Volume-dependent compliance in ARDS: proposal of a new diagnostic concept
Abstract Objective: Adaptation of ventilator settings to the individual's respiratory system mechanics requires information about the pressure-volume relationship and the change of compliance which is dependent on inflated volume. Unfortunately, established methods of obtaining this information...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1999 |
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| Umfang: |
8 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Intensive care medicine - 1975, 25(1999) vom: Okt., Seite 1084-1091 |
| Übergeordnetes Werk: |
volume:25 ; year:1999 ; month:10 ; pages:1084-1091 ; extent:8 |
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NLEJ200017047 |
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| 520 | |a Abstract Objective: Adaptation of ventilator settings to the individual's respiratory system mechanics requires information about the pressure-volume relationship and the change of compliance which is dependent on inflated volume. Unfortunately, established methods of obtaining this information are invasive and time-consuming, and, therefore, not well suited for clinical routine. We propose a new standardized diagnostic concept based on the recently developed slice method. This multiple linear regression method (MLR) determines volume-dependent respiratory system compliance (CSLICE) within the tidal volume (VT) during ongoing mechanical ventilation. The impact of a ventilator strategy, recommended by a consensus conference, on the course of compliance within VT was investigated in patients with the acute respiratory distress syndrome (ARDS) or acute lung injury (ALI).¶Design: Prospective observational study.¶Setting: Intensive care unit of a university hospital.¶Patients: 14 ARDS patients, 2 patients with ALI.¶Interventions: None.¶Measurements and results: After measurement of flow and airway pressure and calculation of tracheal pressure, CSLICE was determined. The resulting course of CSLICE within VT was estimated using a mathematical algorithm. CSLICE data were compared to those obtained by standard MLR. We found decreasing CSLICE mainly in the upper part of VT in all patients. In 7 patients, we found an additional increasing CSLICE mainly in the lower part of VT.¶Conclusions: CSLICE was not constant in patients with ARDS/ALI whose lungs were ventilated according to consensus conference recommendations. The proposed diagnostic concept may serve as a new tool to obtain a standardized estimation of respiratory system compliance within VT non-invasively without interfering with ongoing mechanical ventilation. | ||
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| 700 | 1 | |a Loop, T. |4 oth | |
| 700 | 1 | |a Geiger, K. |4 oth | |
| 700 | 1 | |a Guttmann, J. |4 oth | |
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(DE-627)NLEJ200017047 DE-627 ger DE-627 rakwb eng Volume-dependent compliance in ARDS: proposal of a new diagnostic concept 1999 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Objective: Adaptation of ventilator settings to the individual's respiratory system mechanics requires information about the pressure-volume relationship and the change of compliance which is dependent on inflated volume. Unfortunately, established methods of obtaining this information are invasive and time-consuming, and, therefore, not well suited for clinical routine. We propose a new standardized diagnostic concept based on the recently developed slice method. This multiple linear regression method (MLR) determines volume-dependent respiratory system compliance (CSLICE) within the tidal volume (VT) during ongoing mechanical ventilation. The impact of a ventilator strategy, recommended by a consensus conference, on the course of compliance within VT was investigated in patients with the acute respiratory distress syndrome (ARDS) or acute lung injury (ALI).¶Design: Prospective observational study.¶Setting: Intensive care unit of a university hospital.¶Patients: 14 ARDS patients, 2 patients with ALI.¶Interventions: None.¶Measurements and results: After measurement of flow and airway pressure and calculation of tracheal pressure, CSLICE was determined. The resulting course of CSLICE within VT was estimated using a mathematical algorithm. CSLICE data were compared to those obtained by standard MLR. We found decreasing CSLICE mainly in the upper part of VT in all patients. In 7 patients, we found an additional increasing CSLICE mainly in the lower part of VT.¶Conclusions: CSLICE was not constant in patients with ARDS/ALI whose lungs were ventilated according to consensus conference recommendations. The proposed diagnostic concept may serve as a new tool to obtain a standardized estimation of respiratory system compliance within VT non-invasively without interfering with ongoing mechanical ventilation. Springer Online Journal Archives 1860-2002 Mols, G. oth Brandes, I. oth Kessler, V. oth Lichtwarck-Aschoff, M. oth Loop, T. oth Geiger, K. oth Guttmann, J. oth in Intensive care medicine 1975 25(1999) vom: Okt., Seite 1084-1091 (DE-627)NLEJ188995587 (DE-600)1459201-0 1432-1238 nnns volume:25 year:1999 month:10 pages:1084-1091 extent:8 http://dx.doi.org/10.1007/s001340051016 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 25 1999 10 1084-1091 8 |
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(DE-627)NLEJ200017047 DE-627 ger DE-627 rakwb eng Volume-dependent compliance in ARDS: proposal of a new diagnostic concept 1999 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Objective: Adaptation of ventilator settings to the individual's respiratory system mechanics requires information about the pressure-volume relationship and the change of compliance which is dependent on inflated volume. Unfortunately, established methods of obtaining this information are invasive and time-consuming, and, therefore, not well suited for clinical routine. We propose a new standardized diagnostic concept based on the recently developed slice method. This multiple linear regression method (MLR) determines volume-dependent respiratory system compliance (CSLICE) within the tidal volume (VT) during ongoing mechanical ventilation. The impact of a ventilator strategy, recommended by a consensus conference, on the course of compliance within VT was investigated in patients with the acute respiratory distress syndrome (ARDS) or acute lung injury (ALI).¶Design: Prospective observational study.¶Setting: Intensive care unit of a university hospital.¶Patients: 14 ARDS patients, 2 patients with ALI.¶Interventions: None.¶Measurements and results: After measurement of flow and airway pressure and calculation of tracheal pressure, CSLICE was determined. The resulting course of CSLICE within VT was estimated using a mathematical algorithm. CSLICE data were compared to those obtained by standard MLR. We found decreasing CSLICE mainly in the upper part of VT in all patients. In 7 patients, we found an additional increasing CSLICE mainly in the lower part of VT.¶Conclusions: CSLICE was not constant in patients with ARDS/ALI whose lungs were ventilated according to consensus conference recommendations. The proposed diagnostic concept may serve as a new tool to obtain a standardized estimation of respiratory system compliance within VT non-invasively without interfering with ongoing mechanical ventilation. Springer Online Journal Archives 1860-2002 Mols, G. oth Brandes, I. oth Kessler, V. oth Lichtwarck-Aschoff, M. oth Loop, T. oth Geiger, K. oth Guttmann, J. oth in Intensive care medicine 1975 25(1999) vom: Okt., Seite 1084-1091 (DE-627)NLEJ188995587 (DE-600)1459201-0 1432-1238 nnns volume:25 year:1999 month:10 pages:1084-1091 extent:8 http://dx.doi.org/10.1007/s001340051016 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 25 1999 10 1084-1091 8 |
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(DE-627)NLEJ200017047 DE-627 ger DE-627 rakwb eng Volume-dependent compliance in ARDS: proposal of a new diagnostic concept 1999 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Objective: Adaptation of ventilator settings to the individual's respiratory system mechanics requires information about the pressure-volume relationship and the change of compliance which is dependent on inflated volume. Unfortunately, established methods of obtaining this information are invasive and time-consuming, and, therefore, not well suited for clinical routine. We propose a new standardized diagnostic concept based on the recently developed slice method. This multiple linear regression method (MLR) determines volume-dependent respiratory system compliance (CSLICE) within the tidal volume (VT) during ongoing mechanical ventilation. The impact of a ventilator strategy, recommended by a consensus conference, on the course of compliance within VT was investigated in patients with the acute respiratory distress syndrome (ARDS) or acute lung injury (ALI).¶Design: Prospective observational study.¶Setting: Intensive care unit of a university hospital.¶Patients: 14 ARDS patients, 2 patients with ALI.¶Interventions: None.¶Measurements and results: After measurement of flow and airway pressure and calculation of tracheal pressure, CSLICE was determined. The resulting course of CSLICE within VT was estimated using a mathematical algorithm. CSLICE data were compared to those obtained by standard MLR. We found decreasing CSLICE mainly in the upper part of VT in all patients. In 7 patients, we found an additional increasing CSLICE mainly in the lower part of VT.¶Conclusions: CSLICE was not constant in patients with ARDS/ALI whose lungs were ventilated according to consensus conference recommendations. The proposed diagnostic concept may serve as a new tool to obtain a standardized estimation of respiratory system compliance within VT non-invasively without interfering with ongoing mechanical ventilation. Springer Online Journal Archives 1860-2002 Mols, G. oth Brandes, I. oth Kessler, V. oth Lichtwarck-Aschoff, M. oth Loop, T. oth Geiger, K. oth Guttmann, J. oth in Intensive care medicine 1975 25(1999) vom: Okt., Seite 1084-1091 (DE-627)NLEJ188995587 (DE-600)1459201-0 1432-1238 nnns volume:25 year:1999 month:10 pages:1084-1091 extent:8 http://dx.doi.org/10.1007/s001340051016 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 25 1999 10 1084-1091 8 |
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(DE-627)NLEJ200017047 DE-627 ger DE-627 rakwb eng Volume-dependent compliance in ARDS: proposal of a new diagnostic concept 1999 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Objective: Adaptation of ventilator settings to the individual's respiratory system mechanics requires information about the pressure-volume relationship and the change of compliance which is dependent on inflated volume. Unfortunately, established methods of obtaining this information are invasive and time-consuming, and, therefore, not well suited for clinical routine. We propose a new standardized diagnostic concept based on the recently developed slice method. This multiple linear regression method (MLR) determines volume-dependent respiratory system compliance (CSLICE) within the tidal volume (VT) during ongoing mechanical ventilation. The impact of a ventilator strategy, recommended by a consensus conference, on the course of compliance within VT was investigated in patients with the acute respiratory distress syndrome (ARDS) or acute lung injury (ALI).¶Design: Prospective observational study.¶Setting: Intensive care unit of a university hospital.¶Patients: 14 ARDS patients, 2 patients with ALI.¶Interventions: None.¶Measurements and results: After measurement of flow and airway pressure and calculation of tracheal pressure, CSLICE was determined. The resulting course of CSLICE within VT was estimated using a mathematical algorithm. CSLICE data were compared to those obtained by standard MLR. We found decreasing CSLICE mainly in the upper part of VT in all patients. In 7 patients, we found an additional increasing CSLICE mainly in the lower part of VT.¶Conclusions: CSLICE was not constant in patients with ARDS/ALI whose lungs were ventilated according to consensus conference recommendations. The proposed diagnostic concept may serve as a new tool to obtain a standardized estimation of respiratory system compliance within VT non-invasively without interfering with ongoing mechanical ventilation. Springer Online Journal Archives 1860-2002 Mols, G. oth Brandes, I. oth Kessler, V. oth Lichtwarck-Aschoff, M. oth Loop, T. oth Geiger, K. oth Guttmann, J. oth in Intensive care medicine 1975 25(1999) vom: Okt., Seite 1084-1091 (DE-627)NLEJ188995587 (DE-600)1459201-0 1432-1238 nnns volume:25 year:1999 month:10 pages:1084-1091 extent:8 http://dx.doi.org/10.1007/s001340051016 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 25 1999 10 1084-1091 8 |
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(DE-627)NLEJ200017047 DE-627 ger DE-627 rakwb eng Volume-dependent compliance in ARDS: proposal of a new diagnostic concept 1999 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Objective: Adaptation of ventilator settings to the individual's respiratory system mechanics requires information about the pressure-volume relationship and the change of compliance which is dependent on inflated volume. Unfortunately, established methods of obtaining this information are invasive and time-consuming, and, therefore, not well suited for clinical routine. We propose a new standardized diagnostic concept based on the recently developed slice method. This multiple linear regression method (MLR) determines volume-dependent respiratory system compliance (CSLICE) within the tidal volume (VT) during ongoing mechanical ventilation. The impact of a ventilator strategy, recommended by a consensus conference, on the course of compliance within VT was investigated in patients with the acute respiratory distress syndrome (ARDS) or acute lung injury (ALI).¶Design: Prospective observational study.¶Setting: Intensive care unit of a university hospital.¶Patients: 14 ARDS patients, 2 patients with ALI.¶Interventions: None.¶Measurements and results: After measurement of flow and airway pressure and calculation of tracheal pressure, CSLICE was determined. The resulting course of CSLICE within VT was estimated using a mathematical algorithm. CSLICE data were compared to those obtained by standard MLR. We found decreasing CSLICE mainly in the upper part of VT in all patients. In 7 patients, we found an additional increasing CSLICE mainly in the lower part of VT.¶Conclusions: CSLICE was not constant in patients with ARDS/ALI whose lungs were ventilated according to consensus conference recommendations. The proposed diagnostic concept may serve as a new tool to obtain a standardized estimation of respiratory system compliance within VT non-invasively without interfering with ongoing mechanical ventilation. Springer Online Journal Archives 1860-2002 Mols, G. oth Brandes, I. oth Kessler, V. oth Lichtwarck-Aschoff, M. oth Loop, T. oth Geiger, K. oth Guttmann, J. oth in Intensive care medicine 1975 25(1999) vom: Okt., Seite 1084-1091 (DE-627)NLEJ188995587 (DE-600)1459201-0 1432-1238 nnns volume:25 year:1999 month:10 pages:1084-1091 extent:8 http://dx.doi.org/10.1007/s001340051016 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 25 1999 10 1084-1091 8 |
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Abstract Objective: Adaptation of ventilator settings to the individual's respiratory system mechanics requires information about the pressure-volume relationship and the change of compliance which is dependent on inflated volume. Unfortunately, established methods of obtaining this information are invasive and time-consuming, and, therefore, not well suited for clinical routine. We propose a new standardized diagnostic concept based on the recently developed slice method. This multiple linear regression method (MLR) determines volume-dependent respiratory system compliance (CSLICE) within the tidal volume (VT) during ongoing mechanical ventilation. The impact of a ventilator strategy, recommended by a consensus conference, on the course of compliance within VT was investigated in patients with the acute respiratory distress syndrome (ARDS) or acute lung injury (ALI).¶Design: Prospective observational study.¶Setting: Intensive care unit of a university hospital.¶Patients: 14 ARDS patients, 2 patients with ALI.¶Interventions: None.¶Measurements and results: After measurement of flow and airway pressure and calculation of tracheal pressure, CSLICE was determined. The resulting course of CSLICE within VT was estimated using a mathematical algorithm. CSLICE data were compared to those obtained by standard MLR. We found decreasing CSLICE mainly in the upper part of VT in all patients. In 7 patients, we found an additional increasing CSLICE mainly in the lower part of VT.¶Conclusions: CSLICE was not constant in patients with ARDS/ALI whose lungs were ventilated according to consensus conference recommendations. The proposed diagnostic concept may serve as a new tool to obtain a standardized estimation of respiratory system compliance within VT non-invasively without interfering with ongoing mechanical ventilation. |
| abstractGer |
Abstract Objective: Adaptation of ventilator settings to the individual's respiratory system mechanics requires information about the pressure-volume relationship and the change of compliance which is dependent on inflated volume. Unfortunately, established methods of obtaining this information are invasive and time-consuming, and, therefore, not well suited for clinical routine. We propose a new standardized diagnostic concept based on the recently developed slice method. This multiple linear regression method (MLR) determines volume-dependent respiratory system compliance (CSLICE) within the tidal volume (VT) during ongoing mechanical ventilation. The impact of a ventilator strategy, recommended by a consensus conference, on the course of compliance within VT was investigated in patients with the acute respiratory distress syndrome (ARDS) or acute lung injury (ALI).¶Design: Prospective observational study.¶Setting: Intensive care unit of a university hospital.¶Patients: 14 ARDS patients, 2 patients with ALI.¶Interventions: None.¶Measurements and results: After measurement of flow and airway pressure and calculation of tracheal pressure, CSLICE was determined. The resulting course of CSLICE within VT was estimated using a mathematical algorithm. CSLICE data were compared to those obtained by standard MLR. We found decreasing CSLICE mainly in the upper part of VT in all patients. In 7 patients, we found an additional increasing CSLICE mainly in the lower part of VT.¶Conclusions: CSLICE was not constant in patients with ARDS/ALI whose lungs were ventilated according to consensus conference recommendations. The proposed diagnostic concept may serve as a new tool to obtain a standardized estimation of respiratory system compliance within VT non-invasively without interfering with ongoing mechanical ventilation. |
| abstract_unstemmed |
Abstract Objective: Adaptation of ventilator settings to the individual's respiratory system mechanics requires information about the pressure-volume relationship and the change of compliance which is dependent on inflated volume. Unfortunately, established methods of obtaining this information are invasive and time-consuming, and, therefore, not well suited for clinical routine. We propose a new standardized diagnostic concept based on the recently developed slice method. This multiple linear regression method (MLR) determines volume-dependent respiratory system compliance (CSLICE) within the tidal volume (VT) during ongoing mechanical ventilation. The impact of a ventilator strategy, recommended by a consensus conference, on the course of compliance within VT was investigated in patients with the acute respiratory distress syndrome (ARDS) or acute lung injury (ALI).¶Design: Prospective observational study.¶Setting: Intensive care unit of a university hospital.¶Patients: 14 ARDS patients, 2 patients with ALI.¶Interventions: None.¶Measurements and results: After measurement of flow and airway pressure and calculation of tracheal pressure, CSLICE was determined. The resulting course of CSLICE within VT was estimated using a mathematical algorithm. CSLICE data were compared to those obtained by standard MLR. We found decreasing CSLICE mainly in the upper part of VT in all patients. In 7 patients, we found an additional increasing CSLICE mainly in the lower part of VT.¶Conclusions: CSLICE was not constant in patients with ARDS/ALI whose lungs were ventilated according to consensus conference recommendations. The proposed diagnostic concept may serve as a new tool to obtain a standardized estimation of respiratory system compliance within VT non-invasively without interfering with ongoing mechanical ventilation. |
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Volume-dependent compliance in ARDS: proposal of a new diagnostic concept |
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http://dx.doi.org/10.1007/s001340051016 |
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Mols, G. Brandes, I. Kessler, V. Lichtwarck-Aschoff, M. Loop, T. Geiger, K. Guttmann, J. |
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Mols, G. Brandes, I. Kessler, V. Lichtwarck-Aschoff, M. Loop, T. Geiger, K. Guttmann, J. |
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