base on the incidence of carriage and infection with MREnterobacteriaceae producing an extended spectrum beta-lactamase (ESB). Design After a 10-week prospective survey to ascertain the baseline incidence in two bays (1 and 3) of the same ICU, bay 1 was compared with bay 3 during a further survey of 6 moths. The patients in bya 1. received erythromycin-base. Setting Two non-contiguous bays, 1 and 3, of 4 beds, in the same polyvalent ICU of a university hospital. Patient Consecutive patients with unit stay longer than 2 days; 34 patients were included during the control period, 43 in bay 1 (decontamination) and 46 in bay 3 (control) during the trial period. Intervention Erythromycin-base, 1 g t.i.d. in powder form administered by gastric tube to patients in bay 1 from admission to discharge. Measurements and results Digestive tract carriage was monitored by cultures of gastric and rectal swab specimens, sampled twice a week.Enterobacteriaceae were isolated on Drigalski agar with incorporated ceftazidime (4 mg/l). In bay 1 there was a decrease in ESB producingEnterobacteriaceae (23% vs 10%,p=0.0004) from rectal swab, especially inK. pneumoniae (15% vs 2%,p=10−5), during the decontamination period in comparison to the control period. During the trial period the only differences observed between bays 1 and 3 were in the gastric samples:K. pneumoniae were less often isolated in bay 1 than in bay 3 (0% vs 3%,p=0.03). Intestinal carriage with multiresistantEnterobacteriaceae occurred in 28% patients in bay 1 and 30% patients in bay 3 during the trial period (p=0.79). Erythromycin-base did not delay the carriage by patients in bay 1 (log rank testp=0.42). Conclusion Erythromycin-base was not effective in preventing digestive tract carriage due toEnterobacteriaceae resistant to third generation cephalosporin by production of chromosomal cephalosporinase. The decrease in isolates containingK. pneumoniae in bay 1 cannot be definitively attributed to erythromycin-base, since the number of this species in bay 3 was low. |
| abstractGer |
Abstract Objective To study the effect of selective digestive tract decontamination by erythromycin-base on the incidence of carriage and infection with MREnterobacteriaceae producing an extended spectrum beta-lactamase (ESB). Design After a 10-week prospective survey to ascertain the baseline incidence in two bays (1 and 3) of the same ICU, bay 1 was compared with bay 3 during a further survey of 6 moths. The patients in bya 1. received erythromycin-base. Setting Two non-contiguous bays, 1 and 3, of 4 beds, in the same polyvalent ICU of a university hospital. Patient Consecutive patients with unit stay longer than 2 days; 34 patients were included during the control period, 43 in bay 1 (decontamination) and 46 in bay 3 (control) during the trial period. Intervention Erythromycin-base, 1 g t.i.d. in powder form administered by gastric tube to patients in bay 1 from admission to discharge. Measurements and results Digestive tract carriage was monitored by cultures of gastric and rectal swab specimens, sampled twice a week.Enterobacteriaceae were isolated on Drigalski agar with incorporated ceftazidime (4 mg/l). In bay 1 there was a decrease in ESB producingEnterobacteriaceae (23% vs 10%,p=0.0004) from rectal swab, especially inK. pneumoniae (15% vs 2%,p=10−5), during the decontamination period in comparison to the control period. During the trial period the only differences observed between bays 1 and 3 were in the gastric samples:K. pneumoniae were less often isolated in bay 1 than in bay 3 (0% vs 3%,p=0.03). Intestinal carriage with multiresistantEnterobacteriaceae occurred in 28% patients in bay 1 and 30% patients in bay 3 during the trial period (p=0.79). Erythromycin-base did not delay the carriage by patients in bay 1 (log rank testp=0.42). Conclusion Erythromycin-base was not effective in preventing digestive tract carriage due toEnterobacteriaceae resistant to third generation cephalosporin by production of chromosomal cephalosporinase. The decrease in isolates containingK. pneumoniae in bay 1 cannot be definitively attributed to erythromycin-base, since the number of this species in bay 3 was low. |
| abstract_unstemmed |
Abstract Objective To study the effect of selective digestive tract decontamination by erythromycin-base on the incidence of carriage and infection with MREnterobacteriaceae producing an extended spectrum beta-lactamase (ESB). Design After a 10-week prospective survey to ascertain the baseline incidence in two bays (1 and 3) of the same ICU, bay 1 was compared with bay 3 during a further survey of 6 moths. The patients in bya 1. received erythromycin-base. Setting Two non-contiguous bays, 1 and 3, of 4 beds, in the same polyvalent ICU of a university hospital. Patient Consecutive patients with unit stay longer than 2 days; 34 patients were included during the control period, 43 in bay 1 (decontamination) and 46 in bay 3 (control) during the trial period. Intervention Erythromycin-base, 1 g t.i.d. in powder form administered by gastric tube to patients in bay 1 from admission to discharge. Measurements and results Digestive tract carriage was monitored by cultures of gastric and rectal swab specimens, sampled twice a week.Enterobacteriaceae were isolated on Drigalski agar with incorporated ceftazidime (4 mg/l). In bay 1 there was a decrease in ESB producingEnterobacteriaceae (23% vs 10%,p=0.0004) from rectal swab, especially inK. pneumoniae (15% vs 2%,p=10−5), during the decontamination period in comparison to the control period. During the trial period the only differences observed between bays 1 and 3 were in the gastric samples:K. pneumoniae were less often isolated in bay 1 than in bay 3 (0% vs 3%,p=0.03). Intestinal carriage with multiresistantEnterobacteriaceae occurred in 28% patients in bay 1 and 30% patients in bay 3 during the trial period (p=0.79). Erythromycin-base did not delay the carriage by patients in bay 1 (log rank testp=0.42). Conclusion Erythromycin-base was not effective in preventing digestive tract carriage due toEnterobacteriaceae resistant to third generation cephalosporin by production of chromosomal cephalosporinase. The decrease in isolates containingK. pneumoniae in bay 1 cannot be definitively attributed to erythromycin-base, since the number of this species in bay 3 was low. |
| collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
| title_short |
Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit |
| url |
http://dx.doi.org/10.1007/BF01694769 |
| remote_bool |
true |
| author2 |
Champs, C. L. Guelon, D. P. Garnier, R. M. Poupart, M. C. Mansoor, O. Y. Dissait, F. L. Sirot, J. L. |
| author2Str |
Champs, C. L. Guelon, D. P. Garnier, R. M. Poupart, M. C. Mansoor, O. Y. Dissait, F. L. Sirot, J. L. |
| ppnlink |
NLEJ188995587 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth oth oth |
| up_date |
2024-07-06T01:38:54.924Z |
| _version_ |
1803791824243916800 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ199998531</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506111044.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1993 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ199998531</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Selective digestive decontamination by erythromycin-base in a polyvalent intensive care unit</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1993</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">6</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Objective To study the effect of selective digestive tract decontamination by erythromycin-base on the incidence of carriage and infection with MREnterobacteriaceae producing an extended spectrum beta-lactamase (ESB). Design After a 10-week prospective survey to ascertain the baseline incidence in two bays (1 and 3) of the same ICU, bay 1 was compared with bay 3 during a further survey of 6 moths. The patients in bya 1. received erythromycin-base. Setting Two non-contiguous bays, 1 and 3, of 4 beds, in the same polyvalent ICU of a university hospital. Patient Consecutive patients with unit stay longer than 2 days; 34 patients were included during the control period, 43 in bay 1 (decontamination) and 46 in bay 3 (control) during the trial period. Intervention Erythromycin-base, 1 g t.i.d. in powder form administered by gastric tube to patients in bay 1 from admission to discharge. Measurements and results Digestive tract carriage was monitored by cultures of gastric and rectal swab specimens, sampled twice a week.Enterobacteriaceae were isolated on Drigalski agar with incorporated ceftazidime (4 mg/l). In bay 1 there was a decrease in ESB producingEnterobacteriaceae (23% vs 10%,p=0.0004) from rectal swab, especially inK. pneumoniae (15% vs 2%,p=10−5), during the decontamination period in comparison to the control period. During the trial period the only differences observed between bays 1 and 3 were in the gastric samples:K. pneumoniae were less often isolated in bay 1 than in bay 3 (0% vs 3%,p=0.03). Intestinal carriage with multiresistantEnterobacteriaceae occurred in 28% patients in bay 1 and 30% patients in bay 3 during the trial period (p=0.79). Erythromycin-base did not delay the carriage by patients in bay 1 (log rank testp=0.42). Conclusion Erythromycin-base was not effective in preventing digestive tract carriage due toEnterobacteriaceae resistant to third generation cephalosporin by production of chromosomal cephalosporinase. The decrease in isolates containingK. pneumoniae in bay 1 cannot be definitively attributed to erythromycin-base, since the number of this species in bay 3 was low.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Champs, C. L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Guelon, D. P.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Garnier, R. M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Poupart, M. C.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mansoor, O. Y.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dissait, F. L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sirot, J. L.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Intensive care medicine</subfield><subfield code="d">1975</subfield><subfield code="g">19(1993) vom: Apr., Seite 191-196</subfield><subfield code="w">(DE-627)NLEJ188995587</subfield><subfield code="w">(DE-600)1459201-0</subfield><subfield code="x">1432-1238</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:19</subfield><subfield code="g">year:1993</subfield><subfield code="g">month:04</subfield><subfield code="g">pages:191-196</subfield><subfield code="g">extent:6</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF01694769</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">19</subfield><subfield code="j">1993</subfield><subfield code="c">4</subfield><subfield code="h">191-196</subfield><subfield code="g">6</subfield></datafield></record></collection>
|
| score |
7.402214 |