Nullification of a positive correlation between urinary contents of α1-microglobulin and ulinastatin with intracerebroventricularly administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) in mice
Abstract Striatal dopamine contents in C57BL/6J mice were reduced at 24 h after intracerebroventricular (ICV) administration of 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium (MPP+) in a dose-dependent manner. A dose of 1.8 μg MPP+ significantly (P < 0.05) sup...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1998 |
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| Umfang: |
5 |
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Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Psychopharmacology - 1959, 136(1998) vom: Apr., Seite 374-378 |
| Übergeordnetes Werk: |
volume:136 ; year:1998 ; month:04 ; pages:374-378 ; extent:5 |
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| 245 | 1 | 0 | |a Nullification of a positive correlation between urinary contents of α1-microglobulin and ulinastatin with intracerebroventricularly administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) in mice |
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| 520 | |a Abstract Striatal dopamine contents in C57BL/6J mice were reduced at 24 h after intracerebroventricular (ICV) administration of 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium (MPP+) in a dose-dependent manner. A dose of 1.8 μg MPP+ significantly (P < 0.05) suppressed the dopamine contents, whereas a similar dose of MPTP did not. A definite positive correlation between urinary contents of α1-microglobulin (α1M) and ulinastatin (UT) existed in normal mice. However, this correlation was nullified by ICV administration of 18 and 36 μg MPTP or 1.8 and 18 μg MPP+. With 1.8 μg MPTP, a positive correlation between urinary contents of α1M and UT was displayed. The urine volume, creatinine content, glomerular filtration rate, α1M and UT contents, and α1M/UT ratio of urine collected for 24 h post-ICV administration of MPTP or MPP+, were not statistically different from those of control mice. Our findings suggest that the central effects of MPP+, a neurotoxic metabolite of MPTP, nullify the positive correlation between urinary contents of α1M and UT without affecting renal functions. | ||
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(DE-627)NLEJ200731165 DE-627 ger DE-627 rakwb eng Nullification of a positive correlation between urinary contents of α1-microglobulin and ulinastatin with intracerebroventricularly administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) in mice 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Striatal dopamine contents in C57BL/6J mice were reduced at 24 h after intracerebroventricular (ICV) administration of 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium (MPP+) in a dose-dependent manner. A dose of 1.8 μg MPP+ significantly (P < 0.05) suppressed the dopamine contents, whereas a similar dose of MPTP did not. A definite positive correlation between urinary contents of α1-microglobulin (α1M) and ulinastatin (UT) existed in normal mice. However, this correlation was nullified by ICV administration of 18 and 36 μg MPTP or 1.8 and 18 μg MPP+. With 1.8 μg MPTP, a positive correlation between urinary contents of α1M and UT was displayed. The urine volume, creatinine content, glomerular filtration rate, α1M and UT contents, and α1M/UT ratio of urine collected for 24 h post-ICV administration of MPTP or MPP+, were not statistically different from those of control mice. Our findings suggest that the central effects of MPP+, a neurotoxic metabolite of MPTP, nullify the positive correlation between urinary contents of α1M and UT without affecting renal functions. Springer Online Journal Archives 1860-2002 Kaku, K. oth Shikimi, T. oth Kamisaki, Y. oth Inagaki, T. oth Ishino, H. oth Okunishi, H. oth Takaori, S. oth in Psychopharmacology 1959 136(1998) vom: Apr., Seite 374-378 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:136 year:1998 month:04 pages:374-378 extent:5 http://dx.doi.org/10.1007/s002130050580 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 136 1998 4 374-378 5 |
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(DE-627)NLEJ200731165 DE-627 ger DE-627 rakwb eng Nullification of a positive correlation between urinary contents of α1-microglobulin and ulinastatin with intracerebroventricularly administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) in mice 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Striatal dopamine contents in C57BL/6J mice were reduced at 24 h after intracerebroventricular (ICV) administration of 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium (MPP+) in a dose-dependent manner. A dose of 1.8 μg MPP+ significantly (P < 0.05) suppressed the dopamine contents, whereas a similar dose of MPTP did not. A definite positive correlation between urinary contents of α1-microglobulin (α1M) and ulinastatin (UT) existed in normal mice. However, this correlation was nullified by ICV administration of 18 and 36 μg MPTP or 1.8 and 18 μg MPP+. With 1.8 μg MPTP, a positive correlation between urinary contents of α1M and UT was displayed. The urine volume, creatinine content, glomerular filtration rate, α1M and UT contents, and α1M/UT ratio of urine collected for 24 h post-ICV administration of MPTP or MPP+, were not statistically different from those of control mice. Our findings suggest that the central effects of MPP+, a neurotoxic metabolite of MPTP, nullify the positive correlation between urinary contents of α1M and UT without affecting renal functions. Springer Online Journal Archives 1860-2002 Kaku, K. oth Shikimi, T. oth Kamisaki, Y. oth Inagaki, T. oth Ishino, H. oth Okunishi, H. oth Takaori, S. oth in Psychopharmacology 1959 136(1998) vom: Apr., Seite 374-378 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:136 year:1998 month:04 pages:374-378 extent:5 http://dx.doi.org/10.1007/s002130050580 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 136 1998 4 374-378 5 |
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(DE-627)NLEJ200731165 DE-627 ger DE-627 rakwb eng Nullification of a positive correlation between urinary contents of α1-microglobulin and ulinastatin with intracerebroventricularly administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) in mice 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Striatal dopamine contents in C57BL/6J mice were reduced at 24 h after intracerebroventricular (ICV) administration of 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium (MPP+) in a dose-dependent manner. A dose of 1.8 μg MPP+ significantly (P < 0.05) suppressed the dopamine contents, whereas a similar dose of MPTP did not. A definite positive correlation between urinary contents of α1-microglobulin (α1M) and ulinastatin (UT) existed in normal mice. However, this correlation was nullified by ICV administration of 18 and 36 μg MPTP or 1.8 and 18 μg MPP+. With 1.8 μg MPTP, a positive correlation between urinary contents of α1M and UT was displayed. The urine volume, creatinine content, glomerular filtration rate, α1M and UT contents, and α1M/UT ratio of urine collected for 24 h post-ICV administration of MPTP or MPP+, were not statistically different from those of control mice. Our findings suggest that the central effects of MPP+, a neurotoxic metabolite of MPTP, nullify the positive correlation between urinary contents of α1M and UT without affecting renal functions. Springer Online Journal Archives 1860-2002 Kaku, K. oth Shikimi, T. oth Kamisaki, Y. oth Inagaki, T. oth Ishino, H. oth Okunishi, H. oth Takaori, S. oth in Psychopharmacology 1959 136(1998) vom: Apr., Seite 374-378 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:136 year:1998 month:04 pages:374-378 extent:5 http://dx.doi.org/10.1007/s002130050580 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 136 1998 4 374-378 5 |
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(DE-627)NLEJ200731165 DE-627 ger DE-627 rakwb eng Nullification of a positive correlation between urinary contents of α1-microglobulin and ulinastatin with intracerebroventricularly administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) in mice 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Striatal dopamine contents in C57BL/6J mice were reduced at 24 h after intracerebroventricular (ICV) administration of 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium (MPP+) in a dose-dependent manner. A dose of 1.8 μg MPP+ significantly (P < 0.05) suppressed the dopamine contents, whereas a similar dose of MPTP did not. A definite positive correlation between urinary contents of α1-microglobulin (α1M) and ulinastatin (UT) existed in normal mice. However, this correlation was nullified by ICV administration of 18 and 36 μg MPTP or 1.8 and 18 μg MPP+. With 1.8 μg MPTP, a positive correlation between urinary contents of α1M and UT was displayed. The urine volume, creatinine content, glomerular filtration rate, α1M and UT contents, and α1M/UT ratio of urine collected for 24 h post-ICV administration of MPTP or MPP+, were not statistically different from those of control mice. Our findings suggest that the central effects of MPP+, a neurotoxic metabolite of MPTP, nullify the positive correlation between urinary contents of α1M and UT without affecting renal functions. Springer Online Journal Archives 1860-2002 Kaku, K. oth Shikimi, T. oth Kamisaki, Y. oth Inagaki, T. oth Ishino, H. oth Okunishi, H. oth Takaori, S. oth in Psychopharmacology 1959 136(1998) vom: Apr., Seite 374-378 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:136 year:1998 month:04 pages:374-378 extent:5 http://dx.doi.org/10.1007/s002130050580 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 136 1998 4 374-378 5 |
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(DE-627)NLEJ200731165 DE-627 ger DE-627 rakwb eng Nullification of a positive correlation between urinary contents of α1-microglobulin and ulinastatin with intracerebroventricularly administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) in mice 1998 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Striatal dopamine contents in C57BL/6J mice were reduced at 24 h after intracerebroventricular (ICV) administration of 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium (MPP+) in a dose-dependent manner. A dose of 1.8 μg MPP+ significantly (P < 0.05) suppressed the dopamine contents, whereas a similar dose of MPTP did not. A definite positive correlation between urinary contents of α1-microglobulin (α1M) and ulinastatin (UT) existed in normal mice. However, this correlation was nullified by ICV administration of 18 and 36 μg MPTP or 1.8 and 18 μg MPP+. With 1.8 μg MPTP, a positive correlation between urinary contents of α1M and UT was displayed. The urine volume, creatinine content, glomerular filtration rate, α1M and UT contents, and α1M/UT ratio of urine collected for 24 h post-ICV administration of MPTP or MPP+, were not statistically different from those of control mice. Our findings suggest that the central effects of MPP+, a neurotoxic metabolite of MPTP, nullify the positive correlation between urinary contents of α1M and UT without affecting renal functions. Springer Online Journal Archives 1860-2002 Kaku, K. oth Shikimi, T. oth Kamisaki, Y. oth Inagaki, T. oth Ishino, H. oth Okunishi, H. oth Takaori, S. oth in Psychopharmacology 1959 136(1998) vom: Apr., Seite 374-378 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:136 year:1998 month:04 pages:374-378 extent:5 http://dx.doi.org/10.1007/s002130050580 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 136 1998 4 374-378 5 |
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Nullification of a positive correlation between urinary contents of α1-microglobulin and ulinastatin with intracerebroventricularly administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) in mice |
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Nullification of a positive correlation between urinary contents of α1-microglobulin and ulinastatin with intracerebroventricularly administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) in mice |
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Nullification of a positive correlation between urinary contents of α1-microglobulin and ulinastatin with intracerebroventricularly administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) in mice |
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Nullification of a positive correlation between urinary contents of α1-microglobulin and ulinastatin with intracerebroventricularly administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) in mice |
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nullification of a positive correlation between urinary contents of α1-microglobulin and ulinastatin with intracerebroventricularly administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) and 1-methyl-4-phenylpyridinium (mpp+) in mice |
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Nullification of a positive correlation between urinary contents of α1-microglobulin and ulinastatin with intracerebroventricularly administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) in mice |
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Abstract Striatal dopamine contents in C57BL/6J mice were reduced at 24 h after intracerebroventricular (ICV) administration of 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium (MPP+) in a dose-dependent manner. A dose of 1.8 μg MPP+ significantly (P < 0.05) suppressed the dopamine contents, whereas a similar dose of MPTP did not. A definite positive correlation between urinary contents of α1-microglobulin (α1M) and ulinastatin (UT) existed in normal mice. However, this correlation was nullified by ICV administration of 18 and 36 μg MPTP or 1.8 and 18 μg MPP+. With 1.8 μg MPTP, a positive correlation between urinary contents of α1M and UT was displayed. The urine volume, creatinine content, glomerular filtration rate, α1M and UT contents, and α1M/UT ratio of urine collected for 24 h post-ICV administration of MPTP or MPP+, were not statistically different from those of control mice. Our findings suggest that the central effects of MPP+, a neurotoxic metabolite of MPTP, nullify the positive correlation between urinary contents of α1M and UT without affecting renal functions. |
| abstractGer |
Abstract Striatal dopamine contents in C57BL/6J mice were reduced at 24 h after intracerebroventricular (ICV) administration of 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium (MPP+) in a dose-dependent manner. A dose of 1.8 μg MPP+ significantly (P < 0.05) suppressed the dopamine contents, whereas a similar dose of MPTP did not. A definite positive correlation between urinary contents of α1-microglobulin (α1M) and ulinastatin (UT) existed in normal mice. However, this correlation was nullified by ICV administration of 18 and 36 μg MPTP or 1.8 and 18 μg MPP+. With 1.8 μg MPTP, a positive correlation between urinary contents of α1M and UT was displayed. The urine volume, creatinine content, glomerular filtration rate, α1M and UT contents, and α1M/UT ratio of urine collected for 24 h post-ICV administration of MPTP or MPP+, were not statistically different from those of control mice. Our findings suggest that the central effects of MPP+, a neurotoxic metabolite of MPTP, nullify the positive correlation between urinary contents of α1M and UT without affecting renal functions. |
| abstract_unstemmed |
Abstract Striatal dopamine contents in C57BL/6J mice were reduced at 24 h after intracerebroventricular (ICV) administration of 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium (MPP+) in a dose-dependent manner. A dose of 1.8 μg MPP+ significantly (P < 0.05) suppressed the dopamine contents, whereas a similar dose of MPTP did not. A definite positive correlation between urinary contents of α1-microglobulin (α1M) and ulinastatin (UT) existed in normal mice. However, this correlation was nullified by ICV administration of 18 and 36 μg MPTP or 1.8 and 18 μg MPP+. With 1.8 μg MPTP, a positive correlation between urinary contents of α1M and UT was displayed. The urine volume, creatinine content, glomerular filtration rate, α1M and UT contents, and α1M/UT ratio of urine collected for 24 h post-ICV administration of MPTP or MPP+, were not statistically different from those of control mice. Our findings suggest that the central effects of MPP+, a neurotoxic metabolite of MPTP, nullify the positive correlation between urinary contents of α1M and UT without affecting renal functions. |
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Nullification of a positive correlation between urinary contents of α1-microglobulin and ulinastatin with intracerebroventricularly administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium (MPP+) in mice |
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Kaku, K. Shikimi, T. Kamisaki, Y. Inagaki, T. Ishino, H. Okunishi, H. Takaori, S. |
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