Chronopharmacological study of neuroleptics
Abstract The circadian fluctuation of sedative effect of haloperidol was experimentally studied, as part of the series of investigations on circadian fluctuation of the effect of neuroleptics. Haloperidol of various doses was administered at various times during the day to rats which had been housed...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1979 |
|---|
| Umfang: |
5 |
|---|
| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
|---|---|
| Übergeordnetes Werk: |
in: Psychopharmacology - 1959, 63(1979) vom: Feb., Seite 131-135 |
| Übergeordnetes Werk: |
volume:63 ; year:1979 ; month:02 ; pages:131-135 ; extent:5 |
| Links: |
|---|
| Katalog-ID: |
NLEJ20074545X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ20074545X | ||
| 003 | DE-627 | ||
| 005 | 20230506170031.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 070527s1979 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)NLEJ20074545X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 245 | 1 | 0 | |a Chronopharmacological study of neuroleptics |
| 264 | 1 | |c 1979 | |
| 300 | |a 5 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Abstract The circadian fluctuation of sedative effect of haloperidol was experimentally studied, as part of the series of investigations on circadian fluctuation of the effect of neuroleptics. Haloperidol of various doses was administered at various times during the day to rats which had been housed with strictly controlled lighting schedule and room temperature. It was shown that sedative effect of haloperidol was significantly affected by the time of day of administration, that is, there is a circadian fluctuation, and also that the variation pattern changed with different doses of this drug. In order to study the mechanism underlying this circadian fluctuation, time course changes in plasma and brain concentrations of the drug were measured. No significant difference in the concentrations was observed among the different times of administration. It was thus suggested that the circadian fluctuation of sedative effect of haloperidol might be due to the circadian rhythm of brain susceptibility to the drug. Antiapomorphine action of haloperidol was then examined using stereotyped behavior of the rat as an index. The result indicated the presence of the circadian fluctuation of antiapomorphine action which was in a pattern similar to the variation of the sedative effect of haloperidol. Based on the experimental results thus obtained, the generating mechanism for the circadian fluctuation of sedative effect of haloperidol was discussed. | ||
| 533 | |f Springer Online Journal Archives 1860-2002 | ||
| 700 | 1 | |a Nagayama, H. |4 oth | |
| 700 | 1 | |a Takagi, A. |4 oth | |
| 700 | 1 | |a Sakurai, Y. |4 oth | |
| 700 | 1 | |a Yoshimoto, S. |4 oth | |
| 700 | 1 | |a Nishiwaki, K. |4 oth | |
| 700 | 1 | |a Takahashi, R. |4 oth | |
| 773 | 0 | 8 | |i in |t Psychopharmacology |d 1959 |g 63(1979) vom: Feb., Seite 131-135 |w (DE-627)NLEJ188990615 |w (DE-600)2066933-1 |x 1432-2072 |7 nnns |
| 773 | 1 | 8 | |g volume:63 |g year:1979 |g month:02 |g pages:131-135 |g extent:5 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/BF00429690 |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-SOJ | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 63 |j 1979 |c 2 |h 131-135 |g 5 | ||
| matchkey_str |
article:14322072:1979----::hoohraooiasuyfe |
|---|---|
| hierarchy_sort_str |
1979 |
| publishDate |
1979 |
| allfields |
(DE-627)NLEJ20074545X DE-627 ger DE-627 rakwb eng Chronopharmacological study of neuroleptics 1979 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The circadian fluctuation of sedative effect of haloperidol was experimentally studied, as part of the series of investigations on circadian fluctuation of the effect of neuroleptics. Haloperidol of various doses was administered at various times during the day to rats which had been housed with strictly controlled lighting schedule and room temperature. It was shown that sedative effect of haloperidol was significantly affected by the time of day of administration, that is, there is a circadian fluctuation, and also that the variation pattern changed with different doses of this drug. In order to study the mechanism underlying this circadian fluctuation, time course changes in plasma and brain concentrations of the drug were measured. No significant difference in the concentrations was observed among the different times of administration. It was thus suggested that the circadian fluctuation of sedative effect of haloperidol might be due to the circadian rhythm of brain susceptibility to the drug. Antiapomorphine action of haloperidol was then examined using stereotyped behavior of the rat as an index. The result indicated the presence of the circadian fluctuation of antiapomorphine action which was in a pattern similar to the variation of the sedative effect of haloperidol. Based on the experimental results thus obtained, the generating mechanism for the circadian fluctuation of sedative effect of haloperidol was discussed. Springer Online Journal Archives 1860-2002 Nagayama, H. oth Takagi, A. oth Sakurai, Y. oth Yoshimoto, S. oth Nishiwaki, K. oth Takahashi, R. oth in Psychopharmacology 1959 63(1979) vom: Feb., Seite 131-135 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:63 year:1979 month:02 pages:131-135 extent:5 http://dx.doi.org/10.1007/BF00429690 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 63 1979 2 131-135 5 |
| spelling |
(DE-627)NLEJ20074545X DE-627 ger DE-627 rakwb eng Chronopharmacological study of neuroleptics 1979 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The circadian fluctuation of sedative effect of haloperidol was experimentally studied, as part of the series of investigations on circadian fluctuation of the effect of neuroleptics. Haloperidol of various doses was administered at various times during the day to rats which had been housed with strictly controlled lighting schedule and room temperature. It was shown that sedative effect of haloperidol was significantly affected by the time of day of administration, that is, there is a circadian fluctuation, and also that the variation pattern changed with different doses of this drug. In order to study the mechanism underlying this circadian fluctuation, time course changes in plasma and brain concentrations of the drug were measured. No significant difference in the concentrations was observed among the different times of administration. It was thus suggested that the circadian fluctuation of sedative effect of haloperidol might be due to the circadian rhythm of brain susceptibility to the drug. Antiapomorphine action of haloperidol was then examined using stereotyped behavior of the rat as an index. The result indicated the presence of the circadian fluctuation of antiapomorphine action which was in a pattern similar to the variation of the sedative effect of haloperidol. Based on the experimental results thus obtained, the generating mechanism for the circadian fluctuation of sedative effect of haloperidol was discussed. Springer Online Journal Archives 1860-2002 Nagayama, H. oth Takagi, A. oth Sakurai, Y. oth Yoshimoto, S. oth Nishiwaki, K. oth Takahashi, R. oth in Psychopharmacology 1959 63(1979) vom: Feb., Seite 131-135 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:63 year:1979 month:02 pages:131-135 extent:5 http://dx.doi.org/10.1007/BF00429690 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 63 1979 2 131-135 5 |
| allfields_unstemmed |
(DE-627)NLEJ20074545X DE-627 ger DE-627 rakwb eng Chronopharmacological study of neuroleptics 1979 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The circadian fluctuation of sedative effect of haloperidol was experimentally studied, as part of the series of investigations on circadian fluctuation of the effect of neuroleptics. Haloperidol of various doses was administered at various times during the day to rats which had been housed with strictly controlled lighting schedule and room temperature. It was shown that sedative effect of haloperidol was significantly affected by the time of day of administration, that is, there is a circadian fluctuation, and also that the variation pattern changed with different doses of this drug. In order to study the mechanism underlying this circadian fluctuation, time course changes in plasma and brain concentrations of the drug were measured. No significant difference in the concentrations was observed among the different times of administration. It was thus suggested that the circadian fluctuation of sedative effect of haloperidol might be due to the circadian rhythm of brain susceptibility to the drug. Antiapomorphine action of haloperidol was then examined using stereotyped behavior of the rat as an index. The result indicated the presence of the circadian fluctuation of antiapomorphine action which was in a pattern similar to the variation of the sedative effect of haloperidol. Based on the experimental results thus obtained, the generating mechanism for the circadian fluctuation of sedative effect of haloperidol was discussed. Springer Online Journal Archives 1860-2002 Nagayama, H. oth Takagi, A. oth Sakurai, Y. oth Yoshimoto, S. oth Nishiwaki, K. oth Takahashi, R. oth in Psychopharmacology 1959 63(1979) vom: Feb., Seite 131-135 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:63 year:1979 month:02 pages:131-135 extent:5 http://dx.doi.org/10.1007/BF00429690 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 63 1979 2 131-135 5 |
| allfieldsGer |
(DE-627)NLEJ20074545X DE-627 ger DE-627 rakwb eng Chronopharmacological study of neuroleptics 1979 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The circadian fluctuation of sedative effect of haloperidol was experimentally studied, as part of the series of investigations on circadian fluctuation of the effect of neuroleptics. Haloperidol of various doses was administered at various times during the day to rats which had been housed with strictly controlled lighting schedule and room temperature. It was shown that sedative effect of haloperidol was significantly affected by the time of day of administration, that is, there is a circadian fluctuation, and also that the variation pattern changed with different doses of this drug. In order to study the mechanism underlying this circadian fluctuation, time course changes in plasma and brain concentrations of the drug were measured. No significant difference in the concentrations was observed among the different times of administration. It was thus suggested that the circadian fluctuation of sedative effect of haloperidol might be due to the circadian rhythm of brain susceptibility to the drug. Antiapomorphine action of haloperidol was then examined using stereotyped behavior of the rat as an index. The result indicated the presence of the circadian fluctuation of antiapomorphine action which was in a pattern similar to the variation of the sedative effect of haloperidol. Based on the experimental results thus obtained, the generating mechanism for the circadian fluctuation of sedative effect of haloperidol was discussed. Springer Online Journal Archives 1860-2002 Nagayama, H. oth Takagi, A. oth Sakurai, Y. oth Yoshimoto, S. oth Nishiwaki, K. oth Takahashi, R. oth in Psychopharmacology 1959 63(1979) vom: Feb., Seite 131-135 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:63 year:1979 month:02 pages:131-135 extent:5 http://dx.doi.org/10.1007/BF00429690 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 63 1979 2 131-135 5 |
| allfieldsSound |
(DE-627)NLEJ20074545X DE-627 ger DE-627 rakwb eng Chronopharmacological study of neuroleptics 1979 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The circadian fluctuation of sedative effect of haloperidol was experimentally studied, as part of the series of investigations on circadian fluctuation of the effect of neuroleptics. Haloperidol of various doses was administered at various times during the day to rats which had been housed with strictly controlled lighting schedule and room temperature. It was shown that sedative effect of haloperidol was significantly affected by the time of day of administration, that is, there is a circadian fluctuation, and also that the variation pattern changed with different doses of this drug. In order to study the mechanism underlying this circadian fluctuation, time course changes in plasma and brain concentrations of the drug were measured. No significant difference in the concentrations was observed among the different times of administration. It was thus suggested that the circadian fluctuation of sedative effect of haloperidol might be due to the circadian rhythm of brain susceptibility to the drug. Antiapomorphine action of haloperidol was then examined using stereotyped behavior of the rat as an index. The result indicated the presence of the circadian fluctuation of antiapomorphine action which was in a pattern similar to the variation of the sedative effect of haloperidol. Based on the experimental results thus obtained, the generating mechanism for the circadian fluctuation of sedative effect of haloperidol was discussed. Springer Online Journal Archives 1860-2002 Nagayama, H. oth Takagi, A. oth Sakurai, Y. oth Yoshimoto, S. oth Nishiwaki, K. oth Takahashi, R. oth in Psychopharmacology 1959 63(1979) vom: Feb., Seite 131-135 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:63 year:1979 month:02 pages:131-135 extent:5 http://dx.doi.org/10.1007/BF00429690 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 63 1979 2 131-135 5 |
| language |
English |
| source |
in Psychopharmacology 63(1979) vom: Feb., Seite 131-135 volume:63 year:1979 month:02 pages:131-135 extent:5 |
| sourceStr |
in Psychopharmacology 63(1979) vom: Feb., Seite 131-135 volume:63 year:1979 month:02 pages:131-135 extent:5 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Psychopharmacology |
| authorswithroles_txt_mv |
Nagayama, H. @@oth@@ Takagi, A. @@oth@@ Sakurai, Y. @@oth@@ Yoshimoto, S. @@oth@@ Nishiwaki, K. @@oth@@ Takahashi, R. @@oth@@ |
| publishDateDaySort_date |
1979-02-01T00:00:00Z |
| hierarchy_top_id |
NLEJ188990615 |
| id |
NLEJ20074545X |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ20074545X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506170031.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1979 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ20074545X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Chronopharmacological study of neuroleptics</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1979</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">5</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The circadian fluctuation of sedative effect of haloperidol was experimentally studied, as part of the series of investigations on circadian fluctuation of the effect of neuroleptics. Haloperidol of various doses was administered at various times during the day to rats which had been housed with strictly controlled lighting schedule and room temperature. It was shown that sedative effect of haloperidol was significantly affected by the time of day of administration, that is, there is a circadian fluctuation, and also that the variation pattern changed with different doses of this drug. In order to study the mechanism underlying this circadian fluctuation, time course changes in plasma and brain concentrations of the drug were measured. No significant difference in the concentrations was observed among the different times of administration. It was thus suggested that the circadian fluctuation of sedative effect of haloperidol might be due to the circadian rhythm of brain susceptibility to the drug. Antiapomorphine action of haloperidol was then examined using stereotyped behavior of the rat as an index. The result indicated the presence of the circadian fluctuation of antiapomorphine action which was in a pattern similar to the variation of the sedative effect of haloperidol. Based on the experimental results thus obtained, the generating mechanism for the circadian fluctuation of sedative effect of haloperidol was discussed.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nagayama, H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takagi, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sakurai, Y.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yoshimoto, S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nishiwaki, K.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takahashi, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Psychopharmacology</subfield><subfield code="d">1959</subfield><subfield code="g">63(1979) vom: Feb., Seite 131-135</subfield><subfield code="w">(DE-627)NLEJ188990615</subfield><subfield code="w">(DE-600)2066933-1</subfield><subfield code="x">1432-2072</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:63</subfield><subfield code="g">year:1979</subfield><subfield code="g">month:02</subfield><subfield code="g">pages:131-135</subfield><subfield code="g">extent:5</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00429690</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">63</subfield><subfield code="j">1979</subfield><subfield code="c">2</subfield><subfield code="h">131-135</subfield><subfield code="g">5</subfield></datafield></record></collection>
|
| series2 |
Springer Online Journal Archives 1860-2002 |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ188990615 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| collection |
NL |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1432-2072 |
| topic_title |
Chronopharmacological study of neuroleptics |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
h n hn a t at y s ys s y sy k n kn r t rt |
| hierarchy_parent_title |
Psychopharmacology |
| hierarchy_parent_id |
NLEJ188990615 |
| hierarchy_top_title |
Psychopharmacology |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ188990615 (DE-600)2066933-1 |
| title |
Chronopharmacological study of neuroleptics |
| spellingShingle |
Chronopharmacological study of neuroleptics |
| ctrlnum |
(DE-627)NLEJ20074545X |
| title_full |
Chronopharmacological study of neuroleptics |
| journal |
Psychopharmacology |
| journalStr |
Psychopharmacology |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1979 |
| contenttype_str_mv |
zzz |
| container_start_page |
131 |
| container_volume |
63 |
| physical |
5 |
| format_se |
Elektronische Aufsätze |
| title_sort |
chronopharmacological study of neuroleptics |
| title_auth |
Chronopharmacological study of neuroleptics |
| abstract |
Abstract The circadian fluctuation of sedative effect of haloperidol was experimentally studied, as part of the series of investigations on circadian fluctuation of the effect of neuroleptics. Haloperidol of various doses was administered at various times during the day to rats which had been housed with strictly controlled lighting schedule and room temperature. It was shown that sedative effect of haloperidol was significantly affected by the time of day of administration, that is, there is a circadian fluctuation, and also that the variation pattern changed with different doses of this drug. In order to study the mechanism underlying this circadian fluctuation, time course changes in plasma and brain concentrations of the drug were measured. No significant difference in the concentrations was observed among the different times of administration. It was thus suggested that the circadian fluctuation of sedative effect of haloperidol might be due to the circadian rhythm of brain susceptibility to the drug. Antiapomorphine action of haloperidol was then examined using stereotyped behavior of the rat as an index. The result indicated the presence of the circadian fluctuation of antiapomorphine action which was in a pattern similar to the variation of the sedative effect of haloperidol. Based on the experimental results thus obtained, the generating mechanism for the circadian fluctuation of sedative effect of haloperidol was discussed. |
| abstractGer |
Abstract The circadian fluctuation of sedative effect of haloperidol was experimentally studied, as part of the series of investigations on circadian fluctuation of the effect of neuroleptics. Haloperidol of various doses was administered at various times during the day to rats which had been housed with strictly controlled lighting schedule and room temperature. It was shown that sedative effect of haloperidol was significantly affected by the time of day of administration, that is, there is a circadian fluctuation, and also that the variation pattern changed with different doses of this drug. In order to study the mechanism underlying this circadian fluctuation, time course changes in plasma and brain concentrations of the drug were measured. No significant difference in the concentrations was observed among the different times of administration. It was thus suggested that the circadian fluctuation of sedative effect of haloperidol might be due to the circadian rhythm of brain susceptibility to the drug. Antiapomorphine action of haloperidol was then examined using stereotyped behavior of the rat as an index. The result indicated the presence of the circadian fluctuation of antiapomorphine action which was in a pattern similar to the variation of the sedative effect of haloperidol. Based on the experimental results thus obtained, the generating mechanism for the circadian fluctuation of sedative effect of haloperidol was discussed. |
| abstract_unstemmed |
Abstract The circadian fluctuation of sedative effect of haloperidol was experimentally studied, as part of the series of investigations on circadian fluctuation of the effect of neuroleptics. Haloperidol of various doses was administered at various times during the day to rats which had been housed with strictly controlled lighting schedule and room temperature. It was shown that sedative effect of haloperidol was significantly affected by the time of day of administration, that is, there is a circadian fluctuation, and also that the variation pattern changed with different doses of this drug. In order to study the mechanism underlying this circadian fluctuation, time course changes in plasma and brain concentrations of the drug were measured. No significant difference in the concentrations was observed among the different times of administration. It was thus suggested that the circadian fluctuation of sedative effect of haloperidol might be due to the circadian rhythm of brain susceptibility to the drug. Antiapomorphine action of haloperidol was then examined using stereotyped behavior of the rat as an index. The result indicated the presence of the circadian fluctuation of antiapomorphine action which was in a pattern similar to the variation of the sedative effect of haloperidol. Based on the experimental results thus obtained, the generating mechanism for the circadian fluctuation of sedative effect of haloperidol was discussed. |
| collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
| title_short |
Chronopharmacological study of neuroleptics |
| url |
http://dx.doi.org/10.1007/BF00429690 |
| remote_bool |
true |
| author2 |
Nagayama, H. Takagi, A. Sakurai, Y. Yoshimoto, S. Nishiwaki, K. Takahashi, R. |
| author2Str |
Nagayama, H. Takagi, A. Sakurai, Y. Yoshimoto, S. Nishiwaki, K. Takahashi, R. |
| ppnlink |
NLEJ188990615 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth oth |
| up_date |
2024-07-06T03:44:24.070Z |
| _version_ |
1803799719125712896 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ20074545X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506170031.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1979 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ20074545X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Chronopharmacological study of neuroleptics</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1979</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">5</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The circadian fluctuation of sedative effect of haloperidol was experimentally studied, as part of the series of investigations on circadian fluctuation of the effect of neuroleptics. Haloperidol of various doses was administered at various times during the day to rats which had been housed with strictly controlled lighting schedule and room temperature. It was shown that sedative effect of haloperidol was significantly affected by the time of day of administration, that is, there is a circadian fluctuation, and also that the variation pattern changed with different doses of this drug. In order to study the mechanism underlying this circadian fluctuation, time course changes in plasma and brain concentrations of the drug were measured. No significant difference in the concentrations was observed among the different times of administration. It was thus suggested that the circadian fluctuation of sedative effect of haloperidol might be due to the circadian rhythm of brain susceptibility to the drug. Antiapomorphine action of haloperidol was then examined using stereotyped behavior of the rat as an index. The result indicated the presence of the circadian fluctuation of antiapomorphine action which was in a pattern similar to the variation of the sedative effect of haloperidol. Based on the experimental results thus obtained, the generating mechanism for the circadian fluctuation of sedative effect of haloperidol was discussed.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nagayama, H.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takagi, A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sakurai, Y.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yoshimoto, S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nishiwaki, K.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takahashi, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Psychopharmacology</subfield><subfield code="d">1959</subfield><subfield code="g">63(1979) vom: Feb., Seite 131-135</subfield><subfield code="w">(DE-627)NLEJ188990615</subfield><subfield code="w">(DE-600)2066933-1</subfield><subfield code="x">1432-2072</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:63</subfield><subfield code="g">year:1979</subfield><subfield code="g">month:02</subfield><subfield code="g">pages:131-135</subfield><subfield code="g">extent:5</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00429690</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">63</subfield><subfield code="j">1979</subfield><subfield code="c">2</subfield><subfield code="h">131-135</subfield><subfield code="g">5</subfield></datafield></record></collection>
|
| score |
7.401602 |