Cytomegalovirus infection and disease in renal transplant patients treated with cyclosporin
Abstract In this prospective study, the incidence of cytomegalovirus (CMV) infection and CMV disease was determined in 175 renal transplant recipients on cyclosporin and low-dose prednisone. CMV infection occurred in 51.4% of the patients, CMV disease in 13.7%. The major manifestations of CMV diseas...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1989 |
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| Umfang: |
4 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Transplant international - 1988, 2(1989) vom: Feb., Seite 92-95 |
| Übergeordnetes Werk: |
volume:2 ; year:1989 ; month:02 ; pages:92-95 ; extent:4 |
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NLEJ200041223 |
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| 520 | |a Abstract In this prospective study, the incidence of cytomegalovirus (CMV) infection and CMV disease was determined in 175 renal transplant recipients on cyclosporin and low-dose prednisone. CMV infection occurred in 51.4% of the patients, CMV disease in 13.7%. The major manifestations of CMV disease were fever of unknown origin and leukopenia. In the group with CMV infection, there was an increased occurrence of rejection (60% in infected vs 27% in noninfected patients). In most patients (41/54), the rejection preceded the CMV infection. CMV infection did not lead to a decreased graft survival. There was no close time relationship between the onset of clinical symptoms of CMV disease and the laboratory confirmation of CMV infection. A subgroup of patients at risk for the development of severe CMV disease could not be identified. | ||
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| 700 | 1 | |a Loon, A. M. |4 oth | |
| 700 | 1 | |a Koene, R. A. P. |4 oth | |
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(DE-627)NLEJ200041223 DE-627 ger DE-627 rakwb eng Cytomegalovirus infection and disease in renal transplant patients treated with cyclosporin 1989 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In this prospective study, the incidence of cytomegalovirus (CMV) infection and CMV disease was determined in 175 renal transplant recipients on cyclosporin and low-dose prednisone. CMV infection occurred in 51.4% of the patients, CMV disease in 13.7%. The major manifestations of CMV disease were fever of unknown origin and leukopenia. In the group with CMV infection, there was an increased occurrence of rejection (60% in infected vs 27% in noninfected patients). In most patients (41/54), the rejection preceded the CMV infection. CMV infection did not lead to a decreased graft survival. There was no close time relationship between the onset of clinical symptoms of CMV disease and the laboratory confirmation of CMV infection. A subgroup of patients at risk for the development of severe CMV disease could not be identified. Springer Online Journal Archives 1860-2002 Bosch, F. H. oth Hoitsma, A. J. oth Janssen, H. P. oth Loon, A. M. oth Koene, R. A. P. oth in Transplant international 1988 2(1989) vom: Feb., Seite 92-95 (DE-627)NLEJ188990380 (DE-600)1463183-0 1432-2277 nnns volume:2 year:1989 month:02 pages:92-95 extent:4 http://dx.doi.org/10.1007/BF02459326 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 2 1989 2 92-95 4 |
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(DE-627)NLEJ200041223 DE-627 ger DE-627 rakwb eng Cytomegalovirus infection and disease in renal transplant patients treated with cyclosporin 1989 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In this prospective study, the incidence of cytomegalovirus (CMV) infection and CMV disease was determined in 175 renal transplant recipients on cyclosporin and low-dose prednisone. CMV infection occurred in 51.4% of the patients, CMV disease in 13.7%. The major manifestations of CMV disease were fever of unknown origin and leukopenia. In the group with CMV infection, there was an increased occurrence of rejection (60% in infected vs 27% in noninfected patients). In most patients (41/54), the rejection preceded the CMV infection. CMV infection did not lead to a decreased graft survival. There was no close time relationship between the onset of clinical symptoms of CMV disease and the laboratory confirmation of CMV infection. A subgroup of patients at risk for the development of severe CMV disease could not be identified. Springer Online Journal Archives 1860-2002 Bosch, F. H. oth Hoitsma, A. J. oth Janssen, H. P. oth Loon, A. M. oth Koene, R. A. P. oth in Transplant international 1988 2(1989) vom: Feb., Seite 92-95 (DE-627)NLEJ188990380 (DE-600)1463183-0 1432-2277 nnns volume:2 year:1989 month:02 pages:92-95 extent:4 http://dx.doi.org/10.1007/BF02459326 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 2 1989 2 92-95 4 |
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(DE-627)NLEJ200041223 DE-627 ger DE-627 rakwb eng Cytomegalovirus infection and disease in renal transplant patients treated with cyclosporin 1989 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In this prospective study, the incidence of cytomegalovirus (CMV) infection and CMV disease was determined in 175 renal transplant recipients on cyclosporin and low-dose prednisone. CMV infection occurred in 51.4% of the patients, CMV disease in 13.7%. The major manifestations of CMV disease were fever of unknown origin and leukopenia. In the group with CMV infection, there was an increased occurrence of rejection (60% in infected vs 27% in noninfected patients). In most patients (41/54), the rejection preceded the CMV infection. CMV infection did not lead to a decreased graft survival. There was no close time relationship between the onset of clinical symptoms of CMV disease and the laboratory confirmation of CMV infection. A subgroup of patients at risk for the development of severe CMV disease could not be identified. Springer Online Journal Archives 1860-2002 Bosch, F. H. oth Hoitsma, A. J. oth Janssen, H. P. oth Loon, A. M. oth Koene, R. A. P. oth in Transplant international 1988 2(1989) vom: Feb., Seite 92-95 (DE-627)NLEJ188990380 (DE-600)1463183-0 1432-2277 nnns volume:2 year:1989 month:02 pages:92-95 extent:4 http://dx.doi.org/10.1007/BF02459326 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 2 1989 2 92-95 4 |
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(DE-627)NLEJ200041223 DE-627 ger DE-627 rakwb eng Cytomegalovirus infection and disease in renal transplant patients treated with cyclosporin 1989 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In this prospective study, the incidence of cytomegalovirus (CMV) infection and CMV disease was determined in 175 renal transplant recipients on cyclosporin and low-dose prednisone. CMV infection occurred in 51.4% of the patients, CMV disease in 13.7%. The major manifestations of CMV disease were fever of unknown origin and leukopenia. In the group with CMV infection, there was an increased occurrence of rejection (60% in infected vs 27% in noninfected patients). In most patients (41/54), the rejection preceded the CMV infection. CMV infection did not lead to a decreased graft survival. There was no close time relationship between the onset of clinical symptoms of CMV disease and the laboratory confirmation of CMV infection. A subgroup of patients at risk for the development of severe CMV disease could not be identified. Springer Online Journal Archives 1860-2002 Bosch, F. H. oth Hoitsma, A. J. oth Janssen, H. P. oth Loon, A. M. oth Koene, R. A. P. oth in Transplant international 1988 2(1989) vom: Feb., Seite 92-95 (DE-627)NLEJ188990380 (DE-600)1463183-0 1432-2277 nnns volume:2 year:1989 month:02 pages:92-95 extent:4 http://dx.doi.org/10.1007/BF02459326 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 2 1989 2 92-95 4 |
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(DE-627)NLEJ200041223 DE-627 ger DE-627 rakwb eng Cytomegalovirus infection and disease in renal transplant patients treated with cyclosporin 1989 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract In this prospective study, the incidence of cytomegalovirus (CMV) infection and CMV disease was determined in 175 renal transplant recipients on cyclosporin and low-dose prednisone. CMV infection occurred in 51.4% of the patients, CMV disease in 13.7%. The major manifestations of CMV disease were fever of unknown origin and leukopenia. In the group with CMV infection, there was an increased occurrence of rejection (60% in infected vs 27% in noninfected patients). In most patients (41/54), the rejection preceded the CMV infection. CMV infection did not lead to a decreased graft survival. There was no close time relationship between the onset of clinical symptoms of CMV disease and the laboratory confirmation of CMV infection. A subgroup of patients at risk for the development of severe CMV disease could not be identified. Springer Online Journal Archives 1860-2002 Bosch, F. H. oth Hoitsma, A. J. oth Janssen, H. P. oth Loon, A. M. oth Koene, R. A. P. oth in Transplant international 1988 2(1989) vom: Feb., Seite 92-95 (DE-627)NLEJ188990380 (DE-600)1463183-0 1432-2277 nnns volume:2 year:1989 month:02 pages:92-95 extent:4 http://dx.doi.org/10.1007/BF02459326 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 2 1989 2 92-95 4 |
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cytomegalovirus infection and disease in renal transplant patients treated with cyclosporin |
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Cytomegalovirus infection and disease in renal transplant patients treated with cyclosporin |
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Abstract In this prospective study, the incidence of cytomegalovirus (CMV) infection and CMV disease was determined in 175 renal transplant recipients on cyclosporin and low-dose prednisone. CMV infection occurred in 51.4% of the patients, CMV disease in 13.7%. The major manifestations of CMV disease were fever of unknown origin and leukopenia. In the group with CMV infection, there was an increased occurrence of rejection (60% in infected vs 27% in noninfected patients). In most patients (41/54), the rejection preceded the CMV infection. CMV infection did not lead to a decreased graft survival. There was no close time relationship between the onset of clinical symptoms of CMV disease and the laboratory confirmation of CMV infection. A subgroup of patients at risk for the development of severe CMV disease could not be identified. |
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Abstract In this prospective study, the incidence of cytomegalovirus (CMV) infection and CMV disease was determined in 175 renal transplant recipients on cyclosporin and low-dose prednisone. CMV infection occurred in 51.4% of the patients, CMV disease in 13.7%. The major manifestations of CMV disease were fever of unknown origin and leukopenia. In the group with CMV infection, there was an increased occurrence of rejection (60% in infected vs 27% in noninfected patients). In most patients (41/54), the rejection preceded the CMV infection. CMV infection did not lead to a decreased graft survival. There was no close time relationship between the onset of clinical symptoms of CMV disease and the laboratory confirmation of CMV infection. A subgroup of patients at risk for the development of severe CMV disease could not be identified. |
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Abstract In this prospective study, the incidence of cytomegalovirus (CMV) infection and CMV disease was determined in 175 renal transplant recipients on cyclosporin and low-dose prednisone. CMV infection occurred in 51.4% of the patients, CMV disease in 13.7%. The major manifestations of CMV disease were fever of unknown origin and leukopenia. In the group with CMV infection, there was an increased occurrence of rejection (60% in infected vs 27% in noninfected patients). In most patients (41/54), the rejection preceded the CMV infection. CMV infection did not lead to a decreased graft survival. There was no close time relationship between the onset of clinical symptoms of CMV disease and the laboratory confirmation of CMV infection. A subgroup of patients at risk for the development of severe CMV disease could not be identified. |
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