Failure obtain “cannabis-directed behavior” and abstinence syndrome in rats chronically treated with Cannabis sativa extracts
Abstract Experiments were performed to verify whether chronic treatment with Cannabis saliva extracts would induce dependence and/or abstinence symptoms in rats. In Experiment one, rats ingested cannabis extract as the only fluid for 126 days. On days 1, 43, 48, 62, 80, 92 and 119 when the animals w...
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1974 |
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13 |
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Springer Online Journal Archives 1860-2002 |
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in: Psychopharmacology - 1959, 36(1974) vom: Feb., Seite 133-145 |
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volume:36 ; year:1974 ; month:02 ; pages:133-145 ; extent:13 |
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| 520 | |a Abstract Experiments were performed to verify whether chronic treatment with Cannabis saliva extracts would induce dependence and/or abstinence symptoms in rats. In Experiment one, rats ingested cannabis extract as the only fluid for 126 days. On days 1, 43, 48, 62, 80, 92 and 119 when the animals were in abstinence from previous administration of marihuana for 0 to 96 h, behavioral measures and choice tests between marihuana suspension and control solution were carried out; the rats preferred to drink the control solution and no behavioral symptoms indicating abstinence were noted. In Experiment two, rats were trained to drink a marihuana suspension or control solution in order to be rewarded with sweetened milk. After 22 sessions water was substituted for the milk. Extinction curves for both groups were similar, and in choice tests among cannabis suspension, water and control solution, the animals refused to drink the marihuana suspension. In Experiment three, rats received i.p. injections of a cannabis extract or control solution during 36 days. From days 37–40 the drugs were withheld and sensitivity to penty-lenetetrazol was assessed. Marihuana chronically treated rats were more resistant to convulsions and fewer died after pentylenetetrazol. In Experiment four, rats were treated with marihuana extract, control solution or sodium barbitone during 73 days. At days 74–76, when undergoing 24, 48 and 72 h of abstinence, the animals were exposed to sound from a bell. Animals in abstinence from barbitone showed a high incidence of convulsions; marihuana treated rats did not differ from control animals. These results suggest that rats do not self administer marihuana (Experiments one and two) and do not present abstinence symptoms after prolonged periods of ingestion of the drug (Experiments 1, 3 and 4). | ||
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(DE-627)NLEJ200758527 DE-627 ger DE-627 rakwb eng Failure obtain “cannabis-directed behavior” and abstinence syndrome in rats chronically treated with Cannabis sativa extracts 1974 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Experiments were performed to verify whether chronic treatment with Cannabis saliva extracts would induce dependence and/or abstinence symptoms in rats. In Experiment one, rats ingested cannabis extract as the only fluid for 126 days. On days 1, 43, 48, 62, 80, 92 and 119 when the animals were in abstinence from previous administration of marihuana for 0 to 96 h, behavioral measures and choice tests between marihuana suspension and control solution were carried out; the rats preferred to drink the control solution and no behavioral symptoms indicating abstinence were noted. In Experiment two, rats were trained to drink a marihuana suspension or control solution in order to be rewarded with sweetened milk. After 22 sessions water was substituted for the milk. Extinction curves for both groups were similar, and in choice tests among cannabis suspension, water and control solution, the animals refused to drink the marihuana suspension. In Experiment three, rats received i.p. injections of a cannabis extract or control solution during 36 days. From days 37–40 the drugs were withheld and sensitivity to penty-lenetetrazol was assessed. Marihuana chronically treated rats were more resistant to convulsions and fewer died after pentylenetetrazol. In Experiment four, rats were treated with marihuana extract, control solution or sodium barbitone during 73 days. At days 74–76, when undergoing 24, 48 and 72 h of abstinence, the animals were exposed to sound from a bell. Animals in abstinence from barbitone showed a high incidence of convulsions; marihuana treated rats did not differ from control animals. These results suggest that rats do not self administer marihuana (Experiments one and two) and do not present abstinence symptoms after prolonged periods of ingestion of the drug (Experiments 1, 3 and 4). Springer Online Journal Archives 1860-2002 Leite, José Roberto oth Carlini, E. A. oth in Psychopharmacology 1959 36(1974) vom: Feb., Seite 133-145 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:36 year:1974 month:02 pages:133-145 extent:13 http://dx.doi.org/10.1007/BF00421785 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 36 1974 2 133-145 13 |
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(DE-627)NLEJ200758527 DE-627 ger DE-627 rakwb eng Failure obtain “cannabis-directed behavior” and abstinence syndrome in rats chronically treated with Cannabis sativa extracts 1974 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Experiments were performed to verify whether chronic treatment with Cannabis saliva extracts would induce dependence and/or abstinence symptoms in rats. In Experiment one, rats ingested cannabis extract as the only fluid for 126 days. On days 1, 43, 48, 62, 80, 92 and 119 when the animals were in abstinence from previous administration of marihuana for 0 to 96 h, behavioral measures and choice tests between marihuana suspension and control solution were carried out; the rats preferred to drink the control solution and no behavioral symptoms indicating abstinence were noted. In Experiment two, rats were trained to drink a marihuana suspension or control solution in order to be rewarded with sweetened milk. After 22 sessions water was substituted for the milk. Extinction curves for both groups were similar, and in choice tests among cannabis suspension, water and control solution, the animals refused to drink the marihuana suspension. In Experiment three, rats received i.p. injections of a cannabis extract or control solution during 36 days. From days 37–40 the drugs were withheld and sensitivity to penty-lenetetrazol was assessed. Marihuana chronically treated rats were more resistant to convulsions and fewer died after pentylenetetrazol. In Experiment four, rats were treated with marihuana extract, control solution or sodium barbitone during 73 days. At days 74–76, when undergoing 24, 48 and 72 h of abstinence, the animals were exposed to sound from a bell. Animals in abstinence from barbitone showed a high incidence of convulsions; marihuana treated rats did not differ from control animals. These results suggest that rats do not self administer marihuana (Experiments one and two) and do not present abstinence symptoms after prolonged periods of ingestion of the drug (Experiments 1, 3 and 4). Springer Online Journal Archives 1860-2002 Leite, José Roberto oth Carlini, E. A. oth in Psychopharmacology 1959 36(1974) vom: Feb., Seite 133-145 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:36 year:1974 month:02 pages:133-145 extent:13 http://dx.doi.org/10.1007/BF00421785 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 36 1974 2 133-145 13 |
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(DE-627)NLEJ200758527 DE-627 ger DE-627 rakwb eng Failure obtain “cannabis-directed behavior” and abstinence syndrome in rats chronically treated with Cannabis sativa extracts 1974 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Experiments were performed to verify whether chronic treatment with Cannabis saliva extracts would induce dependence and/or abstinence symptoms in rats. In Experiment one, rats ingested cannabis extract as the only fluid for 126 days. On days 1, 43, 48, 62, 80, 92 and 119 when the animals were in abstinence from previous administration of marihuana for 0 to 96 h, behavioral measures and choice tests between marihuana suspension and control solution were carried out; the rats preferred to drink the control solution and no behavioral symptoms indicating abstinence were noted. In Experiment two, rats were trained to drink a marihuana suspension or control solution in order to be rewarded with sweetened milk. After 22 sessions water was substituted for the milk. Extinction curves for both groups were similar, and in choice tests among cannabis suspension, water and control solution, the animals refused to drink the marihuana suspension. In Experiment three, rats received i.p. injections of a cannabis extract or control solution during 36 days. From days 37–40 the drugs were withheld and sensitivity to penty-lenetetrazol was assessed. Marihuana chronically treated rats were more resistant to convulsions and fewer died after pentylenetetrazol. In Experiment four, rats were treated with marihuana extract, control solution or sodium barbitone during 73 days. At days 74–76, when undergoing 24, 48 and 72 h of abstinence, the animals were exposed to sound from a bell. Animals in abstinence from barbitone showed a high incidence of convulsions; marihuana treated rats did not differ from control animals. These results suggest that rats do not self administer marihuana (Experiments one and two) and do not present abstinence symptoms after prolonged periods of ingestion of the drug (Experiments 1, 3 and 4). Springer Online Journal Archives 1860-2002 Leite, José Roberto oth Carlini, E. A. oth in Psychopharmacology 1959 36(1974) vom: Feb., Seite 133-145 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:36 year:1974 month:02 pages:133-145 extent:13 http://dx.doi.org/10.1007/BF00421785 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 36 1974 2 133-145 13 |
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(DE-627)NLEJ200758527 DE-627 ger DE-627 rakwb eng Failure obtain “cannabis-directed behavior” and abstinence syndrome in rats chronically treated with Cannabis sativa extracts 1974 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Experiments were performed to verify whether chronic treatment with Cannabis saliva extracts would induce dependence and/or abstinence symptoms in rats. In Experiment one, rats ingested cannabis extract as the only fluid for 126 days. On days 1, 43, 48, 62, 80, 92 and 119 when the animals were in abstinence from previous administration of marihuana for 0 to 96 h, behavioral measures and choice tests between marihuana suspension and control solution were carried out; the rats preferred to drink the control solution and no behavioral symptoms indicating abstinence were noted. In Experiment two, rats were trained to drink a marihuana suspension or control solution in order to be rewarded with sweetened milk. After 22 sessions water was substituted for the milk. Extinction curves for both groups were similar, and in choice tests among cannabis suspension, water and control solution, the animals refused to drink the marihuana suspension. In Experiment three, rats received i.p. injections of a cannabis extract or control solution during 36 days. From days 37–40 the drugs were withheld and sensitivity to penty-lenetetrazol was assessed. Marihuana chronically treated rats were more resistant to convulsions and fewer died after pentylenetetrazol. In Experiment four, rats were treated with marihuana extract, control solution or sodium barbitone during 73 days. At days 74–76, when undergoing 24, 48 and 72 h of abstinence, the animals were exposed to sound from a bell. Animals in abstinence from barbitone showed a high incidence of convulsions; marihuana treated rats did not differ from control animals. These results suggest that rats do not self administer marihuana (Experiments one and two) and do not present abstinence symptoms after prolonged periods of ingestion of the drug (Experiments 1, 3 and 4). Springer Online Journal Archives 1860-2002 Leite, José Roberto oth Carlini, E. A. oth in Psychopharmacology 1959 36(1974) vom: Feb., Seite 133-145 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:36 year:1974 month:02 pages:133-145 extent:13 http://dx.doi.org/10.1007/BF00421785 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 36 1974 2 133-145 13 |
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(DE-627)NLEJ200758527 DE-627 ger DE-627 rakwb eng Failure obtain “cannabis-directed behavior” and abstinence syndrome in rats chronically treated with Cannabis sativa extracts 1974 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Experiments were performed to verify whether chronic treatment with Cannabis saliva extracts would induce dependence and/or abstinence symptoms in rats. In Experiment one, rats ingested cannabis extract as the only fluid for 126 days. On days 1, 43, 48, 62, 80, 92 and 119 when the animals were in abstinence from previous administration of marihuana for 0 to 96 h, behavioral measures and choice tests between marihuana suspension and control solution were carried out; the rats preferred to drink the control solution and no behavioral symptoms indicating abstinence were noted. In Experiment two, rats were trained to drink a marihuana suspension or control solution in order to be rewarded with sweetened milk. After 22 sessions water was substituted for the milk. Extinction curves for both groups were similar, and in choice tests among cannabis suspension, water and control solution, the animals refused to drink the marihuana suspension. In Experiment three, rats received i.p. injections of a cannabis extract or control solution during 36 days. From days 37–40 the drugs were withheld and sensitivity to penty-lenetetrazol was assessed. Marihuana chronically treated rats were more resistant to convulsions and fewer died after pentylenetetrazol. In Experiment four, rats were treated with marihuana extract, control solution or sodium barbitone during 73 days. At days 74–76, when undergoing 24, 48 and 72 h of abstinence, the animals were exposed to sound from a bell. Animals in abstinence from barbitone showed a high incidence of convulsions; marihuana treated rats did not differ from control animals. These results suggest that rats do not self administer marihuana (Experiments one and two) and do not present abstinence symptoms after prolonged periods of ingestion of the drug (Experiments 1, 3 and 4). Springer Online Journal Archives 1860-2002 Leite, José Roberto oth Carlini, E. A. oth in Psychopharmacology 1959 36(1974) vom: Feb., Seite 133-145 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:36 year:1974 month:02 pages:133-145 extent:13 http://dx.doi.org/10.1007/BF00421785 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 36 1974 2 133-145 13 |
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In Experiment one, rats ingested cannabis extract as the only fluid for 126 days. On days 1, 43, 48, 62, 80, 92 and 119 when the animals were in abstinence from previous administration of marihuana for 0 to 96 h, behavioral measures and choice tests between marihuana suspension and control solution were carried out; the rats preferred to drink the control solution and no behavioral symptoms indicating abstinence were noted. In Experiment two, rats were trained to drink a marihuana suspension or control solution in order to be rewarded with sweetened milk. After 22 sessions water was substituted for the milk. Extinction curves for both groups were similar, and in choice tests among cannabis suspension, water and control solution, the animals refused to drink the marihuana suspension. In Experiment three, rats received i.p. injections of a cannabis extract or control solution during 36 days. From days 37–40 the drugs were withheld and sensitivity to penty-lenetetrazol was assessed. Marihuana chronically treated rats were more resistant to convulsions and fewer died after pentylenetetrazol. In Experiment four, rats were treated with marihuana extract, control solution or sodium barbitone during 73 days. At days 74–76, when undergoing 24, 48 and 72 h of abstinence, the animals were exposed to sound from a bell. Animals in abstinence from barbitone showed a high incidence of convulsions; marihuana treated rats did not differ from control animals. 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failure obtain “cannabis-directed behavior” and abstinence syndrome in rats chronically treated with cannabis sativa extracts |
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Failure obtain “cannabis-directed behavior” and abstinence syndrome in rats chronically treated with Cannabis sativa extracts |
| abstract |
Abstract Experiments were performed to verify whether chronic treatment with Cannabis saliva extracts would induce dependence and/or abstinence symptoms in rats. In Experiment one, rats ingested cannabis extract as the only fluid for 126 days. On days 1, 43, 48, 62, 80, 92 and 119 when the animals were in abstinence from previous administration of marihuana for 0 to 96 h, behavioral measures and choice tests between marihuana suspension and control solution were carried out; the rats preferred to drink the control solution and no behavioral symptoms indicating abstinence were noted. In Experiment two, rats were trained to drink a marihuana suspension or control solution in order to be rewarded with sweetened milk. After 22 sessions water was substituted for the milk. Extinction curves for both groups were similar, and in choice tests among cannabis suspension, water and control solution, the animals refused to drink the marihuana suspension. In Experiment three, rats received i.p. injections of a cannabis extract or control solution during 36 days. From days 37–40 the drugs were withheld and sensitivity to penty-lenetetrazol was assessed. Marihuana chronically treated rats were more resistant to convulsions and fewer died after pentylenetetrazol. In Experiment four, rats were treated with marihuana extract, control solution or sodium barbitone during 73 days. At days 74–76, when undergoing 24, 48 and 72 h of abstinence, the animals were exposed to sound from a bell. Animals in abstinence from barbitone showed a high incidence of convulsions; marihuana treated rats did not differ from control animals. These results suggest that rats do not self administer marihuana (Experiments one and two) and do not present abstinence symptoms after prolonged periods of ingestion of the drug (Experiments 1, 3 and 4). |
| abstractGer |
Abstract Experiments were performed to verify whether chronic treatment with Cannabis saliva extracts would induce dependence and/or abstinence symptoms in rats. In Experiment one, rats ingested cannabis extract as the only fluid for 126 days. On days 1, 43, 48, 62, 80, 92 and 119 when the animals were in abstinence from previous administration of marihuana for 0 to 96 h, behavioral measures and choice tests between marihuana suspension and control solution were carried out; the rats preferred to drink the control solution and no behavioral symptoms indicating abstinence were noted. In Experiment two, rats were trained to drink a marihuana suspension or control solution in order to be rewarded with sweetened milk. After 22 sessions water was substituted for the milk. Extinction curves for both groups were similar, and in choice tests among cannabis suspension, water and control solution, the animals refused to drink the marihuana suspension. In Experiment three, rats received i.p. injections of a cannabis extract or control solution during 36 days. From days 37–40 the drugs were withheld and sensitivity to penty-lenetetrazol was assessed. Marihuana chronically treated rats were more resistant to convulsions and fewer died after pentylenetetrazol. In Experiment four, rats were treated with marihuana extract, control solution or sodium barbitone during 73 days. At days 74–76, when undergoing 24, 48 and 72 h of abstinence, the animals were exposed to sound from a bell. Animals in abstinence from barbitone showed a high incidence of convulsions; marihuana treated rats did not differ from control animals. These results suggest that rats do not self administer marihuana (Experiments one and two) and do not present abstinence symptoms after prolonged periods of ingestion of the drug (Experiments 1, 3 and 4). |
| abstract_unstemmed |
Abstract Experiments were performed to verify whether chronic treatment with Cannabis saliva extracts would induce dependence and/or abstinence symptoms in rats. In Experiment one, rats ingested cannabis extract as the only fluid for 126 days. On days 1, 43, 48, 62, 80, 92 and 119 when the animals were in abstinence from previous administration of marihuana for 0 to 96 h, behavioral measures and choice tests between marihuana suspension and control solution were carried out; the rats preferred to drink the control solution and no behavioral symptoms indicating abstinence were noted. In Experiment two, rats were trained to drink a marihuana suspension or control solution in order to be rewarded with sweetened milk. After 22 sessions water was substituted for the milk. Extinction curves for both groups were similar, and in choice tests among cannabis suspension, water and control solution, the animals refused to drink the marihuana suspension. In Experiment three, rats received i.p. injections of a cannabis extract or control solution during 36 days. From days 37–40 the drugs were withheld and sensitivity to penty-lenetetrazol was assessed. Marihuana chronically treated rats were more resistant to convulsions and fewer died after pentylenetetrazol. In Experiment four, rats were treated with marihuana extract, control solution or sodium barbitone during 73 days. At days 74–76, when undergoing 24, 48 and 72 h of abstinence, the animals were exposed to sound from a bell. Animals in abstinence from barbitone showed a high incidence of convulsions; marihuana treated rats did not differ from control animals. These results suggest that rats do not self administer marihuana (Experiments one and two) and do not present abstinence symptoms after prolonged periods of ingestion of the drug (Experiments 1, 3 and 4). |
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| title_short |
Failure obtain “cannabis-directed behavior” and abstinence syndrome in rats chronically treated with Cannabis sativa extracts |
| url |
http://dx.doi.org/10.1007/BF00421785 |
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true |
| author2 |
Leite, José Roberto Carlini, E. A. |
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Leite, José Roberto Carlini, E. A. |
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NLEJ188990615 |
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false |
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false |
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oth oth |
| up_date |
2024-07-06T03:46:59.444Z |
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1803799882048208896 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ200758527</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506170104.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1974 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ200758527</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Failure obtain “cannabis-directed behavior” and abstinence syndrome in rats chronically treated with Cannabis sativa extracts</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1974</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">13</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Experiments were performed to verify whether chronic treatment with Cannabis saliva extracts would induce dependence and/or abstinence symptoms in rats. In Experiment one, rats ingested cannabis extract as the only fluid for 126 days. On days 1, 43, 48, 62, 80, 92 and 119 when the animals were in abstinence from previous administration of marihuana for 0 to 96 h, behavioral measures and choice tests between marihuana suspension and control solution were carried out; the rats preferred to drink the control solution and no behavioral symptoms indicating abstinence were noted. In Experiment two, rats were trained to drink a marihuana suspension or control solution in order to be rewarded with sweetened milk. After 22 sessions water was substituted for the milk. Extinction curves for both groups were similar, and in choice tests among cannabis suspension, water and control solution, the animals refused to drink the marihuana suspension. In Experiment three, rats received i.p. injections of a cannabis extract or control solution during 36 days. From days 37–40 the drugs were withheld and sensitivity to penty-lenetetrazol was assessed. Marihuana chronically treated rats were more resistant to convulsions and fewer died after pentylenetetrazol. In Experiment four, rats were treated with marihuana extract, control solution or sodium barbitone during 73 days. At days 74–76, when undergoing 24, 48 and 72 h of abstinence, the animals were exposed to sound from a bell. Animals in abstinence from barbitone showed a high incidence of convulsions; marihuana treated rats did not differ from control animals. These results suggest that rats do not self administer marihuana (Experiments one and two) and do not present abstinence symptoms after prolonged periods of ingestion of the drug (Experiments 1, 3 and 4).</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Leite, José Roberto</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Carlini, E. 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7.3994074 |