Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung
Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1978 |
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| Umfang: |
4 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
|---|---|
| Übergeordnetes Werk: |
in: Archives of toxicology - 1952, 40(1978) vom: März, Seite 207-210 |
| Übergeordnetes Werk: |
volume:40 ; year:1978 ; month:03 ; pages:207-210 ; extent:4 |
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NLEJ200243977 |
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| 520 | |a Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone. | ||
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(DE-627)NLEJ200243977 DE-627 ger DE-627 rakwb eng Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung 1978 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone. Springer Online Journal Archives 1860-2002 Husain, Mirza M. oth Dehnen, Walter oth in Archives of toxicology 1952 40(1978) vom: März, Seite 207-210 (DE-627)NLEJ188994858 (DE-600)1458459-1 1432-0738 nnns volume:40 year:1978 month:03 pages:207-210 extent:4 http://dx.doi.org/10.1007/BF00364652 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 40 1978 3 207-210 4 |
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(DE-627)NLEJ200243977 DE-627 ger DE-627 rakwb eng Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung 1978 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone. Springer Online Journal Archives 1860-2002 Husain, Mirza M. oth Dehnen, Walter oth in Archives of toxicology 1952 40(1978) vom: März, Seite 207-210 (DE-627)NLEJ188994858 (DE-600)1458459-1 1432-0738 nnns volume:40 year:1978 month:03 pages:207-210 extent:4 http://dx.doi.org/10.1007/BF00364652 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 40 1978 3 207-210 4 |
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(DE-627)NLEJ200243977 DE-627 ger DE-627 rakwb eng Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung 1978 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone. Springer Online Journal Archives 1860-2002 Husain, Mirza M. oth Dehnen, Walter oth in Archives of toxicology 1952 40(1978) vom: März, Seite 207-210 (DE-627)NLEJ188994858 (DE-600)1458459-1 1432-0738 nnns volume:40 year:1978 month:03 pages:207-210 extent:4 http://dx.doi.org/10.1007/BF00364652 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 40 1978 3 207-210 4 |
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(DE-627)NLEJ200243977 DE-627 ger DE-627 rakwb eng Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung 1978 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone. Springer Online Journal Archives 1860-2002 Husain, Mirza M. oth Dehnen, Walter oth in Archives of toxicology 1952 40(1978) vom: März, Seite 207-210 (DE-627)NLEJ188994858 (DE-600)1458459-1 1432-0738 nnns volume:40 year:1978 month:03 pages:207-210 extent:4 http://dx.doi.org/10.1007/BF00364652 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 40 1978 3 207-210 4 |
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(DE-627)NLEJ200243977 DE-627 ger DE-627 rakwb eng Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung 1978 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone. Springer Online Journal Archives 1860-2002 Husain, Mirza M. oth Dehnen, Walter oth in Archives of toxicology 1952 40(1978) vom: März, Seite 207-210 (DE-627)NLEJ188994858 (DE-600)1458459-1 1432-0738 nnns volume:40 year:1978 month:03 pages:207-210 extent:4 http://dx.doi.org/10.1007/BF00364652 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 40 1978 3 207-210 4 |
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effect of no2 and so2 inhalation on benzo(a)pyrene metabolism in rat lung |
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Effect of NO2 and SO2 inhalation on benzo(a)pyrene metabolism in rat lung |
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Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone. |
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Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone. |
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Abstract Male Wistar rats were continuously exposed to NO2 (14.4 ppm), SO2 (46.5 ppm) and to a mixture of both gases and their effect on lung microsomal aryl hydrocarbon (benzo(a)pyrene) hydroxylase (AHH) activity was determined. The pre-exposed animals were administered methylcholanthrene (MC) to investigate the exposure effect on enzyme inducibility and pattern of B(a)P metabolites. NO2 significantly increased AHH activity but no marked change was noted with SO2. Induction of AHH by MC was markedly inhibited by SO2, only slightly by mixture of NO2-SO2 but not with NO2 alone. |
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