Fully activated potassium current-voltage relationship in the Ranvier node
Abstract The fully activated I–V relation (ĪK) for the potassium current (IK) in the Ranvier node was obtained in two ways: (a) by measuring IK values on stepping to various potentials, at the end of a depolarizing clamp pulse which fully activated IK; (b) by dividing the time dependent change in IK...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
1980 |
|---|
| Umfang: |
8 |
|---|
| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
|---|---|
| Übergeordnetes Werk: |
in: Pflügers Archiv - 1868, 384(1980) vom: Jan., Seite 49-56 |
| Übergeordnetes Werk: |
volume:384 ; year:1980 ; month:01 ; pages:49-56 ; extent:8 |
| Links: |
|---|
| Katalog-ID: |
NLEJ200964224 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ200964224 | ||
| 003 | DE-627 | ||
| 005 | 20210706063925.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 070527s1980 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)NLEJ200964224 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 245 | 1 | 0 | |a Fully activated potassium current-voltage relationship in the Ranvier node |
| 264 | 1 | |c 1980 | |
| 300 | |a 8 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Abstract The fully activated I–V relation (ĪK) for the potassium current (IK) in the Ranvier node was obtained in two ways: (a) by measuring IK values on stepping to various potentials, at the end of a depolarizing clamp pulse which fully activated IK; (b) by dividing the time dependent change in IK seen on depolarizing to a certain potential, by the time dependent change in IK seen on repolarizing from that potential to the holding potential. In solutions of high external [K+], the true ĪK curve (method a) and the current ratio ĪK curve (method b) were similar. At low external [K+], the current ratio ĪK curve was greatly distorted from the true ĪK curve. This discrepancy is attributed to K+ accumulation and depletion just outside the nodal membrane. Using the true ĪK curves, we calculated the distortion of the current ratio ĪK curves expected on the basis of extra-cellular [K+] changes. The magnitude of diffusion barrier between the nodal membrane and the bulk solution which was necessary to give the observed distortion, is attributable to the position of the nodal membrane between the paranodal myelin. These data support the idea that extra-cellular [K+] changes are an important determinant of the magnitude and time course of IK. | ||
| 533 | |f Springer Online Journal Archives 1860-2002 | ||
| 700 | 1 | |a Attwell, David |4 oth | |
| 700 | 1 | |a Dubois, Jean-Marc |4 oth | |
| 700 | 1 | |a Ojeda, Carlos |4 oth | |
| 773 | 0 | 8 | |i in |t Pflügers Archiv |d 1868 |g 384(1980) vom: Jan., Seite 49-56 |w (DE-627)NLEJ188987363 |w (DE-600)1463014-x |x 1432-2013 |7 nnns |
| 773 | 1 | 8 | |g volume:384 |g year:1980 |g month:01 |g pages:49-56 |g extent:8 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/BF00589513 |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-SOJ | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 384 |j 1980 |c 1 |h 49-56 |g 8 | ||
| matchkey_str |
article:14322013:1980----::ulatvtdoasucretotgrltosi |
|---|---|
| hierarchy_sort_str |
1980 |
| publishDate |
1980 |
| allfields |
(DE-627)NLEJ200964224 DE-627 ger DE-627 rakwb eng Fully activated potassium current-voltage relationship in the Ranvier node 1980 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The fully activated I–V relation (ĪK) for the potassium current (IK) in the Ranvier node was obtained in two ways: (a) by measuring IK values on stepping to various potentials, at the end of a depolarizing clamp pulse which fully activated IK; (b) by dividing the time dependent change in IK seen on depolarizing to a certain potential, by the time dependent change in IK seen on repolarizing from that potential to the holding potential. In solutions of high external [K+], the true ĪK curve (method a) and the current ratio ĪK curve (method b) were similar. At low external [K+], the current ratio ĪK curve was greatly distorted from the true ĪK curve. This discrepancy is attributed to K+ accumulation and depletion just outside the nodal membrane. Using the true ĪK curves, we calculated the distortion of the current ratio ĪK curves expected on the basis of extra-cellular [K+] changes. The magnitude of diffusion barrier between the nodal membrane and the bulk solution which was necessary to give the observed distortion, is attributable to the position of the nodal membrane between the paranodal myelin. These data support the idea that extra-cellular [K+] changes are an important determinant of the magnitude and time course of IK. Springer Online Journal Archives 1860-2002 Attwell, David oth Dubois, Jean-Marc oth Ojeda, Carlos oth in Pflügers Archiv 1868 384(1980) vom: Jan., Seite 49-56 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:384 year:1980 month:01 pages:49-56 extent:8 http://dx.doi.org/10.1007/BF00589513 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 384 1980 1 49-56 8 |
| spelling |
(DE-627)NLEJ200964224 DE-627 ger DE-627 rakwb eng Fully activated potassium current-voltage relationship in the Ranvier node 1980 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The fully activated I–V relation (ĪK) for the potassium current (IK) in the Ranvier node was obtained in two ways: (a) by measuring IK values on stepping to various potentials, at the end of a depolarizing clamp pulse which fully activated IK; (b) by dividing the time dependent change in IK seen on depolarizing to a certain potential, by the time dependent change in IK seen on repolarizing from that potential to the holding potential. In solutions of high external [K+], the true ĪK curve (method a) and the current ratio ĪK curve (method b) were similar. At low external [K+], the current ratio ĪK curve was greatly distorted from the true ĪK curve. This discrepancy is attributed to K+ accumulation and depletion just outside the nodal membrane. Using the true ĪK curves, we calculated the distortion of the current ratio ĪK curves expected on the basis of extra-cellular [K+] changes. The magnitude of diffusion barrier between the nodal membrane and the bulk solution which was necessary to give the observed distortion, is attributable to the position of the nodal membrane between the paranodal myelin. These data support the idea that extra-cellular [K+] changes are an important determinant of the magnitude and time course of IK. Springer Online Journal Archives 1860-2002 Attwell, David oth Dubois, Jean-Marc oth Ojeda, Carlos oth in Pflügers Archiv 1868 384(1980) vom: Jan., Seite 49-56 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:384 year:1980 month:01 pages:49-56 extent:8 http://dx.doi.org/10.1007/BF00589513 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 384 1980 1 49-56 8 |
| allfields_unstemmed |
(DE-627)NLEJ200964224 DE-627 ger DE-627 rakwb eng Fully activated potassium current-voltage relationship in the Ranvier node 1980 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The fully activated I–V relation (ĪK) for the potassium current (IK) in the Ranvier node was obtained in two ways: (a) by measuring IK values on stepping to various potentials, at the end of a depolarizing clamp pulse which fully activated IK; (b) by dividing the time dependent change in IK seen on depolarizing to a certain potential, by the time dependent change in IK seen on repolarizing from that potential to the holding potential. In solutions of high external [K+], the true ĪK curve (method a) and the current ratio ĪK curve (method b) were similar. At low external [K+], the current ratio ĪK curve was greatly distorted from the true ĪK curve. This discrepancy is attributed to K+ accumulation and depletion just outside the nodal membrane. Using the true ĪK curves, we calculated the distortion of the current ratio ĪK curves expected on the basis of extra-cellular [K+] changes. The magnitude of diffusion barrier between the nodal membrane and the bulk solution which was necessary to give the observed distortion, is attributable to the position of the nodal membrane between the paranodal myelin. These data support the idea that extra-cellular [K+] changes are an important determinant of the magnitude and time course of IK. Springer Online Journal Archives 1860-2002 Attwell, David oth Dubois, Jean-Marc oth Ojeda, Carlos oth in Pflügers Archiv 1868 384(1980) vom: Jan., Seite 49-56 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:384 year:1980 month:01 pages:49-56 extent:8 http://dx.doi.org/10.1007/BF00589513 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 384 1980 1 49-56 8 |
| allfieldsGer |
(DE-627)NLEJ200964224 DE-627 ger DE-627 rakwb eng Fully activated potassium current-voltage relationship in the Ranvier node 1980 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The fully activated I–V relation (ĪK) for the potassium current (IK) in the Ranvier node was obtained in two ways: (a) by measuring IK values on stepping to various potentials, at the end of a depolarizing clamp pulse which fully activated IK; (b) by dividing the time dependent change in IK seen on depolarizing to a certain potential, by the time dependent change in IK seen on repolarizing from that potential to the holding potential. In solutions of high external [K+], the true ĪK curve (method a) and the current ratio ĪK curve (method b) were similar. At low external [K+], the current ratio ĪK curve was greatly distorted from the true ĪK curve. This discrepancy is attributed to K+ accumulation and depletion just outside the nodal membrane. Using the true ĪK curves, we calculated the distortion of the current ratio ĪK curves expected on the basis of extra-cellular [K+] changes. The magnitude of diffusion barrier between the nodal membrane and the bulk solution which was necessary to give the observed distortion, is attributable to the position of the nodal membrane between the paranodal myelin. These data support the idea that extra-cellular [K+] changes are an important determinant of the magnitude and time course of IK. Springer Online Journal Archives 1860-2002 Attwell, David oth Dubois, Jean-Marc oth Ojeda, Carlos oth in Pflügers Archiv 1868 384(1980) vom: Jan., Seite 49-56 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:384 year:1980 month:01 pages:49-56 extent:8 http://dx.doi.org/10.1007/BF00589513 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 384 1980 1 49-56 8 |
| allfieldsSound |
(DE-627)NLEJ200964224 DE-627 ger DE-627 rakwb eng Fully activated potassium current-voltage relationship in the Ranvier node 1980 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The fully activated I–V relation (ĪK) for the potassium current (IK) in the Ranvier node was obtained in two ways: (a) by measuring IK values on stepping to various potentials, at the end of a depolarizing clamp pulse which fully activated IK; (b) by dividing the time dependent change in IK seen on depolarizing to a certain potential, by the time dependent change in IK seen on repolarizing from that potential to the holding potential. In solutions of high external [K+], the true ĪK curve (method a) and the current ratio ĪK curve (method b) were similar. At low external [K+], the current ratio ĪK curve was greatly distorted from the true ĪK curve. This discrepancy is attributed to K+ accumulation and depletion just outside the nodal membrane. Using the true ĪK curves, we calculated the distortion of the current ratio ĪK curves expected on the basis of extra-cellular [K+] changes. The magnitude of diffusion barrier between the nodal membrane and the bulk solution which was necessary to give the observed distortion, is attributable to the position of the nodal membrane between the paranodal myelin. These data support the idea that extra-cellular [K+] changes are an important determinant of the magnitude and time course of IK. Springer Online Journal Archives 1860-2002 Attwell, David oth Dubois, Jean-Marc oth Ojeda, Carlos oth in Pflügers Archiv 1868 384(1980) vom: Jan., Seite 49-56 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:384 year:1980 month:01 pages:49-56 extent:8 http://dx.doi.org/10.1007/BF00589513 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 384 1980 1 49-56 8 |
| language |
English |
| source |
in Pflügers Archiv 384(1980) vom: Jan., Seite 49-56 volume:384 year:1980 month:01 pages:49-56 extent:8 |
| sourceStr |
in Pflügers Archiv 384(1980) vom: Jan., Seite 49-56 volume:384 year:1980 month:01 pages:49-56 extent:8 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| isfreeaccess_bool |
false |
| container_title |
Pflügers Archiv |
| authorswithroles_txt_mv |
Attwell, David @@oth@@ Dubois, Jean-Marc @@oth@@ Ojeda, Carlos @@oth@@ |
| publishDateDaySort_date |
1980-01-01T00:00:00Z |
| hierarchy_top_id |
NLEJ188987363 |
| id |
NLEJ200964224 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ200964224</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706063925.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1980 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ200964224</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Fully activated potassium current-voltage relationship in the Ranvier node</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1980</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The fully activated I–V relation (ĪK) for the potassium current (IK) in the Ranvier node was obtained in two ways: (a) by measuring IK values on stepping to various potentials, at the end of a depolarizing clamp pulse which fully activated IK; (b) by dividing the time dependent change in IK seen on depolarizing to a certain potential, by the time dependent change in IK seen on repolarizing from that potential to the holding potential. In solutions of high external [K+], the true ĪK curve (method a) and the current ratio ĪK curve (method b) were similar. At low external [K+], the current ratio ĪK curve was greatly distorted from the true ĪK curve. This discrepancy is attributed to K+ accumulation and depletion just outside the nodal membrane. Using the true ĪK curves, we calculated the distortion of the current ratio ĪK curves expected on the basis of extra-cellular [K+] changes. The magnitude of diffusion barrier between the nodal membrane and the bulk solution which was necessary to give the observed distortion, is attributable to the position of the nodal membrane between the paranodal myelin. These data support the idea that extra-cellular [K+] changes are an important determinant of the magnitude and time course of IK.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Attwell, David</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dubois, Jean-Marc</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ojeda, Carlos</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Pflügers Archiv</subfield><subfield code="d">1868</subfield><subfield code="g">384(1980) vom: Jan., Seite 49-56</subfield><subfield code="w">(DE-627)NLEJ188987363</subfield><subfield code="w">(DE-600)1463014-x</subfield><subfield code="x">1432-2013</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:384</subfield><subfield code="g">year:1980</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:49-56</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00589513</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">384</subfield><subfield code="j">1980</subfield><subfield code="c">1</subfield><subfield code="h">49-56</subfield><subfield code="g">8</subfield></datafield></record></collection>
|
| series2 |
Springer Online Journal Archives 1860-2002 |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ188987363 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| collection |
NL |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1432-2013 |
| topic_title |
Fully activated potassium current-voltage relationship in the Ranvier node |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
d a da j m d jmd c o co |
| hierarchy_parent_title |
Pflügers Archiv |
| hierarchy_parent_id |
NLEJ188987363 |
| hierarchy_top_title |
Pflügers Archiv |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ188987363 (DE-600)1463014-x |
| title |
Fully activated potassium current-voltage relationship in the Ranvier node |
| spellingShingle |
Fully activated potassium current-voltage relationship in the Ranvier node |
| ctrlnum |
(DE-627)NLEJ200964224 |
| title_full |
Fully activated potassium current-voltage relationship in the Ranvier node |
| journal |
Pflügers Archiv |
| journalStr |
Pflügers Archiv |
| lang_code |
eng |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1980 |
| contenttype_str_mv |
zzz |
| container_start_page |
49 |
| container_volume |
384 |
| physical |
8 |
| format_se |
Elektronische Aufsätze |
| title_sort |
fully activated potassium current-voltage relationship in the ranvier node |
| title_auth |
Fully activated potassium current-voltage relationship in the Ranvier node |
| abstract |
Abstract The fully activated I–V relation (ĪK) for the potassium current (IK) in the Ranvier node was obtained in two ways: (a) by measuring IK values on stepping to various potentials, at the end of a depolarizing clamp pulse which fully activated IK; (b) by dividing the time dependent change in IK seen on depolarizing to a certain potential, by the time dependent change in IK seen on repolarizing from that potential to the holding potential. In solutions of high external [K+], the true ĪK curve (method a) and the current ratio ĪK curve (method b) were similar. At low external [K+], the current ratio ĪK curve was greatly distorted from the true ĪK curve. This discrepancy is attributed to K+ accumulation and depletion just outside the nodal membrane. Using the true ĪK curves, we calculated the distortion of the current ratio ĪK curves expected on the basis of extra-cellular [K+] changes. The magnitude of diffusion barrier between the nodal membrane and the bulk solution which was necessary to give the observed distortion, is attributable to the position of the nodal membrane between the paranodal myelin. These data support the idea that extra-cellular [K+] changes are an important determinant of the magnitude and time course of IK. |
| abstractGer |
Abstract The fully activated I–V relation (ĪK) for the potassium current (IK) in the Ranvier node was obtained in two ways: (a) by measuring IK values on stepping to various potentials, at the end of a depolarizing clamp pulse which fully activated IK; (b) by dividing the time dependent change in IK seen on depolarizing to a certain potential, by the time dependent change in IK seen on repolarizing from that potential to the holding potential. In solutions of high external [K+], the true ĪK curve (method a) and the current ratio ĪK curve (method b) were similar. At low external [K+], the current ratio ĪK curve was greatly distorted from the true ĪK curve. This discrepancy is attributed to K+ accumulation and depletion just outside the nodal membrane. Using the true ĪK curves, we calculated the distortion of the current ratio ĪK curves expected on the basis of extra-cellular [K+] changes. The magnitude of diffusion barrier between the nodal membrane and the bulk solution which was necessary to give the observed distortion, is attributable to the position of the nodal membrane between the paranodal myelin. These data support the idea that extra-cellular [K+] changes are an important determinant of the magnitude and time course of IK. |
| abstract_unstemmed |
Abstract The fully activated I–V relation (ĪK) for the potassium current (IK) in the Ranvier node was obtained in two ways: (a) by measuring IK values on stepping to various potentials, at the end of a depolarizing clamp pulse which fully activated IK; (b) by dividing the time dependent change in IK seen on depolarizing to a certain potential, by the time dependent change in IK seen on repolarizing from that potential to the holding potential. In solutions of high external [K+], the true ĪK curve (method a) and the current ratio ĪK curve (method b) were similar. At low external [K+], the current ratio ĪK curve was greatly distorted from the true ĪK curve. This discrepancy is attributed to K+ accumulation and depletion just outside the nodal membrane. Using the true ĪK curves, we calculated the distortion of the current ratio ĪK curves expected on the basis of extra-cellular [K+] changes. The magnitude of diffusion barrier between the nodal membrane and the bulk solution which was necessary to give the observed distortion, is attributable to the position of the nodal membrane between the paranodal myelin. These data support the idea that extra-cellular [K+] changes are an important determinant of the magnitude and time course of IK. |
| collection_details |
GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE |
| title_short |
Fully activated potassium current-voltage relationship in the Ranvier node |
| url |
http://dx.doi.org/10.1007/BF00589513 |
| remote_bool |
true |
| author2 |
Attwell, David Dubois, Jean-Marc Ojeda, Carlos |
| author2Str |
Attwell, David Dubois, Jean-Marc Ojeda, Carlos |
| ppnlink |
NLEJ188987363 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth |
| up_date |
2024-07-06T04:23:46.801Z |
| _version_ |
1803802196627685376 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ200964224</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706063925.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1980 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ200964224</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Fully activated potassium current-voltage relationship in the Ranvier node</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1980</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The fully activated I–V relation (ĪK) for the potassium current (IK) in the Ranvier node was obtained in two ways: (a) by measuring IK values on stepping to various potentials, at the end of a depolarizing clamp pulse which fully activated IK; (b) by dividing the time dependent change in IK seen on depolarizing to a certain potential, by the time dependent change in IK seen on repolarizing from that potential to the holding potential. In solutions of high external [K+], the true ĪK curve (method a) and the current ratio ĪK curve (method b) were similar. At low external [K+], the current ratio ĪK curve was greatly distorted from the true ĪK curve. This discrepancy is attributed to K+ accumulation and depletion just outside the nodal membrane. Using the true ĪK curves, we calculated the distortion of the current ratio ĪK curves expected on the basis of extra-cellular [K+] changes. The magnitude of diffusion barrier between the nodal membrane and the bulk solution which was necessary to give the observed distortion, is attributable to the position of the nodal membrane between the paranodal myelin. These data support the idea that extra-cellular [K+] changes are an important determinant of the magnitude and time course of IK.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Attwell, David</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dubois, Jean-Marc</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ojeda, Carlos</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Pflügers Archiv</subfield><subfield code="d">1868</subfield><subfield code="g">384(1980) vom: Jan., Seite 49-56</subfield><subfield code="w">(DE-627)NLEJ188987363</subfield><subfield code="w">(DE-600)1463014-x</subfield><subfield code="x">1432-2013</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:384</subfield><subfield code="g">year:1980</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:49-56</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00589513</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">384</subfield><subfield code="j">1980</subfield><subfield code="c">1</subfield><subfield code="h">49-56</subfield><subfield code="g">8</subfield></datafield></record></collection>
|
| score |
7.3993025 |