Platelet adenylate cyclase activity in depression and after clomipramine and lithium treatment: relation to serotonergic function
Abstract Adenylate cyclase activity was measured in platelet membranes from 10 healthy controls, 12 depressed patients, and the same patients after treatment with clomipramine (CMI) followed by lithium carbonate (Li) supplementation, in an attempt to determine whether any evidence for an effect on t...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1992 |
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| Umfang: |
4 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Psychopharmacology - 1959, 109(1992) vom: Jan./Feb., Seite 231-234 |
| Übergeordnetes Werk: |
volume:109 ; year:1992 ; month:01/02 ; pages:231-234 ; extent:4 |
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| 520 | |a Abstract Adenylate cyclase activity was measured in platelet membranes from 10 healthy controls, 12 depressed patients, and the same patients after treatment with clomipramine (CMI) followed by lithium carbonate (Li) supplementation, in an attempt to determine whether any evidence for an effect on the serotonergic system could be obtained in peripheral cells. There were no differences in basal, NaF-, PGE1-, or forskolin-stimulated activity either between the control subjects and depressed patients or between activities in the patients measured before treatment, after CMI, and after CMI+Li. The degree of inhibition of forskolin-stimulated adenylate cyclase by 5-HT, an effect putatively mediated by a 5-HT1A-like receptor, was not different in the depressed patients compared to controls or affected by CMI treatment, but was significantly reduced after Li supplementation. | ||
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(DE-627)NLEJ200712683 DE-627 ger DE-627 rakwb eng Platelet adenylate cyclase activity in depression and after clomipramine and lithium treatment: relation to serotonergic function 1992 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Adenylate cyclase activity was measured in platelet membranes from 10 healthy controls, 12 depressed patients, and the same patients after treatment with clomipramine (CMI) followed by lithium carbonate (Li) supplementation, in an attempt to determine whether any evidence for an effect on the serotonergic system could be obtained in peripheral cells. There were no differences in basal, NaF-, PGE1-, or forskolin-stimulated activity either between the control subjects and depressed patients or between activities in the patients measured before treatment, after CMI, and after CMI+Li. The degree of inhibition of forskolin-stimulated adenylate cyclase by 5-HT, an effect putatively mediated by a 5-HT1A-like receptor, was not different in the depressed patients compared to controls or affected by CMI treatment, but was significantly reduced after Li supplementation. Springer Online Journal Archives 1860-2002 Newman, Michael E. oth Lerer, Bernard oth Lichtenberg, Pesach oth Shapira, Baruch oth in Psychopharmacology 1959 109(1992) vom: Jan./Feb., Seite 231-234 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:109 year:1992 month:01/02 pages:231-234 extent:4 http://dx.doi.org/10.1007/BF02245505 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 109 1992 1/2 231-234 4 |
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(DE-627)NLEJ200712683 DE-627 ger DE-627 rakwb eng Platelet adenylate cyclase activity in depression and after clomipramine and lithium treatment: relation to serotonergic function 1992 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Adenylate cyclase activity was measured in platelet membranes from 10 healthy controls, 12 depressed patients, and the same patients after treatment with clomipramine (CMI) followed by lithium carbonate (Li) supplementation, in an attempt to determine whether any evidence for an effect on the serotonergic system could be obtained in peripheral cells. There were no differences in basal, NaF-, PGE1-, or forskolin-stimulated activity either between the control subjects and depressed patients or between activities in the patients measured before treatment, after CMI, and after CMI+Li. The degree of inhibition of forskolin-stimulated adenylate cyclase by 5-HT, an effect putatively mediated by a 5-HT1A-like receptor, was not different in the depressed patients compared to controls or affected by CMI treatment, but was significantly reduced after Li supplementation. Springer Online Journal Archives 1860-2002 Newman, Michael E. oth Lerer, Bernard oth Lichtenberg, Pesach oth Shapira, Baruch oth in Psychopharmacology 1959 109(1992) vom: Jan./Feb., Seite 231-234 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:109 year:1992 month:01/02 pages:231-234 extent:4 http://dx.doi.org/10.1007/BF02245505 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 109 1992 1/2 231-234 4 |
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(DE-627)NLEJ200712683 DE-627 ger DE-627 rakwb eng Platelet adenylate cyclase activity in depression and after clomipramine and lithium treatment: relation to serotonergic function 1992 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Adenylate cyclase activity was measured in platelet membranes from 10 healthy controls, 12 depressed patients, and the same patients after treatment with clomipramine (CMI) followed by lithium carbonate (Li) supplementation, in an attempt to determine whether any evidence for an effect on the serotonergic system could be obtained in peripheral cells. There were no differences in basal, NaF-, PGE1-, or forskolin-stimulated activity either between the control subjects and depressed patients or between activities in the patients measured before treatment, after CMI, and after CMI+Li. The degree of inhibition of forskolin-stimulated adenylate cyclase by 5-HT, an effect putatively mediated by a 5-HT1A-like receptor, was not different in the depressed patients compared to controls or affected by CMI treatment, but was significantly reduced after Li supplementation. Springer Online Journal Archives 1860-2002 Newman, Michael E. oth Lerer, Bernard oth Lichtenberg, Pesach oth Shapira, Baruch oth in Psychopharmacology 1959 109(1992) vom: Jan./Feb., Seite 231-234 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:109 year:1992 month:01/02 pages:231-234 extent:4 http://dx.doi.org/10.1007/BF02245505 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 109 1992 1/2 231-234 4 |
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(DE-627)NLEJ200712683 DE-627 ger DE-627 rakwb eng Platelet adenylate cyclase activity in depression and after clomipramine and lithium treatment: relation to serotonergic function 1992 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Adenylate cyclase activity was measured in platelet membranes from 10 healthy controls, 12 depressed patients, and the same patients after treatment with clomipramine (CMI) followed by lithium carbonate (Li) supplementation, in an attempt to determine whether any evidence for an effect on the serotonergic system could be obtained in peripheral cells. There were no differences in basal, NaF-, PGE1-, or forskolin-stimulated activity either between the control subjects and depressed patients or between activities in the patients measured before treatment, after CMI, and after CMI+Li. The degree of inhibition of forskolin-stimulated adenylate cyclase by 5-HT, an effect putatively mediated by a 5-HT1A-like receptor, was not different in the depressed patients compared to controls or affected by CMI treatment, but was significantly reduced after Li supplementation. Springer Online Journal Archives 1860-2002 Newman, Michael E. oth Lerer, Bernard oth Lichtenberg, Pesach oth Shapira, Baruch oth in Psychopharmacology 1959 109(1992) vom: Jan./Feb., Seite 231-234 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:109 year:1992 month:01/02 pages:231-234 extent:4 http://dx.doi.org/10.1007/BF02245505 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 109 1992 1/2 231-234 4 |
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(DE-627)NLEJ200712683 DE-627 ger DE-627 rakwb eng Platelet adenylate cyclase activity in depression and after clomipramine and lithium treatment: relation to serotonergic function 1992 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Adenylate cyclase activity was measured in platelet membranes from 10 healthy controls, 12 depressed patients, and the same patients after treatment with clomipramine (CMI) followed by lithium carbonate (Li) supplementation, in an attempt to determine whether any evidence for an effect on the serotonergic system could be obtained in peripheral cells. There were no differences in basal, NaF-, PGE1-, or forskolin-stimulated activity either between the control subjects and depressed patients or between activities in the patients measured before treatment, after CMI, and after CMI+Li. The degree of inhibition of forskolin-stimulated adenylate cyclase by 5-HT, an effect putatively mediated by a 5-HT1A-like receptor, was not different in the depressed patients compared to controls or affected by CMI treatment, but was significantly reduced after Li supplementation. Springer Online Journal Archives 1860-2002 Newman, Michael E. oth Lerer, Bernard oth Lichtenberg, Pesach oth Shapira, Baruch oth in Psychopharmacology 1959 109(1992) vom: Jan./Feb., Seite 231-234 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:109 year:1992 month:01/02 pages:231-234 extent:4 http://dx.doi.org/10.1007/BF02245505 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 109 1992 1/2 231-234 4 |
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Platelet adenylate cyclase activity in depression and after clomipramine and lithium treatment: relation to serotonergic function |
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Abstract Adenylate cyclase activity was measured in platelet membranes from 10 healthy controls, 12 depressed patients, and the same patients after treatment with clomipramine (CMI) followed by lithium carbonate (Li) supplementation, in an attempt to determine whether any evidence for an effect on the serotonergic system could be obtained in peripheral cells. There were no differences in basal, NaF-, PGE1-, or forskolin-stimulated activity either between the control subjects and depressed patients or between activities in the patients measured before treatment, after CMI, and after CMI+Li. The degree of inhibition of forskolin-stimulated adenylate cyclase by 5-HT, an effect putatively mediated by a 5-HT1A-like receptor, was not different in the depressed patients compared to controls or affected by CMI treatment, but was significantly reduced after Li supplementation. |
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Abstract Adenylate cyclase activity was measured in platelet membranes from 10 healthy controls, 12 depressed patients, and the same patients after treatment with clomipramine (CMI) followed by lithium carbonate (Li) supplementation, in an attempt to determine whether any evidence for an effect on the serotonergic system could be obtained in peripheral cells. There were no differences in basal, NaF-, PGE1-, or forskolin-stimulated activity either between the control subjects and depressed patients or between activities in the patients measured before treatment, after CMI, and after CMI+Li. The degree of inhibition of forskolin-stimulated adenylate cyclase by 5-HT, an effect putatively mediated by a 5-HT1A-like receptor, was not different in the depressed patients compared to controls or affected by CMI treatment, but was significantly reduced after Li supplementation. |
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Abstract Adenylate cyclase activity was measured in platelet membranes from 10 healthy controls, 12 depressed patients, and the same patients after treatment with clomipramine (CMI) followed by lithium carbonate (Li) supplementation, in an attempt to determine whether any evidence for an effect on the serotonergic system could be obtained in peripheral cells. There were no differences in basal, NaF-, PGE1-, or forskolin-stimulated activity either between the control subjects and depressed patients or between activities in the patients measured before treatment, after CMI, and after CMI+Li. The degree of inhibition of forskolin-stimulated adenylate cyclase by 5-HT, an effect putatively mediated by a 5-HT1A-like receptor, was not different in the depressed patients compared to controls or affected by CMI treatment, but was significantly reduced after Li supplementation. |
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