The role of CYP enzymes in cocaine-induced liver damage
Abstract Cocaine is hepatotoxic in several species, including man. A high dose of cocaine produces metabolism-dependent, mainly pericentral, liver damage. At 24 h after a single dose of cocaine, mouse hepatic P450 content decreases but CYP2A activities; coumarin 7-hydroxylase and testosterone 15α-h...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1995 |
|---|
| Umfang: |
4 |
|---|
| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
|---|---|
| Übergeordnetes Werk: |
in: Archives of toxicology - 1952, 69(1995) vom: Mai, Seite 287-290 |
| Übergeordnetes Werk: |
volume:69 ; year:1995 ; month:05 ; pages:287-290 ; extent:4 |
| Links: |
|---|
| Katalog-ID: |
NLEJ200264141 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ200264141 | ||
| 003 | DE-627 | ||
| 005 | 20210706043609.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 070527s1995 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)NLEJ200264141 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 245 | 1 | 0 | |a The role of CYP enzymes in cocaine-induced liver damage |
| 264 | 1 | |c 1995 | |
| 300 | |a 4 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Abstract Cocaine is hepatotoxic in several species, including man. A high dose of cocaine produces metabolism-dependent, mainly pericentral, liver damage. At 24 h after a single dose of cocaine, mouse hepatic P450 content decreases but CYP2A activities; coumarin 7-hydroxylase and testosterone 15α-hydroxylase increase concomitant with prominent diffuse cell necrosis. Repeated administration of cocaine for up to 5 days decreases CYP1A1/2, 2A4/5, 2Cx, and 2E1 related enzymatic activities. However, after five doses of cocaine, CYP2B10 increases in conjunction with the healing process. In the acute phase, the increased CYP2A activities do not participate in cocaine bioactivation. CYP3A enzymes are principally responsible for the cocaine N-demethylation in human and mouse liver microsomes. The hepatic metabolic CYP enzyme profile will change during prolonged cocaine intake, this being accompanied by altered cell morphology. Possible connections to cocaine toxicity in man are discussed. | ||
| 533 | |f Springer Online Journal Archives 1860-2002 | ||
| 700 | 1 | |a Pasanen, M. |4 oth | |
| 700 | 1 | |a Pellinen, Pertti |4 oth | |
| 700 | 1 | |a Stenbäck, Frej |4 oth | |
| 700 | 1 | |a Juvonen, Risto O. |4 oth | |
| 700 | 1 | |a Raunio, Hannu |4 oth | |
| 700 | 1 | |a Pelkonen, Olavi |4 oth | |
| 773 | 0 | 8 | |i in |t Archives of toxicology |d 1952 |g 69(1995) vom: Mai, Seite 287-290 |w (DE-627)NLEJ188994858 |w (DE-600)1458459-1 |x 1432-0738 |7 nnns |
| 773 | 1 | 8 | |g volume:69 |g year:1995 |g month:05 |g pages:287-290 |g extent:4 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s002040050172 |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-SOJ | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 69 |j 1995 |c 5 |h 287-290 |g 4 | ||
| matchkey_str |
article:14320738:1995----::hrlocpnyeiccienu |
|---|---|
| hierarchy_sort_str |
1995 |
| publishDate |
1995 |
| allfields |
(DE-627)NLEJ200264141 DE-627 ger DE-627 rakwb eng The role of CYP enzymes in cocaine-induced liver damage 1995 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Cocaine is hepatotoxic in several species, including man. A high dose of cocaine produces metabolism-dependent, mainly pericentral, liver damage. At 24 h after a single dose of cocaine, mouse hepatic P450 content decreases but CYP2A activities; coumarin 7-hydroxylase and testosterone 15α-hydroxylase increase concomitant with prominent diffuse cell necrosis. Repeated administration of cocaine for up to 5 days decreases CYP1A1/2, 2A4/5, 2Cx, and 2E1 related enzymatic activities. However, after five doses of cocaine, CYP2B10 increases in conjunction with the healing process. In the acute phase, the increased CYP2A activities do not participate in cocaine bioactivation. CYP3A enzymes are principally responsible for the cocaine N-demethylation in human and mouse liver microsomes. The hepatic metabolic CYP enzyme profile will change during prolonged cocaine intake, this being accompanied by altered cell morphology. Possible connections to cocaine toxicity in man are discussed. Springer Online Journal Archives 1860-2002 Pasanen, M. oth Pellinen, Pertti oth Stenbäck, Frej oth Juvonen, Risto O. oth Raunio, Hannu oth Pelkonen, Olavi oth in Archives of toxicology 1952 69(1995) vom: Mai, Seite 287-290 (DE-627)NLEJ188994858 (DE-600)1458459-1 1432-0738 nnns volume:69 year:1995 month:05 pages:287-290 extent:4 http://dx.doi.org/10.1007/s002040050172 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 69 1995 5 287-290 4 |
| spelling |
(DE-627)NLEJ200264141 DE-627 ger DE-627 rakwb eng The role of CYP enzymes in cocaine-induced liver damage 1995 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Cocaine is hepatotoxic in several species, including man. A high dose of cocaine produces metabolism-dependent, mainly pericentral, liver damage. At 24 h after a single dose of cocaine, mouse hepatic P450 content decreases but CYP2A activities; coumarin 7-hydroxylase and testosterone 15α-hydroxylase increase concomitant with prominent diffuse cell necrosis. Repeated administration of cocaine for up to 5 days decreases CYP1A1/2, 2A4/5, 2Cx, and 2E1 related enzymatic activities. However, after five doses of cocaine, CYP2B10 increases in conjunction with the healing process. In the acute phase, the increased CYP2A activities do not participate in cocaine bioactivation. CYP3A enzymes are principally responsible for the cocaine N-demethylation in human and mouse liver microsomes. The hepatic metabolic CYP enzyme profile will change during prolonged cocaine intake, this being accompanied by altered cell morphology. Possible connections to cocaine toxicity in man are discussed. Springer Online Journal Archives 1860-2002 Pasanen, M. oth Pellinen, Pertti oth Stenbäck, Frej oth Juvonen, Risto O. oth Raunio, Hannu oth Pelkonen, Olavi oth in Archives of toxicology 1952 69(1995) vom: Mai, Seite 287-290 (DE-627)NLEJ188994858 (DE-600)1458459-1 1432-0738 nnns volume:69 year:1995 month:05 pages:287-290 extent:4 http://dx.doi.org/10.1007/s002040050172 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 69 1995 5 287-290 4 |
| allfields_unstemmed |
(DE-627)NLEJ200264141 DE-627 ger DE-627 rakwb eng The role of CYP enzymes in cocaine-induced liver damage 1995 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Cocaine is hepatotoxic in several species, including man. A high dose of cocaine produces metabolism-dependent, mainly pericentral, liver damage. At 24 h after a single dose of cocaine, mouse hepatic P450 content decreases but CYP2A activities; coumarin 7-hydroxylase and testosterone 15α-hydroxylase increase concomitant with prominent diffuse cell necrosis. Repeated administration of cocaine for up to 5 days decreases CYP1A1/2, 2A4/5, 2Cx, and 2E1 related enzymatic activities. However, after five doses of cocaine, CYP2B10 increases in conjunction with the healing process. In the acute phase, the increased CYP2A activities do not participate in cocaine bioactivation. CYP3A enzymes are principally responsible for the cocaine N-demethylation in human and mouse liver microsomes. The hepatic metabolic CYP enzyme profile will change during prolonged cocaine intake, this being accompanied by altered cell morphology. Possible connections to cocaine toxicity in man are discussed. Springer Online Journal Archives 1860-2002 Pasanen, M. oth Pellinen, Pertti oth Stenbäck, Frej oth Juvonen, Risto O. oth Raunio, Hannu oth Pelkonen, Olavi oth in Archives of toxicology 1952 69(1995) vom: Mai, Seite 287-290 (DE-627)NLEJ188994858 (DE-600)1458459-1 1432-0738 nnns volume:69 year:1995 month:05 pages:287-290 extent:4 http://dx.doi.org/10.1007/s002040050172 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 69 1995 5 287-290 4 |
| allfieldsGer |
(DE-627)NLEJ200264141 DE-627 ger DE-627 rakwb eng The role of CYP enzymes in cocaine-induced liver damage 1995 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Cocaine is hepatotoxic in several species, including man. A high dose of cocaine produces metabolism-dependent, mainly pericentral, liver damage. At 24 h after a single dose of cocaine, mouse hepatic P450 content decreases but CYP2A activities; coumarin 7-hydroxylase and testosterone 15α-hydroxylase increase concomitant with prominent diffuse cell necrosis. Repeated administration of cocaine for up to 5 days decreases CYP1A1/2, 2A4/5, 2Cx, and 2E1 related enzymatic activities. However, after five doses of cocaine, CYP2B10 increases in conjunction with the healing process. In the acute phase, the increased CYP2A activities do not participate in cocaine bioactivation. CYP3A enzymes are principally responsible for the cocaine N-demethylation in human and mouse liver microsomes. The hepatic metabolic CYP enzyme profile will change during prolonged cocaine intake, this being accompanied by altered cell morphology. Possible connections to cocaine toxicity in man are discussed. Springer Online Journal Archives 1860-2002 Pasanen, M. oth Pellinen, Pertti oth Stenbäck, Frej oth Juvonen, Risto O. oth Raunio, Hannu oth Pelkonen, Olavi oth in Archives of toxicology 1952 69(1995) vom: Mai, Seite 287-290 (DE-627)NLEJ188994858 (DE-600)1458459-1 1432-0738 nnns volume:69 year:1995 month:05 pages:287-290 extent:4 http://dx.doi.org/10.1007/s002040050172 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 69 1995 5 287-290 4 |
| allfieldsSound |
(DE-627)NLEJ200264141 DE-627 ger DE-627 rakwb eng The role of CYP enzymes in cocaine-induced liver damage 1995 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Cocaine is hepatotoxic in several species, including man. A high dose of cocaine produces metabolism-dependent, mainly pericentral, liver damage. At 24 h after a single dose of cocaine, mouse hepatic P450 content decreases but CYP2A activities; coumarin 7-hydroxylase and testosterone 15α-hydroxylase increase concomitant with prominent diffuse cell necrosis. Repeated administration of cocaine for up to 5 days decreases CYP1A1/2, 2A4/5, 2Cx, and 2E1 related enzymatic activities. However, after five doses of cocaine, CYP2B10 increases in conjunction with the healing process. In the acute phase, the increased CYP2A activities do not participate in cocaine bioactivation. CYP3A enzymes are principally responsible for the cocaine N-demethylation in human and mouse liver microsomes. The hepatic metabolic CYP enzyme profile will change during prolonged cocaine intake, this being accompanied by altered cell morphology. Possible connections to cocaine toxicity in man are discussed. Springer Online Journal Archives 1860-2002 Pasanen, M. oth Pellinen, Pertti oth Stenbäck, Frej oth Juvonen, Risto O. oth Raunio, Hannu oth Pelkonen, Olavi oth in Archives of toxicology 1952 69(1995) vom: Mai, Seite 287-290 (DE-627)NLEJ188994858 (DE-600)1458459-1 1432-0738 nnns volume:69 year:1995 month:05 pages:287-290 extent:4 http://dx.doi.org/10.1007/s002040050172 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 69 1995 5 287-290 4 |
| language |
English |
| source |
in Archives of toxicology 69(1995) vom: Mai, Seite 287-290 volume:69 year:1995 month:05 pages:287-290 extent:4 |
| sourceStr |
in Archives of toxicology 69(1995) vom: Mai, Seite 287-290 volume:69 year:1995 month:05 pages:287-290 extent:4 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Archives of toxicology |
| authorswithroles_txt_mv |
Pasanen, M. @@oth@@ Pellinen, Pertti @@oth@@ Stenbäck, Frej @@oth@@ Juvonen, Risto O. @@oth@@ Raunio, Hannu @@oth@@ Pelkonen, Olavi @@oth@@ |
| publishDateDaySort_date |
1995-05-01T00:00:00Z |
| hierarchy_top_id |
NLEJ188994858 |
| id |
NLEJ200264141 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ200264141</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706043609.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1995 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ200264141</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The role of CYP enzymes in cocaine-induced liver damage</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1995</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">4</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Cocaine is hepatotoxic in several species, including man. A high dose of cocaine produces metabolism-dependent, mainly pericentral, liver damage. At 24 h after a single dose of cocaine, mouse hepatic P450 content decreases but CYP2A activities; coumarin 7-hydroxylase and testosterone 15α-hydroxylase increase concomitant with prominent diffuse cell necrosis. Repeated administration of cocaine for up to 5 days decreases CYP1A1/2, 2A4/5, 2Cx, and 2E1 related enzymatic activities. However, after five doses of cocaine, CYP2B10 increases in conjunction with the healing process. In the acute phase, the increased CYP2A activities do not participate in cocaine bioactivation. CYP3A enzymes are principally responsible for the cocaine N-demethylation in human and mouse liver microsomes. The hepatic metabolic CYP enzyme profile will change during prolonged cocaine intake, this being accompanied by altered cell morphology. Possible connections to cocaine toxicity in man are discussed.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pasanen, M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pellinen, Pertti</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Stenbäck, Frej</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Juvonen, Risto O.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Raunio, Hannu</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pelkonen, Olavi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Archives of toxicology</subfield><subfield code="d">1952</subfield><subfield code="g">69(1995) vom: Mai, Seite 287-290</subfield><subfield code="w">(DE-627)NLEJ188994858</subfield><subfield code="w">(DE-600)1458459-1</subfield><subfield code="x">1432-0738</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:69</subfield><subfield code="g">year:1995</subfield><subfield code="g">month:05</subfield><subfield code="g">pages:287-290</subfield><subfield code="g">extent:4</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/s002040050172</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">69</subfield><subfield code="j">1995</subfield><subfield code="c">5</subfield><subfield code="h">287-290</subfield><subfield code="g">4</subfield></datafield></record></collection>
|
| series2 |
Springer Online Journal Archives 1860-2002 |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ188994858 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| collection |
NL |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1432-0738 |
| topic_title |
The role of CYP enzymes in cocaine-induced liver damage |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
m p mp p p pp f s fs r o j ro roj h r hr o p op |
| hierarchy_parent_title |
Archives of toxicology |
| hierarchy_parent_id |
NLEJ188994858 |
| hierarchy_top_title |
Archives of toxicology |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ188994858 (DE-600)1458459-1 |
| title |
The role of CYP enzymes in cocaine-induced liver damage |
| spellingShingle |
The role of CYP enzymes in cocaine-induced liver damage |
| ctrlnum |
(DE-627)NLEJ200264141 |
| title_full |
The role of CYP enzymes in cocaine-induced liver damage |
| journal |
Archives of toxicology |
| journalStr |
Archives of toxicology |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1995 |
| contenttype_str_mv |
zzz |
| container_start_page |
287 |
| container_volume |
69 |
| physical |
4 |
| format_se |
Elektronische Aufsätze |
| title_sort |
the role of cyp enzymes in cocaine-induced liver damage |
| title_auth |
The role of CYP enzymes in cocaine-induced liver damage |
| abstract |
Abstract Cocaine is hepatotoxic in several species, including man. A high dose of cocaine produces metabolism-dependent, mainly pericentral, liver damage. At 24 h after a single dose of cocaine, mouse hepatic P450 content decreases but CYP2A activities; coumarin 7-hydroxylase and testosterone 15α-hydroxylase increase concomitant with prominent diffuse cell necrosis. Repeated administration of cocaine for up to 5 days decreases CYP1A1/2, 2A4/5, 2Cx, and 2E1 related enzymatic activities. However, after five doses of cocaine, CYP2B10 increases in conjunction with the healing process. In the acute phase, the increased CYP2A activities do not participate in cocaine bioactivation. CYP3A enzymes are principally responsible for the cocaine N-demethylation in human and mouse liver microsomes. The hepatic metabolic CYP enzyme profile will change during prolonged cocaine intake, this being accompanied by altered cell morphology. Possible connections to cocaine toxicity in man are discussed. |
| abstractGer |
Abstract Cocaine is hepatotoxic in several species, including man. A high dose of cocaine produces metabolism-dependent, mainly pericentral, liver damage. At 24 h after a single dose of cocaine, mouse hepatic P450 content decreases but CYP2A activities; coumarin 7-hydroxylase and testosterone 15α-hydroxylase increase concomitant with prominent diffuse cell necrosis. Repeated administration of cocaine for up to 5 days decreases CYP1A1/2, 2A4/5, 2Cx, and 2E1 related enzymatic activities. However, after five doses of cocaine, CYP2B10 increases in conjunction with the healing process. In the acute phase, the increased CYP2A activities do not participate in cocaine bioactivation. CYP3A enzymes are principally responsible for the cocaine N-demethylation in human and mouse liver microsomes. The hepatic metabolic CYP enzyme profile will change during prolonged cocaine intake, this being accompanied by altered cell morphology. Possible connections to cocaine toxicity in man are discussed. |
| abstract_unstemmed |
Abstract Cocaine is hepatotoxic in several species, including man. A high dose of cocaine produces metabolism-dependent, mainly pericentral, liver damage. At 24 h after a single dose of cocaine, mouse hepatic P450 content decreases but CYP2A activities; coumarin 7-hydroxylase and testosterone 15α-hydroxylase increase concomitant with prominent diffuse cell necrosis. Repeated administration of cocaine for up to 5 days decreases CYP1A1/2, 2A4/5, 2Cx, and 2E1 related enzymatic activities. However, after five doses of cocaine, CYP2B10 increases in conjunction with the healing process. In the acute phase, the increased CYP2A activities do not participate in cocaine bioactivation. CYP3A enzymes are principally responsible for the cocaine N-demethylation in human and mouse liver microsomes. The hepatic metabolic CYP enzyme profile will change during prolonged cocaine intake, this being accompanied by altered cell morphology. Possible connections to cocaine toxicity in man are discussed. |
| collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
| title_short |
The role of CYP enzymes in cocaine-induced liver damage |
| url |
http://dx.doi.org/10.1007/s002040050172 |
| remote_bool |
true |
| author2 |
Pasanen, M. Pellinen, Pertti Stenbäck, Frej Juvonen, Risto O. Raunio, Hannu Pelkonen, Olavi |
| author2Str |
Pasanen, M. Pellinen, Pertti Stenbäck, Frej Juvonen, Risto O. Raunio, Hannu Pelkonen, Olavi |
| ppnlink |
NLEJ188994858 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth oth |
| up_date |
2024-07-06T02:29:13.234Z |
| _version_ |
1803794989180780545 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ200264141</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706043609.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1995 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ200264141</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The role of CYP enzymes in cocaine-induced liver damage</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1995</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">4</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Cocaine is hepatotoxic in several species, including man. A high dose of cocaine produces metabolism-dependent, mainly pericentral, liver damage. At 24 h after a single dose of cocaine, mouse hepatic P450 content decreases but CYP2A activities; coumarin 7-hydroxylase and testosterone 15α-hydroxylase increase concomitant with prominent diffuse cell necrosis. Repeated administration of cocaine for up to 5 days decreases CYP1A1/2, 2A4/5, 2Cx, and 2E1 related enzymatic activities. However, after five doses of cocaine, CYP2B10 increases in conjunction with the healing process. In the acute phase, the increased CYP2A activities do not participate in cocaine bioactivation. CYP3A enzymes are principally responsible for the cocaine N-demethylation in human and mouse liver microsomes. The hepatic metabolic CYP enzyme profile will change during prolonged cocaine intake, this being accompanied by altered cell morphology. Possible connections to cocaine toxicity in man are discussed.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pasanen, M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pellinen, Pertti</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Stenbäck, Frej</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Juvonen, Risto O.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Raunio, Hannu</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pelkonen, Olavi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Archives of toxicology</subfield><subfield code="d">1952</subfield><subfield code="g">69(1995) vom: Mai, Seite 287-290</subfield><subfield code="w">(DE-627)NLEJ188994858</subfield><subfield code="w">(DE-600)1458459-1</subfield><subfield code="x">1432-0738</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:69</subfield><subfield code="g">year:1995</subfield><subfield code="g">month:05</subfield><subfield code="g">pages:287-290</subfield><subfield code="g">extent:4</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/s002040050172</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">69</subfield><subfield code="j">1995</subfield><subfield code="c">5</subfield><subfield code="h">287-290</subfield><subfield code="g">4</subfield></datafield></record></collection>
|
| score |
7.3995275 |