Actions of prostaglandins and indomethacin on the electrical and mechanical properties of smooth muscle cells of the guinea-pig ileocecal junction
Abstract The effects of prostaglandins (PGs) and indomethacin on the mechanical and membrane properties of the smooth muscle cells of the guinea-pig ileocecal junction were studied using microelectrode and tension recording techniques and radioimmunoassay to determine levels of PGs. In the guinea-pi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1982 |
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| Umfang: |
8 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Pflügers Archiv - 1868, 394(1982) vom: Apr., Seite 347-354 |
| Übergeordnetes Werk: |
volume:394 ; year:1982 ; month:04 ; pages:347-354 ; extent:8 |
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| 245 | 1 | 0 | |a Actions of prostaglandins and indomethacin on the electrical and mechanical properties of smooth muscle cells of the guinea-pig ileocecal junction |
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| 520 | |a Abstract The effects of prostaglandins (PGs) and indomethacin on the mechanical and membrane properties of the smooth muscle cells of the guinea-pig ileocecal junction were studied using microelectrode and tension recording techniques and radioimmunoassay to determine levels of PGs. In the guinea-pig ileocecal junction, we found two distinct cell populations-cells with, and without spontaneous electrical and mechanical activities. PGs (PGE1, PGE2, PGF2α) in low concentrations suppressed spontaneous mechanical activity. Correspondingly, PGs (>10−7 M) suppressed both spontaneously generated spikes and evoked spikes, presumably due to an increase in the threshold for generation of action potential. On the contrary, indomethacin evoked rhythmic spontaneous contractions in the mechanically quiescent muscle preparations and reduced the PGE and PGF content of the muscle. Spontaneous spike discharges occurred during the indomethacin-induced contractions. The spontaneous electrical and mechanical activities induced by indomethacin were suppressed by PGs, in low concentrations. These results indicate that under physiological conditions, the endogenous PGs in the muscle may play an important role in regulating muscle tone as well as the membrane properties, thereby contributing to the regulation of motility of the intestine and possibly the sphincter. | ||
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(DE-627)NLEJ200971980 DE-627 ger DE-627 rakwb eng Actions of prostaglandins and indomethacin on the electrical and mechanical properties of smooth muscle cells of the guinea-pig ileocecal junction 1982 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of prostaglandins (PGs) and indomethacin on the mechanical and membrane properties of the smooth muscle cells of the guinea-pig ileocecal junction were studied using microelectrode and tension recording techniques and radioimmunoassay to determine levels of PGs. In the guinea-pig ileocecal junction, we found two distinct cell populations-cells with, and without spontaneous electrical and mechanical activities. PGs (PGE1, PGE2, PGF2α) in low concentrations suppressed spontaneous mechanical activity. Correspondingly, PGs (>10−7 M) suppressed both spontaneously generated spikes and evoked spikes, presumably due to an increase in the threshold for generation of action potential. On the contrary, indomethacin evoked rhythmic spontaneous contractions in the mechanically quiescent muscle preparations and reduced the PGE and PGF content of the muscle. Spontaneous spike discharges occurred during the indomethacin-induced contractions. The spontaneous electrical and mechanical activities induced by indomethacin were suppressed by PGs, in low concentrations. These results indicate that under physiological conditions, the endogenous PGs in the muscle may play an important role in regulating muscle tone as well as the membrane properties, thereby contributing to the regulation of motility of the intestine and possibly the sphincter. Springer Online Journal Archives 1860-2002 Kubota, Masayuki oth Ito, Yushi oth Domae, Mariko oth in Pflügers Archiv 1868 394(1982) vom: Apr., Seite 347-354 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:394 year:1982 month:04 pages:347-354 extent:8 http://dx.doi.org/10.1007/BF00583700 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 394 1982 4 347-354 8 |
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(DE-627)NLEJ200971980 DE-627 ger DE-627 rakwb eng Actions of prostaglandins and indomethacin on the electrical and mechanical properties of smooth muscle cells of the guinea-pig ileocecal junction 1982 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of prostaglandins (PGs) and indomethacin on the mechanical and membrane properties of the smooth muscle cells of the guinea-pig ileocecal junction were studied using microelectrode and tension recording techniques and radioimmunoassay to determine levels of PGs. In the guinea-pig ileocecal junction, we found two distinct cell populations-cells with, and without spontaneous electrical and mechanical activities. PGs (PGE1, PGE2, PGF2α) in low concentrations suppressed spontaneous mechanical activity. Correspondingly, PGs (>10−7 M) suppressed both spontaneously generated spikes and evoked spikes, presumably due to an increase in the threshold for generation of action potential. On the contrary, indomethacin evoked rhythmic spontaneous contractions in the mechanically quiescent muscle preparations and reduced the PGE and PGF content of the muscle. Spontaneous spike discharges occurred during the indomethacin-induced contractions. The spontaneous electrical and mechanical activities induced by indomethacin were suppressed by PGs, in low concentrations. These results indicate that under physiological conditions, the endogenous PGs in the muscle may play an important role in regulating muscle tone as well as the membrane properties, thereby contributing to the regulation of motility of the intestine and possibly the sphincter. Springer Online Journal Archives 1860-2002 Kubota, Masayuki oth Ito, Yushi oth Domae, Mariko oth in Pflügers Archiv 1868 394(1982) vom: Apr., Seite 347-354 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:394 year:1982 month:04 pages:347-354 extent:8 http://dx.doi.org/10.1007/BF00583700 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 394 1982 4 347-354 8 |
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(DE-627)NLEJ200971980 DE-627 ger DE-627 rakwb eng Actions of prostaglandins and indomethacin on the electrical and mechanical properties of smooth muscle cells of the guinea-pig ileocecal junction 1982 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of prostaglandins (PGs) and indomethacin on the mechanical and membrane properties of the smooth muscle cells of the guinea-pig ileocecal junction were studied using microelectrode and tension recording techniques and radioimmunoassay to determine levels of PGs. In the guinea-pig ileocecal junction, we found two distinct cell populations-cells with, and without spontaneous electrical and mechanical activities. PGs (PGE1, PGE2, PGF2α) in low concentrations suppressed spontaneous mechanical activity. Correspondingly, PGs (>10−7 M) suppressed both spontaneously generated spikes and evoked spikes, presumably due to an increase in the threshold for generation of action potential. On the contrary, indomethacin evoked rhythmic spontaneous contractions in the mechanically quiescent muscle preparations and reduced the PGE and PGF content of the muscle. Spontaneous spike discharges occurred during the indomethacin-induced contractions. The spontaneous electrical and mechanical activities induced by indomethacin were suppressed by PGs, in low concentrations. These results indicate that under physiological conditions, the endogenous PGs in the muscle may play an important role in regulating muscle tone as well as the membrane properties, thereby contributing to the regulation of motility of the intestine and possibly the sphincter. Springer Online Journal Archives 1860-2002 Kubota, Masayuki oth Ito, Yushi oth Domae, Mariko oth in Pflügers Archiv 1868 394(1982) vom: Apr., Seite 347-354 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:394 year:1982 month:04 pages:347-354 extent:8 http://dx.doi.org/10.1007/BF00583700 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 394 1982 4 347-354 8 |
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(DE-627)NLEJ200971980 DE-627 ger DE-627 rakwb eng Actions of prostaglandins and indomethacin on the electrical and mechanical properties of smooth muscle cells of the guinea-pig ileocecal junction 1982 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of prostaglandins (PGs) and indomethacin on the mechanical and membrane properties of the smooth muscle cells of the guinea-pig ileocecal junction were studied using microelectrode and tension recording techniques and radioimmunoassay to determine levels of PGs. In the guinea-pig ileocecal junction, we found two distinct cell populations-cells with, and without spontaneous electrical and mechanical activities. PGs (PGE1, PGE2, PGF2α) in low concentrations suppressed spontaneous mechanical activity. Correspondingly, PGs (>10−7 M) suppressed both spontaneously generated spikes and evoked spikes, presumably due to an increase in the threshold for generation of action potential. On the contrary, indomethacin evoked rhythmic spontaneous contractions in the mechanically quiescent muscle preparations and reduced the PGE and PGF content of the muscle. Spontaneous spike discharges occurred during the indomethacin-induced contractions. The spontaneous electrical and mechanical activities induced by indomethacin were suppressed by PGs, in low concentrations. These results indicate that under physiological conditions, the endogenous PGs in the muscle may play an important role in regulating muscle tone as well as the membrane properties, thereby contributing to the regulation of motility of the intestine and possibly the sphincter. Springer Online Journal Archives 1860-2002 Kubota, Masayuki oth Ito, Yushi oth Domae, Mariko oth in Pflügers Archiv 1868 394(1982) vom: Apr., Seite 347-354 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:394 year:1982 month:04 pages:347-354 extent:8 http://dx.doi.org/10.1007/BF00583700 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 394 1982 4 347-354 8 |
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(DE-627)NLEJ200971980 DE-627 ger DE-627 rakwb eng Actions of prostaglandins and indomethacin on the electrical and mechanical properties of smooth muscle cells of the guinea-pig ileocecal junction 1982 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The effects of prostaglandins (PGs) and indomethacin on the mechanical and membrane properties of the smooth muscle cells of the guinea-pig ileocecal junction were studied using microelectrode and tension recording techniques and radioimmunoassay to determine levels of PGs. In the guinea-pig ileocecal junction, we found two distinct cell populations-cells with, and without spontaneous electrical and mechanical activities. PGs (PGE1, PGE2, PGF2α) in low concentrations suppressed spontaneous mechanical activity. Correspondingly, PGs (>10−7 M) suppressed both spontaneously generated spikes and evoked spikes, presumably due to an increase in the threshold for generation of action potential. On the contrary, indomethacin evoked rhythmic spontaneous contractions in the mechanically quiescent muscle preparations and reduced the PGE and PGF content of the muscle. Spontaneous spike discharges occurred during the indomethacin-induced contractions. The spontaneous electrical and mechanical activities induced by indomethacin were suppressed by PGs, in low concentrations. These results indicate that under physiological conditions, the endogenous PGs in the muscle may play an important role in regulating muscle tone as well as the membrane properties, thereby contributing to the regulation of motility of the intestine and possibly the sphincter. Springer Online Journal Archives 1860-2002 Kubota, Masayuki oth Ito, Yushi oth Domae, Mariko oth in Pflügers Archiv 1868 394(1982) vom: Apr., Seite 347-354 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:394 year:1982 month:04 pages:347-354 extent:8 http://dx.doi.org/10.1007/BF00583700 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 394 1982 4 347-354 8 |
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actions of prostaglandins and indomethacin on the electrical and mechanical properties of smooth muscle cells of the guinea-pig ileocecal junction |
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Actions of prostaglandins and indomethacin on the electrical and mechanical properties of smooth muscle cells of the guinea-pig ileocecal junction |
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Abstract The effects of prostaglandins (PGs) and indomethacin on the mechanical and membrane properties of the smooth muscle cells of the guinea-pig ileocecal junction were studied using microelectrode and tension recording techniques and radioimmunoassay to determine levels of PGs. In the guinea-pig ileocecal junction, we found two distinct cell populations-cells with, and without spontaneous electrical and mechanical activities. PGs (PGE1, PGE2, PGF2α) in low concentrations suppressed spontaneous mechanical activity. Correspondingly, PGs (>10−7 M) suppressed both spontaneously generated spikes and evoked spikes, presumably due to an increase in the threshold for generation of action potential. On the contrary, indomethacin evoked rhythmic spontaneous contractions in the mechanically quiescent muscle preparations and reduced the PGE and PGF content of the muscle. Spontaneous spike discharges occurred during the indomethacin-induced contractions. The spontaneous electrical and mechanical activities induced by indomethacin were suppressed by PGs, in low concentrations. These results indicate that under physiological conditions, the endogenous PGs in the muscle may play an important role in regulating muscle tone as well as the membrane properties, thereby contributing to the regulation of motility of the intestine and possibly the sphincter. |
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Abstract The effects of prostaglandins (PGs) and indomethacin on the mechanical and membrane properties of the smooth muscle cells of the guinea-pig ileocecal junction were studied using microelectrode and tension recording techniques and radioimmunoassay to determine levels of PGs. In the guinea-pig ileocecal junction, we found two distinct cell populations-cells with, and without spontaneous electrical and mechanical activities. PGs (PGE1, PGE2, PGF2α) in low concentrations suppressed spontaneous mechanical activity. Correspondingly, PGs (>10−7 M) suppressed both spontaneously generated spikes and evoked spikes, presumably due to an increase in the threshold for generation of action potential. On the contrary, indomethacin evoked rhythmic spontaneous contractions in the mechanically quiescent muscle preparations and reduced the PGE and PGF content of the muscle. Spontaneous spike discharges occurred during the indomethacin-induced contractions. The spontaneous electrical and mechanical activities induced by indomethacin were suppressed by PGs, in low concentrations. These results indicate that under physiological conditions, the endogenous PGs in the muscle may play an important role in regulating muscle tone as well as the membrane properties, thereby contributing to the regulation of motility of the intestine and possibly the sphincter. |
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Abstract The effects of prostaglandins (PGs) and indomethacin on the mechanical and membrane properties of the smooth muscle cells of the guinea-pig ileocecal junction were studied using microelectrode and tension recording techniques and radioimmunoassay to determine levels of PGs. In the guinea-pig ileocecal junction, we found two distinct cell populations-cells with, and without spontaneous electrical and mechanical activities. PGs (PGE1, PGE2, PGF2α) in low concentrations suppressed spontaneous mechanical activity. Correspondingly, PGs (>10−7 M) suppressed both spontaneously generated spikes and evoked spikes, presumably due to an increase in the threshold for generation of action potential. On the contrary, indomethacin evoked rhythmic spontaneous contractions in the mechanically quiescent muscle preparations and reduced the PGE and PGF content of the muscle. Spontaneous spike discharges occurred during the indomethacin-induced contractions. The spontaneous electrical and mechanical activities induced by indomethacin were suppressed by PGs, in low concentrations. These results indicate that under physiological conditions, the endogenous PGs in the muscle may play an important role in regulating muscle tone as well as the membrane properties, thereby contributing to the regulation of motility of the intestine and possibly the sphincter. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ200971980</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706064037.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1982 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ200971980</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Actions of prostaglandins and indomethacin on the electrical and mechanical properties of smooth muscle cells of the guinea-pig ileocecal junction</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1982</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The effects of prostaglandins (PGs) and indomethacin on the mechanical and membrane properties of the smooth muscle cells of the guinea-pig ileocecal junction were studied using microelectrode and tension recording techniques and radioimmunoassay to determine levels of PGs. In the guinea-pig ileocecal junction, we found two distinct cell populations-cells with, and without spontaneous electrical and mechanical activities. PGs (PGE1, PGE2, PGF2α) in low concentrations suppressed spontaneous mechanical activity. Correspondingly, PGs (>10−7 M) suppressed both spontaneously generated spikes and evoked spikes, presumably due to an increase in the threshold for generation of action potential. On the contrary, indomethacin evoked rhythmic spontaneous contractions in the mechanically quiescent muscle preparations and reduced the PGE and PGF content of the muscle. Spontaneous spike discharges occurred during the indomethacin-induced contractions. The spontaneous electrical and mechanical activities induced by indomethacin were suppressed by PGs, in low concentrations. These results indicate that under physiological conditions, the endogenous PGs in the muscle may play an important role in regulating muscle tone as well as the membrane properties, thereby contributing to the regulation of motility of the intestine and possibly the sphincter.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kubota, Masayuki</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ito, Yushi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Domae, Mariko</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Pflügers Archiv</subfield><subfield code="d">1868</subfield><subfield code="g">394(1982) vom: Apr., Seite 347-354</subfield><subfield code="w">(DE-627)NLEJ188987363</subfield><subfield code="w">(DE-600)1463014-x</subfield><subfield code="x">1432-2013</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:394</subfield><subfield code="g">year:1982</subfield><subfield code="g">month:04</subfield><subfield code="g">pages:347-354</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00583700</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">394</subfield><subfield code="j">1982</subfield><subfield code="c">4</subfield><subfield code="h">347-354</subfield><subfield code="g">8</subfield></datafield></record></collection>
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