Cyclosporin A blood levels during use of cyclosporin as oral solution or in capsules: comparison of pharmacokinetic parameters
Abstract Recently cyclosporin A (CsA) capsules have been introduced to meet a number of disadvantages associated with the use of the oral solution. We compared the pharmacokinetics of the oral solution and the capsules in a group of nine renal transplant patients during the first 3 weeks after trans...
Ausführliche Beschreibung
Gespeichert in:
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1991 |
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| Umfang: |
3 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Transplant international - 1988, 4(1991) vom: Feb., Seite 125-127 |
| Übergeordnetes Werk: |
volume:4 ; year:1991 ; month:02 ; pages:125-127 ; extent:3 |
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NLEJ200042408 |
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| 245 | 1 | 0 | |a Cyclosporin A blood levels during use of cyclosporin as oral solution or in capsules: comparison of pharmacokinetic parameters |
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| 520 | |a Abstract Recently cyclosporin A (CsA) capsules have been introduced to meet a number of disadvantages associated with the use of the oral solution. We compared the pharmacokinetics of the oral solution and the capsules in a group of nine renal transplant patients during the first 3 weeks after transplantation. After a morning dose of CsA, whole blood concentrations were measured at regular intervals for 12 h. Subsequently, a cross-over was made to the alternative form of administration, and 3 or 4 days later a second pharmacokinetic profile was obtained. Comparison of the trough level, the maximum concentration, the time to reach the maximal concentration and the area under the blood concentration curve, showed no significant differences. Our findings thus suggest a similar bioavailability of CsA administered as oral solution or in capsules in the early post-transplant period. | ||
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| 700 | 1 | |a Berg, J. W. O. |4 oth | |
| 700 | 1 | |a Koene, R. A. P. |4 oth | |
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(DE-627)NLEJ200042408 DE-627 ger DE-627 rakwb eng Cyclosporin A blood levels during use of cyclosporin as oral solution or in capsules: comparison of pharmacokinetic parameters 1991 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Recently cyclosporin A (CsA) capsules have been introduced to meet a number of disadvantages associated with the use of the oral solution. We compared the pharmacokinetics of the oral solution and the capsules in a group of nine renal transplant patients during the first 3 weeks after transplantation. After a morning dose of CsA, whole blood concentrations were measured at regular intervals for 12 h. Subsequently, a cross-over was made to the alternative form of administration, and 3 or 4 days later a second pharmacokinetic profile was obtained. Comparison of the trough level, the maximum concentration, the time to reach the maximal concentration and the area under the blood concentration curve, showed no significant differences. Our findings thus suggest a similar bioavailability of CsA administered as oral solution or in capsules in the early post-transplant period. Springer Online Journal Archives 1860-2002 Hilbrands, L. B. oth Hoitsma, A. J. oth Berg, J. W. O. oth Koene, R. A. P. oth in Transplant international 1988 4(1991) vom: Feb., Seite 125-127 (DE-627)NLEJ188990380 (DE-600)1463183-0 1432-2277 nnns volume:4 year:1991 month:02 pages:125-127 extent:3 http://dx.doi.org/10.1007/BF00336411 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 4 1991 2 125-127 3 |
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(DE-627)NLEJ200042408 DE-627 ger DE-627 rakwb eng Cyclosporin A blood levels during use of cyclosporin as oral solution or in capsules: comparison of pharmacokinetic parameters 1991 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Recently cyclosporin A (CsA) capsules have been introduced to meet a number of disadvantages associated with the use of the oral solution. We compared the pharmacokinetics of the oral solution and the capsules in a group of nine renal transplant patients during the first 3 weeks after transplantation. After a morning dose of CsA, whole blood concentrations were measured at regular intervals for 12 h. Subsequently, a cross-over was made to the alternative form of administration, and 3 or 4 days later a second pharmacokinetic profile was obtained. Comparison of the trough level, the maximum concentration, the time to reach the maximal concentration and the area under the blood concentration curve, showed no significant differences. Our findings thus suggest a similar bioavailability of CsA administered as oral solution or in capsules in the early post-transplant period. Springer Online Journal Archives 1860-2002 Hilbrands, L. B. oth Hoitsma, A. J. oth Berg, J. W. O. oth Koene, R. A. P. oth in Transplant international 1988 4(1991) vom: Feb., Seite 125-127 (DE-627)NLEJ188990380 (DE-600)1463183-0 1432-2277 nnns volume:4 year:1991 month:02 pages:125-127 extent:3 http://dx.doi.org/10.1007/BF00336411 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 4 1991 2 125-127 3 |
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(DE-627)NLEJ200042408 DE-627 ger DE-627 rakwb eng Cyclosporin A blood levels during use of cyclosporin as oral solution or in capsules: comparison of pharmacokinetic parameters 1991 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Recently cyclosporin A (CsA) capsules have been introduced to meet a number of disadvantages associated with the use of the oral solution. We compared the pharmacokinetics of the oral solution and the capsules in a group of nine renal transplant patients during the first 3 weeks after transplantation. After a morning dose of CsA, whole blood concentrations were measured at regular intervals for 12 h. Subsequently, a cross-over was made to the alternative form of administration, and 3 or 4 days later a second pharmacokinetic profile was obtained. Comparison of the trough level, the maximum concentration, the time to reach the maximal concentration and the area under the blood concentration curve, showed no significant differences. Our findings thus suggest a similar bioavailability of CsA administered as oral solution or in capsules in the early post-transplant period. Springer Online Journal Archives 1860-2002 Hilbrands, L. B. oth Hoitsma, A. J. oth Berg, J. W. O. oth Koene, R. A. P. oth in Transplant international 1988 4(1991) vom: Feb., Seite 125-127 (DE-627)NLEJ188990380 (DE-600)1463183-0 1432-2277 nnns volume:4 year:1991 month:02 pages:125-127 extent:3 http://dx.doi.org/10.1007/BF00336411 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 4 1991 2 125-127 3 |
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(DE-627)NLEJ200042408 DE-627 ger DE-627 rakwb eng Cyclosporin A blood levels during use of cyclosporin as oral solution or in capsules: comparison of pharmacokinetic parameters 1991 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Recently cyclosporin A (CsA) capsules have been introduced to meet a number of disadvantages associated with the use of the oral solution. We compared the pharmacokinetics of the oral solution and the capsules in a group of nine renal transplant patients during the first 3 weeks after transplantation. After a morning dose of CsA, whole blood concentrations were measured at regular intervals for 12 h. Subsequently, a cross-over was made to the alternative form of administration, and 3 or 4 days later a second pharmacokinetic profile was obtained. Comparison of the trough level, the maximum concentration, the time to reach the maximal concentration and the area under the blood concentration curve, showed no significant differences. Our findings thus suggest a similar bioavailability of CsA administered as oral solution or in capsules in the early post-transplant period. Springer Online Journal Archives 1860-2002 Hilbrands, L. B. oth Hoitsma, A. J. oth Berg, J. W. O. oth Koene, R. A. P. oth in Transplant international 1988 4(1991) vom: Feb., Seite 125-127 (DE-627)NLEJ188990380 (DE-600)1463183-0 1432-2277 nnns volume:4 year:1991 month:02 pages:125-127 extent:3 http://dx.doi.org/10.1007/BF00336411 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 4 1991 2 125-127 3 |
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(DE-627)NLEJ200042408 DE-627 ger DE-627 rakwb eng Cyclosporin A blood levels during use of cyclosporin as oral solution or in capsules: comparison of pharmacokinetic parameters 1991 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Recently cyclosporin A (CsA) capsules have been introduced to meet a number of disadvantages associated with the use of the oral solution. We compared the pharmacokinetics of the oral solution and the capsules in a group of nine renal transplant patients during the first 3 weeks after transplantation. After a morning dose of CsA, whole blood concentrations were measured at regular intervals for 12 h. Subsequently, a cross-over was made to the alternative form of administration, and 3 or 4 days later a second pharmacokinetic profile was obtained. Comparison of the trough level, the maximum concentration, the time to reach the maximal concentration and the area under the blood concentration curve, showed no significant differences. Our findings thus suggest a similar bioavailability of CsA administered as oral solution or in capsules in the early post-transplant period. Springer Online Journal Archives 1860-2002 Hilbrands, L. B. oth Hoitsma, A. J. oth Berg, J. W. O. oth Koene, R. A. P. oth in Transplant international 1988 4(1991) vom: Feb., Seite 125-127 (DE-627)NLEJ188990380 (DE-600)1463183-0 1432-2277 nnns volume:4 year:1991 month:02 pages:125-127 extent:3 http://dx.doi.org/10.1007/BF00336411 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 4 1991 2 125-127 3 |
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cyclosporin a blood levels during use of cyclosporin as oral solution or in capsules: comparison of pharmacokinetic parameters |
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Cyclosporin A blood levels during use of cyclosporin as oral solution or in capsules: comparison of pharmacokinetic parameters |
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Abstract Recently cyclosporin A (CsA) capsules have been introduced to meet a number of disadvantages associated with the use of the oral solution. We compared the pharmacokinetics of the oral solution and the capsules in a group of nine renal transplant patients during the first 3 weeks after transplantation. After a morning dose of CsA, whole blood concentrations were measured at regular intervals for 12 h. Subsequently, a cross-over was made to the alternative form of administration, and 3 or 4 days later a second pharmacokinetic profile was obtained. Comparison of the trough level, the maximum concentration, the time to reach the maximal concentration and the area under the blood concentration curve, showed no significant differences. Our findings thus suggest a similar bioavailability of CsA administered as oral solution or in capsules in the early post-transplant period. |
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Abstract Recently cyclosporin A (CsA) capsules have been introduced to meet a number of disadvantages associated with the use of the oral solution. We compared the pharmacokinetics of the oral solution and the capsules in a group of nine renal transplant patients during the first 3 weeks after transplantation. After a morning dose of CsA, whole blood concentrations were measured at regular intervals for 12 h. Subsequently, a cross-over was made to the alternative form of administration, and 3 or 4 days later a second pharmacokinetic profile was obtained. Comparison of the trough level, the maximum concentration, the time to reach the maximal concentration and the area under the blood concentration curve, showed no significant differences. Our findings thus suggest a similar bioavailability of CsA administered as oral solution or in capsules in the early post-transplant period. |
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Abstract Recently cyclosporin A (CsA) capsules have been introduced to meet a number of disadvantages associated with the use of the oral solution. We compared the pharmacokinetics of the oral solution and the capsules in a group of nine renal transplant patients during the first 3 weeks after transplantation. After a morning dose of CsA, whole blood concentrations were measured at regular intervals for 12 h. Subsequently, a cross-over was made to the alternative form of administration, and 3 or 4 days later a second pharmacokinetic profile was obtained. Comparison of the trough level, the maximum concentration, the time to reach the maximal concentration and the area under the blood concentration curve, showed no significant differences. Our findings thus suggest a similar bioavailability of CsA administered as oral solution or in capsules in the early post-transplant period. |
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