Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases
Summary Acute effects of a single intraperitoneal dose of allyl alcohol (AA, 64 mg/kg), dimethylnitrosamine (DMNA, 30 mg/kg), hexachlorobutadiene (HCBD, 50 mg/kg), carbon tetrachloride (CCl4, 24 mg/kg), cocaine (60 mg/kg) and pyrazole (300 mg/kg) on the hepatic histology and monooxygenases in DBA/2...
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| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1993 |
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| Umfang: |
9 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Naunyn-Schmiedeberg's archives of pharmacology - 1873, 348(1993) vom: Apr., Seite 435-443 |
| Übergeordnetes Werk: |
volume:348 ; year:1993 ; month:04 ; pages:435-443 ; extent:9 |
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NLEJ20063514X |
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| 520 | |a Summary Acute effects of a single intraperitoneal dose of allyl alcohol (AA, 64 mg/kg), dimethylnitrosamine (DMNA, 30 mg/kg), hexachlorobutadiene (HCBD, 50 mg/kg), carbon tetrachloride (CCl4, 24 mg/kg), cocaine (60 mg/kg) and pyrazole (300 mg/kg) on the hepatic histology and monooxygenases in DBA/2 and C57B1/6 strains of mice were investigated. All substances caused histologically verified injury to the liver, which varied in appearance and severity depending on the compound and the mouse strain. Responses of P450-catalyzed reactions were highly dependent on the toxin and varied between different monooxygenase (MO) reactions and two mouse strains. In DBA/2 strain, coumarin 7-hydroxylase (COH) activity was increased from 3- to 5-fold by pyrazole, cocaine, HCBD and CCl4. With respect to P450 content and other MO activities, no changes or even decreases were generally observed. Some exceptions to this rule were found: HCBD significantly increased T15αOH, PROD and EROD activities in C57B1/6 mice, whereas cocaine caused a significant stimulation of Tl5αOH and PROD in DBA/2 mice, It is concluded that (i) different hepatoxins cause different types of liver injury and responses of the monooxygenase complex (“hepatotoxin-specific finger prints”), (ii) although DBA/2 and C57B1/6 mice responded rather similarly to hepatotoxins, also with respect to P450 content and most MO activities, they displayed a profound difference in the behaviour of COH activity, and (iii) within the P450 superfamily, the regulation of COH activity seems to be rather unique, also when compared to its structurally close enzyme, testosterone 15α-hydroxylase. | ||
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(DE-627)NLEJ20063514X DE-627 ger DE-627 rakwb eng Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases 1993 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Acute effects of a single intraperitoneal dose of allyl alcohol (AA, 64 mg/kg), dimethylnitrosamine (DMNA, 30 mg/kg), hexachlorobutadiene (HCBD, 50 mg/kg), carbon tetrachloride (CCl4, 24 mg/kg), cocaine (60 mg/kg) and pyrazole (300 mg/kg) on the hepatic histology and monooxygenases in DBA/2 and C57B1/6 strains of mice were investigated. All substances caused histologically verified injury to the liver, which varied in appearance and severity depending on the compound and the mouse strain. Responses of P450-catalyzed reactions were highly dependent on the toxin and varied between different monooxygenase (MO) reactions and two mouse strains. In DBA/2 strain, coumarin 7-hydroxylase (COH) activity was increased from 3- to 5-fold by pyrazole, cocaine, HCBD and CCl4. With respect to P450 content and other MO activities, no changes or even decreases were generally observed. Some exceptions to this rule were found: HCBD significantly increased T15αOH, PROD and EROD activities in C57B1/6 mice, whereas cocaine caused a significant stimulation of Tl5αOH and PROD in DBA/2 mice, It is concluded that (i) different hepatoxins cause different types of liver injury and responses of the monooxygenase complex (“hepatotoxin-specific finger prints”), (ii) although DBA/2 and C57B1/6 mice responded rather similarly to hepatotoxins, also with respect to P450 content and most MO activities, they displayed a profound difference in the behaviour of COH activity, and (iii) within the P450 superfamily, the regulation of COH activity seems to be rather unique, also when compared to its structurally close enzyme, testosterone 15α-hydroxylase. Springer Online Journal Archives 1860-2002 Pellinen, Pertti oth Stenbäck, Frej oth Rautio, Arja oth Pelkonen, Olavi oth Lang, Matti oth Pasanen, Markku oth in Naunyn-Schmiedeberg's archives of pharmacology 1873 348(1993) vom: Apr., Seite 435-443 (DE-627)NLEJ188984607 (DE-600)1462940-9 1432-1912 nnns volume:348 year:1993 month:04 pages:435-443 extent:9 http://dx.doi.org/10.1007/BF00171345 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 348 1993 4 435-443 9 |
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(DE-627)NLEJ20063514X DE-627 ger DE-627 rakwb eng Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases 1993 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Acute effects of a single intraperitoneal dose of allyl alcohol (AA, 64 mg/kg), dimethylnitrosamine (DMNA, 30 mg/kg), hexachlorobutadiene (HCBD, 50 mg/kg), carbon tetrachloride (CCl4, 24 mg/kg), cocaine (60 mg/kg) and pyrazole (300 mg/kg) on the hepatic histology and monooxygenases in DBA/2 and C57B1/6 strains of mice were investigated. All substances caused histologically verified injury to the liver, which varied in appearance and severity depending on the compound and the mouse strain. Responses of P450-catalyzed reactions were highly dependent on the toxin and varied between different monooxygenase (MO) reactions and two mouse strains. In DBA/2 strain, coumarin 7-hydroxylase (COH) activity was increased from 3- to 5-fold by pyrazole, cocaine, HCBD and CCl4. With respect to P450 content and other MO activities, no changes or even decreases were generally observed. Some exceptions to this rule were found: HCBD significantly increased T15αOH, PROD and EROD activities in C57B1/6 mice, whereas cocaine caused a significant stimulation of Tl5αOH and PROD in DBA/2 mice, It is concluded that (i) different hepatoxins cause different types of liver injury and responses of the monooxygenase complex (“hepatotoxin-specific finger prints”), (ii) although DBA/2 and C57B1/6 mice responded rather similarly to hepatotoxins, also with respect to P450 content and most MO activities, they displayed a profound difference in the behaviour of COH activity, and (iii) within the P450 superfamily, the regulation of COH activity seems to be rather unique, also when compared to its structurally close enzyme, testosterone 15α-hydroxylase. Springer Online Journal Archives 1860-2002 Pellinen, Pertti oth Stenbäck, Frej oth Rautio, Arja oth Pelkonen, Olavi oth Lang, Matti oth Pasanen, Markku oth in Naunyn-Schmiedeberg's archives of pharmacology 1873 348(1993) vom: Apr., Seite 435-443 (DE-627)NLEJ188984607 (DE-600)1462940-9 1432-1912 nnns volume:348 year:1993 month:04 pages:435-443 extent:9 http://dx.doi.org/10.1007/BF00171345 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 348 1993 4 435-443 9 |
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(DE-627)NLEJ20063514X DE-627 ger DE-627 rakwb eng Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases 1993 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Acute effects of a single intraperitoneal dose of allyl alcohol (AA, 64 mg/kg), dimethylnitrosamine (DMNA, 30 mg/kg), hexachlorobutadiene (HCBD, 50 mg/kg), carbon tetrachloride (CCl4, 24 mg/kg), cocaine (60 mg/kg) and pyrazole (300 mg/kg) on the hepatic histology and monooxygenases in DBA/2 and C57B1/6 strains of mice were investigated. All substances caused histologically verified injury to the liver, which varied in appearance and severity depending on the compound and the mouse strain. Responses of P450-catalyzed reactions were highly dependent on the toxin and varied between different monooxygenase (MO) reactions and two mouse strains. In DBA/2 strain, coumarin 7-hydroxylase (COH) activity was increased from 3- to 5-fold by pyrazole, cocaine, HCBD and CCl4. With respect to P450 content and other MO activities, no changes or even decreases were generally observed. Some exceptions to this rule were found: HCBD significantly increased T15αOH, PROD and EROD activities in C57B1/6 mice, whereas cocaine caused a significant stimulation of Tl5αOH and PROD in DBA/2 mice, It is concluded that (i) different hepatoxins cause different types of liver injury and responses of the monooxygenase complex (“hepatotoxin-specific finger prints”), (ii) although DBA/2 and C57B1/6 mice responded rather similarly to hepatotoxins, also with respect to P450 content and most MO activities, they displayed a profound difference in the behaviour of COH activity, and (iii) within the P450 superfamily, the regulation of COH activity seems to be rather unique, also when compared to its structurally close enzyme, testosterone 15α-hydroxylase. Springer Online Journal Archives 1860-2002 Pellinen, Pertti oth Stenbäck, Frej oth Rautio, Arja oth Pelkonen, Olavi oth Lang, Matti oth Pasanen, Markku oth in Naunyn-Schmiedeberg's archives of pharmacology 1873 348(1993) vom: Apr., Seite 435-443 (DE-627)NLEJ188984607 (DE-600)1462940-9 1432-1912 nnns volume:348 year:1993 month:04 pages:435-443 extent:9 http://dx.doi.org/10.1007/BF00171345 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 348 1993 4 435-443 9 |
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(DE-627)NLEJ20063514X DE-627 ger DE-627 rakwb eng Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases 1993 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Acute effects of a single intraperitoneal dose of allyl alcohol (AA, 64 mg/kg), dimethylnitrosamine (DMNA, 30 mg/kg), hexachlorobutadiene (HCBD, 50 mg/kg), carbon tetrachloride (CCl4, 24 mg/kg), cocaine (60 mg/kg) and pyrazole (300 mg/kg) on the hepatic histology and monooxygenases in DBA/2 and C57B1/6 strains of mice were investigated. All substances caused histologically verified injury to the liver, which varied in appearance and severity depending on the compound and the mouse strain. Responses of P450-catalyzed reactions were highly dependent on the toxin and varied between different monooxygenase (MO) reactions and two mouse strains. In DBA/2 strain, coumarin 7-hydroxylase (COH) activity was increased from 3- to 5-fold by pyrazole, cocaine, HCBD and CCl4. With respect to P450 content and other MO activities, no changes or even decreases were generally observed. Some exceptions to this rule were found: HCBD significantly increased T15αOH, PROD and EROD activities in C57B1/6 mice, whereas cocaine caused a significant stimulation of Tl5αOH and PROD in DBA/2 mice, It is concluded that (i) different hepatoxins cause different types of liver injury and responses of the monooxygenase complex (“hepatotoxin-specific finger prints”), (ii) although DBA/2 and C57B1/6 mice responded rather similarly to hepatotoxins, also with respect to P450 content and most MO activities, they displayed a profound difference in the behaviour of COH activity, and (iii) within the P450 superfamily, the regulation of COH activity seems to be rather unique, also when compared to its structurally close enzyme, testosterone 15α-hydroxylase. Springer Online Journal Archives 1860-2002 Pellinen, Pertti oth Stenbäck, Frej oth Rautio, Arja oth Pelkonen, Olavi oth Lang, Matti oth Pasanen, Markku oth in Naunyn-Schmiedeberg's archives of pharmacology 1873 348(1993) vom: Apr., Seite 435-443 (DE-627)NLEJ188984607 (DE-600)1462940-9 1432-1912 nnns volume:348 year:1993 month:04 pages:435-443 extent:9 http://dx.doi.org/10.1007/BF00171345 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 348 1993 4 435-443 9 |
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response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases |
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Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases |
| abstract |
Summary Acute effects of a single intraperitoneal dose of allyl alcohol (AA, 64 mg/kg), dimethylnitrosamine (DMNA, 30 mg/kg), hexachlorobutadiene (HCBD, 50 mg/kg), carbon tetrachloride (CCl4, 24 mg/kg), cocaine (60 mg/kg) and pyrazole (300 mg/kg) on the hepatic histology and monooxygenases in DBA/2 and C57B1/6 strains of mice were investigated. All substances caused histologically verified injury to the liver, which varied in appearance and severity depending on the compound and the mouse strain. Responses of P450-catalyzed reactions were highly dependent on the toxin and varied between different monooxygenase (MO) reactions and two mouse strains. In DBA/2 strain, coumarin 7-hydroxylase (COH) activity was increased from 3- to 5-fold by pyrazole, cocaine, HCBD and CCl4. With respect to P450 content and other MO activities, no changes or even decreases were generally observed. Some exceptions to this rule were found: HCBD significantly increased T15αOH, PROD and EROD activities in C57B1/6 mice, whereas cocaine caused a significant stimulation of Tl5αOH and PROD in DBA/2 mice, It is concluded that (i) different hepatoxins cause different types of liver injury and responses of the monooxygenase complex (“hepatotoxin-specific finger prints”), (ii) although DBA/2 and C57B1/6 mice responded rather similarly to hepatotoxins, also with respect to P450 content and most MO activities, they displayed a profound difference in the behaviour of COH activity, and (iii) within the P450 superfamily, the regulation of COH activity seems to be rather unique, also when compared to its structurally close enzyme, testosterone 15α-hydroxylase. |
| abstractGer |
Summary Acute effects of a single intraperitoneal dose of allyl alcohol (AA, 64 mg/kg), dimethylnitrosamine (DMNA, 30 mg/kg), hexachlorobutadiene (HCBD, 50 mg/kg), carbon tetrachloride (CCl4, 24 mg/kg), cocaine (60 mg/kg) and pyrazole (300 mg/kg) on the hepatic histology and monooxygenases in DBA/2 and C57B1/6 strains of mice were investigated. All substances caused histologically verified injury to the liver, which varied in appearance and severity depending on the compound and the mouse strain. Responses of P450-catalyzed reactions were highly dependent on the toxin and varied between different monooxygenase (MO) reactions and two mouse strains. In DBA/2 strain, coumarin 7-hydroxylase (COH) activity was increased from 3- to 5-fold by pyrazole, cocaine, HCBD and CCl4. With respect to P450 content and other MO activities, no changes or even decreases were generally observed. Some exceptions to this rule were found: HCBD significantly increased T15αOH, PROD and EROD activities in C57B1/6 mice, whereas cocaine caused a significant stimulation of Tl5αOH and PROD in DBA/2 mice, It is concluded that (i) different hepatoxins cause different types of liver injury and responses of the monooxygenase complex (“hepatotoxin-specific finger prints”), (ii) although DBA/2 and C57B1/6 mice responded rather similarly to hepatotoxins, also with respect to P450 content and most MO activities, they displayed a profound difference in the behaviour of COH activity, and (iii) within the P450 superfamily, the regulation of COH activity seems to be rather unique, also when compared to its structurally close enzyme, testosterone 15α-hydroxylase. |
| abstract_unstemmed |
Summary Acute effects of a single intraperitoneal dose of allyl alcohol (AA, 64 mg/kg), dimethylnitrosamine (DMNA, 30 mg/kg), hexachlorobutadiene (HCBD, 50 mg/kg), carbon tetrachloride (CCl4, 24 mg/kg), cocaine (60 mg/kg) and pyrazole (300 mg/kg) on the hepatic histology and monooxygenases in DBA/2 and C57B1/6 strains of mice were investigated. All substances caused histologically verified injury to the liver, which varied in appearance and severity depending on the compound and the mouse strain. Responses of P450-catalyzed reactions were highly dependent on the toxin and varied between different monooxygenase (MO) reactions and two mouse strains. In DBA/2 strain, coumarin 7-hydroxylase (COH) activity was increased from 3- to 5-fold by pyrazole, cocaine, HCBD and CCl4. With respect to P450 content and other MO activities, no changes or even decreases were generally observed. Some exceptions to this rule were found: HCBD significantly increased T15αOH, PROD and EROD activities in C57B1/6 mice, whereas cocaine caused a significant stimulation of Tl5αOH and PROD in DBA/2 mice, It is concluded that (i) different hepatoxins cause different types of liver injury and responses of the monooxygenase complex (“hepatotoxin-specific finger prints”), (ii) although DBA/2 and C57B1/6 mice responded rather similarly to hepatotoxins, also with respect to P450 content and most MO activities, they displayed a profound difference in the behaviour of COH activity, and (iii) within the P450 superfamily, the regulation of COH activity seems to be rather unique, also when compared to its structurally close enzyme, testosterone 15α-hydroxylase. |
| collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
| title_short |
Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases |
| url |
http://dx.doi.org/10.1007/BF00171345 |
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| author2 |
Pellinen, Pertti Stenbäck, Frej Rautio, Arja Pelkonen, Olavi Lang, Matti Pasanen, Markku |
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