Electrophysiological function of the delayed rectifier (I K) in bullfrog sympathetic ganglion neurones
Abstract Neurones of the bullfrog sympathetic ganglion exhibit at least 5 distinct K+ currents. Two calcium-dependent K+ currentsI C andI AHP, the delayed rectifierI K, the muscarinic-sensitiveI M and the transient outward currentI A. Each current plays a unique role in controlling the shapes and fi...
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1989 |
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| Umfang: |
5 |
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| Reproduktion: |
Springer Online Journal Archives 1860-2002 |
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| Übergeordnetes Werk: |
in: Pflügers Archiv - 1868, 413(1989) vom: Mai, Seite 482-486 |
| Übergeordnetes Werk: |
volume:413 ; year:1989 ; month:05 ; pages:482-486 ; extent:5 |
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NLEJ200988484 |
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| 245 | 1 | 0 | |a Electrophysiological function of the delayed rectifier (I K) in bullfrog sympathetic ganglion neurones |
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| 520 | |a Abstract Neurones of the bullfrog sympathetic ganglion exhibit at least 5 distinct K+ currents. Two calcium-dependent K+ currentsI C andI AHP, the delayed rectifierI K, the muscarinic-sensitiveI M and the transient outward currentI A. Each current plays a unique role in controlling the shapes and firing patterns of action potentials observed in these neurones. We have found that 3,4-diaminopyridine (DAP) (>0.1 mM) will selectively blockI K andI A. Concentrations as high as 2 mM have no effect onI C,I AHP orI M. SinceI A is mostly inactivated at resting potentials in these cells, DAP can be used to explore the electrophysiological function ofI K. Under normal conditions DAP has no effect on action potential duration or on patterns of repetitive activity. This indicates thatI K is normally not involved in modulating these parameters. WhenI C andI AHP are blocked by removing extracellular calcium, however, inhibition ofI K prolongs action potential duration, reduces a fast afterhypolarization and enhances spike frequency adaptation. WhenI M andI AHP are reduced by barium (1 mM), inhibition ofI K by DAP has smaller effects on action potential duration and atterhyperpolarization amplitude, but still enhances spike frequency adaptation. We conclude that electrophysiological effects of blockingI K are critically dependent on the levels of other K+ currents found in these cells. | ||
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(DE-627)NLEJ200988484 DE-627 ger DE-627 rakwb eng Electrophysiological function of the delayed rectifier (I K) in bullfrog sympathetic ganglion neurones 1989 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Neurones of the bullfrog sympathetic ganglion exhibit at least 5 distinct K+ currents. Two calcium-dependent K+ currentsI C andI AHP, the delayed rectifierI K, the muscarinic-sensitiveI M and the transient outward currentI A. Each current plays a unique role in controlling the shapes and firing patterns of action potentials observed in these neurones. We have found that 3,4-diaminopyridine (DAP) (>0.1 mM) will selectively blockI K andI A. Concentrations as high as 2 mM have no effect onI C,I AHP orI M. SinceI A is mostly inactivated at resting potentials in these cells, DAP can be used to explore the electrophysiological function ofI K. Under normal conditions DAP has no effect on action potential duration or on patterns of repetitive activity. This indicates thatI K is normally not involved in modulating these parameters. WhenI C andI AHP are blocked by removing extracellular calcium, however, inhibition ofI K prolongs action potential duration, reduces a fast afterhypolarization and enhances spike frequency adaptation. WhenI M andI AHP are reduced by barium (1 mM), inhibition ofI K by DAP has smaller effects on action potential duration and atterhyperpolarization amplitude, but still enhances spike frequency adaptation. We conclude that electrophysiological effects of blockingI K are critically dependent on the levels of other K+ currents found in these cells. Springer Online Journal Archives 1860-2002 Goh, Joanne W. oth Kelly, Melanie E. M. oth Pennefather, Peter S. oth in Pflügers Archiv 1868 413(1989) vom: Mai, Seite 482-486 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:413 year:1989 month:05 pages:482-486 extent:5 http://dx.doi.org/10.1007/BF00594177 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 413 1989 5 482-486 5 |
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(DE-627)NLEJ200988484 DE-627 ger DE-627 rakwb eng Electrophysiological function of the delayed rectifier (I K) in bullfrog sympathetic ganglion neurones 1989 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Neurones of the bullfrog sympathetic ganglion exhibit at least 5 distinct K+ currents. Two calcium-dependent K+ currentsI C andI AHP, the delayed rectifierI K, the muscarinic-sensitiveI M and the transient outward currentI A. Each current plays a unique role in controlling the shapes and firing patterns of action potentials observed in these neurones. We have found that 3,4-diaminopyridine (DAP) (>0.1 mM) will selectively blockI K andI A. Concentrations as high as 2 mM have no effect onI C,I AHP orI M. SinceI A is mostly inactivated at resting potentials in these cells, DAP can be used to explore the electrophysiological function ofI K. Under normal conditions DAP has no effect on action potential duration or on patterns of repetitive activity. This indicates thatI K is normally not involved in modulating these parameters. WhenI C andI AHP are blocked by removing extracellular calcium, however, inhibition ofI K prolongs action potential duration, reduces a fast afterhypolarization and enhances spike frequency adaptation. WhenI M andI AHP are reduced by barium (1 mM), inhibition ofI K by DAP has smaller effects on action potential duration and atterhyperpolarization amplitude, but still enhances spike frequency adaptation. We conclude that electrophysiological effects of blockingI K are critically dependent on the levels of other K+ currents found in these cells. Springer Online Journal Archives 1860-2002 Goh, Joanne W. oth Kelly, Melanie E. M. oth Pennefather, Peter S. oth in Pflügers Archiv 1868 413(1989) vom: Mai, Seite 482-486 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:413 year:1989 month:05 pages:482-486 extent:5 http://dx.doi.org/10.1007/BF00594177 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 413 1989 5 482-486 5 |
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(DE-627)NLEJ200988484 DE-627 ger DE-627 rakwb eng Electrophysiological function of the delayed rectifier (I K) in bullfrog sympathetic ganglion neurones 1989 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Neurones of the bullfrog sympathetic ganglion exhibit at least 5 distinct K+ currents. Two calcium-dependent K+ currentsI C andI AHP, the delayed rectifierI K, the muscarinic-sensitiveI M and the transient outward currentI A. Each current plays a unique role in controlling the shapes and firing patterns of action potentials observed in these neurones. We have found that 3,4-diaminopyridine (DAP) (>0.1 mM) will selectively blockI K andI A. Concentrations as high as 2 mM have no effect onI C,I AHP orI M. SinceI A is mostly inactivated at resting potentials in these cells, DAP can be used to explore the electrophysiological function ofI K. Under normal conditions DAP has no effect on action potential duration or on patterns of repetitive activity. This indicates thatI K is normally not involved in modulating these parameters. WhenI C andI AHP are blocked by removing extracellular calcium, however, inhibition ofI K prolongs action potential duration, reduces a fast afterhypolarization and enhances spike frequency adaptation. WhenI M andI AHP are reduced by barium (1 mM), inhibition ofI K by DAP has smaller effects on action potential duration and atterhyperpolarization amplitude, but still enhances spike frequency adaptation. We conclude that electrophysiological effects of blockingI K are critically dependent on the levels of other K+ currents found in these cells. Springer Online Journal Archives 1860-2002 Goh, Joanne W. oth Kelly, Melanie E. M. oth Pennefather, Peter S. oth in Pflügers Archiv 1868 413(1989) vom: Mai, Seite 482-486 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:413 year:1989 month:05 pages:482-486 extent:5 http://dx.doi.org/10.1007/BF00594177 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 413 1989 5 482-486 5 |
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(DE-627)NLEJ200988484 DE-627 ger DE-627 rakwb eng Electrophysiological function of the delayed rectifier (I K) in bullfrog sympathetic ganglion neurones 1989 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Neurones of the bullfrog sympathetic ganglion exhibit at least 5 distinct K+ currents. Two calcium-dependent K+ currentsI C andI AHP, the delayed rectifierI K, the muscarinic-sensitiveI M and the transient outward currentI A. Each current plays a unique role in controlling the shapes and firing patterns of action potentials observed in these neurones. We have found that 3,4-diaminopyridine (DAP) (>0.1 mM) will selectively blockI K andI A. Concentrations as high as 2 mM have no effect onI C,I AHP orI M. SinceI A is mostly inactivated at resting potentials in these cells, DAP can be used to explore the electrophysiological function ofI K. Under normal conditions DAP has no effect on action potential duration or on patterns of repetitive activity. This indicates thatI K is normally not involved in modulating these parameters. WhenI C andI AHP are blocked by removing extracellular calcium, however, inhibition ofI K prolongs action potential duration, reduces a fast afterhypolarization and enhances spike frequency adaptation. WhenI M andI AHP are reduced by barium (1 mM), inhibition ofI K by DAP has smaller effects on action potential duration and atterhyperpolarization amplitude, but still enhances spike frequency adaptation. We conclude that electrophysiological effects of blockingI K are critically dependent on the levels of other K+ currents found in these cells. Springer Online Journal Archives 1860-2002 Goh, Joanne W. oth Kelly, Melanie E. M. oth Pennefather, Peter S. oth in Pflügers Archiv 1868 413(1989) vom: Mai, Seite 482-486 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:413 year:1989 month:05 pages:482-486 extent:5 http://dx.doi.org/10.1007/BF00594177 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 413 1989 5 482-486 5 |
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(DE-627)NLEJ200988484 DE-627 ger DE-627 rakwb eng Electrophysiological function of the delayed rectifier (I K) in bullfrog sympathetic ganglion neurones 1989 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Neurones of the bullfrog sympathetic ganglion exhibit at least 5 distinct K+ currents. Two calcium-dependent K+ currentsI C andI AHP, the delayed rectifierI K, the muscarinic-sensitiveI M and the transient outward currentI A. Each current plays a unique role in controlling the shapes and firing patterns of action potentials observed in these neurones. We have found that 3,4-diaminopyridine (DAP) (>0.1 mM) will selectively blockI K andI A. Concentrations as high as 2 mM have no effect onI C,I AHP orI M. SinceI A is mostly inactivated at resting potentials in these cells, DAP can be used to explore the electrophysiological function ofI K. Under normal conditions DAP has no effect on action potential duration or on patterns of repetitive activity. This indicates thatI K is normally not involved in modulating these parameters. WhenI C andI AHP are blocked by removing extracellular calcium, however, inhibition ofI K prolongs action potential duration, reduces a fast afterhypolarization and enhances spike frequency adaptation. WhenI M andI AHP are reduced by barium (1 mM), inhibition ofI K by DAP has smaller effects on action potential duration and atterhyperpolarization amplitude, but still enhances spike frequency adaptation. We conclude that electrophysiological effects of blockingI K are critically dependent on the levels of other K+ currents found in these cells. Springer Online Journal Archives 1860-2002 Goh, Joanne W. oth Kelly, Melanie E. M. oth Pennefather, Peter S. oth in Pflügers Archiv 1868 413(1989) vom: Mai, Seite 482-486 (DE-627)NLEJ188987363 (DE-600)1463014-x 1432-2013 nnns volume:413 year:1989 month:05 pages:482-486 extent:5 http://dx.doi.org/10.1007/BF00594177 GBV_USEFLAG_U ZDB-1-SOJ GBV_NL_ARTICLE AR 413 1989 5 482-486 5 |
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Electrophysiological function of the delayed rectifier (I K) in bullfrog sympathetic ganglion neurones |
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Abstract Neurones of the bullfrog sympathetic ganglion exhibit at least 5 distinct K+ currents. Two calcium-dependent K+ currentsI C andI AHP, the delayed rectifierI K, the muscarinic-sensitiveI M and the transient outward currentI A. Each current plays a unique role in controlling the shapes and firing patterns of action potentials observed in these neurones. We have found that 3,4-diaminopyridine (DAP) (>0.1 mM) will selectively blockI K andI A. Concentrations as high as 2 mM have no effect onI C,I AHP orI M. SinceI A is mostly inactivated at resting potentials in these cells, DAP can be used to explore the electrophysiological function ofI K. Under normal conditions DAP has no effect on action potential duration or on patterns of repetitive activity. This indicates thatI K is normally not involved in modulating these parameters. WhenI C andI AHP are blocked by removing extracellular calcium, however, inhibition ofI K prolongs action potential duration, reduces a fast afterhypolarization and enhances spike frequency adaptation. WhenI M andI AHP are reduced by barium (1 mM), inhibition ofI K by DAP has smaller effects on action potential duration and atterhyperpolarization amplitude, but still enhances spike frequency adaptation. We conclude that electrophysiological effects of blockingI K are critically dependent on the levels of other K+ currents found in these cells. |
| abstractGer |
Abstract Neurones of the bullfrog sympathetic ganglion exhibit at least 5 distinct K+ currents. Two calcium-dependent K+ currentsI C andI AHP, the delayed rectifierI K, the muscarinic-sensitiveI M and the transient outward currentI A. Each current plays a unique role in controlling the shapes and firing patterns of action potentials observed in these neurones. We have found that 3,4-diaminopyridine (DAP) (>0.1 mM) will selectively blockI K andI A. Concentrations as high as 2 mM have no effect onI C,I AHP orI M. SinceI A is mostly inactivated at resting potentials in these cells, DAP can be used to explore the electrophysiological function ofI K. Under normal conditions DAP has no effect on action potential duration or on patterns of repetitive activity. This indicates thatI K is normally not involved in modulating these parameters. WhenI C andI AHP are blocked by removing extracellular calcium, however, inhibition ofI K prolongs action potential duration, reduces a fast afterhypolarization and enhances spike frequency adaptation. WhenI M andI AHP are reduced by barium (1 mM), inhibition ofI K by DAP has smaller effects on action potential duration and atterhyperpolarization amplitude, but still enhances spike frequency adaptation. We conclude that electrophysiological effects of blockingI K are critically dependent on the levels of other K+ currents found in these cells. |
| abstract_unstemmed |
Abstract Neurones of the bullfrog sympathetic ganglion exhibit at least 5 distinct K+ currents. Two calcium-dependent K+ currentsI C andI AHP, the delayed rectifierI K, the muscarinic-sensitiveI M and the transient outward currentI A. Each current plays a unique role in controlling the shapes and firing patterns of action potentials observed in these neurones. We have found that 3,4-diaminopyridine (DAP) (>0.1 mM) will selectively blockI K andI A. Concentrations as high as 2 mM have no effect onI C,I AHP orI M. SinceI A is mostly inactivated at resting potentials in these cells, DAP can be used to explore the electrophysiological function ofI K. Under normal conditions DAP has no effect on action potential duration or on patterns of repetitive activity. This indicates thatI K is normally not involved in modulating these parameters. WhenI C andI AHP are blocked by removing extracellular calcium, however, inhibition ofI K prolongs action potential duration, reduces a fast afterhypolarization and enhances spike frequency adaptation. WhenI M andI AHP are reduced by barium (1 mM), inhibition ofI K by DAP has smaller effects on action potential duration and atterhyperpolarization amplitude, but still enhances spike frequency adaptation. We conclude that electrophysiological effects of blockingI K are critically dependent on the levels of other K+ currents found in these cells. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ200988484</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210706064305.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">070527s1989 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ200988484</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Electrophysiological function of the delayed rectifier (I K) in bullfrog sympathetic ganglion neurones</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1989</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">5</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Neurones of the bullfrog sympathetic ganglion exhibit at least 5 distinct K+ currents. Two calcium-dependent K+ currentsI C andI AHP, the delayed rectifierI K, the muscarinic-sensitiveI M and the transient outward currentI A. Each current plays a unique role in controlling the shapes and firing patterns of action potentials observed in these neurones. We have found that 3,4-diaminopyridine (DAP) (>0.1 mM) will selectively blockI K andI A. Concentrations as high as 2 mM have no effect onI C,I AHP orI M. SinceI A is mostly inactivated at resting potentials in these cells, DAP can be used to explore the electrophysiological function ofI K. Under normal conditions DAP has no effect on action potential duration or on patterns of repetitive activity. This indicates thatI K is normally not involved in modulating these parameters. WhenI C andI AHP are blocked by removing extracellular calcium, however, inhibition ofI K prolongs action potential duration, reduces a fast afterhypolarization and enhances spike frequency adaptation. WhenI M andI AHP are reduced by barium (1 mM), inhibition ofI K by DAP has smaller effects on action potential duration and atterhyperpolarization amplitude, but still enhances spike frequency adaptation. We conclude that electrophysiological effects of blockingI K are critically dependent on the levels of other K+ currents found in these cells.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="f">Springer Online Journal Archives 1860-2002</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Goh, Joanne W.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kelly, Melanie E. M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pennefather, Peter S.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">in</subfield><subfield code="t">Pflügers Archiv</subfield><subfield code="d">1868</subfield><subfield code="g">413(1989) vom: Mai, Seite 482-486</subfield><subfield code="w">(DE-627)NLEJ188987363</subfield><subfield code="w">(DE-600)1463014-x</subfield><subfield code="x">1432-2013</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:413</subfield><subfield code="g">year:1989</subfield><subfield code="g">month:05</subfield><subfield code="g">pages:482-486</subfield><subfield code="g">extent:5</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1007/BF00594177</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-SOJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">413</subfield><subfield code="j">1989</subfield><subfield code="c">5</subfield><subfield code="h">482-486</subfield><subfield code="g">5</subfield></datafield></record></collection>
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