Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development
Abstract The effects of the oral administration of imipramine (IM) or clomipramine (CIM) in adult female rats before pregnancy or during nursing were evaluated. IM caused a significant decrease of body weight in both groups of animals and affected the body weight of litters when administered during...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1978 |
|---|
| Umfang: |
9 |
|---|
| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
|---|---|
| Übergeordnetes Werk: |
in: Psychopharmacology - 1959, 56(1978) vom: Jan., Seite 93-101 |
| Übergeordnetes Werk: |
volume:56 ; year:1978 ; month:01 ; pages:93-101 ; extent:9 |
| Links: |
|---|
| Katalog-ID: |
NLEJ200768514 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ200768514 | ||
| 003 | DE-627 | ||
| 005 | 20230506113318.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 070527s1978 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)NLEJ200768514 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 245 | 1 | 0 | |a Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development |
| 264 | 1 | |c 1978 | |
| 300 | |a 9 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Abstract The effects of the oral administration of imipramine (IM) or clomipramine (CIM) in adult female rats before pregnancy or during nursing were evaluated. IM caused a significant decrease of body weight in both groups of animals and affected the body weight of litters when administered during nursing. CIM reduced the increase of weight in the mothers throughout the experiment. Both IM and CIM decreased water and food intake and locomotor activity of the adult rats. Rats treated during nursing with IM showed decreased maternal behavior at various times of treatment. The milk intake of pups from drug-treated mothers also decreased. Pup eyeopening was delayed by CIM both before pregnancy and during nursing and by IM treatment during nursing. Vaginal opening was retarded in female litters from mothers treated during nursing. Openfield behavior showed modifications at 60 days of age in male pups from mothers exposed to IM during nursing. Results indicate that the two tricyclic drugs were able to produce general and behavioral modifications in both mothers and their litters. These modifications seem to depend on whether the drug is given before pregnancy or during nursing. Control experiments in dams fed with a restricted diet suggest that the observed alterations in maternal behavior and litter development is not due to the undernourishment caused by drug administration. | ||
| 533 | |f Springer Online Journal Archives 1860-2002 | ||
| 700 | 1 | |a Broitman, Susana T. |4 oth | |
| 700 | 1 | |a Donoso, A. O. |4 oth | |
| 773 | 0 | 8 | |i in |t Psychopharmacology |d 1959 |g 56(1978) vom: Jan., Seite 93-101 |w (DE-627)NLEJ188990615 |w (DE-600)2066933-1 |x 1432-2072 |7 nnns |
| 773 | 1 | 8 | |g volume:56 |g year:1978 |g month:01 |g pages:93-101 |g extent:9 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/BF00571415 |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-SOJ | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 56 |j 1978 |c 1 |h 93-101 |g 9 | ||
| matchkey_str |
article:14322072:1978----::fetocrncmpaiencoirmnoaamnsrtoomtrabh |
|---|---|
| hierarchy_sort_str |
1978 |
| publishDate |
1978 |
| allfields |
(DE-627)NLEJ200768514 DE-627 ger DE-627 rakwb eng Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development 1978 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of the oral administration of imipramine (IM) or clomipramine (CIM) in adult female rats before pregnancy or during nursing were evaluated. IM caused a significant decrease of body weight in both groups of animals and affected the body weight of litters when administered during nursing. CIM reduced the increase of weight in the mothers throughout the experiment. Both IM and CIM decreased water and food intake and locomotor activity of the adult rats. Rats treated during nursing with IM showed decreased maternal behavior at various times of treatment. The milk intake of pups from drug-treated mothers also decreased. Pup eyeopening was delayed by CIM both before pregnancy and during nursing and by IM treatment during nursing. Vaginal opening was retarded in female litters from mothers treated during nursing. Openfield behavior showed modifications at 60 days of age in male pups from mothers exposed to IM during nursing. Results indicate that the two tricyclic drugs were able to produce general and behavioral modifications in both mothers and their litters. These modifications seem to depend on whether the drug is given before pregnancy or during nursing. Control experiments in dams fed with a restricted diet suggest that the observed alterations in maternal behavior and litter development is not due to the undernourishment caused by drug administration. Springer Online Journal Archives 1860-2002 Broitman, Susana T. oth Donoso, A. O. oth in Psychopharmacology 1959 56(1978) vom: Jan., Seite 93-101 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:56 year:1978 month:01 pages:93-101 extent:9 http://dx.doi.org/10.1007/BF00571415 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 56 1978 1 93-101 9 |
| spelling |
(DE-627)NLEJ200768514 DE-627 ger DE-627 rakwb eng Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development 1978 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of the oral administration of imipramine (IM) or clomipramine (CIM) in adult female rats before pregnancy or during nursing were evaluated. IM caused a significant decrease of body weight in both groups of animals and affected the body weight of litters when administered during nursing. CIM reduced the increase of weight in the mothers throughout the experiment. Both IM and CIM decreased water and food intake and locomotor activity of the adult rats. Rats treated during nursing with IM showed decreased maternal behavior at various times of treatment. The milk intake of pups from drug-treated mothers also decreased. Pup eyeopening was delayed by CIM both before pregnancy and during nursing and by IM treatment during nursing. Vaginal opening was retarded in female litters from mothers treated during nursing. Openfield behavior showed modifications at 60 days of age in male pups from mothers exposed to IM during nursing. Results indicate that the two tricyclic drugs were able to produce general and behavioral modifications in both mothers and their litters. These modifications seem to depend on whether the drug is given before pregnancy or during nursing. Control experiments in dams fed with a restricted diet suggest that the observed alterations in maternal behavior and litter development is not due to the undernourishment caused by drug administration. Springer Online Journal Archives 1860-2002 Broitman, Susana T. oth Donoso, A. O. oth in Psychopharmacology 1959 56(1978) vom: Jan., Seite 93-101 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:56 year:1978 month:01 pages:93-101 extent:9 http://dx.doi.org/10.1007/BF00571415 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 56 1978 1 93-101 9 |
| allfields_unstemmed |
(DE-627)NLEJ200768514 DE-627 ger DE-627 rakwb eng Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development 1978 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of the oral administration of imipramine (IM) or clomipramine (CIM) in adult female rats before pregnancy or during nursing were evaluated. IM caused a significant decrease of body weight in both groups of animals and affected the body weight of litters when administered during nursing. CIM reduced the increase of weight in the mothers throughout the experiment. Both IM and CIM decreased water and food intake and locomotor activity of the adult rats. Rats treated during nursing with IM showed decreased maternal behavior at various times of treatment. The milk intake of pups from drug-treated mothers also decreased. Pup eyeopening was delayed by CIM both before pregnancy and during nursing and by IM treatment during nursing. Vaginal opening was retarded in female litters from mothers treated during nursing. Openfield behavior showed modifications at 60 days of age in male pups from mothers exposed to IM during nursing. Results indicate that the two tricyclic drugs were able to produce general and behavioral modifications in both mothers and their litters. These modifications seem to depend on whether the drug is given before pregnancy or during nursing. Control experiments in dams fed with a restricted diet suggest that the observed alterations in maternal behavior and litter development is not due to the undernourishment caused by drug administration. Springer Online Journal Archives 1860-2002 Broitman, Susana T. oth Donoso, A. O. oth in Psychopharmacology 1959 56(1978) vom: Jan., Seite 93-101 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:56 year:1978 month:01 pages:93-101 extent:9 http://dx.doi.org/10.1007/BF00571415 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 56 1978 1 93-101 9 |
| allfieldsGer |
(DE-627)NLEJ200768514 DE-627 ger DE-627 rakwb eng Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development 1978 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of the oral administration of imipramine (IM) or clomipramine (CIM) in adult female rats before pregnancy or during nursing were evaluated. IM caused a significant decrease of body weight in both groups of animals and affected the body weight of litters when administered during nursing. CIM reduced the increase of weight in the mothers throughout the experiment. Both IM and CIM decreased water and food intake and locomotor activity of the adult rats. Rats treated during nursing with IM showed decreased maternal behavior at various times of treatment. The milk intake of pups from drug-treated mothers also decreased. Pup eyeopening was delayed by CIM both before pregnancy and during nursing and by IM treatment during nursing. Vaginal opening was retarded in female litters from mothers treated during nursing. Openfield behavior showed modifications at 60 days of age in male pups from mothers exposed to IM during nursing. Results indicate that the two tricyclic drugs were able to produce general and behavioral modifications in both mothers and their litters. These modifications seem to depend on whether the drug is given before pregnancy or during nursing. Control experiments in dams fed with a restricted diet suggest that the observed alterations in maternal behavior and litter development is not due to the undernourishment caused by drug administration. Springer Online Journal Archives 1860-2002 Broitman, Susana T. oth Donoso, A. O. oth in Psychopharmacology 1959 56(1978) vom: Jan., Seite 93-101 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:56 year:1978 month:01 pages:93-101 extent:9 http://dx.doi.org/10.1007/BF00571415 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 56 1978 1 93-101 9 |
| allfieldsSound |
(DE-627)NLEJ200768514 DE-627 ger DE-627 rakwb eng Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development 1978 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of the oral administration of imipramine (IM) or clomipramine (CIM) in adult female rats before pregnancy or during nursing were evaluated. IM caused a significant decrease of body weight in both groups of animals and affected the body weight of litters when administered during nursing. CIM reduced the increase of weight in the mothers throughout the experiment. Both IM and CIM decreased water and food intake and locomotor activity of the adult rats. Rats treated during nursing with IM showed decreased maternal behavior at various times of treatment. The milk intake of pups from drug-treated mothers also decreased. Pup eyeopening was delayed by CIM both before pregnancy and during nursing and by IM treatment during nursing. Vaginal opening was retarded in female litters from mothers treated during nursing. Openfield behavior showed modifications at 60 days of age in male pups from mothers exposed to IM during nursing. Results indicate that the two tricyclic drugs were able to produce general and behavioral modifications in both mothers and their litters. These modifications seem to depend on whether the drug is given before pregnancy or during nursing. Control experiments in dams fed with a restricted diet suggest that the observed alterations in maternal behavior and litter development is not due to the undernourishment caused by drug administration. Springer Online Journal Archives 1860-2002 Broitman, Susana T. oth Donoso, A. O. oth in Psychopharmacology 1959 56(1978) vom: Jan., Seite 93-101 (DE-627)NLEJ188990615 (DE-600)2066933-1 1432-2072 nnns volume:56 year:1978 month:01 pages:93-101 extent:9 http://dx.doi.org/10.1007/BF00571415 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 56 1978 1 93-101 9 |
| language |
English |
| source |
in Psychopharmacology 56(1978) vom: Jan., Seite 93-101 volume:56 year:1978 month:01 pages:93-101 extent:9 |
| sourceStr |
in Psychopharmacology 56(1978) vom: Jan., Seite 93-101 volume:56 year:1978 month:01 pages:93-101 extent:9 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Psychopharmacology |
| authorswithroles_txt_mv |
Broitman, Susana T. @@oth@@ Donoso, A. O. @@oth@@ |
| publishDateDaySort_date |
1978-01-01T00:00:00Z |
| hierarchy_top_id |
NLEJ188990615 |
| id |
NLEJ200768514 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ200768514</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506113318.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1978 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ200768514</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1978</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">9</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The effects of the oral administration of imipramine (IM) or clomipramine (CIM) in adult female rats before pregnancy or during nursing were evaluated. IM caused a significant decrease of body weight in both groups of animals and affected the body weight of litters when administered during nursing. CIM reduced the increase of weight in the mothers throughout the experiment. Both IM and CIM decreased water and food intake and locomotor activity of the adult rats. Rats treated during nursing with IM showed decreased maternal behavior at various times of treatment. The milk intake of pups from drug-treated mothers also decreased. Pup eyeopening was delayed by CIM both before pregnancy and during nursing and by IM treatment during nursing. Vaginal opening was retarded in female litters from mothers treated during nursing. Openfield behavior showed modifications at 60 days of age in male pups from mothers exposed to IM during nursing. Results indicate that the two tricyclic drugs were able to produce general and behavioral modifications in both mothers and their litters. These modifications seem to depend on whether the drug is given before pregnancy or during nursing. Control experiments in dams fed with a restricted diet suggest that the observed alterations in maternal behavior and litter development is not due to the undernourishment caused by drug administration.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Broitman, Susana T.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Donoso, A. O.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Psychopharmacology</subfield><subfield code="d">1959</subfield><subfield code="g">56(1978) vom: Jan., Seite 93-101</subfield><subfield code="w">(DE-627)NLEJ188990615</subfield><subfield code="w">(DE-600)2066933-1</subfield><subfield code="x">1432-2072</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:56</subfield><subfield code="g">year:1978</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:93-101</subfield><subfield code="g">extent:9</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00571415</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">56</subfield><subfield code="j">1978</subfield><subfield code="c">1</subfield><subfield code="h">93-101</subfield><subfield code="g">9</subfield></datafield></record></collection>
|
| series2 |
Springer Online Journal Archives 1860-2002 |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ188990615 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| collection |
NL |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1432-2072 |
| topic_title |
Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
s t b st stb a o d ao aod |
| hierarchy_parent_title |
Psychopharmacology |
| hierarchy_parent_id |
NLEJ188990615 |
| hierarchy_top_title |
Psychopharmacology |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ188990615 (DE-600)2066933-1 |
| title |
Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development |
| spellingShingle |
Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development |
| ctrlnum |
(DE-627)NLEJ200768514 |
| title_full |
Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development |
| journal |
Psychopharmacology |
| journalStr |
Psychopharmacology |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1978 |
| contenttype_str_mv |
zzz |
| container_start_page |
93 |
| container_volume |
56 |
| physical |
9 |
| format_se |
Elektronische Aufsätze |
| title_sort |
effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development |
| title_auth |
Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development |
| abstract |
Abstract The effects of the oral administration of imipramine (IM) or clomipramine (CIM) in adult female rats before pregnancy or during nursing were evaluated. IM caused a significant decrease of body weight in both groups of animals and affected the body weight of litters when administered during nursing. CIM reduced the increase of weight in the mothers throughout the experiment. Both IM and CIM decreased water and food intake and locomotor activity of the adult rats. Rats treated during nursing with IM showed decreased maternal behavior at various times of treatment. The milk intake of pups from drug-treated mothers also decreased. Pup eyeopening was delayed by CIM both before pregnancy and during nursing and by IM treatment during nursing. Vaginal opening was retarded in female litters from mothers treated during nursing. Openfield behavior showed modifications at 60 days of age in male pups from mothers exposed to IM during nursing. Results indicate that the two tricyclic drugs were able to produce general and behavioral modifications in both mothers and their litters. These modifications seem to depend on whether the drug is given before pregnancy or during nursing. Control experiments in dams fed with a restricted diet suggest that the observed alterations in maternal behavior and litter development is not due to the undernourishment caused by drug administration. |
| abstractGer |
Abstract The effects of the oral administration of imipramine (IM) or clomipramine (CIM) in adult female rats before pregnancy or during nursing were evaluated. IM caused a significant decrease of body weight in both groups of animals and affected the body weight of litters when administered during nursing. CIM reduced the increase of weight in the mothers throughout the experiment. Both IM and CIM decreased water and food intake and locomotor activity of the adult rats. Rats treated during nursing with IM showed decreased maternal behavior at various times of treatment. The milk intake of pups from drug-treated mothers also decreased. Pup eyeopening was delayed by CIM both before pregnancy and during nursing and by IM treatment during nursing. Vaginal opening was retarded in female litters from mothers treated during nursing. Openfield behavior showed modifications at 60 days of age in male pups from mothers exposed to IM during nursing. Results indicate that the two tricyclic drugs were able to produce general and behavioral modifications in both mothers and their litters. These modifications seem to depend on whether the drug is given before pregnancy or during nursing. Control experiments in dams fed with a restricted diet suggest that the observed alterations in maternal behavior and litter development is not due to the undernourishment caused by drug administration. |
| abstract_unstemmed |
Abstract The effects of the oral administration of imipramine (IM) or clomipramine (CIM) in adult female rats before pregnancy or during nursing were evaluated. IM caused a significant decrease of body weight in both groups of animals and affected the body weight of litters when administered during nursing. CIM reduced the increase of weight in the mothers throughout the experiment. Both IM and CIM decreased water and food intake and locomotor activity of the adult rats. Rats treated during nursing with IM showed decreased maternal behavior at various times of treatment. The milk intake of pups from drug-treated mothers also decreased. Pup eyeopening was delayed by CIM both before pregnancy and during nursing and by IM treatment during nursing. Vaginal opening was retarded in female litters from mothers treated during nursing. Openfield behavior showed modifications at 60 days of age in male pups from mothers exposed to IM during nursing. Results indicate that the two tricyclic drugs were able to produce general and behavioral modifications in both mothers and their litters. These modifications seem to depend on whether the drug is given before pregnancy or during nursing. Control experiments in dams fed with a restricted diet suggest that the observed alterations in maternal behavior and litter development is not due to the undernourishment caused by drug administration. |
| collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
| title_short |
Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development |
| url |
http://dx.doi.org/10.1007/BF00571415 |
| remote_bool |
true |
| author2 |
Broitman, Susana T. Donoso, A. O. |
| author2Str |
Broitman, Susana T. Donoso, A. O. |
| ppnlink |
NLEJ188990615 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth |
| up_date |
2024-07-06T03:48:53.449Z |
| _version_ |
1803800001589018624 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ200768514</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506113318.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1978 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ200768514</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Effects of chronic imipramine and clomipramine oral administration on maternal behavior and litter development</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1978</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">9</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The effects of the oral administration of imipramine (IM) or clomipramine (CIM) in adult female rats before pregnancy or during nursing were evaluated. IM caused a significant decrease of body weight in both groups of animals and affected the body weight of litters when administered during nursing. CIM reduced the increase of weight in the mothers throughout the experiment. Both IM and CIM decreased water and food intake and locomotor activity of the adult rats. Rats treated during nursing with IM showed decreased maternal behavior at various times of treatment. The milk intake of pups from drug-treated mothers also decreased. Pup eyeopening was delayed by CIM both before pregnancy and during nursing and by IM treatment during nursing. Vaginal opening was retarded in female litters from mothers treated during nursing. Openfield behavior showed modifications at 60 days of age in male pups from mothers exposed to IM during nursing. Results indicate that the two tricyclic drugs were able to produce general and behavioral modifications in both mothers and their litters. These modifications seem to depend on whether the drug is given before pregnancy or during nursing. Control experiments in dams fed with a restricted diet suggest that the observed alterations in maternal behavior and litter development is not due to the undernourishment caused by drug administration.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Broitman, Susana T.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Donoso, A. O.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Psychopharmacology</subfield><subfield code="d">1959</subfield><subfield code="g">56(1978) vom: Jan., Seite 93-101</subfield><subfield code="w">(DE-627)NLEJ188990615</subfield><subfield code="w">(DE-600)2066933-1</subfield><subfield code="x">1432-2072</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:56</subfield><subfield code="g">year:1978</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:93-101</subfield><subfield code="g">extent:9</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00571415</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">56</subfield><subfield code="j">1978</subfield><subfield code="c">1</subfield><subfield code="h">93-101</subfield><subfield code="g">9</subfield></datafield></record></collection>
|
| score |
7.4010077 |